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thyroxine and Angiogenesis, Pathologic

thyroxine has been researched along with Angiogenesis, Pathologic in 23 studies

Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.

Research Excerpts

ExcerptRelevanceReference
"The aim was to evaluate tetraiodothyroacetic acid (tetrac), a thyroid hormone analog of L-thyroxin, conjugated to poly(lactic-co-glycolic acid) nanoparticles (T-PLGA-NPs) both in vitro and in vivo for the treatment of drug-resistant breast cancer."7.79Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer. ( Bharali, DJ; Davis, PJ; Mousa, SA; Yalcin, M, 2013)
"These data indicate that the cardiac hypertrophy induced by acute treatment with thyroid hormone precedes the angiogenic process, which probably occurs later."5.33Early cardiac hypertrophy induced by thyroxine is accompanied by an increase in VEGF-A expression but not by an increase in capillary density. ( Anjos-Ramos, L; Barreto-Chaves, ML; Carneiro-Ramos, MS; Diniz, GP; Martins-Silva, J, 2006)
"The aim was to evaluate tetraiodothyroacetic acid (tetrac), a thyroid hormone analog of L-thyroxin, conjugated to poly(lactic-co-glycolic acid) nanoparticles (T-PLGA-NPs) both in vitro and in vivo for the treatment of drug-resistant breast cancer."3.79Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer. ( Bharali, DJ; Davis, PJ; Mousa, SA; Yalcin, M, 2013)
"Human pancreatic cancer cell (PANC-1 and MPanc96) xenografts were established in nude mice, and the effects of tetrac versus Tetrac NP on tumor growth and tumor angiogenesis were determined."1.39Response of human pancreatic cancer cell xenografts to tetraiodothyroacetic acid nanoparticles. ( Bharali, DJ; Davis, FB; Davis, PJ; Lin, HY; Meng, R; Mousa, SA; Stain, SC; Sudha, T; Tang, HY; Yalcin, M, 2013)
"Renal cell carcinoma is the most lethal of the common urologic malignancies, with no available effective therapeutics."1.35Tetraidothyroacetic acid (tetrac) and tetrac nanoparticles inhibit growth of human renal cell carcinoma xenografts. ( Bharali, DJ; Davis, FB; Davis, PJ; Dyskin, E; Hercbergs, A; Lansing, L; Mousa, SA; Mousa, SS; Yalcin, M, 2009)
"These data indicate that the cardiac hypertrophy induced by acute treatment with thyroid hormone precedes the angiogenic process, which probably occurs later."1.33Early cardiac hypertrophy induced by thyroxine is accompanied by an increase in VEGF-A expression but not by an increase in capillary density. ( Anjos-Ramos, L; Barreto-Chaves, ML; Carneiro-Ramos, MS; Diniz, GP; Martins-Silva, J, 2006)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19903 (13.04)18.7374
1990's2 (8.70)18.2507
2000's3 (13.04)29.6817
2010's13 (56.52)24.3611
2020's2 (8.70)2.80

Authors

AuthorsStudies
Schmohl, KA3
Müller, AM2
Nelson, PJ3
Spitzweg, C3
Kim, H1
Koo, HJ2
Ahn, J1
Kim, JY1
Choi, JY1
Lee, KH1
Kim, BT1
Choe, YS2
Sudha, T2
Bharali, DJ5
Sell, S1
Darwish, NHE1
Davis, PJ7
Mousa, SA7
Rajabi, M1
Yalcin, M5
Latteyer, S1
Christoph, S1
Theurer, S1
Hönes, GS1
Schmid, KW1
Führer, D1
Moeller, LC1
Lin, HY3
Meng, R1
Tang, HY1
Davis, FB4
Stain, SC1
Kang, CM1
Lee, S1
Lee, KC1
Oh, YK1
Wechselberger, A1
Rühland, S1
Salb, N1
Schwenk, N1
Heuer, H1
Carlsen, J1
Göke, B1
Corssac, GB1
de Castro, AL1
Tavares, AV1
Campos, C1
Fernandes, RO1
Ortiz, VD1
Siqueira, R1
Fernandes, TR1
Belló-Klein, A1
Araujo, AS1
Tu, Y1
Wang, Y1
Ding, L1
Zhang, J1
Wu, W1
Sabatino, L1
Kusmic, C1
Nicolini, G1
Amato, R1
Casini, G1
Iervasi, G1
Balzan, S1
Hercbergs, A2
Lansing, L2
Dyskin, E2
Mousa, SS2
Bridoux, A1
Hercbergs, AH1
Glinsky, GV1
Glinskii, A1
Ma, J1
SOULAIRAC, A1
CAHN, J1
BARON, J1
Anjos-Ramos, L1
Carneiro-Ramos, MS1
Diniz, GP1
Martins-Silva, J1
Barreto-Chaves, ML1
Leonard, JL1
Ryan, U1
Slavkin, H1
Revel, JP1
Massaro, D1
Gail, D1
Rongish, BJ1
Torry, RJ1
Tomanek, RJ2
Rakusan, K1
Chilian, WM1
Wangler, RD1
Peters, KG1
Marcus, ML1

Reviews

5 reviews available for thyroxine and Angiogenesis, Pathologic

ArticleYear
Thyroid Hormone Effects on Mesenchymal Stem Cell Biology in the Tumour Microenvironment.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2020, Volume: 128, Issue:6-07

    Topics: Animals; Humans; Integrin alphaVbeta3; Mesenchymal Stem Cells; Neoplasms; Neovascularization, Pathol

2020
Tetrac as an anti-angiogenic agent in cancer.
    Endocrine-related cancer, 2019, 06-01, Volume: 26, Issue:6

    Topics: Angiogenesis Inhibitors; Animals; Humans; Mesenchymal Stem Cells; Neoplasms; Neovascularization, Pat

2019
Possible contributions of thyroid hormone replacement to specific behaviors of cancer.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84

    Topics: Animals; Apoptosis; Hormone Replacement Therapy; Humans; Hypothyroidism; Neoplasms; Neovascularizati

2016
Mechanisms of nongenomic actions of thyroid hormone.
    Frontiers in neuroendocrinology, 2008, Volume: 29, Issue:2

    Topics: Actins; Animals; Cell Line, Tumor; Cell Proliferation; Genome; Humans; Integrin alphaVbeta3; Mitogen

2008
Coronary angiogenesis. From morphometry to molecular biology and back.
    Annals of the New York Academy of Sciences, 1995, Mar-27, Volume: 752

    Topics: Aging; Animals; Capillaries; Coronary Vessels; Growth Substances; Heart; Humans; Inflammation; Model

1995

Other Studies

18 other studies available for thyroxine and Angiogenesis, Pathologic

ArticleYear
Synthesis and characterization of
    Bioorganic & medicinal chemistry, 2020, 01-01, Volume: 28, Issue:1

    Topics: Animals; Brain Neoplasms; Carbocyanines; Cells, Cultured; Copper Radioisotopes; Humans; Mice; Mice,

2020
Nanoparticulate Tetrac Inhibits Growth and Vascularity of Glioblastoma Xenografts.
    Hormones & cancer, 2017, Volume: 8, Issue:3

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Hypothyroidism; Inte

2017
Synthesis of new analogs of tetraiodothyroacetic acid (tetrac) as novel angiogenesis inhibitors for treatment of cancer.
    Bioorganic & medicinal chemistry letters, 2018, 04-15, Volume: 28, Issue:7

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Proliferation; Disease Models, Animal;

2018
Thyroxine promotes lung cancer growth in an orthotopic mouse model.
    Endocrine-related cancer, 2019, Volume: 26, Issue:6

    Topics: Animals; Apoptosis; Carcinoma, Lewis Lung; Cell Proliferation; Hypothyroidism; Male; Mice; Mice, Inb

2019
Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer.
    Nanomedicine (London, England), 2013, Volume: 8, Issue:12

    Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxo

2013
Response of human pancreatic cancer cell xenografts to tetraiodothyroacetic acid nanoparticles.
    Hormones & cancer, 2013, Volume: 4, Issue:3

    Topics: Animals; bcl-X Protein; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic

2013
64Cu-Labeled tetraiodothyroacetic acid-conjugated liposomes for PET imaging of tumor angiogenesis.
    Nuclear medicine and biology, 2013, Volume: 40, Issue:8

    Topics: Animals; Cattle; Cell Line, Tumor; Cell Transformation, Neoplastic; Copper Radioisotopes; Drug Stabi

2013
Thyroid hormones and tetrac: new regulators of tumour stroma formation via integrin αvβ3.
    Endocrine-related cancer, 2015, Volume: 22, Issue:6

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Differentia

2015
Thyroid hormones effects on oxidative stress and cardiac remodeling in the right ventricle of infarcted rats.
    Life sciences, 2016, Feb-01, Volume: 146

    Topics: Animals; Echocardiography; Hydrogen Peroxide; Hypertrophy, Right Ventricular; Myocardial Infarction;

2016
Development of a Novel Thyroid Function Fluctuated Animal Model for Thyroid-Associated Ophthalmopathy.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Animals; Body Weight; Disease Models, Animal; Drug Administration Schedule; Endoplasmic Reticulum; G

2016
T3 enhances Ang2 in rat aorta in myocardial I/R: comparison with left ventricle.
    Journal of molecular endocrinology, 2016, Volume: 57, Issue:3

    Topics: Angiopoietin-2; Animals; Aorta; Disease Models, Animal; Echocardiography; Endothelial Cells; Gene Ex

2016
Tetraidothyroacetic acid (tetrac) and tetrac nanoparticles inhibit growth of human renal cell carcinoma xenografts.
    Anticancer research, 2009, Volume: 29, Issue:10

    Topics: Animals; Carcinoma, Renal Cell; Cell Growth Processes; Cell Line, Tumor; Chick Embryo; Chorioallanto

2009
Tetraiodothyroacetic acid (tetrac) and nanoparticulate tetrac arrest growth of medullary carcinoma of the thyroid.
    The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:4

    Topics: Animals; Antineoplastic Agents; Body Weight; Carcinoma, Medullary; Cells, Cultured; Chick Embryo; Ch

2010
[Protective action of D-thyroxin on disorders of ocular vascularization induced in the rabbit by an experimental hypercholesterolemic hyperlipemia].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1963, Jul-10, Volume: 157

    Topics: Animals; Eye; Hypercholesterolemia; Hyperlipidemias; Neovascularization, Pathologic; Rabbits; Retina

1963
Early cardiac hypertrophy induced by thyroxine is accompanied by an increase in VEGF-A expression but not by an increase in capillary density.
    Virchows Archiv : an international journal of pathology, 2006, Volume: 448, Issue:4

    Topics: Animals; Capillaries; Cardiomegaly; Coronary Vessels; Disease Models, Animal; Dose-Response Relation

2006
Conference report: cell-to-cell interactions in the developing lung. Report of a conference held 3-5 June 1984.
    Tissue & cell, 1984, Volume: 16, Issue:6

    Topics: Animals; Blood Vessels; Cell Communication; Cell Differentiation; Dihydrotestosterone; Endothelium;

1984
Coronary neovascularization of embryonic rat hearts cultured in oculo is independent of thyroid hormones.
    The American journal of physiology, 1995, Volume: 268, Issue:2 Pt 2

    Topics: Animals; Antithyroid Agents; Coronary Vessels; Fetal Tissue Transplantation; Heart Transplantation;

1995
Thyroxine-induced left ventricular hypertrophy in the rat. Anatomical and physiological evidence for angiogenesis.
    Circulation research, 1985, Volume: 57, Issue:4

    Topics: Animals; Blood Flow Velocity; Blood Pressure; Body Weight; Capillaries; Cardiomegaly; Coronary Circu

1985