thyroxine has been researched along with Age-Related Memory Disorders in 23 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperthyroidism was induced in rats by daily injections of L-thyroxine (0." | 8.02 | Maternal L-thyroxine treatment during lactation affects learning and anxiety-like behaviors but not spatial memory in adult rat progeny. ( Aşçıoğlu, M; Bakkaloğlu, U; Süer, C; Tan, B, 2021) |
| "The major purpose of this study was to investigate the effect of resveratrol (RES) on the spatial learning and memory ability in subclinical hypothyroidism (SCH) rat model and the potential mechanism." | 7.81 | Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization. ( Chen, FH; Chu, CH; Ge, JF; Li, N; Qin, G; Qiu, GL; Wang, CY; Xu, YY; Zhang, Y, 2015) |
| "In congenital hypothyroidism (CH) it has been questioned whether high dose thyroxine replacement therapy has detrimental effects on memory, attention, and behaviour." | 7.73 | Congenital hypothyroidism: no adverse effects of high dose thyroxine treatment on adult memory, attention, and behaviour. ( Heyerdahl, S; Kase, BF; Oerbeck, B; Sundet, K, 2005) |
| "Hyperthyroidism was induced in rats by daily injections of L-thyroxine (0." | 4.02 | Maternal L-thyroxine treatment during lactation affects learning and anxiety-like behaviors but not spatial memory in adult rat progeny. ( Aşçıoğlu, M; Bakkaloğlu, U; Süer, C; Tan, B, 2021) |
| "The major purpose of this study was to investigate the effect of resveratrol (RES) on the spatial learning and memory ability in subclinical hypothyroidism (SCH) rat model and the potential mechanism." | 3.81 | Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization. ( Chen, FH; Chu, CH; Ge, JF; Li, N; Qin, G; Qiu, GL; Wang, CY; Xu, YY; Zhang, Y, 2015) |
| "In congenital hypothyroidism (CH) it has been questioned whether high dose thyroxine replacement therapy has detrimental effects on memory, attention, and behaviour." | 3.73 | Congenital hypothyroidism: no adverse effects of high dose thyroxine treatment on adult memory, attention, and behaviour. ( Heyerdahl, S; Kase, BF; Oerbeck, B; Sundet, K, 2005) |
| "Associative memory deficits persisted in the overt hypothyroid group." | 2.74 | Evidence for a specific defect in hippocampal memory in overt and subclinical hypothyroidism. ( Boran, G; Cooke, G; Correia, N; Feeney, J; Fitzgibbon, M; Gibney, J; Mullally, S; O'Mara, S; Phelan, N; Tun, TK, 2009) |
| "Overt hypothyroidism has major effects on neuropsychiatric function, but patients with mild hypothyroidism may attribute unrelated neuropsychiatric symptoms to their thyroid condition." | 2.50 | Psychiatric and cognitive manifestations of hypothyroidism. ( Samuels, MH, 2014) |
| "An animal model of the Alzheimer's disease (AD) was established by intracerebroventricular injection of STZ (3 mg/kg) in male Wistar rats (250 ± 50 g)." | 1.56 | Effects of levothyroxine on learning and memory deficits in a rat model of Alzheimer's disease: the role of BDNF and oxidative stress. ( Ashaari, Z; Bafadam, S; Bavarsad, K; Beheshti, F; Hadjzadeh, MA; Hosseini, M; Pakdel, R, 2020) |
| " Functional magnetic resonance imaging (MRI) was performed using a working memory task (n-back task) and neuropsychological tests were performed before and 52-54 days after the induction of subclinical hypothyroidism by reducing the pretest levothyroxine dosage by 30%." | 1.51 | Partial withdrawal of levothyroxine treated disease leads to brain activations and effects on performance in a working memory task: A pilot study. ( Brabant, G; Göbel, A; Goerges, R; Göttlich, M; Heldmann, M; Münte, TF; Nieberding, R; Sartorius, A, 2019) |
| "Hippocampus-based learning and memory deficits are key symptoms of FASD." | 1.48 | Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin. ( Ferreira, A; Lim, PH; Redei, EE; Tunc-Ozcan, E; Wert, SL, 2018) |
| "Age-related cognitive decline has been associated with changes in endogenous hormones and epigenetic modification of chromatin, including histone acetylation." | 1.43 | Accelerated reduction of serum thyroxine and hippocampal histone acetylation links to exacerbation of spatial memory impairment in aged CD-1 mice pubertally exposed to bisphenol-a. ( Cao, L; Chen, GH; Ge, H; Jiang, W; Li, XW; Wang, F; Wu, PC, 2016) |
| "Autoimmune encephalopathy associated with Hashimoto thyroiditis is already known to present with either stroke-like episodes or diffuse progressive deterioration." | 1.38 | A selective memory deficit caused by autoimmune encephalopathy associated with Hashimoto thyroiditis. ( Bonakis, A; Economou, A; Kalfakis, N; Koros, C; Mastorakos, G; Papageorgiou, SG, 2012) |
| "This study shows that thyroxin treatment reverses hypothyroidism-induced impairment of hippocampus-dependent cognition, and L-LTP, probably by restoring the levels of signaling molecule important for these processes." | 1.35 | Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: Behavioral, electrophysiological, and molecular studies. ( Aleisa, AM; Alkadhi, KA; Alzoubi, KH; Gerges, NZ, 2009) |
| "Hypothyroidism was associated with a decrease in retrieval from memory (p = 0." | 1.31 | Hypothyroidism and cognition: preliminary evidence for a specific defect in memory. ( Burmeister, LA; DeKosky, ST; Dodge, HH; Ganguli, M; Nebes, RD; Toczek, T, 2001) |
| "Hypothyroidism was achieved by thyroidectomy, and the 'intruder' stress was used as a model of chronic psychosocial stress." | 1.31 | Combination of hypothyroidism and stress abolishes early LTP in the CA1 but not dentate gyrus of hippocampus of adult rats. ( Alkadhi, KA; Gerges, NZ; Stringer, JL, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (39.13) | 29.6817 |
| 2010's | 11 (47.83) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Sahin, L | 1 |
| Keloglan Müsüroglu, S | 1 |
| Selin Cevik, O | 1 |
| Cevik, K | 1 |
| Orekici Temel, G | 1 |
| Tan, B | 1 |
| Bakkaloğlu, U | 1 |
| Aşçıoğlu, M | 1 |
| Süer, C | 2 |
| Tunc-Ozcan, E | 1 |
| Wert, SL | 1 |
| Lim, PH | 1 |
| Ferreira, A | 1 |
| Redei, EE | 1 |
| Bavarsad, K | 1 |
| Hadjzadeh, MA | 2 |
| Hosseini, M | 2 |
| Pakdel, R | 1 |
| Beheshti, F | 1 |
| Bafadam, S | 1 |
| Ashaari, Z | 1 |
| Göbel, A | 1 |
| Heldmann, M | 1 |
| Göttlich, M | 1 |
| Goerges, R | 1 |
| Nieberding, R | 1 |
| Sartorius, A | 1 |
| Brabant, G | 1 |
| Münte, TF | 1 |
| Seyedhosseini Tamijani, SM | 1 |
| Beirami, E | 1 |
| Ahmadiani, A | 1 |
| Dargahi, L | 1 |
| Moon, JH | 1 |
| Ahn, S | 1 |
| Seo, J | 1 |
| Han, JW | 1 |
| Kim, KM | 1 |
| Choi, SH | 1 |
| Lim, S | 1 |
| Park, YJ | 1 |
| Park, DJ | 1 |
| Kim, KW | 1 |
| Jang, HC | 1 |
| Samuels, MH | 1 |
| Ge, JF | 1 |
| Xu, YY | 1 |
| Li, N | 1 |
| Zhang, Y | 1 |
| Qiu, GL | 1 |
| Chu, CH | 1 |
| Wang, CY | 1 |
| Qin, G | 1 |
| Chen, FH | 1 |
| Jiang, W | 1 |
| Cao, L | 1 |
| Wang, F | 1 |
| Ge, H | 1 |
| Wu, PC | 1 |
| Li, XW | 1 |
| Chen, GH | 1 |
| Alzoubi, KH | 1 |
| Gerges, NZ | 2 |
| Aleisa, AM | 1 |
| Alkadhi, KA | 2 |
| Correia, N | 1 |
| Mullally, S | 1 |
| Cooke, G | 1 |
| Tun, TK | 1 |
| Phelan, N | 1 |
| Feeney, J | 1 |
| Fitzgibbon, M | 1 |
| Boran, G | 1 |
| O'Mara, S | 1 |
| Gibney, J | 1 |
| Dastghaib, SS | 1 |
| Rafatpanah, H | 1 |
| Nahrevanian, H | 1 |
| Farrokhi, I | 1 |
| Taşkın, E | 1 |
| Artis, AS | 1 |
| Bitiktas, S | 1 |
| Dolu, N | 1 |
| Liman, N | 1 |
| Koros, C | 1 |
| Economou, A | 1 |
| Mastorakos, G | 1 |
| Bonakis, A | 1 |
| Kalfakis, N | 1 |
| Papageorgiou, SG | 1 |
| Yin, JJ | 1 |
| Liao, LM | 1 |
| Luo, DX | 1 |
| Xu, K | 1 |
| Ma, SH | 1 |
| Wang, ZX | 2 |
| Le, HB | 1 |
| Huang, RR | 1 |
| Cai, ZL | 1 |
| Zhang, J | 1 |
| Burmeister, LA | 1 |
| Ganguli, M | 1 |
| Dodge, HH | 1 |
| Toczek, T | 1 |
| DeKosky, ST | 1 |
| Nebes, RD | 1 |
| Rekand, T | 1 |
| Vedeler, C | 1 |
| Gramstad, A | 1 |
| Bindoff, L | 1 |
| Oerbeck, B | 1 |
| Sundet, K | 1 |
| Kase, BF | 1 |
| Heyerdahl, S | 1 |
| Regalbuto, C | 1 |
| Alagona, C | 1 |
| Maiorana, R | 1 |
| Di Paola, R | 1 |
| Cianci, M | 1 |
| Alagona, G | 1 |
| Sapienza, S | 1 |
| Vigneri, R | 1 |
| Pezzino, V | 1 |
| Miller, KJ | 1 |
| Parsons, TD | 1 |
| Whybrow, PC | 1 |
| van Herle, K | 1 |
| Rasgon, N | 1 |
| van Herle, A | 1 |
| Martinez, D | 1 |
| Silverman, DH | 1 |
| Bauer, M | 1 |
| Zhu, DF | 1 |
| Zhang, DR | 1 |
| Pan, ZL | 1 |
| He, S | 1 |
| Hu, XP | 1 |
| Chen, XC | 1 |
| Zhou, JN | 1 |
| Stringer, JL | 1 |
1 review available for thyroxine and Age-Related Memory Disorders
| Article | Year |
|---|---|
Psychiatric and cognitive manifestations of hypothyroidism.
Topics: Cognition Disorders; Dose-Response Relationship, Drug; Executive Function; Hormone Replacement Thera | 2014 |
3 trials available for thyroxine and Age-Related Memory Disorders
| Article | Year |
|---|---|
Evidence for a specific defect in hippocampal memory in overt and subclinical hypothyroidism.
Topics: Adult; Aged; Attention; Case-Control Studies; Female; Hippocampus; Hospitals, Teaching; Humans; Hypo | 2009 |
Spatial working memory impairment in subclinical hypothyroidism: an FMRI study.
Topics: Adolescent; Adult; Brain; Female; Functional Neuroimaging; Humans; Hypothyroidism; Magnetic Resonanc | 2013 |
Memory improvement with treatment of hypothyroidism.
Topics: Adolescent; Adult; Analysis of Variance; Female; Follow-Up Studies; Humans; Hypothyroidism; Male; Me | 2006 |
19 other studies available for thyroxine and Age-Related Memory Disorders
| Article | Year |
|---|---|
Hyperthyroidism leads learning and memory impairment possibly via GRIN2B expression alterations.
Topics: Animals; Hippocampus; Hyperthyroidism; Learning; Male; Maze Learning; Memory Disorders; Rats; Thyrox | 2023 |
Maternal L-thyroxine treatment during lactation affects learning and anxiety-like behaviors but not spatial memory in adult rat progeny.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Female; Hippocampus; Hyperthyroidism; La | 2021 |
Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin.
Topics: Alcohol Drinking; Alleles; Animals; Ethanol; Fear; Female; Fetal Alcohol Spectrum Disorders; Hippoca | 2018 |
Effects of levothyroxine on learning and memory deficits in a rat model of Alzheimer's disease: the role of BDNF and oxidative stress.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Brain-Derived Neurotrophic Factor; Disease Models, A | 2020 |
Partial withdrawal of levothyroxine treated disease leads to brain activations and effects on performance in a working memory task: A pilot study.
Topics: Adult; Brain; Female; Humans; Hypothyroidism; Magnetic Resonance Imaging; Male; Memory; Memory Disor | 2019 |
Thyroid hormone treatment alleviates the impairments of neurogenesis, mitochondrial biogenesis and memory performance induced by methamphetamine.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Cognition; Cognition Disorders; Double | 2019 |
The effect of long-term thyroid-stimulating hormone suppressive therapy on the cognitive function of elderly patients with differentiated thyroid carcinoma.
Topics: Aged; Aging; Case-Control Studies; Cell Differentiation; Cognition Disorders; Cross-Sectional Studie | 2014 |
Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization.
Topics: Animals; Antioxidants; Asymptomatic Diseases; Behavior, Animal; Brain-Derived Neurotrophic Factor; D | 2015 |
Accelerated reduction of serum thyroxine and hippocampal histone acetylation links to exacerbation of spatial memory impairment in aged CD-1 mice pubertally exposed to bisphenol-a.
Topics: Acetylation; Aging; Animals; Behavior Rating Scale; Benzhydryl Compounds; Cognitive Dysfunction; Dis | 2016 |
Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: Behavioral, electrophysiological, and molecular studies.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Hippocampus; Hypothyroidism; Learning; Long-Te | 2009 |
Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth.
Topics: Animals; Antithyroid Agents; Female; Hippocampus; Hypothyroidism; Learning Disabilities; Memory Diso | 2010 |
Experimentally induced hyperthyroidism disrupts hippocampal long-term potentiation in adult rats.
Topics: Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Electrophysiological Phenomena; Hipp | 2011 |
A selective memory deficit caused by autoimmune encephalopathy associated with Hashimoto thyroiditis.
Topics: Attention; Brain Diseases; Dexamethasone; Executive Function; Female; Glucocorticoids; Hashimoto Dis | 2012 |
Hypothyroidism and cognition: preliminary evidence for a specific defect in memory.
Topics: Adult; Cognition; Depression; Educational Status; Female; Humans; Hypothyroidism; Male; Memory Disor | 2001 |
Hashimoto's encephalopathy: a treatable cause of mental impairment, stroke and seizures.
Topics: Female; Humans; Memory Disorders; Mental Disorders; Middle Aged; Seizures; Stroke; Thyroiditis, Auto | 2003 |
Congenital hypothyroidism: no adverse effects of high dose thyroxine treatment on adult memory, attention, and behaviour.
Topics: Adult; Analysis of Variance; Attention; Child; Child, Preschool; Congenital Hypothyroidism; Drug Adm | 2005 |
Acute changes in clinical parameters and thyroid function peripheral markers following L-T4 withdrawal in patients totally thyroidectomized for thyroid cancer.
Topics: Adolescent; Adult; Attention; Blood Pressure; Cardiovascular System; Female; Heart Rate; Humans; Hyp | 2006 |
fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism.
Topics: Adolescent; Adult; Brain Mapping; Female; Follow-Up Studies; Frontal Lobe; Humans; Hypothyroidism; M | 2006 |
Combination of hypothyroidism and stress abolishes early LTP in the CA1 but not dentate gyrus of hippocampus of adult rats.
Topics: Animals; Body Weight; Corticosterone; Dentate Gyrus; Electric Stimulation; Excitatory Postsynaptic P | 2001 |