thyroxine has been researched along with Affective Disorders in 30 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although supplementation with supraphysiological doses of levothyroxine (T4) has been an effective treatment for refractory affective disorders in open studies, questions remain as to the tolerability of this treatment." | 9.09 | Subjective response to and tolerability of long-term supraphysiological doses of levothyroxine in refractory mood disorders. ( Bauer, M; Berghöfer, A; Bschor, T; Kiesslinger, U; Priebe, S; Whybrow, PC, 2001) |
| "To investigate long-term effects of adjunctive prophylactic treatment with supraphysiologic doses of levothyroxine (L-T4) on cardiovascular tolerability in 23 patients with treatment-refractory mood disorders." | 7.88 | Long-term treatment with supraphysiologic doses of levothyroxine in treatment-refractory mood disorders - A prospective study of cardiovascular tolerability. ( Bauer, M; Berghöfer, A; Berghöfer, G; Kühnle, Y; Mayer-Pelinski, R; Möckel, M; Pilhatsch, M; Ricken, R; Sauer, C; Whybrow, PC, 2018) |
| "While clinical hypothyroidism is associated with frank neuropsychological and affective alterations and is considered one of the causes of reversible dementia, the occurrence of these alterations and their treatment in mild hypothyroidism (MH) remains a controversial issue." | 5.32 | Cognitive and affective status in mild hypothyroidism and interactions with L-thyroxine treatment. ( Blandini, F; Bono, G; Fancellu, R; Mauri, M; Santoro, G, 2004) |
| "Although supplementation with supraphysiological doses of levothyroxine (T4) has been an effective treatment for refractory affective disorders in open studies, questions remain as to the tolerability of this treatment." | 5.09 | Subjective response to and tolerability of long-term supraphysiological doses of levothyroxine in refractory mood disorders. ( Bauer, M; Berghöfer, A; Bschor, T; Kiesslinger, U; Priebe, S; Whybrow, PC, 2001) |
| "The efficacy resulting from adjunctive use of supraphysiological doses of levothyroxine has emerged as a promising approach to therapy and prophylaxis for refractory mood disorders." | 4.82 | Thyroid, brain and mood modulation in affective disorder: insights from molecular research and functional brain imaging. ( Bauer, M; Kirchheiner, J; London, ED; Rasgon, N; Silverman, DH; Whybrow, PC, 2003) |
| "A prospective cohort study was conducted, in which, patients with differentiated thyroid carcinoma and benign thyroid nodules were given oral L-T4 therapy after surgery, after meeting the criteria of TSH suppression therapy and thyroxine replacement therapy, respectively, the patients were continually given L-T4 therapy for 6 and 12 months, and then, the neuropsychological test was performed." | 3.91 | Naming difficulties after thyroid stimulating hormone suppression therapy in patients with differentiated thyroid carcinoma: a prospective cohort study. ( Ai, JW; Bai, Y; Bao, W; Jin, S; Liu, Y; Yang, YT; Yong, H, 2019) |
| "To investigate long-term effects of adjunctive prophylactic treatment with supraphysiologic doses of levothyroxine (L-T4) on cardiovascular tolerability in 23 patients with treatment-refractory mood disorders." | 3.88 | Long-term treatment with supraphysiologic doses of levothyroxine in treatment-refractory mood disorders - A prospective study of cardiovascular tolerability. ( Bauer, M; Berghöfer, A; Berghöfer, G; Kühnle, Y; Mayer-Pelinski, R; Möckel, M; Pilhatsch, M; Ricken, R; Sauer, C; Whybrow, PC, 2018) |
| "To investigate the long-term effects of supraphysiological, TSH suppressive doses of levothyroxine (TSDL) on bone mineral density (BMD) in patients with affective disorders during an average treatment duration of 69 months." | 3.78 | Long-term treatment with supraphysiological doses of thyroid hormone in affective disorders - effects on bone mineral density. ( Adli, M; Bauer, M; Bermpohl, F; Bschor, T; Mönter, N; Ricken, R; Schlattmann, P, 2012) |
| "Physicians should actively address psychiatric and cognitive aspects of hypothyroidism and in addition to thyroxine offer supportive treatment, especially to those depressed." | 3.71 | [Psychiatric and cognitive aspects of hypothyroidism]. ( Bjerke, SN; Bjøro, T; Heyerdahl, S, 2001) |
| "Serum free thyroxine (FT4) and total thyroxine (TT4) levels were measured at 2-week intervals during the course of hospitalization in 29 male inpatients in the following four diagnostic groups: paranoid schizophrenia (PS); undifferentiated schizophrenia; bipolar I disorder, manic; and major depressive disorder, endogenous type." | 3.67 | Serum thyroxine levels in schizophrenic and affective disorder diagnostic subgroups. ( Giller, EL; Kennedy, JL; Kosten, TR; Mason, JW, 1989) |
| "Overt hypothyroidism has major effects on neuropsychiatric function, but patients with mild hypothyroidism may attribute unrelated neuropsychiatric symptoms to their thyroid condition." | 2.50 | Psychiatric and cognitive manifestations of hypothyroidism. ( Samuels, MH, 2014) |
| "Hypothyroidism impacts aspects of cognitive functioning and mood." | 2.44 | Neuropsychiatric aspects of hypothyroidism and treatment reversibility. . ( Davis, JD; Tremont, G, 2007) |
| "The successful treatment of affective disorders with thyroid hormone exemplifies the suggested inter-relationship between endocrine and neuronal systems in these disorders." | 2.41 | Thyroid hormone, neural tissue and mood modulation. ( Bauer, M; Whybrow, PC, 2001) |
| "Also, depression is assessed with special focus on the two key symptoms: depressed mood and anhedonia." | 1.40 | The HAPPY study (Holistic Approach to Pregnancy and the first Postpartum Year): design of a large prospective cohort study. ( Broeren, MA; Kuppens, SM; Meems, M; Nabbe, KC; Oei, SG; Pop, VJ; Truijens, SE; van Son, MJ; Wijnen, HA, 2014) |
| "While clinical hypothyroidism is associated with frank neuropsychological and affective alterations and is considered one of the causes of reversible dementia, the occurrence of these alterations and their treatment in mild hypothyroidism (MH) remains a controversial issue." | 1.32 | Cognitive and affective status in mild hypothyroidism and interactions with L-thyroxine treatment. ( Blandini, F; Bono, G; Fancellu, R; Mauri, M; Santoro, G, 2004) |
| "Hyperthyroidism was diagnosed when FT4 >1." | 1.31 | High prevalence of thyroid abnormalities in a Chilean psychiatric outpatient population. ( Barroilhet, S; Fardella, C; Figueroa, R; Foradori, A; Gajardo, C; Gloger, S; Salgado, C; Santis, R, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 6 (20.00) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 12 (40.00) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Tufekci, D | 1 |
| Ayaz, T | 1 |
| Sahin, SB | 1 |
| Hocaoglu, C | 1 |
| Romero-Gómez, B | 1 |
| Guerrero-Alonso, P | 1 |
| Carmona-Torres, JM | 1 |
| Notario-Pacheco, B | 1 |
| Cobo-Cuenca, AI | 1 |
| Kuś, A | 1 |
| Kjaergaard, AD | 1 |
| Marouli, E | 1 |
| Del Greco M, F | 1 |
| Sterenborg, RBTM | 1 |
| Chaker, L | 1 |
| Peeters, RP | 1 |
| Bednarczuk, T | 1 |
| Åsvold, BO | 1 |
| Burgess, S | 1 |
| Deloukas, P | 1 |
| Teumer, A | 1 |
| Ellervik, C | 1 |
| Medici, M | 1 |
| Pilhatsch, M | 1 |
| Berghöfer, A | 3 |
| Mayer-Pelinski, R | 1 |
| Berghöfer, G | 1 |
| Ricken, R | 2 |
| Möckel, M | 1 |
| Kühnle, Y | 1 |
| Sauer, C | 1 |
| Whybrow, PC | 4 |
| Bauer, M | 6 |
| Jin, S | 1 |
| Yang, YT | 1 |
| Bao, W | 1 |
| Bai, Y | 1 |
| Ai, JW | 1 |
| Liu, Y | 1 |
| Yong, H | 1 |
| Feng, G | 1 |
| Kang, C | 1 |
| Yuan, J | 1 |
| Zhang, Y | 1 |
| Wei, Y | 1 |
| Xu, L | 1 |
| Zhou, F | 1 |
| Fan, X | 1 |
| Yang, J | 1 |
| Radhakrishnan, R | 1 |
| Calvin, S | 1 |
| Singh, JK | 1 |
| Thomas, B | 1 |
| Srinivasan, K | 1 |
| Samuels, MH | 1 |
| Truijens, SE | 1 |
| Meems, M | 1 |
| Kuppens, SM | 1 |
| Broeren, MA | 1 |
| Nabbe, KC | 1 |
| Wijnen, HA | 1 |
| Oei, SG | 1 |
| van Son, MJ | 1 |
| Pop, VJ | 1 |
| Lombardi, CP | 1 |
| Bocale, R | 1 |
| Barini, A | 2 |
| D'Amore, A | 1 |
| Boscherini, M | 1 |
| Bellantone, R | 1 |
| Zepf, FD | 1 |
| Vloet, TD | 1 |
| Polier, GG | 1 |
| Baurmann, D | 1 |
| Bubenzer, S | 1 |
| Helmbold, K | 1 |
| Gaber, TJ | 1 |
| Schmidt, T | 1 |
| Herpertz-Dahlmann, B | 1 |
| Wöckel, L | 1 |
| Bermpohl, F | 1 |
| Schlattmann, P | 1 |
| Bschor, T | 3 |
| Adli, M | 2 |
| Mönter, N | 1 |
| Jaracz, J | 1 |
| Kucharska, A | 1 |
| Rajewska-Rager, A | 1 |
| Lacka, K | 1 |
| Joffe, RT | 1 |
| Pearce, EN | 1 |
| Hennessey, JV | 1 |
| Ryan, JJ | 1 |
| Stern, RA | 1 |
| Baumgartner, A | 1 |
| Kiesslinger, U | 2 |
| Hellweg, R | 1 |
| Baethge, C | 1 |
| Müller-Oerlinghausen, B | 1 |
| London, ED | 1 |
| Silverman, DH | 1 |
| Rasgon, N | 1 |
| Kirchheiner, J | 1 |
| Bono, G | 1 |
| Fancellu, R | 1 |
| Blandini, F | 1 |
| Santoro, G | 1 |
| Mauri, M | 1 |
| Danilo, Q | 1 |
| Gloger, S | 2 |
| Valdivieso, S | 1 |
| Ivelic, J | 1 |
| Fardella, C | 2 |
| Davis, JD | 1 |
| Tremont, G | 1 |
| Del Zompo, M | 1 |
| Bocchetta, A | 1 |
| Loviselli, A | 1 |
| Martino, E | 1 |
| Post, RM | 2 |
| Ketter, TA | 2 |
| Baldini, IM | 1 |
| Vita, A | 1 |
| Mauri, MC | 1 |
| Amodei, V | 1 |
| Carrisi, M | 1 |
| Bravin, S | 1 |
| Cantalamessa, L | 1 |
| Parekh, PI | 1 |
| Altshuler, L | 1 |
| Frye, MA | 1 |
| Callahan, A | 1 |
| Marangell, L | 1 |
| Deodhar, SD | 1 |
| Singh, B | 1 |
| Pathak, CM | 1 |
| Sharan, P | 1 |
| Kulhara, P | 1 |
| Figueroa, R | 1 |
| Santis, R | 1 |
| Gajardo, C | 1 |
| Salgado, C | 1 |
| Barroilhet, S | 1 |
| Foradori, A | 1 |
| Priebe, S | 1 |
| Bjerke, SN | 1 |
| Bjøro, T | 1 |
| Heyerdahl, S | 1 |
| Szabadi, E | 1 |
| Little, KY | 1 |
| Kearfott, KS | 1 |
| Castellanos, X | 1 |
| Rinker, A | 1 |
| Whitley, R | 1 |
| Mason, JW | 1 |
| Kennedy, JL | 1 |
| Kosten, TR | 1 |
| Giller, EL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Bio-psycho-social Correlates of Psychological Distress in Patients With Graves' Disease in Euthyroid Status[NCT02620085] | 500 participants (Anticipated) | Observational | 2011-07-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for thyroxine and Affective Disorders
| Article | Year |
|---|---|
Psychiatric and cognitive manifestations of hypothyroidism.
Topics: Cognition Disorders; Dose-Response Relationship, Drug; Executive Function; Hormone Replacement Thera | 2014 |
Subclinical hypothyroidism, mood, and cognition in older adults: a review.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Consensus; Hormone Replacement Therapy; Humans; Hypoth | 2013 |
Thyroid hormone, neural tissue and mood modulation.
Topics: Brain; Clinical Trials as Topic; Humans; Mood Disorders; Thyroid Gland; Thyroid Hormones; Thyroxine | 2001 |
Thyroid, brain and mood modulation in affective disorder: insights from molecular research and functional brain imaging.
Topics: Animals; Bipolar Disorder; Brain; Humans; Hypothyroidism; Limbic System; Mood Disorders; Norepinephr | 2003 |
[Mood disorders, psychopharmacology and thyroid hormones].
Topics: Central Nervous System; Drug Interactions; Humans; Hyperthyroidism; Hypothyroidism; Mood Disorders; | 2004 |
Neuropsychiatric aspects of hypothyroidism and treatment reversibility. .
Topics: Adult; Age Factors; Aged; Animals; Autoantibodies; Brain; Cerebrovascular Circulation; Cognition Dis | 2007 |
5 trials available for thyroxine and Affective Disorders
| Article | Year |
|---|---|
Comparative study between the effects of replacement therapy with liquid and tablet formulations of levothyroxine on mood states, self-perceived psychological well-being and thyroid hormone profile in recently thyroidectomized patients.
Topics: Adult; Affect; Drug Compounding; Female; Health Status; Hormone Replacement Therapy; Humans; Insulin | 2017 |
Supraphysiological doses of L-thyroxine in the maintenance treatment of prophylaxis-resistant affective disorders.
Topics: Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug R | 2002 |
Relationships between thyroid hormone and antidepressant responses to total sleep deprivation in mood disorder patients.
Topics: Adult; Depressive Disorder; Female; Humans; Male; Mood Disorders; Psychiatric Status Rating Scales; | 1998 |
Thyroid functions in lithium-treated psychiatric patients: a cross-sectional study.
Topics: Adolescent; Adult; Aged; Cross-Sectional Studies; Female; Humans; Iodine Radioisotopes; Lithium; Mal | 1999 |
Subjective response to and tolerability of long-term supraphysiological doses of levothyroxine in refractory mood disorders.
Topics: Adult; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug | 2001 |
19 other studies available for thyroxine and Affective Disorders
| Article | Year |
|---|---|
The "Non-Treated" Versus "LT3-Treated" Protocols of Short-Term Hypothyroidism Induction in Differentiated Thyroid Cancer: An Analysis of Hypothyroid Complications, Mood Disorders, and Quality of Life.
Topics: Humans; Hypothyroidism; Iodine Radioisotopes; Mood Disorders; Quality of Life; Thyroid Neoplasms; Th | 2023 |
Mood Disorders in Levothyroxine-Treated Hypothyroid Women.
Topics: Adult; Case-Control Studies; Female; Humans; Hypothyroidism; Mood Disorders; Prevalence; Surveys and | 2019 |
Thyroid Function and Mood Disorders: A Mendelian Randomization Study.
Topics: Adult; Bipolar Disorder; Depressive Disorder, Major; Genome-Wide Association Study; Humans; Male; Me | 2021 |
Long-term treatment with supraphysiologic doses of levothyroxine in treatment-refractory mood disorders - A prospective study of cardiovascular tolerability.
Topics: Adult; Affect; Antidepressive Agents; Dose-Response Relationship, Drug; Electrocardiography; Female; | 2018 |
Naming difficulties after thyroid stimulating hormone suppression therapy in patients with differentiated thyroid carcinoma: a prospective cohort study.
Topics: Adult; Anomia; Carcinoma; Cognitive Dysfunction; Female; Hormone Replacement Therapy; Humans; Male; | 2019 |
Neuroendocrine abnormalities associated with untreated first episode patients with major depressive disorder and bipolar disorder.
Topics: Adrenocorticotropic Hormone; Adult; Bipolar Disorder; Depressive Disorder, Major; Endocrine System; | 2019 |
Thyroid dysfunction in major psychiatric disorders in a hospital based sample.
Topics: Adult; Bipolar Disorder; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Mood Di | 2013 |
The HAPPY study (Holistic Approach to Pregnancy and the first Postpartum Year): design of a large prospective cohort study.
Topics: Anhedonia; Autoantibodies; Breast Feeding; Carpal Tunnel Syndrome; Chorionic Gonadotropin; Delivery, | 2014 |
No association between affective and behavioral dysregulation and parameters of thyroid function in youths.
Topics: Adolescent; Adult; Bipolar Disorder; Child; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; M | 2011 |
Long-term treatment with supraphysiological doses of thyroid hormone in affective disorders - effects on bone mineral density.
Topics: Absorptiometry, Photon; Adult; Bone Density; Female; Femur Neck; Follow-Up Studies; Humans; Male; Mi | 2012 |
Cognitive functions and mood during chronic thyrotropin-suppressive therapy with L-thyroxine in patients with differentiated thyroid carcinoma.
Topics: Adenocarcinoma; Adult; Cell Differentiation; Cognition Disorders; Depression; Female; Humans; Hypert | 2012 |
Cognitive and affective status in mild hypothyroidism and interactions with L-thyroxine treatment.
Topics: Adult; Age Factors; Aged; Attention; Cognition Disorders; Depressive Disorder; Female; Homeostasis; | 2004 |
Thyroid function during carbamazepine.
Topics: Carbamazepine; Humans; Hypothyroidism; Mood Disorders; Thyroid Function Tests; Thyroid Hormones; Thy | 1994 |
Psychopathological and cognitive features in subclinical hypothyroidism.
Topics: Adult; Aged; Anxiety; Brief Psychiatric Rating Scale; Cognition Disorders; Depression; Female; Goite | 1997 |
High prevalence of thyroid abnormalities in a Chilean psychiatric outpatient population.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies; Chile; Female; Humans; Hyperthyroidism; Hypo | 2000 |
[Psychiatric and cognitive aspects of hypothyroidism].
Topics: Adult; Anxiety Disorders; Cognition Disorders; Depression; Female; Humans; Hypothyroidism; Male; Men | 2001 |
Thyroid dysfunction and affective illness.
Topics: Humans; Hypothalamo-Hypophyseal System; Mood Disorders; Thyroid Diseases; Thyroid Gland; Thyroxine | 1991 |
Increased detection of elevated TSH using immunoradiometric assay.
Topics: Feeding and Eating Disorders; Humans; Hypothyroidism; Immunoradiometric Assay; Mental Disorders; Moo | 1990 |
Serum thyroxine levels in schizophrenic and affective disorder diagnostic subgroups.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Diagnosis, Differential; Humans; Male; Middle Aged; Mo | 1989 |