thyroxine has been researched along with Adverse Drug Event in 27 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "0%) patients received levothyroxine for hypothyroidism, 24 (8." | 5.30 | Management of anlotinib-related adverse events in patients with advanced non-small cell lung cancer: Experiences in ALTER-0303. ( Chen, W; Cheng, Y; Han, B; Jin, F; Li, K; Luo, Y; Nan, K; Shi, J; Shi, Y; Si, X; Wang, H; Wang, M; Wang, Q; Wang, X; Wang, Z; Zhang, L; Zhang, X, 2019) |
| " Usually only myxedema coma requires levothyroxine parenterally; all other forms of hypothyroidism can be treated with oral levothyroxine." | 4.82 | Thyroid disorders in elderly patients. ( Brzezinski, W; Cope, DW; Rehman, SU; Senseney, AD, 2005) |
| "Of the 200 patients included in the study, 19% developed clinical hypothyroidism (TSH > 10 µIU/mL, or required initiation of or dose increase in levothyroxine)." | 4.12 | Outcomes and Management of Immune Checkpoint Inhibitor-Induced Hypothyroidism: A Retrospective Analysis. ( Phillips, AL; Reeves, DJ, 2022) |
| "A text describing a signal of levothyroxine and panic attacks was tailored to patients' needs, in terms of language, style and content, with emphasis placed on what to do when experiencing the symptoms described." | 3.96 | Communicating Adverse Drug Reaction Insights Through Patient Organizations: Experiences from a Pilot Study in the Netherlands. ( Härmark, L; Meijer, R; Norén, GN; Santoro, F; van Hunsel, F; Weits, G, 2020) |
| "ADR = adverse drug reaction; DHR = drug hypersensitivity reaction; FDA = Food and Drug Administration; LT3 = liothyronine; LT4 = levothyroxine; SCAR = severe cutaneous adverse drug reaction; TRT = thyroid replacement therapy." | 3.96 | Self-Reported Allergy to Thyroid Replacement Therapy: A Multicenter Retrospective Chart Review. ( Bernet, VJ; Carrillo-Martin, I; Chamorro-Pareja, N; Gonzalez-Estrada, A; Haehn, DA; Park, MA; Westphal, SA, 2020) |
| " Positive control was amiodarone and thyroxine, as a marker of amiodarone-induced hypothyroidism, a known adverse event with a clear temporal relationship to amiodarone initiation." | 3.81 | Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries. ( Chan, EW; Choi, NK; Kao Yang, YH; Kimura, M; Kimura, T; Kubota, K; Lai, EC; Man, KK; Ooba, N; Park, BJ; Pratt, N; Roughead, EE; Sato, T; Shin, JY; Wong, IC, 2015) |
| "To compare the therapeutic effect and side effect of the treatments on hyperthyroid exophthalmos with the combination of acupuncture and medication and with medication only." | 2.75 | [Therapeutic effect and side effect of treatment on hyperthyroid exophthalmos with the combination of acupuncture and medication]. ( He, JS; Li, Y; Liu, SM; Shu, S; Xia, Y, 2010) |
| " Despite previously established purity and bioequivalence of the new and old formulations, reports of adverse events substantially increased following reformulation." | 1.62 | Comparison of Safety Profiles of the New and Old Formulations of Levothyroxine in a First Global Introduction in France. ( Castello-Bridoux, C; Channaiah, B; Hildemann, S; Lehnert, H; Martiniere, K; Wémeau, JL, 2021) |
| "Thyroid hormone extract is used for the treatment of thyroid disorders, but limited data exist on adverse events commonly noted by the physicians associated with this use." | 1.46 | ADVERSE EVENT REPORTING IN PATIENTS TREATED WITH THYROID HORMONE EXTRACT. ( Haugen, BR; Hennessey, JV; Levy, EG; Malabanan, A; Shrestha, RT, 2017) |
| " These findings have an important impact on the long-term use of a number of frequently used clinical agents in the treatment of chronic disease with respect to aging and carcinogenesis." | 1.35 | Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation. ( Engel, N; Mahlknecht, U, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (25.93) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 6 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Paixão, P | 1 |
| Guerreiro, RB | 1 |
| Silva, N | 1 |
| Blake, K | 1 |
| Bonelli, M | 1 |
| Morais, JAG | 1 |
| Garcia Arieta, A | 1 |
| Gouveia, LF | 1 |
| Phillips, AL | 1 |
| Reeves, DJ | 1 |
| Doherty, AS | 1 |
| Shahid, F | 1 |
| Moriarty, F | 1 |
| Boland, F | 1 |
| Clyne, B | 1 |
| Dreischulte, T | 1 |
| Fahey, T | 1 |
| Kennelly, SP | 1 |
| Wallace, E | 1 |
| Funazo, TY | 1 |
| Nomizo, T | 1 |
| Ozasa, H | 1 |
| Tsuji, T | 1 |
| Yasuda, Y | 1 |
| Yoshida, H | 1 |
| Sakamori, Y | 1 |
| Nagai, H | 1 |
| Hirai, T | 1 |
| Kim, YH | 1 |
| Härmark, L | 1 |
| Weits, G | 1 |
| Meijer, R | 1 |
| Santoro, F | 1 |
| Norén, GN | 1 |
| van Hunsel, F | 2 |
| Chamorro-Pareja, N | 1 |
| Carrillo-Martin, I | 1 |
| Haehn, DA | 1 |
| Westphal, SA | 1 |
| Park, MA | 1 |
| Bernet, VJ | 1 |
| Gonzalez-Estrada, A | 1 |
| Lehnert, H | 1 |
| Castello-Bridoux, C | 1 |
| Channaiah, B | 1 |
| Martiniere, K | 1 |
| Hildemann, S | 1 |
| Wémeau, JL | 1 |
| Si, X | 1 |
| Zhang, L | 1 |
| Wang, H | 1 |
| Zhang, X | 1 |
| Wang, M | 1 |
| Han, B | 1 |
| Li, K | 1 |
| Wang, Q | 1 |
| Shi, J | 1 |
| Wang, Z | 1 |
| Cheng, Y | 1 |
| Shi, Y | 1 |
| Chen, W | 1 |
| Wang, X | 1 |
| Luo, Y | 1 |
| Nan, K | 1 |
| Jin, F | 1 |
| Pratt, N | 1 |
| Chan, EW | 1 |
| Choi, NK | 1 |
| Kimura, M | 1 |
| Kimura, T | 1 |
| Kubota, K | 1 |
| Lai, EC | 1 |
| Man, KK | 1 |
| Ooba, N | 1 |
| Park, BJ | 1 |
| Sato, T | 1 |
| Shin, JY | 1 |
| Wong, IC | 1 |
| Kao Yang, YH | 1 |
| Roughead, EE | 1 |
| Rolfes, L | 1 |
| Taxis, K | 1 |
| van Puijenbroek, E | 1 |
| Shrestha, RT | 1 |
| Malabanan, A | 1 |
| Haugen, BR | 1 |
| Levy, EG | 1 |
| Hennessey, JV | 1 |
| Xia, Y | 1 |
| Shu, S | 1 |
| Li, Y | 1 |
| Liu, SM | 1 |
| He, JS | 1 |
| SELYE, H | 1 |
| MISHRA, RK | 1 |
| Rehman, SU | 1 |
| Cope, DW | 1 |
| Senseney, AD | 1 |
| Brzezinski, W | 1 |
| Engel, N | 1 |
| Mahlknecht, U | 1 |
| Schimpff, SC | 1 |
| Diggs, CH | 1 |
| Wiswell, JG | 1 |
| Salvatore, PC | 1 |
| Wiernik, PH | 1 |
| Vanderpump, MP | 1 |
| Tunbridge, WM | 1 |
| Wenzel, KW | 1 |
| Ghayad, E | 1 |
| Choueiri Medlej, R | 1 |
| Sapin, R | 1 |
| Schlienger, JL | 1 |
| Drinka, PJ | 1 |
| Muckle, DS | 1 |
| Baruch, AL | 1 |
| Davis, C | 1 |
| Hodkinson, HM | 1 |
| Eipe, J | 1 |
| Twrdy, E | 1 |
| Kuntzman, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Multicenter, Single-arm Clinical Study of the Combination of Anlotinib and Aumolertinib in the First-line Treatment of Advanced Non-small Cell Lung Cancer With EGFR 21L858R Mutation[NCT06102928] | 30 participants (Anticipated) | Interventional | 2023-10-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for thyroxine and Adverse Drug Event
| Article | Year |
|---|---|
Prescribing cascades in community-dwelling adults: A systematic review.
Topics: Acetylcholinesterase; Aged; Antifungal Agents; Antipsychotic Agents; Calcium Channel Blockers; Choli | 2022 |
Thyroid disorders in elderly patients.
Topics: Aged; Antithyroid Agents; Drug-Related Side Effects and Adverse Reactions; Humans; Hyperthyroidism; | 2005 |
The effects of drugs on endocrine function.
Topics: Drug-Related Side Effects and Adverse Reactions; Endocrine Glands; Endocrine System Diseases; Female | 1993 |
Disturbances of thyroid function tests by drugs.
Topics: Amiodarone; Diagnosis, Differential; Drug-Related Side Effects and Adverse Reactions; Humans; Predic | 1996 |
[Changes in thyroid tests in non-thyroid diseases].
Topics: Disease; Drug-Related Side Effects and Adverse Reactions; Humans; Hyperthyroxinemia; Thyroid Hormone | 1996 |
[A functional biologic study of the thyroid: pitfalls to avoid].
Topics: Age Factors; Aged; Child; Drug-Related Side Effects and Adverse Reactions; Humans; Thyroid Diseases; | 1999 |
Drugs affecting therapy with anticoagulants.
Topics: Anticoagulants; Chloramphenicol; Clofibrate; Contraceptives, Oral; Coumarins; Diuretics; Drug Intera | 1972 |
Drugs and enzyme induction.
Topics: Animals; Bilirubin; Blood Proteins; Cytochromes; Drug Synergism; Drug Therapy; Drug-Related Side Eff | 1969 |
2 trials available for thyroxine and Adverse Drug Event
| Article | Year |
|---|---|
Management of anlotinib-related adverse events in patients with advanced non-small cell lung cancer: Experiences in ALTER-0303.
Topics: Adult; Aged; Anaplastic Lymphoma Kinase; Carcinoma, Non-Small-Cell Lung; Drug-Related Side Effects a | 2019 |
[Therapeutic effect and side effect of treatment on hyperthyroid exophthalmos with the combination of acupuncture and medication].
Topics: Acupuncture Points; Acupuncture Therapy; Adult; Combined Modality Therapy; Drug-Related Side Effects | 2010 |
17 other studies available for thyroxine and Adverse Drug Event
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A Proposed Approach for the Determination of the Bioequivalence Acceptance Range for Narrow Therapeutic Index Drugs in the European Union.
Topics: Biological Variation, Individual; Colchicine; Computer Simulation; Cyclosporine; Dose-Response Relat | 2022 |
Outcomes and Management of Immune Checkpoint Inhibitor-Induced Hypothyroidism: A Retrospective Analysis.
Topics: Adult; Disease Progression; Drug-Related Side Effects and Adverse Reactions; Humans; Hypothyroidism; | 2022 |
Clinical impact of low serum free T4 in patients with non-small cell lung cancer treated with nivolumab.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Immunological; B7-H1 Antigen; Biomarkers, Tum | 2019 |
Communicating Adverse Drug Reaction Insights Through Patient Organizations: Experiences from a Pilot Study in the Netherlands.
Topics: Communication; Consumer Organizations; Drug-Related Side Effects and Adverse Reactions; Humans; Inte | 2020 |
Self-Reported Allergy to Thyroid Replacement Therapy: A Multicenter Retrospective Chart Review.
Topics: Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hypersensitivity; Male; Middle Aged | 2020 |
Comparison of Safety Profiles of the New and Old Formulations of Levothyroxine in a First Global Introduction in France.
Topics: Drug Compounding; Drug-Related Side Effects and Adverse Reactions; France; Humans; Retrospective Stu | 2021 |
Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries.
Topics: Adverse Drug Reaction Reporting Systems; Amiodarone; Analysis of Variance; Asia; Australia; Chi-Squa | 2015 |
The Impact of Experiencing Adverse Drug Reactions on the Patient's Quality of Life: A Retrospective Cross-Sectional Study in the Netherlands.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Cross-Sectional Studies; Dr | 2016 |
ADVERSE EVENT REPORTING IN PATIENTS TREATED WITH THYROID HORMONE EXTRACT.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Drug-Related Side Effects and Adverse Reactions; Hor | 2017 |
Protection by thyroxine against intoxication with elementary yellow phosphorus.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Phosphorus; Thyroxine | 1958 |
Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation.
Topics: Adolescent; Adult; Aging; Blood Donors; Cell Fractionation; Cell Survival; Cells, Cultured; Drug-Rel | 2008 |
Radiation-related thyroid dysfunction: implications for the treatment of Hodgkin's disease.
Topics: Adolescent; Adult; Child; Drug-Related Side Effects and Adverse Reactions; Follow-Up Studies; Head a | 1980 |
Abnormal TSH: a rational approach to the older patient.
Topics: Aged; Diagnosis, Differential; Drug-Related Side Effects and Adverse Reactions; Humans; Thyroid Dise | 1999 |
Iatrogenic factors in femoral neck fractures.
Topics: Adrenal Cortex Hormones; Aged; Anticonvulsants; Diuretics; Drug-Related Side Effects and Adverse Rea | 1976 |
Causes of high free-thyroxine index values in sick euthyroid elderly patients.
Topics: Atrial Fibrillation; Digitalis Glycosides; Disease; Diuretics; Drug-Related Side Effects and Adverse | 1976 |
[Diagnosis and therapy of the secondary disease: geriatrics].
Topics: Aged; Central Nervous System Diseases; Cerebrovascular Disorders; Cortisone; Diabetes Mellitus; Digi | 1973 |