thyroxine has been researched along with Abortion, Recurrent in 24 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Compared with placebo, levothyroxine treatment did not result in higher live birth rates in euthyroid women with recurrent pregnancy loss who were positive for TPO-Ab." | 9.51 | Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. ( Bisschop, PH; Broeze, KA; Christiansen, OB; de Bruin, JP; de Koning, CH; de Weerd, S; Fliers, E; Goddijn, M; Hoek, A; Koks, C; Kuchenbecker, WK; Papatsonis, DNM; Sikkema, JM; Torrance, H; van der Hoorn, MP; van der Post, JAM; van Dijk, MM; van Wely, M; Verhoeve, HR; Verpoest, W; Vissenberg, R, 2022) |
| " Of 401 women with a subsequent pregnancy of known outcome at 10 gestational weeks, 21% received treatment with levothyroxine." | 7.96 | Prevalence of thyroid autoimmunity and effect of levothyroxine treatment in a cohort of 1064 patients with recurrent pregnancy loss. ( Abdelhafez, F; Abdelkareem, AO; Bedaiwy, MA; Bloomenthal, D; Iews, M; Leduc-Robert, G; Williams, C, 2020) |
| "Compared with placebo, levothyroxine treatment did not result in higher live birth rates in euthyroid women with recurrent pregnancy loss who were positive for TPO-Ab." | 5.51 | Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. ( Bisschop, PH; Broeze, KA; Christiansen, OB; de Bruin, JP; de Koning, CH; de Weerd, S; Fliers, E; Goddijn, M; Hoek, A; Koks, C; Kuchenbecker, WK; Papatsonis, DNM; Sikkema, JM; Torrance, H; van der Hoorn, MP; van der Post, JAM; van Dijk, MM; van Wely, M; Verhoeve, HR; Verpoest, W; Vissenberg, R, 2022) |
| " The evidence demonstrates that the treatments to consider are first-trimester progesterone administration, levothyroxine in women with subclinical hypothyroidism, and the combination of aspirin and heparin in women with antiphospholipid antibodies." | 5.41 | Interventions to prevent miscarriage. ( Coomarasamy, A; Devall, A; Dhillon-Smith, RK; Fox, E; Kaur, R; Melo, P; Woodhead, N, 2023) |
| "The purpose of this study was to explore if thyroperoxidase antibody positivity impacts thyroid stimulating hormone levels during pregnancies following the index visit and how live birth rate is impacted when treated subclinical hypothyroidism is treated with levothyroxine or not." | 4.12 | Temporal trends in thyroid-stimulating hormone and live birth rate in subclinical hypothyroid patients in a recurrent pregnancy loss population. ( AbdelHafez, FF; Albert, A; Bedaiwy, MA; Jansen, S; Leduc-Robert, G; Mayer, U, 2022) |
| " Of 401 women with a subsequent pregnancy of known outcome at 10 gestational weeks, 21% received treatment with levothyroxine." | 3.96 | Prevalence of thyroid autoimmunity and effect of levothyroxine treatment in a cohort of 1064 patients with recurrent pregnancy loss. ( Abdelhafez, F; Abdelkareem, AO; Bedaiwy, MA; Bloomenthal, D; Iews, M; Leduc-Robert, G; Williams, C, 2020) |
| "Recent studies have associated pregnancy loss with subclinical hypothyroidism, defined as elevated thyroid-stimulating-hormone level, with normal free thyroxine." | 3.79 | Prevalence of subclinical and undiagnosed overt hypothyroidism in a pregnancy loss clinic. ( Joyce, C; Khalid, AS; O'Donoghue, K, 2013) |
| "5 mIU/L with a normal free thyroxine or free thyroxine index); from 2008 onward, levothyroxine treatment prepregnancy to maintain TSH ≤2." | 3.79 | Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss. ( Bernardi, LA; Cohen, RN; Stephenson, MD, 2013) |
| "Thyroxine replacement (50 μg daily during pregnancy) was begun in some patients who tested positive for thyroid peroxidase antibody, irrespective of TSH level." | 3.78 | Thyroid peroxidase antibody in women with unexplained recurrent miscarriage: prevalence, prognostic value, and response to empirical thyroxine therapy. ( Chen, ZJ; Egner, W; Li, TC; Saravelos, SH; Sripada, S; Yan, J, 2012) |
| "A characteristic thyroid test profile is observed in pregnancy; it consists of an elevated serum thyroxine (T4I), thyroxine binding globulin (TBG) and electrophoretic index (EI) with lowered triiodothyronine resin uptake (T3U), the free thyroxine index (FTI) remaining in the normal range." | 3.65 | The predictive value of thyroid "test profile" in habitual abortion. ( Malinek, M; Winikoff, D, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.33) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 5 (20.83) | 24.3611 |
| 2020's | 11 (45.83) | 2.80 |
| Authors | Studies |
|---|---|
| van Dijk, MM | 1 |
| Vissenberg, R | 2 |
| Fliers, E | 2 |
| van der Post, JAM | 1 |
| van der Hoorn, MP | 1 |
| de Weerd, S | 1 |
| Kuchenbecker, WK | 1 |
| Hoek, A | 1 |
| Sikkema, JM | 1 |
| Verhoeve, HR | 1 |
| Broeze, KA | 1 |
| de Koning, CH | 1 |
| Verpoest, W | 1 |
| Christiansen, OB | 1 |
| Koks, C | 1 |
| de Bruin, JP | 1 |
| Papatsonis, DNM | 1 |
| Torrance, H | 1 |
| van Wely, M | 2 |
| Bisschop, PH | 2 |
| Goddijn, M | 2 |
| Korevaar, TIM | 1 |
| Dhillon-Smith, R | 1 |
| Leng, T | 1 |
| Li, X | 1 |
| Zhang, H | 1 |
| Dhillon-Smith, RK | 2 |
| Boelaert, K | 1 |
| Jeve, YB | 1 |
| Maheshwari, A | 1 |
| Coomarasamy, A | 2 |
| Jansen, S | 1 |
| Leduc-Robert, G | 2 |
| AbdelHafez, FF | 1 |
| Albert, A | 1 |
| Mayer, U | 1 |
| Bedaiwy, MA | 2 |
| Yu, M | 1 |
| Long, Y | 1 |
| Wang, Y | 1 |
| Zhang, R | 1 |
| Tao, L | 1 |
| Melo, P | 1 |
| Kaur, R | 1 |
| Fox, E | 1 |
| Devall, A | 1 |
| Woodhead, N | 1 |
| Quan, X | 1 |
| Lan, Y | 1 |
| Yang, X | 1 |
| Iews, M | 1 |
| Abdelkareem, AO | 1 |
| Williams, C | 1 |
| Bloomenthal, D | 1 |
| Abdelhafez, F | 1 |
| Xie, J | 1 |
| Jiang, L | 1 |
| Sadhukhan, A | 1 |
| Yang, S | 1 |
| Yao, Q | 1 |
| Zhou, P | 1 |
| Rao, J | 1 |
| Jin, M | 1 |
| Yoshihara, H | 1 |
| Sugiura-Ogasawara, M | 2 |
| Goto, S | 1 |
| Kitaori, T | 1 |
| Khalid, AS | 1 |
| Joyce, C | 1 |
| O'Donoghue, K | 1 |
| Bernardi, LA | 1 |
| Cohen, RN | 1 |
| Stephenson, MD | 1 |
| Bozic Antic, I | 1 |
| Macut, D | 1 |
| Popovic, B | 1 |
| Isailovic, T | 1 |
| Petakov, M | 1 |
| Ognjanovic, S | 1 |
| Damjanovic, S | 1 |
| van der Post, JA | 1 |
| Gärtner, R | 1 |
| Yan, J | 1 |
| Sripada, S | 1 |
| Saravelos, SH | 1 |
| Chen, ZJ | 1 |
| Egner, W | 1 |
| Li, TC | 1 |
| Kato, K | 1 |
| Mostafa, MH | 1 |
| Mann, K | 1 |
| Schindler, AE | 1 |
| Hoermann, R | 1 |
| Ozaki, Y | 1 |
| Sonta, S | 1 |
| Makino, T | 1 |
| Suzumori, K | 1 |
| Gudakova, NT | 1 |
| Gubaidullina, FN | 1 |
| Pratt, D | 1 |
| Novotny, M | 1 |
| Kaberlein, G | 1 |
| Dudkiewicz, A | 1 |
| Gleicher, N | 1 |
| Roberts, J | 1 |
| Jenkins, C | 1 |
| Wilson, R | 1 |
| Pearson, C | 1 |
| Franklin, IA | 1 |
| MacLean, MA | 1 |
| McKillop, JH | 1 |
| Walker, JJ | 1 |
| Sarkissian, G | 1 |
| Dace, A | 1 |
| Mesmacque, A | 1 |
| Bony-Trifunovic, H | 1 |
| Malezet-Desmoulins, C | 1 |
| Torresani, J | 1 |
| Margotat, A | 1 |
| Winikoff, D | 1 |
| Malinek, M | 1 |
4 reviews available for thyroxine and Abortion, Recurrent
| Article | Year |
|---|---|
Effect of levothyroxine on the pregnancy outcomes in recurrent pregnancy loss women with subclinical hypothyroidism and thyroperoxidase antibody positivity: a systematic review and meta-analysis.
Topics: Abortion, Habitual; Female; Humans; Hypothyroidism; Pregnancy; Pregnancy Outcome; Premature Birth; T | 2023 |
Interventions to prevent miscarriage.
Topics: Abortion, Habitual; Abortion, Spontaneous; Aspirin; Female; Heparin; Humans; Hypothyroidism; Pregnan | 2023 |
Thyroid autoimmunity and future pregnancy outcome in women of recurrent pregnancy loss: a meta-analysis.
Topics: Abortion, Habitual; Autoimmunity; Female; Humans; Pregnancy; Pregnancy Outcome; Prospective Studies; | 2023 |
Effect of antithyroid antibodies on women with recurrent miscarriage: A meta-analysis.
Topics: Abortion, Habitual; Animals; Autoantibodies; Female; Humans; Iodide Peroxidase; Pregnancy; Prevalenc | 2020 |
2 trials available for thyroxine and Abortion, Recurrent
| Article | Year |
|---|---|
Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.
Topics: Abortion, Habitual; Adolescent; Adult; Double-Blind Method; Female; Humans; Immunoglobulin G; Immuno | 2022 |
Levothyroxine treatment for subclinical hypothyroidism improves the rate of live births in pregnant women with recurrent pregnancy loss: a randomized clinical trial.
Topics: Abortion, Habitual; Female; Humans; Hypothyroidism; Live Birth; Pregnancy; Pregnancy Complications; | 2022 |
18 other studies available for thyroxine and Abortion, Recurrent
| Article | Year |
|---|---|
Levothyroxine treatment in euthyroid women positive for thyroid peroxidase antibodies and recurrent pregnancy loss.
Topics: Abortion, Habitual; Female; Humans; Iodide Peroxidase; Pregnancy; Thyroxine | 2022 |
Subclinical hypothyroidism and antithyroid autoantibodies in women with subfertility or recurrent pregnancy loss: Scientific Impact Paper No. 70 June 2022: Scientific Impact Paper No. 70 June 2022.
Topics: Abortion, Habitual; Autoantibodies; Female; Humans; Hypothyroidism; Infertility; Pregnancy; Pregnanc | 2022 |
Temporal trends in thyroid-stimulating hormone and live birth rate in subclinical hypothyroid patients in a recurrent pregnancy loss population.
Topics: Abortion, Habitual; Birth Rate; Female; Humans; Hypothyroidism; Live Birth; Pregnancy; Retrospective | 2022 |
Prevalence of thyroid autoimmunity and effect of levothyroxine treatment in a cohort of 1064 patients with recurrent pregnancy loss.
Topics: Abortion, Habitual; Adult; Autoimmunity; Female; Humans; Hypothyroidism; Pregnancy; Pregnancy Outcom | 2020 |
Levothyroxine and subclinical hypothyroidism in patients with recurrent pregnancy loss.
Topics: Abortion, Habitual; Adult; Asymptomatic Infections; Birth Rate; Cohort Studies; Female; Humans; Hypo | 2021 |
Prevalence of subclinical and undiagnosed overt hypothyroidism in a pregnancy loss clinic.
Topics: Abortion, Habitual; Abortion, Spontaneous; Adolescent; Adult; Ambulatory Care; Case-Control Studies; | 2013 |
Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss.
Topics: Abortion, Habitual; Abortion, Spontaneous; Academic Medical Centers; Adult; Asymptomatic Diseases; B | 2013 |
Recurrent spontaneous abortions, Hashimoto thyroiditis and alopecia totalis: response to anticoagulation and intravenous immunoglobulin therapy.
Topics: Abortion, Habitual; Adult; Alopecia; Anticoagulants; Female; Hashimoto Disease; Humans; Immunoglobul | 2014 |
Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies.
Topics: Abortion, Habitual; Adult; Autoantibodies; Autoantigens; Female; Humans; Iodide Peroxidase; Iron-Bin | 2016 |
[Hashimoto thyreoiditis].
Topics: Abortion, Habitual; Adult; Diagnosis, Differential; Female; Hashimoto Disease; Humans; Pregnancy; Th | 2009 |
Thyroid peroxidase antibody in women with unexplained recurrent miscarriage: prevalence, prognostic value, and response to empirical thyroxine therapy.
Topics: Abortion, Habitual; Adult; Autoantibodies; Biomarkers; Cohort Studies; Female; Humans; Iodide Peroxi | 2012 |
Human chorionic gonadotropin exhibits normal biological activity in patients with recurrent pregnancy loss.
Topics: Abortion, Habitual; Adolescent; Adult; Animals; Case-Control Studies; CHO Cells; Chorionic Gonadotro | 2002 |
Exposure to bisphenol A is associated with recurrent miscarriage.
Topics: Abortion, Habitual; Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Benzhydryl Compoun | 2005 |
[Thyroid function indices in women suffering from habitual abortion].
Topics: Abortion, Habitual; Adult; Female; Humans; Pregnancy; Thyroid Gland; Thyrotropin; Thyroxine | 1982 |
Antithyroid antibodies and the association with non-organ-specific antibodies in recurrent pregnancy loss.
Topics: Abortion, Habitual; Adolescent; Adult; Antibodies, Antiphospholipid; Autoantibodies; Female; Histone | 1993 |
Recurrent miscarriage is associated with increased numbers of CD5/20 positive lymphocytes and an increased incidence of thyroid antibodies.
Topics: Abortion, Habitual; Abortion, Induced; Adult; Antigens, CD20; Autoantibodies; B-Lymphocytes; CD5 Ant | 1996 |
A novel resistance to thyroid hormone associated with a new mutation (T329N) in the thyroid hormone receptor beta gene.
Topics: Abortion, Habitual; Adult; Dextrothyroxine; Dimerization; Female; Humans; Male; Pedigree; Point Muta | 1999 |
The predictive value of thyroid "test profile" in habitual abortion.
Topics: Abortion, Habitual; Female; Humans; Pregnancy; Pregnancy Trimester, First; Thyroid Function Tests; T | 1975 |