thyroxine has been researched along with Abnormalities, Drug-Induced in 31 studies
Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Several studies have shown that exposure to methimazole (MMI) during the first trimester of pregnancy increases the incidence of specific congenital anomalies that are collectively referred to as MMI embryopathy." | 7.81 | Substituting Potassium Iodide for Methimazole as the Treatment for Graves' Disease During the First Trimester May Reduce the Incidence of Congenital Anomalies: A Retrospective Study at a Single Medical Institution in Japan. ( Ito, K; Iwaku, K; Kameda, T; Kobayashi, S; Kunii, Y; Matsumoto, M; Mukasa, K; Noh, JY; Ohye, H; Sugino, K; Suzuki, M; Suzuki, N; Watanabe, N; Yoshihara, A, 2015) |
| "Blood levels of phenytoin, total thyroxine, and free thyroxine were determined in 10 epileptic women during and following pregnancy." | 7.66 | Epilepsy and pregnancy. Serum thyroxine levels during phenytoin therapy. ( Ramsay, RE; Spellacy, WN; Strauss, RG; Wilder, BJ; Willmore, LJ, 1979) |
| " Since propylthiouracil is an equally effective antithyroid agent and has not been associated with ACC, it is the preferred thioamide for hyperthyroidism during pregnancy." | 4.79 | Review of antithyroid drug use during pregnancy and report of a case of aplasia cutis. ( Brent, GA; Larsen, PR; Mandel, SJ, 1994) |
| " Pregnant women with overt and subclinical hypothyroidism should be treated using L-Thyroxine with the bTSH between 1 and 2 mU/l." | 4.79 | [Therapy of hypo- and hyperthyroidism in pregnancy]. ( Lind, P, 1997) |
| " Several studies have shown that exposure to methimazole (MMI) during the first trimester of pregnancy increases the incidence of specific congenital anomalies that are collectively referred to as MMI embryopathy." | 3.81 | Substituting Potassium Iodide for Methimazole as the Treatment for Graves' Disease During the First Trimester May Reduce the Incidence of Congenital Anomalies: A Retrospective Study at a Single Medical Institution in Japan. ( Ito, K; Iwaku, K; Kameda, T; Kobayashi, S; Kunii, Y; Matsumoto, M; Mukasa, K; Noh, JY; Ohye, H; Sugino, K; Suzuki, M; Suzuki, N; Watanabe, N; Yoshihara, A, 2015) |
| "Blood levels of phenytoin, total thyroxine, and free thyroxine were determined in 10 epileptic women during and following pregnancy." | 3.66 | Epilepsy and pregnancy. Serum thyroxine levels during phenytoin therapy. ( Ramsay, RE; Spellacy, WN; Strauss, RG; Wilder, BJ; Willmore, LJ, 1979) |
| "Thyroid diseases are common in women of childbearing age and it is well known that untreated thyroid disturbances result in an increased rate of adverse events, particularly miscarriage, preterm birth and gestational hypertension." | 2.47 | Thyroid disease in pregnancy. ( Mestman, JH; Negro, R, 2011) |
| "Genetic murine models of craniosynostosis exist, but often imperfectly model human patients." | 1.43 | Effects of thyroxine exposure on the Twist 1 +/- phenotype: A test of gene-environment interaction modeling for craniosynostosis. ( Bennfors, G; Black, L; Cray, JJ; Durham, EL; Elsalanty, M; Howie, RN; Parsons, TE; Weinberg, SM; Yu, JC, 2016) |
| " A host of birth defects, including cleft palate, anasarca, ventricular septal defect, and enlargement of the right atrium, were seen in both rats and mice, primarily in the 10 and 20 mg/kg dosage groups, respectively." | 1.32 | Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations. ( Barbee, BD; Butenhoff, JL; Grey, BE; Hanson, RG; Lau, C; Richards, JH; Rogers, JM; Stevenson, LA; Thibodeaux, JR, 2003) |
| "Although exposure to cyanogenic plants or cyanide during pregnancy has adverse effects, no teratological study with cyanide has been conducted in goats or any other ruminant." | 1.32 | Prenatal toxicity of cyanide in goats--a model for teratological studies in ruminants. ( Górniak, SL; Soto-Blanco, B, 2004) |
| "Nitrofen treatment led to decreased plasma T3 and T4 levels without TSH changes." | 1.30 | Thyroid hormones in the pathogenesis of lung hypoplasia and immaturity induced in fetal rats by prenatal exposure to nitrofen. ( Alfonso, LF; Alvarez, FJ; Arnaiz, A; Diez-Pardo, JA; Morreale de Escobar, G; Qi, B; Tovar, JA; Valls-i-Soler, A, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (67.74) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 4 (12.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yoshihara, A | 1 |
| Noh, JY | 1 |
| Watanabe, N | 1 |
| Mukasa, K | 1 |
| Ohye, H | 1 |
| Suzuki, M | 1 |
| Matsumoto, M | 1 |
| Kunii, Y | 1 |
| Suzuki, N | 1 |
| Kameda, T | 1 |
| Iwaku, K | 1 |
| Kobayashi, S | 1 |
| Sugino, K | 1 |
| Ito, K | 1 |
| Durham, EL | 1 |
| Howie, RN | 1 |
| Black, L | 1 |
| Bennfors, G | 1 |
| Parsons, TE | 1 |
| Elsalanty, M | 1 |
| Yu, JC | 1 |
| Weinberg, SM | 1 |
| Cray, JJ | 1 |
| Feng, X | 1 |
| Cao, X | 1 |
| Zhao, S | 1 |
| Wang, X | 1 |
| Hua, X | 1 |
| Chen, L | 2 |
| Negro, R | 1 |
| Mestman, JH | 1 |
| Thibodeaux, JR | 1 |
| Hanson, RG | 1 |
| Rogers, JM | 1 |
| Grey, BE | 1 |
| Barbee, BD | 1 |
| Richards, JH | 1 |
| Butenhoff, JL | 1 |
| Stevenson, LA | 1 |
| Lau, C | 1 |
| FAUCOUNAU, N | 6 |
| STOLL, R | 7 |
| MARAUD, R | 7 |
| COULAUD, H | 3 |
| FRASER, FC | 1 |
| SCANLON, RT | 1 |
| CROUGHS, W | 1 |
| VISSER, HK | 1 |
| Soto-Blanco, B | 1 |
| Górniak, SL | 1 |
| Christie, GA | 1 |
| Miyamoto, S | 1 |
| Gray, LE | 1 |
| Kavlock, RJ | 1 |
| Chernoff, N | 1 |
| Ferrell, J | 1 |
| McLamb, J | 1 |
| Ostby, J | 1 |
| Mandel, SJ | 1 |
| Brent, GA | 1 |
| Larsen, PR | 1 |
| Tovar, JA | 1 |
| Qi, B | 1 |
| Diez-Pardo, JA | 1 |
| Alfonso, LF | 1 |
| Arnaiz, A | 1 |
| Alvarez, FJ | 1 |
| Valls-i-Soler, A | 1 |
| Morreale de Escobar, G | 1 |
| Lind, P | 1 |
| Mujtaba, Q | 1 |
| Burrow, GN | 1 |
| Momotani, N | 1 |
| Hamada, N | 1 |
| Ban, Y | 1 |
| Mimura, T | 1 |
| Nishikawa, Y | 1 |
| Strauss, RG | 1 |
| Ramsay, RE | 1 |
| Willmore, LJ | 1 |
| Spellacy, WN | 1 |
| Wilder, BJ | 1 |
| Harvey, JE | 1 |
| Srebnik, HH | 1 |
| Kuzan, FB | 1 |
| Prahlad, KV | 1 |
| Gottesfeld, Z | 1 |
| Silverman, PB | 1 |
| Senior, B | 1 |
| Chernoff, HL | 1 |
| Deol, MS | 1 |
| Thibodeau, GA | 1 |
| Swanson, RN | 1 |
3 reviews available for thyroxine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Thyroid disease in pregnancy.
Topics: Abnormalities, Drug-Induced; Antithyroid Agents; Autoimmunity; Female; Humans; Hyperemesis Gravidaru | 2011 |
Review of antithyroid drug use during pregnancy and report of a case of aplasia cutis.
Topics: Abnormalities, Drug-Induced; Adult; Antithyroid Agents; Child Development; Female; Humans; Hyperthyr | 1994 |
[Therapy of hypo- and hyperthyroidism in pregnancy].
Topics: Abnormalities, Drug-Induced; Antithyroid Agents; Dose-Response Relationship, Drug; Female; Humans; H | 1997 |
28 other studies available for thyroxine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Substituting Potassium Iodide for Methimazole as the Treatment for Graves' Disease During the First Trimester May Reduce the Incidence of Congenital Anomalies: A Retrospective Study at a Single Medical Institution in Japan.
Topics: Abnormalities, Drug-Induced; Adult; Antithyroid Agents; Drug Substitution; Female; Graves Disease; H | 2015 |
Effects of thyroxine exposure on the Twist 1 +/- phenotype: A test of gene-environment interaction modeling for craniosynostosis.
Topics: Abnormalities, Drug-Induced; Animals; Craniosynostoses; Disease Models, Animal; Gene Expression Regu | 2016 |
Exposure of Pregnant Mice to Perfluorobutanesulfonate Causes Hypothyroxinemia and Developmental Abnormalities in Female Offspring.
Topics: Abnormalities, Drug-Induced; Animals; Congenital Hypothyroidism; Estrogens; Female; Fluorocarbons; G | 2017 |
Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Alkanesulfonic Acids; Animals; Body Weight; Dose- | 2003 |
[ON THE TERATOGENIC ACTION OF N-DESACETYL-THIOCOLCHICINE ALONE OR COMBINED WITH THYROXIN].
Topics: Abnormalities, Drug-Induced; Chick Embryo; Colchicine; Encephalocele; Genetics; Research; Teratogene | 1963 |
[ON THE TERATOGENIC ACTION OF TRICHLORETHYLAMINE, ASSOCIATED OR NOT WITH THYROXIN].
Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Chick Embryo; Pharmacology; Research; Teratogene | 1963 |
[ON THE TERATOGENIC ACTION, IN THE CHICK EMBRYO, OF RUFOCHROMOMYCIN ASSOCIATED OR NOT WITH THYROXIN].
Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Antibiotics, Antitubercular; Chick Embryo; Derma | 1963 |
EXPERIMENTAL TERATOGENESIS IN RELATION TO CONGENITAL MALFORMATIONS IN MAN.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Bacterial Agents; Caffeine; Cortisone; Insulin; Lagomorph | 1964 |
PLACENTAL TRANSMISSION OF DRUGS.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Bacterial Agents; Barbiturates; Chloramph | 1964 |
[ON THE PRODUCTION OF STROPHOSOMIA BY THYROXINE IN THE CHICK EMBRYO].
Topics: Abnormalities, Drug-Induced; Abnormalities, Severe Teratoid; Animals; Chick Embryo; Meat; Pharmacolo | 1964 |
FAMILIAL IODIDE-INDUCED GOITER. EVIDENCE FOR AN ABNORMALITY IN THE PITUITARY-THYROID HOMEOSTATIC CONTROL.
Topics: Abnormalities, Drug-Induced; Female; Genetics, Medical; Goiter; Homeostasis; Humans; Hypothyroidism; | 1965 |
Prenatal toxicity of cyanide in goats--a model for teratological studies in ruminants.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Goats; Male; Models, Animal; Potassium Cy | 2004 |
Influence of thyroid function on the teratogenic activity of trypan blue in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Basal Metabolism; Female; Fetal Death; Pregnancy; Pregnancy, A | 1966 |
[Association of thyroid drugs on the teratogenic action of ethylurethan in mice].
Topics: Abnormalities, Drug-Induced; Animals; Female; Methylthiouracil; Mice; Pregnancy; Thyroxine; Urethane | 1967 |
Prenatal exposure to the herbicide 2,4-dichlorophenyl-p-nitrophenyl ether destroys the rodent Harderian gland.
Topics: Abnormalities, Drug-Induced; Animals; Female; Harderian Gland; Lacrimal Apparatus; Male; Mice; Pheny | 1982 |
Thyroid hormones in the pathogenesis of lung hypoplasia and immaturity induced in fetal rats by prenatal exposure to nitrofen.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Disease Models, Animal; Female; Herni | 1997 |
Treatment of hyperthyroidism in pregnancy with propylthiouracil and methimazole.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Female; Fetal Blood; Fetal Death; Goiter; | 1975 |
[Management of patients with thyrotoxicosis of childbearing age (author's transl)].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Antithyroid Agents; Female; Graves Diseas | 1977 |
Epilepsy and pregnancy. Serum thyroxine levels during phenytoin therapy.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Epilepsy; Female; Fetus; Humans; Infant, Newborn; | 1979 |
Induction of malformations by actinomycin D at mid-pregnancy in the rat and protection by L-thyroxine.
Topics: Abnormalities, Drug-Induced; Animals; Clubfoot; Dactinomycin; Female; Gestational Age; Injections, S | 1978 |
The effects of 1, 2, 3, 4, 10, 10-hexachloro-1, 4, 4a, 5, 8, 8a-hexahydroxy endo, exo-5, 8-dimethionaphthalene (aldrin) and sodium ethylenebisdithiocarbomate (nabam) on the chick.
Topics: Abnormalities, Drug-Induced; Aldrin; Animals; Chick Embryo; Chickens; Eggs; Ethylenebis(dithiocarbam | 1975 |
Developmental delays associated with prenatal alcohol exposure are reversed by thyroid hormone treatment.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Disease Models, Animal; Embryonic and Fetal | 1990 |
[Co-teratogenic action of antithyroid agents in the chick embryo].
Topics: Abnormalities, Drug-Induced; Animals; Antithyroid Agents; Chick Embryo; Drug Synergism; Semicarbazid | 1970 |
[The influence of certain solutions on strophosomus induced by thyroxine in the chick embryo].
Topics: Abnormalities, Drug-Induced; Amino Acids; Animals; Chick Embryo; Sodium Chloride; Solvents; Thyroxin | 1967 |
Iodide goiter in the newborn.
Topics: Abnormalities, Drug-Induced; Anus, Imperforate; Cardiac Catheterization; Cardiomegaly; Female; Goite | 1971 |
An experimental approach to the understanding and treatment of hereditary syndromes with congenital deafness and hypothyroidism.
Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Cochlea; Deafness; Disease Models, Animal; Female | 1973 |
[Mechanism of teratogenic action of thyroxine in the chick embryo].
Topics: Abnormalities, Drug-Induced; Adenosine Triphosphate; Animals; Antimetabolites; Antimycin A; Chick Em | 1973 |
Sodium D-thyroixine induced cardiac alterations (in utero) observed in newborn rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Female; Fetal Heart; Organ Size; Pregnancy; | 1968 |