thyrotropin-releasing-hormone and Respiration-Disorders

The effect of TRH and its synthetic analogue (PR-546) devoid of hormonal activity was studied in acute experiments on rats on the model of neurogenic lung edema caused by skull injury. It was proved that the preliminary (for 30 min before the injury) i/p introduction of TRH (in doses 0.5-1 mg/kg) and PR-546 (in doses 4-8 mg/kg) prevented the development of acute edema and the changes of blood gas compositions as well as disorders in breathing after skull injury. It was assumed that the protective effect of studied peptides is possibly achieved through the intensification of breathing and cardiovascular centers activity.

Topics: Animals; Brain Edema; Brain Injuries; Male; Pulmonary Gas Exchange; Rats; Respiration Disorders; Thyrotropin-Releasing Hormone; Time Factors