thyronines and Myxedema

Topics: Diuretics; Heart Diseases; Humans; Myxedema; Thyroid Diseases; Thyroid Hormones; Thyronines; Thyroxine

Topics: Blood; Body Fluids; Calcium; Congenital Hypothyroidism; Drug Therapy; Hyperthyroidism; Hypothyroidism; Myxedema; Nitrogen; Pharmacology; Phosphorus; Thyronines; Thyroxine; Toxicology; Urine

The authors, in reporting 7 personal cases, confront their findings with previously published data. The study of cases presented as myxedema comas consistently demonstrates a precipitating cause, which in itself can produce a low T3 and T4 syndrome. The occurrence of such a cause in a patient with hypothyroidism can lead to acute decompensation, but should such conditions be considered as myxedema comas since treatment is above all aimed against the acute aggression?

Topics: Aged; Coma; Female; Humans; Male; Myxedema; Thyronines; Thyrotropin; Thyroxine

The metabolic, cardiovascular, renal, and pulmonary responses of 10 hypothyroid patients were studied during the first week of therapy with intravenous levothyroxine (L-thyroxine), 100 micrograms per day. Mean serum thyroxine, triiodothyronine, and reverse triiodothyronine concentrations were normalized within four days. Significant decreases in serum thyrotropin, creatine phosphokinase, and cholesterol levels, and an increase in the basal metabolic rate, were observed. An early cardiovascular response was demonstrated by serial measurement of the mean pre-ejection period (138 to 134 msec, p less than 0.05), its ratio to left ventricular ejection time (0.49 to 0.46, p less than 0.02), and pulse-wave arrival time (236 to 224 msec, p less than 0.05). The mean renal excretion of a water load (four hours) increased (54 to 77 percent, p less than 0.02) by the fourth day. The blunted ventilatory responses to hypercapnea seen in two patients were improved. We conclude that a physiologic replacement dose of intravenous L-thyroxine for one week produces significant responses in organ systems responsible for the common clinical complications of myxedema.

Topics: Adult; Aged; Basal Metabolism; Body Water; Cholesterol; Creatine Kinase; Female; Humans; Hypothyroidism; Injections, Intravenous; Male; Middle Aged; Myxedema; Pituitary Function Tests; Stroke Volume; Thyroid Function Tests; Thyronines; Thyrotropin; Thyroxine

Topics: Blood Pressure; Feces; Female; Humans; Iodine Radioisotopes; Male; Myxedema; Pregnancy; Speech; Thyroglobulin; Thyroid Function Tests; Thyronines; Thyrotropin; Thyroxine; Triiodothyronine

Topics: Aged; Coma; Female; Humans; Myxedema; Prednisolone; Respiration, Artificial; Thyronines

Topics: Chlorpromazine; Depression; Electroconvulsive Therapy; Female; Humans; Middle Aged; Myxedema; Psychotic Disorders; Thyronines

Topics: Adolescent; Adult; Autoradiography; Female; Goiter; Humans; Hyperthyroidism; Male; Middle Aged; Myxedema; Technetium; Thyroid Diseases; Thyroid Gland; Thyronines; Thyroxine; Tyrosine

Topics: Cholesterol; Coronary Disease; Electrocardiography; Iodine Isotopes; Myxedema; Thyroid Neoplasms; Thyroidectomy; Thyronines

Topics: Hypothyroidism; Iodine Isotopes; Methysergide; Myxedema; Selective Serotonin Reuptake Inhibitors; Serotonin; Thyroid Function Tests; Thyronines; Thyroxine; Toxicology

Topics: Blood Chemical Analysis; Chromatography; Geriatrics; Goiter; Hyperthyroidism; Iodine Isotopes; Monoiodotyrosine; Myxedema; Neoplasms; Propylthiouracil; Thiourea; Thyronines; Thyroxine; Tyrosine

Topics: Drug Therapy; Goiter; Hyperthyroidism; Hypothyroidism; Iodine Isotopes; Myxedema; Thyroid Function Tests; Thyroidectomy; Thyronines; Thyroxine

Topics: Basal Metabolism; Diagnosis; Hypothyroidism; Iodine Isotopes; Myxedema; Thyroid Function Tests; Thyronines; Thyroxine; Triiodothyronine

Topics: Bile; Body Fluids; Humans; Myxedema; Thyronines; Triiodothyronine

Topics: Coma; Humans; Myxedema; Thyronines; Triiodothyronine

Topics: Myxedema; Thyronines; Thyroxine

Topics: Humans; Myxedema; Thyronines

Topics: Dextrothyroxine; Electrocardiography; Humans; Myxedema; Thyronines; Thyroxine