thyronines has been researched along with Hypopituitarism* in 3 studies
3 other study(ies) available for thyronines and Hypopituitarism
| Article | Year |
|---|---|
Evidence for extrathyroidal formation of 3-iodothyronamine in humans as provided by a novel monoclonal antibody-based chemiluminescent serum immunoassay.
Thyronamines are thyronergic metabolites of thyroid hormones. Lack of reliable and sensitive detection methods for endogenous 3-iodothyronamine (3-T(1)AM) has so far hampered progress in understanding their physiological action and role in endocrine homeostasis or pathophysiology of diseases.. We characterized newly generated mouse monoclonal 3-T(1)AM antibodies and established a monoclonal antibody-based chemiluminescence immunoassay as a powerful tool for monitoring 3-T(1)AM levels in investigations addressing altered serum profiles and potential sites of origin and action of 3-T(1)AM in humans.. Our exploratory study on 3-T(1)AM serum levels in humans measured 3-T(1)AM concentrations in comparison with thyroid hormones.. Thirteen adult healthy subjects, 10 patients with pituitary insufficiency, and 105 thyroid cancer patients participated.. INTERVENTIONS included l-T(4) withdrawal in patients with pituitary insufficiency as well as TSH-suppressive T(4) substitution in thyroid cancer patients.. 3-T(1)AM was reliably quantified in human serum and stable after storage at room temperature and 4 C overnight as well as after four freeze-thaw cycles. The median serum concentration in healthy subjects was 66 ± 26 nm. 3-T(1)AM was also detected in T(4)-substituted thyroid cancer patients. Although free T(4) and T(3) significantly decreased during T(4) withdrawal, 3-T(1)AM levels remained constant for 6 d.. Because higher 3-T(1)AM levels are detectable in T(4)-substituted thyroid cancer patients after thyroidectomy/radioiodine treatment compared with healthy controls, we concluded that 3-T(1)AM is mainly produced by extrathyroidal tissues. The serum profile during T(4) withdrawal suggests either a long half-life or persisting 3-T(1)AM release into serum from intracellular thyroid hormone precursors or stores. Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypopituitarism; Luminescent Measurements; Male; Middle Aged; Thyroid Hormones; Thyroid Neoplasms; Thyronines | 2011 |
[Experimental and clinical evaluations of T4 determination by the column method].
Topics: Colorimetry; Goiter; Humans; Hyperthyroidism; Hypopituitarism; Ion Exchange Resins; Thyroiditis; Thyronines; Thyroxine | 1971 |
[Panhypopituitarism].
Topics: Adrenocorticotropic Hormone; Hypopituitarism; Testosterone; Thyronines | 1963 |