thyronines and Chronic-Disease

Thyroid hormone metabolites might affect the heart. The endogenous aminergic metabolite 3-iodothyronamine (T1am) reduces left ventricular ejection fraction (LVEF) in rodents.. To investigate concentration of T1am and its association with LVEF and biomarkers of heart function in patients with chronic heart failure (CHF) without thyroid disease, including patients with cardiac cachexia (nonedematous weight loss >5% over 6 months).. Cross-sectional study. CHF was characterized by LVEF <45% and symptoms. Three groups were included (n = 19 in each group, matched on age, sex, and kidney function): patients with cachexia (CAC), patients without (non-CAC), and control (C) patients with prior myocardial infarction and LVEF >45%. T1am was measured by a monoclonal antibody-based chemiluminescence immunoassay. N-amino terminal pro-BNP (NT-proBNP) concentrations were also analyzed.. Mean (SD) LVEF: CAC, 32 ± 9%; non-CAC, 38 ± 8%; and C, 60 ± 8% (P < 0.0001). TSH, T4, and T3 levels did not differ between groups and did not correlate to T1am. Serum T1am (nmol/L) concentrations were higher in CHF: CAC (mean ± SD), 12.4 ± 6.6; non-CAC, 9.1 ± 5; and C, 7.3 ± 2.9. A negative association between T1am and LVEF was present after adjusting for sex, age, T3, and estimated glomerular filtration rate (P = 0.03). Further, serum T1am levels tended to be associated with NT-proBNP (P = 0.053).. Serum T1am levels were increased in patients with CHF and numerically highest (although nonsignificant) in patients with cardiac cachexia. Increasing T1am concentrations were independently associated with reduced LVEF, suggesting a direct effect on the human heart.

Topics: Aged; Aged, 80 and over; Biomarkers; Cachexia; Chronic Disease; Cohort Studies; Cross-Sectional Studies; Female; Heart; Heart Failure; Humans; Male; Thyronines; Ventricular Function, Left

Concentrations of triiodothyronine (T3), thyroxine (T4), reflecting the thyroid status, and thyrotropin, a hormone of the anterior pituitary were investigated in 123 patients with exacerbation of chronic pancreatitis. T3 and T4 levels were considerably decreased, and a TSH level was raised (P less than 0.001). By the end of therapy the latter was markedly decreased, and T3 and T4 concentrations showed a rising tendency. The greatest changes in the levels of the thyroid hormones were observed in patients with a marked decrease in pancreatic excretory function.

Topics: Adolescent; Adult; Chronic Disease; Female; Humans; Male; Middle Aged; Pancreatitis; Thyronines; Thyrotropin; Triiodothyronine

Urinary 3,5-diiodotyrosine (DIT) and thyronine (T0) excretion was investigated in 18 patients with chronic renal disease. In accord with previous findings serum T4 and thyroid hormone binding proteins measured in 17 patients were in the low or normal range. Urinary albumin excretion was elevated in all 18 and T4 binding prealbumin (TBPA) in 15 of the 18. Urinary T0 excretion measured in 12 patients was also significantly lower than normal (mean +/- SD 4.4 +/- 2.6 vs 15.8 +/- 5.8 nmol/24 h renal vs normal 2 P less than 0.001). In contrast urinary DIT excretion was significantly elevated in renal patients compared with normal subjects (2.0 +/- 1.5 vs 0.75 +/- 0.41 nmol/24 h, respectively). Possible sources of the increased DIT are discussed.

Topics: Adult; Aged; Chronic Disease; Diiodotyrosine; Female; Humans; Kidney Diseases; Male; Middle Aged; Thyronines; Thyroxine-Binding Proteins

Topics: Chronic Disease; Diagnosis; Geriatrics; Humans; Hypothyroidism; Middle Aged; Therapeutics; Thyroid Function Tests; Thyroid Hormones; Thyronines