thymosin-beta(4) and Uremia

thymosin-beta(4) has been researched along with Uremia* in 1 studies

Other Studies

1 other study(ies) available for thymosin-beta(4) and Uremia

ArticleYear
Synthesis of a thymosin beta 4-like peptide, deacetyl-thymosin beta Xen4, and its restorative effect on depressed lymphocyte blastogenic response to phytohemagglutinin (PHA) in uremic patients.
    Chemical & pharmaceutical bulletin, 1989, Volume: 37, Issue:9

    An analog of thymosin beta Xen4 isolated from oocytes of Xenopus laevis, deacetyl-thymosin beta Xen4, was synthesized by assembling 6 peptide fragments, followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole (molar ratio, 1:1) in trifluoroacetic acid in the presence of dimethylselenium. Finally, the deprotected peptide was incubated with dithiothreitol to reduce sulfoxide on the methionine side chain. The synthetic tritetracontapeptide was found to have a restoring effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients.

    Topics: Amino Acid Sequence; Humans; In Vitro Techniques; Lymphocyte Activation; Molecular Sequence Data; Phytohemagglutinins; Thymosin; Uremia

1989
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