thymosin-beta(4) has been researched along with Immunologic-Deficiency-Syndromes* in 2 studies
1 review(s) available for thymosin-beta(4) and Immunologic-Deficiency-Syndromes
| Article | Year |
|---|---|
[Thymic hormones. Neuroendocrine interactions and clinical use in congenital and acquired immune deficiencies].
The epithelial cells of the thymus synthesize at least 30 different polypeptides: the thymic hormones. The structure of 4 of them is well known. They are named thymosin alpha 1, thymopoietin, thymulin and thymic humoral factor. Biological functions and secretion regulation of thymic hormones are described as well as the interactions between brain, thymus and endocrine glands. Blood levels and clinical usefulness of thymic hormones are reviewed in different congenital or acquired immunodeficient states and in autoimmune diseases. Topics: Acquired Immunodeficiency Syndrome; Autoimmune Diseases; Humans; Immunologic Deficiency Syndromes; Peptide Fragments; Thymalfasin; Thymic Factor, Circulating; Thymopentin; Thymopoietins; Thymosin; Thymus Extracts; Thymus Hormones | 1984 |
1 other study(ies) available for thymosin-beta(4) and Immunologic-Deficiency-Syndromes
| Article | Year |
|---|---|
Effect of two thymosin fraction 5 polypeptides on human peripheral blood lymphocytes.
Thymosin fraction 5 polypeptides beta 4 and alpha 1 were tested for their ability to affect certain immunological parameters of human peripheral blood lymphocytes (PBL). PBL were cultured with various concentrations of the peptides for 24 hours. Thymosin beta 4 was found to induce a significant decrease in the expression of the Fc alpha receptors of PBL, as well as in their ability to express antibody dependent cellular cytotoxic (ADCC) activity. In addition, this peptide had the ability to increase the percentage of T4 lymphocytes in normal and immunosuppressed donors and to decrease the percentage of T8 positive cells in normal donors. Finally, beta 4 peptide caused a small increase in the capacity of peripheral blood lymphocytes to form sheep red blood cell (SRBC) rosettes (ER). In parallel experiments thymosin alpha 1 was found inactive. The results presented here indicate that thymosin beta 4 may be used as an immunoregulatory molecule in patients with immunodeficiencies. Topics: Adjuvants, Immunologic; Antibody-Dependent Cell Cytotoxicity; Humans; Immunologic Deficiency Syndromes; In Vitro Techniques; Lymphocytes; Receptors, Fc; Receptors, IgG; Rosette Formation; T-Lymphocytes; Thymalfasin; Thymosin | 1987 |