thymosin-beta(4) and Carcinogenesis

thymosin-beta(4) has been researched along with Carcinogenesis* in 2 studies

Other Studies

2 other study(ies) available for thymosin-beta(4) and Carcinogenesis

Article	Year
Di-(2-ethylhexyl) phthalate-induced tumor growth is regulated by primary cilium formation via the axis of H International journal of medical sciences, 2021, Volume: 18, Issue:5 Di-(2-ethylhexyl) phthalate (DEHP) that is one of the most commonly used phthalates in manufacturing plastic wares regulates tumorigenesis. Thymosin beta-4 (TB4), an actin-sequestering protein, has been reported as a novel regulator to form primary cilia that are antenna-like organelles playing a role in various physiological homeostasis and pathological development including tumorigenesis. Here, we investigated whether DEHP affects tumor growth via primary cilium (PC) formation via the axis of TB4 gene expression and the production of reactive oxygen species (ROS). Tumor growth was increased by DEHP treatment that enhanced TB4 expression, PC formation and ROS production. The number of cells with primary cilia was enhanced time-dependently higher in HeLa cells incubated in the culture medium with 0.1% fetal bovine serum (FBS). The number of cells with primary cilia was decreased by the inhibition of TB4 expression. The incubation of cells with 0.1% FBS enhanced ROS production and the transcriptional activity of TB4 that was reduced by ciliobrevin A (CilioA), the inhibitor of ciliogenesis. ROS production was decreased by catalase treatment but not by mito-TEMPO, which affected to PC formation with the same trend. H Topics: Animals; Carcinogenesis; Cell Survival; Cilia; Diethylhexyl Phthalate; HEK293 Cells; HeLa Cells; Humans; Hydrogen Peroxide; Injections, Intraperitoneal; Male; Melanoma, Experimental; Mice; Plasticizers; Skin Neoplasms; Thymosin	2021
Changes in Biomechanical Properties of A375 Cells Due to the Silencing of Cells, 2021, 03-31, Volume: 10, Issue:4 Thymosin β4 (Tβ4) is a small, 44-amino acid polypeptide. It has been implicated in multiple processes, including cell movement, angiogenesis, and stemness. Previously, we reported that melanoma cell lines differ in Tβ4 levels. Studies on stable clones with silenced Topics: Actin Cytoskeleton; Biomarkers, Tumor; Biomechanical Phenomena; Carcinogenesis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Shape; Gene Silencing; Humans; Intermediate Filaments; Melanoma; Models, Biological; Neoplastic Stem Cells; Nestin; Thymosin; Vimentin	2021

Article

Year

Di-(2-ethylhexyl) phthalate-induced tumor growth is regulated by primary cilium formation via the axis of H

International journal of medical sciences, 2021, Volume: 18, Issue:5

Di-(2-ethylhexyl) phthalate (DEHP) that is one of the most commonly used phthalates in manufacturing plastic wares regulates tumorigenesis. Thymosin beta-4 (TB4), an actin-sequestering protein, has been reported as a novel regulator to form primary cilia that are antenna-like organelles playing a role in various physiological homeostasis and pathological development including tumorigenesis. Here, we investigated whether DEHP affects tumor growth via primary cilium (PC) formation via the axis of TB4 gene expression and the production of reactive oxygen species (ROS). Tumor growth was increased by DEHP treatment that enhanced TB4 expression, PC formation and ROS production. The number of cells with primary cilia was enhanced time-dependently higher in HeLa cells incubated in the culture medium with 0.1% fetal bovine serum (FBS). The number of cells with primary cilia was decreased by the inhibition of TB4 expression. The incubation of cells with 0.1% FBS enhanced ROS production and the transcriptional activity of TB4 that was reduced by ciliobrevin A (CilioA), the inhibitor of ciliogenesis. ROS production was decreased by catalase treatment but not by mito-TEMPO, which affected to PC formation with the same trend. H

Topics: Animals; Carcinogenesis; Cell Survival; Cilia; Diethylhexyl Phthalate; HEK293 Cells; HeLa Cells; Humans; Hydrogen Peroxide; Injections, Intraperitoneal; Male; Melanoma, Experimental; Mice; Plasticizers; Skin Neoplasms; Thymosin

2021

Changes in Biomechanical Properties of A375 Cells Due to the Silencing of

Cells, 2021, 03-31, Volume: 10, Issue:4

Thymosin β4 (Tβ4) is a small, 44-amino acid polypeptide. It has been implicated in multiple processes, including cell movement, angiogenesis, and stemness. Previously, we reported that melanoma cell lines differ in Tβ4 levels. Studies on stable clones with silenced

Topics: Actin Cytoskeleton; Biomarkers, Tumor; Biomechanical Phenomena; Carcinogenesis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Shape; Gene Silencing; Humans; Intermediate Filaments; Melanoma; Models, Biological; Neoplastic Stem Cells; Nestin; Thymosin; Vimentin

2021