thymosin and Spondylitis--Ankylosing

thymosin has been researched along with Spondylitis--Ankylosing* in 2 studies

Other Studies

2 other study(ies) available for thymosin and Spondylitis--Ankylosing

Article	Year
In vitro thymosin effect on T lymphocytes in ankylosing spondylitis. Thymus, 1981, Volume: 3, Issue:6 Peripheral blood "total" and "avid" T-cell rosettes (ER) were enumerated in 35 patients with ankylosing spondylitis (AS). The in vitro effect of thymosin fraction 5 on "avid" ER formation was also determined. "Total" ER numbers, but not proportions, were lower in patients with AS as compared to matched controls, Both the proportion and number of "avid" ER were lower in the patient group. Thymosin induced a significant increase in "avid" ER proportions and numbers in the patient group with no such effect observed in the controls. It is suggested that there are increased numbers of circulating T lymphocytes in patients with AS that can respond to exogenous thymic factors and acquire the capability to form "avid"ER. Topics: Adult; Humans; Male; Rosette Formation; Spondylitis, Ankylosing; T-Lymphocytes; Thymosin; Thymus Hormones	1981
T and B lymphocytes in patients with acute anterior uveitis and ankylosing spondylitis, and in their household contacts. Lancet (London, England), 1979, Sep-22, Volume: 2, Issue:8143 During episodes of acute anterior uveitis, patients had a T-lymphopenia and a temporary increase in B-lymphocytes. The T-lymphopenia was not present in patients investigated early in their first attacks, and it persisted after the patients recovered clinically. In household contacts of patients with uveitis, there was a temporary T-lymphopenia. A similar degree of T-lymphopenia was present in patients with ankylosing spondylitis who had not had uveitis, but not in their household contacts. In patients with spondylitis, there was no greater reduction of T-cells when they had episodes of uveitis. In all groups of subjects studied, T-lymphopenia could be abolished, in vitro, with thymosin, a bovine thymic-hormone estract. The finding of T-lymphocyte depletion in the contacts of uveitis patients, as well as in the patients themselves, suggests that there may be lateral transmission of an infective agent (or agents) in the households during (or before) attacks of uveitis. Topics: Acute Disease; Animals; B-Lymphocytes; Cattle; Humans; In Vitro Techniques; Interpersonal Relations; Leukocyte Count; Lymphopenia; Rosette Formation; Spondylitis, Ankylosing; T-Lymphocytes; Thymosin; Uveitis, Anterior	1979

Article

Year

In vitro thymosin effect on T lymphocytes in ankylosing spondylitis.

Thymus, 1981, Volume: 3, Issue:6

Peripheral blood "total" and "avid" T-cell rosettes (ER) were enumerated in 35 patients with ankylosing spondylitis (AS). The in vitro effect of thymosin fraction 5 on "avid" ER formation was also determined. "Total" ER numbers, but not proportions, were lower in patients with AS as compared to matched controls, Both the proportion and number of "avid" ER were lower in the patient group. Thymosin induced a significant increase in "avid" ER proportions and numbers in the patient group with no such effect observed in the controls. It is suggested that there are increased numbers of circulating T lymphocytes in patients with AS that can respond to exogenous thymic factors and acquire the capability to form "avid"ER.

Topics: Adult; Humans; Male; Rosette Formation; Spondylitis, Ankylosing; T-Lymphocytes; Thymosin; Thymus Hormones

1981

T and B lymphocytes in patients with acute anterior uveitis and ankylosing spondylitis, and in their household contacts.

Lancet (London, England), 1979, Sep-22, Volume: 2, Issue:8143

During episodes of acute anterior uveitis, patients had a T-lymphopenia and a temporary increase in B-lymphocytes. The T-lymphopenia was not present in patients investigated early in their first attacks, and it persisted after the patients recovered clinically. In household contacts of patients with uveitis, there was a temporary T-lymphopenia. A similar degree of T-lymphopenia was present in patients with ankylosing spondylitis who had not had uveitis, but not in their household contacts. In patients with spondylitis, there was no greater reduction of T-cells when they had episodes of uveitis. In all groups of subjects studied, T-lymphopenia could be abolished, in vitro, with thymosin, a bovine thymic-hormone estract. The finding of T-lymphocyte depletion in the contacts of uveitis patients, as well as in the patients themselves, suggests that there may be lateral transmission of an infective agent (or agents) in the households during (or before) attacks of uveitis.

Topics: Acute Disease; Animals; B-Lymphocytes; Cattle; Humans; In Vitro Techniques; Interpersonal Relations; Leukocyte Count; Lymphopenia; Rosette Formation; Spondylitis, Ankylosing; T-Lymphocytes; Thymosin; Uveitis, Anterior

1979