thymosin has been researched along with Liver-Cirrhosis--Biliary* in 2 studies
2 other study(ies) available for thymosin and Liver-Cirrhosis--Biliary
| Article | Year |
|---|---|
Thymosin effects on immunoglobulin synthesis and suppressor T cell activity in normal subjects and patients with primary biliary cirrhosis.
Peripheral blood lymphocytes from patients with primary biliary cirrhosis previously have been reported to demonstrate reduced pokeweed mitogen-stimulated immunoglobulin synthesis and diminished function of suppressor T cells. To determine whether thymic hormone preparations reverse these immunologic defects in vitro, the effects of thymosin fraction 5 and thymosin alpha 1 on immunoglobulin synthesis and concanavalin A-induced suppression of immunoglobulin synthesis were investigated in normal subjects and patients with primary biliary cirrhosis. In normal subjects, no effects of thymosin were observed on unstimulated and pokeweed mitogen-stimulated immunoglobulin synthesis, nor on Con A-induced suppressor cell activity. Lymphocytes from patients with PBC synthesized less IgG and IgM than normals when stimulated by pokeweed mitogen, and this difference was enhanced by both thymosin fraction 5 and thymosin alpha 1. Con A suppression of immunoglobulin synthesis was abnormal in only one PBC subject so that thymosin effects on impaired suppressor T cell activity could not be tested. Topics: Adult; Aged; Cells, Cultured; Concanavalin A; Female; Humans; Immunoglobulin G; Immunoglobulin M; Liver Cirrhosis, Biliary; Lymphocytes; Male; Middle Aged; Pokeweed Mitogens; T-Lymphocytes, Regulatory; Thymalfasin; Thymosin | 1986 |
Peripheral blood lymphocyte populations in chronic liver disease.
Mature T lymphocyte concentrations are reduced, null cell concentrations are increased, and Fc receptor bearing (B and K) lymphocyte concentrations are normal, in the peripheral blood of patients with chronic hepatocellular or cholestatic liver disease. Some null cells can be stimulated by either thymosin or levamisole to form rosettes with sheep erythrocytes. These changes are present in viral, alcohol associated and 'autoimmune' liver disease and are therefore probably secondary phenomena relating to liver damage. Topics: Adult; Female; Hepatitis; Hepatitis B Antigens; Humans; Leukocyte Count; Levamisole; Liver Cirrhosis, Biliary; Liver Diseases; Lymphocytes; Male; Middle Aged; T-Lymphocytes; Thymosin | 1976 |