thymoquinone has been researched along with Disease Models, Animal in 101 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (1.98) | 18.2507 |
| 2000's | 12 (11.88) | 29.6817 |
| 2010's | 67 (66.34) | 24.3611 |
| 2020's | 20 (19.80) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, J; Fu, J; Fu, S; Liu, X; Peng, J; Wang, Q; Wei, C; Xiao, T; Xie, X; Zou, H | 1 |
| Farooq, RK; Hanif, R; Javed, A; Nasir, S; Nazir, S | 1 |
| Acar, A; Alagoz, E; Atci, T; Dasci, MF; Gok Yurttas, A; Gulec, MA; Uslu, M; Yaprak Sarac, E | 1 |
| Foad-Noorbakhsh, M; Iraji, A; Meimandi Parizi, A; Sayyari, M; Soltanfar, A | 1 |
| Akçay, E; Çakir, Z; Gevrek, F; Özsoy, Ş | 1 |
| Abdel-Hamid, AAHM; Ayuob, NN; Helal, GMM; Mubarak, WA | 1 |
| Bugdayci, G; Dagistan, Y; Kilinc, E; Tore, F | 1 |
| Ahmed, I; Alfhili, MA; Chandramoorthy, HC; Dera, AA; Rajagopalan, P | 1 |
| Bisht, A; Hemrajani, C; Katare, OP; Negi, P; Rathore, C; Raza, K; Sharma, I | 1 |
| Abdel-Salam, B; Al-Tamimi, JH; Alhazza, IM; Ebaid, H; Hassan, I; Mashaly, AMA; Rady, AM | 1 |
| Karabag, H; Koçarslan, S | 1 |
| Ahmad, FJ; Akhtar, M; Alam, M; Imam, SS; Najmi, AK; Zameer, S | 1 |
| Aras, Ö; Bilgin, ES; Çakar, B; Ergönül, A; Göker, E; Güldü, ÖK; İnce, İ; Medine, Eİ; Müftüler, ZB; Parlak, Y; Takan, G; Ünak, P; Yıldırım, Y | 1 |
| Abd Rabo, AA; Abd-El Daim, TM; Elfeky, AS; Fahmy, HM; Khadrawy, YA; Mostafa, IT; Mustafa, AB | 1 |
| Ahmed, I; Al Fayi, M; Chandramoorthy, HC; Dera, AA; Rajagopalan, P | 1 |
| Fan, C; Han, H; Pu, X; Sun, Y; Tian, F; Yang, X; Zhao, X | 1 |
| Akkaya, E; Çalış, F; Çevik, S; Evran, Ş; Hanımoğlu, H; Hatiboğlu, MA; Karataş, E; Katar, S; Kaynar, MY; Koçyiğit, A; Sağlam, MY | 1 |
| Ali, J; Baboota, S; Iqubal, A; Khan, SA; Nabi, B; Nehal, N; Parvez, S; Pathak, A; Rehman, S; Yar, MS | 1 |
| Datta, K; Kumar, S; Saha, P; Tyagi, RK | 1 |
| Bergonzi, MC; Buonvicino, D; Landucci, E; Mazzantini, C; Pellegrini-Giampietro, DE | 1 |
| Adrian, TE; Ahmed, KJ; Alhassani, AS; Alhassani, AT; Almarzooqi, S; Attoub, S; Ojha, SK; Raj, V; Subramanian, VS; Subramanya, SB; Venkataraman, B | 1 |
| Abdel-Moneim, AH; Abdellatif, AAH; Al Rugaie, O; Alsharidah, AS; Alsharidah, M; Faisal Lutfi, M; Mobark, MA; Mohany, KM; Saleem, IY | 1 |
| Abu-Yousef, IA; Majdalawieh, AF; Yousef, SM | 1 |
| Cheikh, HB; Mabrouk, A | 1 |
| Dokuyucu, R; Gökçe, H; Gülmez, Mİ; Okuyucu, Ş | 1 |
| Chen, Y; Feng, Y; Li, B; Luo, Q; Ren, Z; Shao, Y; Xie, Y; Zhu, L | 1 |
| Ebrahimi, SS; Hassanzadeh, K; Izadpanah, E; Oryan, S | 1 |
| Arlı, C; Demirel, H; Dokuyucu, R; İnci, M; Özgür, T | 1 |
| Alp, HH; Aras, A; Çelik, S; Kiziltan, R; Kotan, Ç; Yildirm, S; Yilmaz, Ö | 1 |
| Anaeigoudari, A; Baghcheghi, Y; Beheshti, F; Hosseini, M; Salmani, H | 1 |
| Akbas, F; Beker, M; Dalli, T; Elibol, B; Terzioglu-Usak, S | 1 |
| Abulfadl, YS; Ahmed, AAE; Badary, OA; El-Maraghy, NN; Nofal, S | 1 |
| Arslan, M; Bostanci, H; Comu, FM; Dikmen, K; Kucuk, A | 1 |
| Ahmad, A; Alkharfy, KM; Jan, BL; Raish, M | 1 |
| Akbas, F; Demirel, MH; Meral, I; Pala, M; Ustunova, S; Yildiz, C | 1 |
| Ramachandran, S; Thangarajan, S | 2 |
| Mahboubi, M; Mohammad Taghizadeh Kashani, L | 1 |
| Dong, H; Dong, Y; Du, L; Hou, Q; Li, D; Liu, L; Wu, J | 1 |
| Aldebasi, YH; AlSahli, MA; Alsuhaibani, SA; Alzohairy, MA; Khan, A; Khan, MA; Younus, H | 1 |
| Balkaya, M; Çakmak, H; Dayanır, V; Ekici, M; Erkan, E; Karul Büyüköztürk, A; Kocatürk, T; Meteoğlu, İ; Yavaşoğlu, İ | 1 |
| El-Sayed, SAE; Igarashi, I; Rizk, MA; Yokoyama, N | 1 |
| Arjumand, S; Shabbir, A; Shahzad, M; Yousaf, MZ | 1 |
| Al-Gayyar, MM; Almasri, D; Alshaman, US; Bagalagel, A; Diri, R; Hamdan, AM; Noor, AO; Prabahar, K; Shams, MEE | 1 |
| Ghanem, M; Harphoush, S; Le, G; Qiuli, G; Shi, Y; Wu, G; Zaitoun, M | 1 |
| Eissa, LA; El Gayar, AM; El-Karef, A; El-Mesery, M; Helmy, SA | 1 |
| El-Baba, CO; Fakhoury, IH; Gali-Muhtasib, HU; Schneider-Stock, R; Zaki, AM | 1 |
| Davarci, I; Karcioglu, M; Nacar, A; Rifaioglu, MM; Sefil, NK; Yonden, Z; Yuksel, R; Zorba, OU | 1 |
| Ahn, KS; Chng, WJ; Kannaiyan, R; Kumar, AP; Li, F; Mustafa, N; Sethi, G; Siveen, KS | 1 |
| Akhtar, M; Aquib, M; Najmi, AK | 1 |
| Ben Cheikh, H; Mabrouk, A | 1 |
| Amin, B; Hosseinzadeh, H; Taheri, MM | 1 |
| Dinda, AK; Gupta, YK; Maulik, SK; Prabhakar, P; Reeta, KH | 1 |
| Campregher, C; Edelmann, W; Evstatiev, R; Gasche, C; Khare, V; Kortüm, B; Kucherlapati, MH; Lang, M; Mittlböck, M; Pinter, M; Scharl, T; Schmid, G | 1 |
| Genrikhs, EE; Isaev, NK; Kapay, NA; Korshunova, GA; Popova, OV; Skrebitsky, VG; Skulachev, VP; Stelmashook, EV; Sumbatyan, NV | 1 |
| Aljarbou, AN; Khan, A; Khan, MA; Younus, H | 1 |
| Arumugam, G; Ganesan, VS; Periyanayagam, S; Ravikumar, A | 1 |
| Abdel-Wahab, WM | 1 |
| Bayoğlu Tekin, Y; Cumhur Cüre, M; Kalkan, Y; Mete Ural, Ü; Şehitoğlu, İ | 1 |
| Barham, W; Khabele, D; Saskowski, J; Wilson, AJ; Yull, F | 2 |
| El-Far, AH | 1 |
| Gulyaev, MV; Korshunova, GA; Pevzner, IB; Pirogov, YA; Plotnikov, EY; Silachev, DN; Skulachev, VP; Sumbatyan, NV; Zorov, DB; Zorova, LD | 1 |
| Ahmad, A; Al-Jenoobi, FI; Al-Mohizea, AM; Alkharfy, KM; Khan, RM; Raish, M | 1 |
| Arif, M; Datta, K; Thakur, SC | 1 |
| Alwadani, F; Fouad, AA | 1 |
| Aksoy, N; Alagöz, F; Cemil, B; Erdoğan, B; Gökce, A; Gökce, EC; Güvenç, Y; Kahveci, O; Kahveci, R; Kısa, Ü; Sargon, MF | 1 |
| Bel Hadj Salah, I; Ben Cheikh, H; Chaieb, W; Mabrouk, A | 1 |
| Kang, J; Kong, L; Ren, Y; Su, X; Yu, N | 1 |
| Boskabady, MH; Gholamnezhad, Z; Havakhah, S | 1 |
| Hu, W; Huang, J; Lv, L; Xiang, Y; Ye, S; Zeng, C; Zhao, X; Zhu, N | 1 |
| Abd-Elbaset, M; Abdel-Bakky, MS; Arafa, EA; El Sherbiny, GA; Elgendy, AN | 1 |
| Bu, JY; Li, GW; Xiao, XY; Zhou, JH; Zhou, SP; Zhu, YX | 1 |
| Dur, A; Ismayilova, M; Kocaman, O; Kocyigit, A; Kose, H; Sonmez, FC | 1 |
| Ak, H; Akyol, V; Gökalp, A; Gülşen, İ; Kara, M; Koçak, ÖF; Rağbetli, MÇ | 1 |
| Ahmad, SS; Akhtar, M; Kaundal, M; Najmi, AK | 1 |
| Hadjzadeh, MA; Mohammadian, N; Rahmani, Z; Rassouli, FB | 1 |
| Attia, A; Elbarbry, F; Eldin, WS; Gazarin, S; Ragheb, A; Shoker, A | 1 |
| el-Agamy, DS; Nader, MA; Suddek, GM | 1 |
| Duru, M; Gökçe, A; Gonenci, R; Koc, A; Oktar, S; Yalcinkaya, F; Yonden, Z | 1 |
| Al-Attas, OS; Al-Daghri, NM; Alkharfy, KM; Alokail, MS | 1 |
| Asim, MB; Hayat, K; Li, M; Nawaz, M; Sun, N; Zhang, L | 1 |
| Awad, AS; Kamel, R; Sherief, MA | 1 |
| Dhingra, D; Gilhotra, N | 1 |
| Ay, S; Erciyas, K; Kara, MI; Ozdemir, H; Ozer, H | 1 |
| El-Sayed, WM | 1 |
| Hosseinzadeh, H; Nassiri-Asl, M; Taiari, S | 1 |
| Aydin, M; Davarci, M; Inci, M; Motor, S; Nacar, E; Sefil, NK; Yalcinkaya, FR; Zararsiz, I | 1 |
| Hanan, el-A; Magdy, MA; Nabila, el-M | 1 |
| Mahgoub, AA | 1 |
| Bayram, I; Isik, AF; Kati, I; Ozbek, H | 1 |
| Dreskin, SC; El Gazzar, M; El Mezayen, R; Marecki, JC; Nicolls, MR | 1 |
| Canastar, A; Dreskin, SC; El Gazzar, M; El Mezayen, R; Marecki, JC; Nicolls, MR | 1 |
| Dreskin, SC; El Gazzar, M; El Mezayen, R; Marecki, JC; Nicolls, MR; Nomiyama, H | 1 |
| Al-Majed, AA; Al-Omar, FA; Nagi, MN | 1 |
| Demiralp, L; Dogan, A; Tekeoglu, I | 1 |
| Budancamanak, M; Demirel, A; Dogan, A; Ediz, L; Tekeoglu, I | 1 |
| Aydin, B; Erdurmus, M; Hepsen, IF; Karadag, R; Turkmen, C; Yagci, R; Yilmaz, B | 1 |
| al-Bekairi, AM; al-Gharably, NM; al-Rikabi, AC; al-Shabanah, OA; Badary, OA; Nagi, MN | 1 |
| Al-Rikabi, AC; Al-Shabanah, OA; Badary, OA; Elmazar, MM; Nagi, MN | 1 |
| Badary, OA; Gamal El-Din, AM | 1 |
6 review(s) available for thymoquinone and Disease Models, Animal
| Article | Year |
|---|---|
Thymoquinone, a major constituent in Nigella sativa seeds, is a potential preventative and treatment option for atherosclerosis.
Topics: Animals; Atherosclerosis; Benzoquinones; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Hyperlipidemias; Inflammation; Nigella sativa; Oxidative Stress; Seeds; Treatment Outcome | 2021 |
Nigella sativa fixed oil as alternative treatment in management of pain in arthritis rheumatoid.
Topics: Animals; Arthritis, Rheumatoid; Benzoquinones; Disease Models, Animal; Humans; Nigella sativa; Pain; Plant Oils; Randomized Controlled Trials as Topic; Seeds | 2018 |
Thymoquinone: fifty years of success in the battle against cancer models.
Topics: Animals; Antineoplastic Agents, Phytogenic; Benzoquinones; Disease Models, Animal; Humans; Neoplasms; Nigella sativa | 2014 |
Thymoquinone Anticancer Discovery: Possible Mechanisms.
Topics: Animals; Antineoplastic Agents, Phytogenic; Benzoquinones; Cell Transformation, Neoplastic; Chemoprevention; Disease Models, Animal; Drug Discovery; Humans; Neoplasms; Nigella sativa; Signal Transduction | 2015 |
Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review.
Topics: Animals; Benzoquinones; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ethnopharmacology; Humans; Nigella sativa; Phytotherapy; Plant Extracts; Plants, Medicinal; Risk Assessment; Seeds; Toxicity Tests | 2016 |
The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Cytoprotection; Disease Models, Animal; Humans; Kidney; Kidney Diseases; Oxidative Stress; Reactive Oxygen Species; Treatment Outcome | 2009 |
95 other study(ies) available for thymoquinone and Disease Models, Animal
| Article | Year |
|---|---|
TQFL12, a novel synthetic derivative of TQ, inhibits triple-negative breast cancer metastasis and invasion through activating AMPK/ACC pathway.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Benzoquinones; Cell Cycle; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Drug Tapering; Humans; Mice; Models, Molecular; Protein Binding; Signal Transduction; Structure-Activity Relationship; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2021 |
Therapeutic effect of Thymoquinone on behavioural response to UCMS and neuroinflammation in hippocampus and amygdala in BALB/c mice model.
Topics: Amygdala; Animals; Benzoquinones; Depression; Depressive Disorder, Major; Disease Models, Animal; Hippocampus; Mice; Mice, Inbred BALB C; Neuroinflammatory Diseases; Stress, Psychological | 2022 |
The effects of thymoquinone on steroid-induced femoral head osteonecrosis: An experimental study in rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Femur Head; Femur Head Necrosis; Lipopolysaccharides; Methylprednisolone; Rats; Steroids; Vascular Endothelial Growth Factor A; X-Ray Microtomography | 2022 |
The healing effects of thymoquinone on experimentally induced traumatic tendinopathy in rabbits.
Topics: Achilles Tendon; Animals; Collagen; Dimethyl Sulfoxide; Disease Models, Animal; Rabbits; Tendinopathy | 2023 |
Effects of thymoquinone and memantine alone and in combination on memory and hippocampal morphology in rats with streptozotocin-induced Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memantine; Neurodegenerative Diseases; Rats; Streptozocin | 2023 |
Thymoquinone reverses nonalcoholic fatty liver disease (NAFLD) associated with experimental hypothyroidism.
Topics: Animals; Benzoquinones; Disease Models, Animal; Hypothyroidism; Male; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar | 2019 |
Thymoquinone Inhibits Neurogenic Inflammation Underlying Migraine Through Modulation of Calcitonin Gene-Related Peptide Release and Stabilization of Meningeal Mast Cells in Glyceryltrinitrate-Induced Migraine Model in Rats.
Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Calcitonin Gene-Related Peptide; Disease Models, Animal; Male; Mast Cells; Meninges; Migraine Disorders; Neurogenic Inflammation; Nitroglycerin; Phytochemicals; Rats; Rats, Wistar | 2020 |
Thymoquinone attenuates oxidative stress of kidney mitochondria and exerts nephroprotective effects in oxonic acid-induced hyperuricemia rats.
Topics: Animals; Benzoquinones; Disease Models, Animal; Hyperuricemia; Kidney; Kidney Diseases; Male; Mitochondria; Oxidative Stress; Oxonic Acid; Rats; Rats, Sprague-Dawley | 2020 |
Thymoquinone-loaded lipid vesicles: a promising nanomedicine for psoriasis.
Topics: Animals; Benzoquinones; Disease Models, Animal; Drug Carriers; Mice; Nanomedicine; Nigella sativa; Phospholipids; Psoriasis; Skin; Skin Absorption | 2019 |
Thymoquinone ameliorates Pachycondyla sennaarensis venom-induced acute toxic shock in male rats.
Topics: Acute Disease; Animals; Ant Venoms; Anti-Inflammatory Agents; Ants; B7-1 Antigen; B7-2 Antigen; Benzoquinones; Biomarkers; Disease Models, Animal; Immunity, Innate; Insect Bites and Stings; Kidney Function Tests; Liver Function Tests; Male; Nigella sativa; Plant Extracts; Rats; Rats, Wistar | 2019 |
Comparison of the effects of thymoquinone and silymarin on the brain of rats having ischemia-reperfusion in the lower extremities.
Topics: Animals; Antioxidants; Benzoquinones; Brain Diseases; Disease Models, Animal; Lower Extremity; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Silymarin | 2020 |
Thymoquinone Loaded Solid Lipid Nanoparticles Demonstrated Antidepressant-Like Activity in Rats via Indoleamine 2, 3- Dioxygenase Pathway.
Topics: Animals; Antidepressive Agents; Behavior Observation Techniques; Behavior, Animal; Benzoquinones; Depression; Disease Models, Animal; Drug Carriers; Hippocampus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipids; Male; Nanoparticles; Nigella sativa; Rats; Serotonin; Signal Transduction; Tryptophan | 2020 |
Thymoquinone Glucuronide Conjugated Magnetic Nanoparticle for Bimodal Imaging and Treatment of Cancer as a Novel Theranostic Platform.
Topics: Animals; Benzoquinones; Cell Line, Tumor; Disease Models, Animal; Glucuronides; Iodine Radioisotopes; Lung; Lung Neoplasms; Magnetic Resonance Imaging; Magnetite Nanoparticles; Mice; Mice, Nude; Precision Medicine; Rabbits; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon | 2021 |
Thymoquinone-encapsulated chitosan nanoparticles coated with polysorbate 80 as a novel treatment agent in a reserpine-induced depression animal model.
Topics: Animals; Benzoquinones; Chitosan; Depression; Disease Models, Animal; Nanoparticles; Polysorbates; Rats; Reserpine | 2020 |
Indirubin-3-monoxime and thymoquinone exhibit synergistic efficacy as therapeutic combination in in-vitro and in-vivo models of Lung cancer.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Benzoquinones; Cell Cycle; Cell Line; Cell Proliferation; Disease Models, Animal; Drug Combinations; Drug Screening Assays, Antitumor; Female; Humans; In Vitro Techniques; Indoles; Lung Neoplasms; Mice; Mice, Nude; Models, Biological; Neoplasms, Experimental; Oximes | 2020 |
The Effect of Thymoquinone on the Characteristics of the Brain Extracellular Space in Transient Middle Cerebral Artery Occlusion Rats.
Topics: Animals; Benzoquinones; Brain; Disease Models, Animal; Extracellular Space; Humans; Infarction, Middle Cerebral Artery; Ischemic Stroke; Magnetic Resonance Imaging; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2020 |
Thymoquinone ameliorates delayed cerebral injury and cerebral vasospasm secondary to experimental subarachnoid haemorrhage.
Topics: Animals; Basilar Artery; Benzoquinones; Disease Models, Animal; Humans; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2020 |
Chitosan coated synergistically engineered nanoemulsion of Ropinirole and nigella oil in the management of Parkinson's disease: Formulation perspective and In vitro and In vivo assessment.
Topics: Animals; Benzoquinones; Chitosan; Disease Models, Animal; Drug Stability; Drug Synergism; Emulsions; Female; Humans; Indoles; Male; Molecular Docking Simulation; Nanoparticles; NF-kappa B; Nigella; Oxidopamine; Parkinson Disease; Plant Oils; Rats; Tumor Necrosis Factor-alpha | 2021 |
Upsurge in autophagy, associated with mifepristone-treated polycystic ovarian condition, is reversed upon thymoquinone treatment.
Topics: Androgens; Animals; Autophagy; Beclin-1; Benzoquinones; Disease Models, Animal; eIF-2 Kinase; Female; Gene Expression Regulation; Granulosa Cells; Humans; Insulin Resistance; Mifepristone; Ovary; Ovulation; Polycystic Ovary Syndrome; Rats; Receptors, Androgen | 2021 |
Neuroprotective Effects of Thymoquinone by the Modulation of ER Stress and Apoptotic Pathway in In Vitro Model of Excitotoxicity.
Topics: Animals; Apoptosis; Benzoquinones; CA3 Region, Hippocampal; Disease Models, Animal; Disks Large Homolog 4 Protein; Endoplasmic Reticulum Stress; Epilepsy; Excitatory Amino Acid Agonists; Female; In Vitro Techniques; Kainic Acid; Male; Neuronal Plasticity; Neuroprotective Agents; Rats; Rats, Wistar | 2021 |
Thymoquinone, a Dietary Bioactive Compound, Exerts Anti-Inflammatory Effects in Colitis by Stimulating Expression of the Colonic Epithelial PPAR-γ Transcription Factor.
Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Phytochemicals; PPAR gamma; Signal Transduction; Transcription Factors | 2021 |
Thymoquinone Lowers Blood Glucose and Reduces Oxidative Stress in a Rat Model of Diabetes.
Topics: Animals; Antioxidants; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Humans; Hypoglycemia; Kidney; Oxidative Stress; Rats | 2021 |
Thymoquinone ameliorates lead-induced suppression of the antioxidant system in rat kidneys.
Topics: Acute Kidney Injury; Animals; Antioxidants; Benzoquinones; Disease Models, Animal; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Kidney; Lead; Male; Nigella sativa; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Superoxide Dismutase | 2016 |
The effect of caffeic acid phenethyl ester and thymoquinone on otitis media with effusion in rats.
Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Caffeic Acids; Disease Models, Animal; Eustachian Tube; Injections, Intraperitoneal; Male; Otitis Media with Effusion; Phenylethyl Alcohol; Rats; Rats, Wistar; Temporal Bone | 2017 |
Involvement of microRNA-146a in the Inflammatory Response of S tatus Epilepticus Rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Inflammation; Lithium Chloride; Male; MicroRNAs; Muscarinic Agonists; NF-kappa B; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2017 |
Thymoquinone exerts neuroprotective effect in animal model of Parkinson's disease.
Topics: Animals; Antioxidants; Basal Ganglia; Behavior, Animal; Benzoquinones; Cytoprotection; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Dynamins; Male; Motor Activity; Neuroprotective Agents; Oxidative Stress; Parkinsonian Disorders; Rats, Wistar; Rotenone; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Ubiquitin-Protein Ligases | 2017 |
The Role of Topical Thymoquinone in the Treatment of Acute Otitis Externa; an Experimental Study in Rats.
Topics: Acute Disease; Administration, Topical; Animals; Benzoquinones; Dexamethasone; Disease Models, Animal; Ear Canal; Glucocorticoids; Male; Otitis Externa; Rats; Rats, Wistar; Treatment Outcome | 2018 |
Comparison of icodextrin with thymoquinone: A new hope for postoperative adhesions.
Topics: Animals; Benzoquinones; Disease Models, Animal; Glucans; Glucose; Humans; Icodextrin; Injections, Intraperitoneal; Male; Postoperative Complications; Rats; Rats, Wistar; Tissue Adhesions; Ubiquinone | 2017 |
Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats.
Topics: Animals; Antioxidants; Antithyroid Agents; Avoidance Learning; Benzoquinones; Brain Injuries; Catalase; Disease Models, Animal; Hippocampus; Hypothyroidism; Learning Disabilities; Male; Malondialdehyde; Maze Learning; Memory Disorders; Nitric Oxide; Oxidative Stress; Propylthiouracil; Rats, Wistar; Superoxide Dismutase | 2018 |
Thymoquinone activates MAPK pathway in hippocampus of streptozotocin-treated rat model.
Topics: Alzheimer Disease; Animals; Benzoquinones; Disease Models, Animal; Female; Gene Expression Regulation; Hippocampus; MAP Kinase Signaling System; Memory Disorders; Nerve Degeneration; Phosphorylation; Rats, Sprague-Dawley; Streptozocin; tau Proteins | 2018 |
Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes.
Topics: Aluminum Chloride; Aluminum Compounds; Alzheimer Disease; Animals; Behavior, Animal; Benzoquinones; Brain; Chlorides; Cognitive Dysfunction; Disease Models, Animal; Galactose; Male; Memory; Neuroprotective Agents; Rats, Sprague-Dawley | 2018 |
Investigation of the effects of thymoquinone on erythrocyte deformability in sepsis treatment which created by cecal perforation in rat.
Topics: Animals; Benzoquinones; Cecum; Disease Models, Animal; Erythrocyte Deformability; Intestinal Perforation; Ligation; Male; Nigella sativa; Rats; Sepsis | 2018 |
Thymoquinone reduces mortality and suppresses early acute inflammatory markers of sepsis in a mouse model.
Topics: Acute Disease; Animals; Benzoquinones; Biomarkers; C-Reactive Protein; Disease Models, Animal; Escherichia coli; Inflammation; Kaplan-Meier Estimate; Mice, Inbred BALB C; Proteoglycans; Sepsis; Survival Analysis; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2018 |
Effects of thymoquinone on liver miRNAs and oxidative stress in Ehrlich acid mouse solid tumor model.
Topics: Animals; Antioxidants; Benzoquinones; Disease Models, Animal; Liver; Male; Mice, Inbred BALB C; MicroRNAs; Neoplasms; Oxidative Stress | 2018 |
Thymoquinone loaded solid lipid nanoparticles counteracts 3-Nitropropionic acid induced motor impairments and neuroinflammation in rat model of Huntington's disease.
Topics: Animals; Benzoquinones; Disease Models, Animal; Drug Delivery Systems; Encephalitis; Huntington Disease; Male; Motor Activity; Nanoparticles; Neuroprotective Agents; Nitro Compounds; Oxidative Stress; Propionates; Rats | 2018 |
Effects of Thymoquinone on radiation enteritis in mice.
Topics: Animals; Apoptosis; Benzoquinones; Biomarkers; Disease Models, Animal; Enteritis; Enterocytes; Fluorescent Antibody Technique; Intestinal Mucosa; Intestine, Small; Mice; Radiation Injuries; Radiation-Protective Agents; Survival Rate; Treatment Outcome | 2018 |
Therapeutic potential of thymoquinone liposomes against the systemic infection of Candida albicans in diabetic mice.
Topics: Animals; Benzoquinones; Blood Glucose; Candida albicans; Candidiasis; Diabetes Mellitus, Experimental; Disease Models, Animal; Humans; Liposomes; Liver; Mice | 2018 |
Effects of Topical Thymoquinone in an Experimental Dry Eye Model
Topics: Administration, Topical; Animals; Benzoquinones; Conjunctiva; Cytokines; Disease Models, Animal; Dry Eye Syndromes; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Lacrimal Apparatus; Male; Mice; Mice, Inbred BALB C; Random Allocation; T-Lymphocytes; Tears | 2018 |
Evaluation of the in vitro and in vivo inhibitory effect of thymoquinone on piroplasm parasites.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Babesia; Babesiosis; Benzoquinones; Diminazene; Disease Models, Animal; Female; Inhibitory Concentration 50; Mice; Phytochemicals; Theileria; Theileriasis | 2019 |
Thymoquinone attenuates rheumatoid arthritis by downregulating TLR2, TLR4, TNF-α, IL-1, and NFκB expression levels.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Benzoquinones; Biomarkers; Disease Models, Animal; Down-Regulation; Inflammation; Interleukin-1beta; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2019 |
Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives.
Topics: Animals; Benzoquinones; Cytokines; Disease Models, Animal; Electron Transport Complex IV; Encephalitis; Food Preservatives; Gene Expression Regulation; Glutathione; Male; Mice; Oxidative Stress; Plant Oils; Sodium Nitrite | 2019 |
Thymoquinone ameliorates obesity-induced metabolic dysfunction, improves reproductive efficiency exhibiting a dose-organ relationship.
Topics: Animals; Antioxidants; Benzoquinones; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Fasting; Female; Lactation; Litter Size; Mammary Glands, Animal; Mice; Mice, Inbred C57BL; Mitochondria; Obesity; Oxidative Stress; Reproduction; Transcriptome | 2019 |
Thymoquinone upregulates TRAIL/TRAILR2 expression and attenuates hepatocellular carcinoma in vivo model.
Topics: Animals; Apoptosis; Benzoquinones; Carcinoma, Hepatocellular; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand | 2019 |
Antioxidative and anti-inflammatory effect of thymoquinone in an acute Pseudomonas prostatitis rat model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Catalase; Disease Models, Animal; Glutathione Peroxidase; Inflammation; Male; Malondialdehyde; Nitric Oxide; Prostatitis; Pseudomonas; Rats; Rats, Wistar; Superoxide Dismutase | 2013 |
Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzoquinones; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Synergism; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Multiple Myeloma; NF-kappa B; Pyrazines; Random Allocation; Signal Transduction; Xenograft Model Antitumor Assays | 2014 |
Antidepressant Effect of Thymoquinone in Animal Models of Depression.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Benzoquinones; Brain; Depression; Disease Models, Animal; Drug Synergism; Fluoxetine; Glutathione; Male; Mice; Serotonin; Thiobarbituric Acid Reactive Substances | 2015 |
Thymoquinone supplementation ameliorates lead-induced testis function impairment in adult rats.
Topics: Animals; Benzoquinones; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Lead; Male; Nigella sativa; Protective Agents; Rats; Rats, Wistar; Reproduction; Sperm Count; Spermatogenesis; Spermatozoa; Testicular Diseases; Testis; Testosterone | 2016 |
Effects of intraperitoneal thymoquinone on chronic neuropathic pain in rats.
Topics: Analgesics, Non-Narcotic; Animals; bcl-2-Associated X Protein; Benzoquinones; Chronic Pain; Disease Models, Animal; Glutathione; Hyperalgesia; Male; Malondialdehyde; Neuralgia; Neuroglia; Nigella sativa; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Sciatic Nerve; Spinal Cord | 2014 |
Protective effect of thymoquinone against high-fructose diet-induced metabolic syndrome in rats.
Topics: Animals; Benzoquinones; Catalase; Cholesterol, HDL; Cholesterol, LDL; Disease Models, Animal; Dose-Response Relationship, Drug; Fructose; Glucose Tolerance Test; Glutathione; Hyperglycemia; Insulin Resistance; Liver; Male; Metabolic Syndrome; Oxidative Stress; Rats; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Triglycerides | 2015 |
Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cell Proliferation; Colorectal Neoplasms, Hereditary Nonpolyposis; Disease Models, Animal; Female; Frameshift Mutation; HCT116 Cells; Humans; Intestinal Mucosa; Male; Mesalamine; Mice; Microsatellite Instability; Mutation Rate; MutS Homolog 2 Protein; Tumor Burden | 2015 |
Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Benzoquinones; CA1 Region, Hippocampal; Disease Models, Animal; Injections, Intraperitoneal; Long-Term Potentiation; Male; Mitochondria; Neuroprotective Agents; Organophosphorus Compounds; Peptide Fragments; Rats; Rats, Wistar | 2015 |
Liposomal thymoquinone effectively combats fluconazole-resistant Candida albicans in a murine model.
Topics: Animals; Antifungal Agents; Benzoquinones; Candida albicans; Candidiasis; Disease Models, Animal; Drug Resistance, Fungal; Female; Fluconazole; Liposomes; Macrophages; Mice; Microbial Sensitivity Tests | 2015 |
Thymoquinone ameliorates NLRP3-mediated inflammation in the pancreas of albino Wistar rats fed ethanol and high-fat diet.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis Regulatory Proteins; Benzoquinones; CARD Signaling Adaptor Proteins; Carrier Proteins; Caspase 1; Cytokines; Diet, High-Fat; Disease Models, Animal; Ethanol; Inflammasomes; Inflammation; Inflammation Mediators; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Pancreatitis; Rats; Rats, Wistar; RNA, Messenger; Up-Regulation | 2015 |
Thymoquinone attenuates toxicity and oxidative stress induced by bisphenol A in liver of male rats.
Topics: Animals; Antioxidants; Benzhydryl Compounds; Benzoquinones; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Lipid Peroxidation; Liver; Male; Organ Size; Oxidative Stress; Phenols; Rats, Sprague-Dawley; Time Factors | 2014 |
Biochemical, Histopathological and Immunohistochemical Evaluation of the Protective and Therapeutic Effects of Thymoquinone against Ischemia and Ischemia/Reperfusion Injury in the Rat Ovary.
Topics: Animals; Benzoquinones; Disease Models, Animal; Female; Ischemia; Ovarian Diseases; Rats; Rats, Wistar; Reperfusion Injury | 2016 |
Thymoquinone enhances cisplatin-response through direct tumor effects in a syngeneic mouse model of ovarian cancer.
Topics: Animals; Apoptosis; Benzoquinones; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; NF-kappa B; Ovarian Neoplasms; Tumor Necrosis Factor-alpha | 2015 |
Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury.
Topics: Animals; Antioxidants; Benzoquinones; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Infarction, Middle Cerebral Artery; Male; Mitochondria; Neuroprotective Agents; Oxidative Stress; Plastoquinone; Random Allocation; Rats; Reactive Oxygen Species; Reperfusion Injury | 2015 |
Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Blood Glucose; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Interactions; Glyburide; Humans; Hypoglycemic Agents; Male; Nigella; Plant Extracts; Rats; Rats, Wistar; Steroid 16-alpha-Hydroxylase | 2015 |
Implication of thymoquinone as a remedy for polycystic ovary in rat.
Topics: Animals; Benzoquinones; Cell Line; Cell Survival; Disease Models, Animal; Female; Inflammation Mediators; Mice; NF-kappa B; Polycystic Ovary Syndrome; Rats; Rats, Wistar | 2016 |
Ameliorative effects of thymoquinone against eye lens changes in streptozotocin diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Gene Expression Regulation; Hypoglycemic Agents; Lens, Crystalline; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Streptozocin | 2015 |
Microenvironmental effects limit efficacy of thymoquinone treatment in a mouse model of ovarian cancer.
Topics: Animals; Antinematodal Agents; Apoptosis; Benzoquinones; Cell Line, Tumor; Clodronic Acid; Disease Models, Animal; Female; Macrophages; Mice; Mice, Inbred C57BL; NF-kappa B; Ovarian Neoplasms | 2015 |
Neuroprotective effects of thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Benzoquinones; Caspase 3; Disease Models, Animal; Interleukin-1; Male; Malondialdehyde; Motor Neurons; Neuroimmunomodulation; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Random Allocation; Rats, Wistar; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia; Tumor Necrosis Factor-alpha | 2016 |
Protective effect of thymoquinone against lead-induced hepatic toxicity in rats.
Topics: Animals; Antioxidants; Benzoquinones; Chemical and Drug Induced Liver Injury; Dietary Supplements; Disease Models, Animal; Environmental Pollutants; Lead; Lipid Peroxidation; Liver; Liver Function Tests; Male; Nigella sativa; Oils, Volatile; Random Allocation; Rats, Wistar; Seeds | 2016 |
A novel therapeutic application of solid lipid nanoparticles encapsulated thymoquinone (TQ-SLNs) on 3-nitroproponic acid induced Huntington's disease-like symptoms in wistar rats.
Topics: Animals; Benzoquinones; Corpus Striatum; Disease Models, Animal; Drug Carriers; Huntington Disease; Lipids; Male; Memory; Nanoparticles; Neuroprotective Agents; Nitro Compounds; Oxidative Stress; Propionates; Rats, Wistar; Spatial Navigation | 2016 |
Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice.
Topics: Airway Remodeling; Animals; Asthma; Benzoquinones; Disease Models, Animal; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Signaling Peptides and Proteins; Interleukin-4; Interleukin-5; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Nerve Tissue Proteins; Nigella sativa; Oncogene Protein v-akt; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
Thymoquinone attenuates monocrotaline-induced pulmonary artery hypertension via inhibiting pulmonary arterial remodeling in rats.
Topics: Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Benzoquinones; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Signal Transduction; Treatment Outcome; Vascular Remodeling | 2016 |
Thymoquinone mitigate ischemia-reperfusion-induced liver injury in rats: a pivotal role of nitric oxide signaling pathway.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Benzoquinones; Biomarkers; Cytoprotection; Disease Models, Animal; Glutathione; Lipid Peroxidation; Liver; Liver Diseases; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxidase; Rats, Wistar; Reperfusion Injury; Signal Transduction | 2017 |
Evaluation of Neuroprotective Effect of Thymoquinone Nanoformulation in the Rodent Cerebral Ischemia-Reperfusion Model.
Topics: Animals; Benzoquinones; Brain; Brain Chemistry; Brain Ischemia; Disease Models, Animal; Drug Delivery Systems; Male; Nanoparticles; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury | 2016 |
The anti-inflammatory and antioxidant effects of thymoquinone on ceruleine induced acute pancreatitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Ceruletide; Disease Models, Animal; Interleukin-1beta; Male; Oxidative Stress; Pancreas; Pancreatitis, Acute Necrotizing; Rats; Rats, Wistar | 2016 |
The acute effects of thymoquinone on acute peripheral nerve injury: an experimental study.
Topics: Animals; Benzoquinones; Disease Models, Animal; Female; Nerve Regeneration; Neuroprotective Agents; Peripheral Nerve Injuries; Random Allocation; Rats; Sciatic Nerve | 2016 |
Gastroprotective Effect of Thymoquinone on Water Immersion Restraint Stress Induced Ulceration in Rats.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Benzoquinones; Disease Models, Animal; Drug Therapy, Combination; Gastric Acid; Gastric Juice; Gastric Mucosa; Male; Oxidative Stress; Ranitidine; Rats; Rats, Wistar; Restraint, Physical; Stomach Ulcer; Stress, Psychological | 2017 |
Effect of thymoquinone on ethylene glycol-induced kidney calculi in rats.
Topics: Animals; Benzoquinones; Calcium Oxalate; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylene Glycol; Injections, Intraperitoneal; Kidney Calculi; Male; Nigella sativa; Rats; Rats, Wistar | 2008 |
Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits.
Topics: Animals; Antioxidants; Aorta; Atherosclerosis; Benzoquinones; Cholesterol, Dietary; Disease Models, Animal; Kidney; Kidney Function Tests; Lipids; Male; Propolis; Pulmonary Artery; Rabbits | 2010 |
Protective effect of thymoquinone in experimental testicular torsion.
Topics: Analysis of Variance; Animals; Antioxidants; Benzoquinones; Cytoprotection; Disease Models, Animal; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Oxidative Stress; Peroxidase; Reperfusion Injury; Spermatic Cord Torsion; Testis; Time Factors | 2010 |
The protective effect of thymoquinone against sepsis syndrome morbidity and mortality in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Disease Models, Animal; Dose-Response Relationship, Drug; Kaplan-Meier Estimate; Lipopolysaccharides; Male; Mice; Molecular Structure; Nigella sativa; Systemic Inflammatory Response Syndrome | 2011 |
Ameliorative effect of thymoquinone on ovalbumin-induced allergic conjunctivitis in Balb/c mice.
Topics: Animals; Benzoquinones; Chromatography, High Pressure Liquid; Conjunctivitis, Allergic; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophils; Histamine; Immunoglobulin E; Leukocyte Count; Mice; Mice, Inbred BALB C; Ovalbumin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Effect of thymoquinone on hepatorenal dysfunction and alteration of CYP3A1 and spermidine/spermine N-1-acetyl-transferase gene expression induced by renal ischaemia-reperfusion in rats.
Topics: Acetyltransferases; Alanine Transaminase; Animals; Antioxidants; Benzoquinones; Creatinine; Cytochrome P-450 CYP3A; Disease Models, Animal; Gene Expression; Glutathione Transferase; Ischemia; Kidney; Kidney Diseases; Liver; Male; Malondialdehyde; Nigella sativa; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Seeds; Spermidine; Superoxide Dismutase | 2011 |
Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzoquinones; Brain; Cyclic GMP; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Methylene Blue; Mice; Nigella sativa; Nitric Oxide; Stress, Psychological | 2011 |
Preventive effects of thymoquinone in a rat periodontitis model: a morphometric and histopathological study.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Cell Count; Cell Shape; Disease Models, Animal; Disease Progression; Male; Osteoblasts; Osteoclasts; Osteogenesis; Periodontitis; Random Allocation; Rats; Rats, Wistar | 2012 |
Upregulation of chemoprotective enzymes and glutathione by Nigella sativa (black seed) and thymoquinone in CCl4-intoxicated rats.
Topics: Animals; Benzoquinones; Carbon Tetrachloride Poisoning; Cysteine; Disease Models, Animal; Epoxide Hydrolases; Glutathione; Glutathione Disulfide; Glutathione Transferase; Male; NAD(P)H Dehydrogenase (Quinone); Nigella sativa; Plant Extracts; Protective Agents; Rats; Rats, Wistar; RNA, Messenger; Seeds; Up-Regulation | 2011 |
Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia-reperfusion in rat skeletal muscle.
Topics: Animals; Benzoquinones; Disease Models, Animal; Electromyography; Hindlimb; Male; Malondialdehyde; Muscle, Skeletal; Nigella sativa; Oxidative Stress; Phytotherapy; Protective Agents; Rats; Rats, Wistar; Reperfusion Injury; Sulfhydryl Compounds | 2012 |
Anti-inflammatory and antioxidant activity of thymoquinone in a rat model of acute bacterial prostatitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Catalase; Disease Models, Animal; Escherichia coli Infections; Glutathione Peroxidase; Male; Malondialdehyde; Prostatitis; Rats; Rats, Wistar; Superoxide Dismutase | 2013 |
Thymoquinone: Novel gastroprotective mechanisms.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Benzoquinones; Cytoprotection; Disease Models, Animal; Gastric Acid; Gastric Mucins; Gastric Mucosa; Glutathione; H(+)-K(+)-Exchanging ATPase; Lipid Peroxides; Male; Neutrophil Infiltration; Nitric Oxide; Omeprazole; Pepsin A; Peroxidase; Proton Pump Inhibitors; Rats; Rats, Wistar; Reperfusion Injury; Stomach Ulcer; Superoxide Dismutase; Time Factors | 2012 |
Thymoquinone protects against experimental colitis in rats.
Topics: Acetic Acid; Animals; Benzoquinones; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Histamine; Male; Peroxidase; Platelet Activating Factor; Rats; Rats, Wistar; Rectum | 2003 |
A new agent for treatment of acute respiratory distress syndrome: thymoquinone. An experimental study in a rat model.
Topics: Acute Disease; Animals; Anti-Infective Agents, Local; Benzoquinones; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Ethanol; Glucocorticoids; Lung; Lung Compliance; Lung Injury; Male; Methylprednisolone; Oxygen; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome | 2005 |
Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma.
Topics: Animals; Arachidonate 5-Lipoxygenase; Asthma; Benzoquinones; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Down-Regulation; Female; Hypersensitivity; Inflammation; Leukotrienes; Lung; Male; Mice; Mice, Inbred BALB C; Nigella sativa | 2006 |
Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation.
Topics: Allergens; Animals; Anti-Inflammatory Agents; Benzoquinones; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Goblet Cells; Immunoglobulin E; Immunoglobulin G; Leukocyte Count; Lung; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Pneumonia; Respiratory Hypersensitivity; Th2 Cells | 2006 |
Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation.
Topics: Allergens; Animals; Anti-Inflammatory Agents; Benzoquinones; Bronchial Hyperreactivity; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Dinoprostone; Disease Models, Animal; Female; Gene Expression Regulation; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Prostaglandin D2; Th2 Cells | 2006 |
Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus.
Topics: Animals; Benzoquinones; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Hippocampus; Ischemic Attack, Transient; Lipid Peroxidation; Male; Neuroprotective Agents; Oxidative Stress; Prosencephalon; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase | 2006 |
Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Benzoquinones; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Interleukin-1beta; Male; Nigella sativa; Oils, Volatile; Plant Oils; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tumor Necrosis Factor-alpha | 2006 |
Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Benzoquinones; Disease Models, Animal; Female; Freund's Adjuvant; Male; Nigella sativa; Phytotherapy; Plant Oils; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2007 |
Inhibitory effects of topical thymoquinone on corneal neovascularization.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Corneal Neovascularization; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Rats; Rats, Wistar; Triamcinolone Acetonide | 2007 |
Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity.
Topics: Animals; Antibiotics, Antineoplastic; Benzoquinones; Carcinoma, Ehrlich Tumor; Creatine Kinase; Disease Models, Animal; Doxorubicin; Drug Interactions; Female; Heart Diseases; Mice; Myocardium | 1998 |
Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Benzo(a)pyrene; Benzoquinones; Carcinoma, Squamous Cell; Chemoprevention; Disease Models, Animal; Female; Gastric Fundus; Gastric Mucosa; Liver; Mice; Mice, Inbred Strains; Probability; Reference Values; Stomach Neoplasms | 1999 |
Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Carcinogens; Disease Models, Animal; DNA Repair; Fibrosarcoma; Male; Methylcholanthrene; Mice; Mice, Inbred Strains | 2001 |