thymoquinone has been researched along with Alloxan Diabetes in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (21.62) | 29.6817 |
| 2010's | 21 (56.76) | 24.3611 |
| 2020's | 8 (21.62) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmad, A; Alkharfy, KM; El-Asrar, AA; Ghulam, M; Siddiquei, MM | 1 |
| Abdelkader, DH; Ahmed, HM; Almukainzi, M; El-Masry, TA; Elekhnawy, E; Negm, WA; Saleh, A; Sayed, AE | 1 |
| Abdel-Moneim, A; El-Shahawy, AAG; Eldin, ZE; Hosni, A; Hussien, M; Zanaty, MI | 1 |
| Aboubaker, EM; Ali, FEM; Hofni, A; Ibrahim, ARN | 1 |
| Ahmad, A; Ahmad, I; Ahmad, M; Ali, SM; Chaturvedi, A; Chavda, V; Chen, P; Desai, B; Khan, M; Paithankar, M; Panchal, DT; Patel, A; Patel, P; Patel, R; Saboo, BD; Shah, K; Sheikh, S | 1 |
| Abdel-Moneim, AH; Abdellatif, AAH; Al Rugaie, O; Alsharidah, AS; Alsharidah, M; Faisal Lutfi, M; Mobark, MA; Mohany, KM; Saleem, IY | 1 |
| Aktas, I; Gur, FM | 1 |
| Aktaş, İ; Mehmet Gür, F | 1 |
| Al Jaouni, SK; Almadaly, EA; Assar, DH; Atta, MS; El-Far, AH; Mousa, SA; Saleh, RM | 1 |
| Alsaegh, A; El-Shemi, AG; Kensara, OA; Mukhtar, MH | 1 |
| Heart, EA; Karandrea, S; Liang, X; Slitt, AL; Yin, H | 1 |
| Dahiya, S; Dhingra, D; Dilbaghi, N; Kim, KH; Kumar, S; Rani, R | 1 |
| Alam, MF; Anwer, T; Khan, G; Masmali, AUM; Qumayri, HM; Safhi, MM; Siddiqui, R | 1 |
| Abdel-Daim, MM; Al Jaouni, SK; Atta, MS; El-Far, AH; Farrag, FA; Mousa, SA | 1 |
| Aldebasi, YH; AlSahli, MA; Alsuhaibani, SA; Alzohairy, MA; Khan, A; Khan, MA; Younus, H | 1 |
| Dahiya, S; Dhingra, D; Dilbaghi, N; Kaushik, A; Kim, KH; Kumar, S; Rani, R | 1 |
| Al Wafai, RJ | 1 |
| Al-Abdin, OZ; Badr, G; Farhat, K; Mahmoud, MH; Rabah, DM; Waly, H | 1 |
| Omran, OM | 1 |
| Ahmad, A; Al-Jenoobi, FI; Al-Mohizea, AM; Alkharfy, KM; Khan, RM; Raish, M | 1 |
| Alwadani, F; Fouad, AA | 1 |
| Jiang, YN; Li, N; Liu, H; Liu, HY | 1 |
| Al-Batayneh, K; Al-Trad, B; Alaraj, M; Alhazimi, A; Aljumaili, O; Alkofahi, E; El-Metwally, S; Ginawi, I; Kosba, A | 1 |
| Chen, B; Chen, L; Chen, Y; Li, B; Luo, Q; Shao, Y; Shi, X | 1 |
| Al-Enazi, MM | 1 |
| Kanter, M | 2 |
| Hamdy, NM; Taha, RA | 1 |
| Pari, L; Sankaranarayanan, C | 2 |
| Elsonosy, YA; Fararh, KM; Ibrahim, AK | 1 |
| Abdelmeguid, NE; Al Wafai, RJ; Fakhoury, R; Kamal, SM | 1 |
| Alhazza, I; Alwasel, S; Badr, G; Ebaid, H; Mohany, M | 1 |
| Sayed, AA | 1 |
| El-Mahmoudy, A; El-Sayed, M; Matsuyama, H; Shiina, T; Shimizu, Y; Takewaki, T | 1 |
| Fararh, KM; Ghanem, MM; Nikami, H; Shiina, T; Shimizu, Y; Takewaki, T | 1 |
| Ammon, HP; El-Dakhakhny, M; Lembert, N; Mady, N | 1 |
1 trial(s) available for thymoquinone and Alloxan Diabetes
| Article | Year |
|---|---|
Thymoquinone with Metformin Decreases Fasting, Post Prandial Glucose, and HbA1c in Type 2 Diabetic Patients.
Topics: Administration, Oral; Adult; Animals; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Mice; Middle Aged; Prospective Studies; Streptozocin | 2021 |
36 other study(ies) available for thymoquinone and Alloxan Diabetes
| Article | Year |
|---|---|
Thymoquinone Attenuates Retinal Expression of Mediators and Markers of Neurodegeneration in a Diabetic Animal Model.
Topics: Animals; Brain-Derived Neurotrophic Factor; Caspase 3; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Hyperglycemia; Models, Animal; Rats; Reactive Oxygen Species; Retina | 2023 |
Co-delivery of gentiopicroside and thymoquinone using electrospun m-PEG/PVP nanofibers: In-vitro and In vivo studies for antibacterial wound dressing in diabetic rats.
Topics: Animals; Anti-Bacterial Agents; Bandages; Benzoquinones; Diabetes Mellitus, Experimental; Iridoid Glucosides; Methyl Ethers; Nanofibers; Polyethylene Glycols; Polymers; Polyvinyls; Pyrrolidines; Rats | 2022 |
Therapeutic significance of thymoquinone-loaded chitosan nanoparticles on streptozotocin/nicotinamide-induced diabetic rats: In vitro and in vivo functional analysis.
Topics: Animals; Benzoquinones; Chitosan; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Nanoparticles; Niacinamide; Rats; Streptozocin | 2022 |
Renoprotective Effect of Thymoquinone against Streptozotocin-Induced Diabetic Nephropathy: Role of NOX2 and Nrf2 Signals.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; NF-E2-Related Factor 2; Oxidative Stress; Rats; Streptozocin | 2023 |
Thymoquinone Lowers Blood Glucose and Reduces Oxidative Stress in a Rat Model of Diabetes.
Topics: Animals; Antioxidants; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Humans; Hypoglycemia; Kidney; Oxidative Stress; Rats | 2021 |
The ameliorative effects of thymoquinone and beta-aminoisobutyric acid on streptozotocin-induced diabetic cardiomyopathy.
Topics: Aminoisobutyric Acids; Animals; Benzoquinones; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Male; Rats; Rats, Sprague-Dawley | 2021 |
Hepato-protective effects of thymoquinone and beta-aminoisobutyric acid in streptozocin induced diabetic rats.
Topics: Aminoisobutyric Acids; Animals; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Male; Rats; Streptozocin | 2022 |
Thymoquinone Defeats Diabetes-Induced Testicular Damage in Rats Targeting Antioxidant, Inflammatory and Aromatase Expression.
Topics: Animals; Antioxidants; Aromatase; Benzoquinones; Body Weight; Diabetes Mellitus, Experimental; Glutathione; Male; Malondialdehyde; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Spermatogenesis; Streptozocin; Superoxide Dismutase; Testis; Up-Regulation | 2017 |
Pharmacotherapy with Thymoquinone Improved Pancreatic β-Cell Integrity and Functional Activity, Enhanced Islets Revascularization, and Alleviated Metabolic and Hepato-Renal Disturbances in Streptozotocin-Induced Diabetes in Rats.
Topics: Animals; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Glutathione; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Interleukin-10; Kidney; Liver; Male; Microtubule-Associated Proteins; Platelet Endothelial Cell Adhesion Molecule-1; Rats, Wistar; Superoxide Dismutase; Survivin; Vascular Endothelial Growth Factor A | 2018 |
Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways.
Topics: Animals; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Hep G2 Cells; Humans; Insulin; Lipids; Male; Mice; Mice, Obese; Obesity; Phosphorylation; Sirtuin 1 | 2017 |
Improvement of antihyperglycemic activity of nano-thymoquinone in rat model of type-2 diabetes.
Topics: Administration, Oral; Animals; Benzoquinones; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Hypoglycemic Agents; Nanoparticles; Particle Size; Rats; Rats, Wistar; Surface Properties | 2018 |
Thymoquinone and fluoxetine alleviate depression via attenuating oxidative damage and inflammatory markers in type-2 diabetic rats.
Topics: Animals; Antioxidants; Behavior, Animal; Benzoquinones; Biomarkers; Cytokines; Depression; Diabetes Mellitus, Experimental; Drug Interactions; Fluoxetine; Frontal Lobe; Glutathione; Inflammation; Male; Oxidative Stress; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2019 |
Thymoquinone Attenuates Cardiomyopathy in Streptozotocin-Treated Diabetic Rats.
Topics: Animals; Antioxidants; Benzoquinones; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Gene Expression Regulation; Male; Malondialdehyde; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2018 |
Therapeutic potential of thymoquinone liposomes against the systemic infection of Candida albicans in diabetic mice.
Topics: Animals; Benzoquinones; Blood Glucose; Candida albicans; Candidiasis; Diabetes Mellitus, Experimental; Disease Models, Animal; Humans; Liposomes; Liver; Mice | 2018 |
Antidiabetic activity enhancement in streptozotocin + nicotinamide-induced diabetic rats through combinational polymeric nanoformulation.
Topics: Animals; Benzoquinones; Blood Glucose; Body Weight; Calorimetry, Differential Scanning; Diabetes Mellitus, Experimental; Drug Compounding; Female; Glycated Hemoglobin; Glycyrrhizic Acid; Hypoglycemic Agents; Lipids; Nanoparticles; Niacinamide; Polymers; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Streptozocin | 2019 |
Nigella sativa and thymoquinone suppress cyclooxygenase-2 and oxidative stress in pancreatic tissue of streptozotocin-induced diabetic rats.
Topics: Analysis of Variance; Animals; Benzoquinones; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Gene Expression; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Malondialdehyde; Nigella sativa; Oxidative Stress; Pancreas; Plant Extracts; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase | 2013 |
Maternal supplementation of diabetic mice with thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and free radical production and restoring lymphocyte proliferation via PI3K/AKT signaling.
Topics: Administration, Oral; Animals; Antioxidants; Benzoquinones; Blood Glucose; Body Weight; Cell Proliferation; Cytokines; Diabetes Mellitus, Experimental; Female; Free Radicals; Gene Expression Regulation; Hypoglycemic Agents; Lipid Metabolism; Litter Size; Lymphocytes; Mice; Obesity; Phosphatidylinositol 3-Kinases; Pregnancy; Proto-Oncogene Proteins c-akt; Signal Transduction | 2013 |
Effects of thymoquinone on STZ-induced diabetic nephropathy: an immunohistochemical study.
Topics: Animals; Benzoquinones; Calcium-Binding Proteins; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Immunohistochemistry; Kidney; Male; Matrix Metalloproteinase 17; Rats | 2014 |
Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Blood Glucose; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Interactions; Glyburide; Humans; Hypoglycemic Agents; Male; Nigella; Plant Extracts; Rats; Rats, Wistar; Steroid 16-alpha-Hydroxylase | 2015 |
Ameliorative effects of thymoquinone against eye lens changes in streptozotocin diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Gene Expression Regulation; Hypoglycemic Agents; Lens, Crystalline; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Streptozocin | 2015 |
Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Benzoquinones; Blood Glucose; Cardiotonic Agents; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Drug Evaluation, Preclinical; Inflammation; Male; Malondialdehyde; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Rats, Wistar; Signal Transduction; Tumor Necrosis Factor-alpha | 2016 |
Nigella sativa oil and thymoquinone ameliorate albuminuria and renal extracellular matrix accumulation in the experimental diabetic rats.
Topics: Albuminuria; Animals; Benzoquinones; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Extracellular Matrix; Plant Oils; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A | 2016 |
Thymoquinone Alleviates the Experimental Diabetic Peripheral Neuropathy by Modulation of Inflammation.
Topics: Animals; Benzoquinones; Cell Line; Cell Proliferation; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Interleukin-1beta; Interleukin-6; Male; Rats; Rats, Wistar; Schwann Cells | 2016 |
Effect of thymoquinone on malformations and oxidative stress-induced diabetic mice.
Topics: Animals; Antioxidants; Benzoquinones; Congenital Abnormalities; Cricetinae; Diabetes Mellitus, Experimental; Female; Glutathione; Liver; Malondialdehyde; Mice; Models, Biological; Oxidative Stress; Pregnancy; Pregnancy, Animal | 2007 |
Protective effects of thymoquinone on streptozotocin-induced diabetic nephropathy.
Topics: Animals; Benzoquinones; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Immunohistochemistry; Kidney; Male; Microscopy, Electron, Transmission; Nitric Oxide Synthase Type II; Rats; Streptozocin | 2009 |
Effects of Nigella sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Benzoquinones; Brain; Diabetes Mellitus, Experimental; Dopamine; Heart; Male; Norepinephrine; Oxidative Stress; Plant Oils; Rats; Rats, Wistar; Serotonin; Streptozocin | 2009 |
Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats.
Topics: Animals; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Liver; Male; Molecular Structure; Niacinamide; Rats; Rats, Wistar; Reference Standards; Streptozocin | 2009 |
Thymoquinone enhances the activities of enzymes related to energy metabolism in peripheral leukocytes of diabetic rats.
Topics: Animals; Benzoquinones; Diabetes Mellitus, Experimental; DNA Primers; Energy Metabolism; L-Lactate Dehydrogenase; Leukocytes; Malate Dehydrogenase; Male; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Streptozocin | 2010 |
Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats.
Topics: Animals; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Insulin; Insulin-Secreting Cells; Male; Malondialdehyde; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Oils; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2010 |
Perinatal supplementation with thymoquinone improves diabetic complications and T cell immune responses in rat offspring.
Topics: Actins; Animals; Antioxidants; Apoptosis; Benzoquinones; Blood Glucose; Cell Proliferation; Cytokines; Diabetes Complications; Diabetes Mellitus, Experimental; Female; Interleukin-2; Litter Size; Lymphocyte Activation; Lymphocyte Count; Pregnancy; Pregnancy in Diabetics; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Reactive Oxygen Species; T-Lymphocyte Subsets | 2011 |
Thymoquinone ameliorates chemical induced oxidative stress and β-cell damage in experimental hyperglycemic rats.
Topics: Animals; Ascorbic Acid; Benzoquinones; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Insulin; Insulin-Secreting Cells; Male; Oxidative Stress; Rats; Rats, Wistar; Vitamin E | 2011 |
Thymoquinone and proanthocyanidin attenuation of diabetic nephropathy in rats.
Topics: Animals; Benzoquinones; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Therapy, Combination; Glutathione; Interleukin-6; Lipid Peroxidation; Male; Proanthocyanidins; Rats; Streptozocin | 2012 |
Successful abrogation by thymoquinone against induction of diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism.
Topics: Animals; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; I-kappa B Proteins; Insulin; Macrophages, Peritoneal; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; p38 Mitogen-Activated Protein Kinases; Pancreas; Rats; Rats, Wistar; Streptozocin; Transcription Factor RelA | 2005 |
Thymoquinone reduces hepatic glucose production in diabetic hamsters.
Topics: Animals; Benzoquinones; Cricetinae; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Glycated Hemoglobin; Hypoglycemic Agents; Liver; Male | 2005 |
Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy.
Topics: Animals; Benzoquinones; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Immunohistochemistry; Male; Microscopy, Electron; Nigella sativa; Rats; Sciatic Nerve; Streptozocin | 2008 |
The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions.
Topics: Animals; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Pancreas; Plant Oils; Rats; Rats, Wistar | 2002 |