thymopoietin-iii and Diabetes-Mellitus--Type-1

Forty-seven children suffering from insulin-dependent diabetes mellitus were examined for criteria of the efficacy of the immunocorrecting drugs prodigiosan, sodium nucleinate, decaris and splenin. Certain differences were discovered in the clinicoimmunologic efficiency of the drugs enumerated. The treatment of choice should be conducted on an individual basis under control of the immunologic status with regard to the clinicometabolic effect. The necessity has been shown of including the immunocorrecting remedies into multimodality treatment of diabetes mellitus. Decaris and splenin have been found to possess the greatest immunocorrecting activity in respect of the cellular component of immunity and the highest clinicometabolic efficacy.

Topics: Adjuvants, Immunologic; Adolescent; Child; Diabetes Mellitus, Type 1; Drug Evaluation; Female; Humans; Levamisole; Male; Nucleic Acids; Polysaccharides, Bacterial; Prodigiozan; Thymopoietins; Thymus Hormones