thymopoietin-iii and Chronic-Disease

Topics: Adjuvants, Immunologic; Adult; Antioxidants; Biliary Tract Diseases; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Liver Diseases; Nucleic Acids; Pregnancy; Pregnancy Complications; Quercetin; Spleen; Thymopoietins

Immunological indices were compared in 138 patients with angina and concomitant bronchitis; 86 of them received antibiotics, splenin and vylosen; 52 received routine treatment. It was established that use of a combination of splenin and vylosen produces a pronounced immunodulating effect in primary immunodeficiency states due to recurrences of angina and concomitant pathology of the bronchopulmonary in workers of a large industrial enterprise. Immunomodulators are indicated in the treatment of repeat and relapsing angina, especially in the presence of concomitant bronchitis.

Topics: Adjuvants, Immunologic; Adult; Bronchitis; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pharyngitis; Recurrence; Spleen; Thymopoietins; Thymus Extracts

The clinical efficacy of sodium nucleinate (SN) combined with splenin and quercetin given for lingering Flexner's dysentery in a group of 43 patients was compared with that of routine therapy used in a group of the same number of patients. It has been established that the above drug combination favours the elimination of the pathological symptoms of dyspepsia, the arrest of bacterial isolation and normalization of the immune status. Provided the effect of the combined drug treatment is insufficient, the method of choice is the administration of gene engineering alpha 2-interferon (reaferon) in combination with tocopherol acetate and rectal suppositories containing methyluracil.

Topics: Adjuvants, Immunologic; Adult; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Dysentery, Bacillary; Humans; Immunity, Cellular; Middle Aged; Nucleic Acids; Quercetin; RNA, Fungal; Shigella flexneri; Thymopoietins; Time Factors

Immunological studies on 20 patients with frequently recurrent Herpes simplex labialis were performed. Disorders of the cell-mediated immunity were often observed which do not only occur during the relapses. The number of T cells and their function were especially reduced. On the other hand there were no alterations of the CD4/CD8 ratio and the suppressor-activity. In vitro studies with peptides of thymopoietin and splenin justify the assumption that these peptides have therapeutic effects in recurrent herpes simplex infections.

Topics: Amino Acid Sequence; Antigens, Differentiation, T-Lymphocyte; CD4-Positive T-Lymphocytes; CD8 Antigens; Chronic Disease; Herpes Simplex; Humans; Immunoglobulin G; Immunoglobulin M; Lymphocyte Activation; Molecular Sequence Data; Peptide Fragments; Structure-Activity Relationship; T-Lymphocytes; Thymopentin; Thymopoietins; Thymus Extracts; Thymus Hormones

Topics: Adolescent; Adult; Chronic Disease; Diabetic Ketoacidosis; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Spleen; Thymopoietins; Tissue Extracts