thymodepressin and Purpura--Thrombocytopenic--Idiopathic

To study influence of thymodepressin on the course of autoimmune cytopenia.. Thymodepressin is a new synthetic hemoregulatory dipeptide (gamma-D-Glu-D-Trp). It was used for the treatment of 22 patients with autoimmune cytopenia.. Hemoglobin levels were elevated in autoimmune hemolytic anemia and platelet levels were high in idiopathic thrombocytopenic purpura. A thymodepressin course resulted in a fall of total lymphocyte count and activated CD3+CD69+ lymphocytes.. The above results, safety, absence of toxicity and allergenicity, parenteral and intranasal useability open perspectives for further studies of therapeutic action of thymodepressin as an immunodepressant in autoimmune processes.

Topics: Adult; Aged; Anemia, Hemolytic; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Female; Humans; Immunosuppressive Agents; Lectins, C-Type; Lymphocytes; Male; Middle Aged; Peptides; Purpura, Thrombocytopenic, Idiopathic