thymodepressin and Graft-vs-Host-Disease

The paper summarizes the available information concerning the biological properties and biomedical applications of Thymodepressin. This synthetic peptide drug displays pronounced immunoinhibitory activity across a wide range of conditions in vitro and in vivo. The history of its unforeseen discovery is briefly reviewed, and the current as well as potential expansion areas of medicinal practice are outlined. Additional experimental evidence is obtained, demonstrating several potential advantages of Thymodepressin over another actively used immunosuppressor drug, cyclosporin A.

Topics: Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Graft vs Host Disease; Immunosuppressive Agents; Mice; Mice, Transgenic; Molecular Structure; Peptides