thymine has been researched along with Parkinson Disease in 10 studies
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Certain mutations (TT homozygous; CT heterozygous; CC wild-type) of the methylenetetrahydrofolate (MTHFR) gene and long-term levodopa application in patients with Parkinson's disease (PD) support onset of hyperhomocysteinemia." | 7.72 | MTHFR C677T polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patients with Parkinson's disease. ( Kuhn, W; Müller, T; Woitalla, D, 2004) |
| "Certain mutations (TT homozygous; CT heterozygous; CC wild-type) of the methylenetetrahydrofolate (MTHFR) gene and long-term levodopa application in patients with Parkinson's disease (PD) support onset of hyperhomocysteinemia." | 3.72 | MTHFR C677T polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patients with Parkinson's disease. ( Kuhn, W; Müller, T; Woitalla, D, 2004) |
| "Congenital hydrocephalus (CH) is caused by genetic mutations, but whether factors impacting human genetic mutations are disease-specific remains elusive." | 2.72 | Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositions. ( Hart, C; McKnight, I; Park, IH; Shim, JW, 2021) |
| " We found that early accumulation of KARs occurs in the DA neurons of the parkinQ311X mouse, and that chronic administration of the KAR antagonist UBP310 prevents DA neuron loss." | 1.56 | Pharmacological antagonism of kainate receptor rescues dysfunction and loss of dopamine neurons in a mouse model of human parkin-induced toxicity. ( Albanese, F; Bagnati, R; Cattaneo, S; Ciammola, A; Consalez, GG; Croci, L; Davoli, E; Di Fonzo, A; Mercatelli, D; Morari, M; Novello, S; Passafaro, M; Passoni, A; Regoni, M; Sassone, J; Serratto, GM; Taverna, S; Valtorta, F; Zanetti, L, 2020) |
| "Monogenic forms of Parkinson's disease (PD) provide an opportunity to examine mechanisms underlying phenotypic variation." | 1.34 | Glutathione S-transferase polymorphisms and onset age in alpha-synuclein A53T mutant Parkinson's disease. ( Athanassiadou, A; Bonifati, V; Di Iorio, G; Golbe, LI; Johnson, WG; Markopoulou, K; Papapetropoulos, S; Spychala, JR; Stenroos, ES; Vance, JM; Watts, RL; Williams, TA, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hart, M | 1 |
| Conrad, J | 1 |
| Barrett, E | 1 |
| Legg, K | 1 |
| Ivey, G | 1 |
| Lee, PHU | 1 |
| Yung, YC | 1 |
| Shim, JW | 2 |
| McKnight, I | 1 |
| Hart, C | 1 |
| Park, IH | 1 |
| Regoni, M | 1 |
| Cattaneo, S | 1 |
| Mercatelli, D | 1 |
| Novello, S | 1 |
| Passoni, A | 1 |
| Bagnati, R | 1 |
| Davoli, E | 1 |
| Croci, L | 1 |
| Consalez, GG | 1 |
| Albanese, F | 1 |
| Zanetti, L | 1 |
| Passafaro, M | 1 |
| Serratto, GM | 1 |
| Di Fonzo, A | 1 |
| Valtorta, F | 1 |
| Ciammola, A | 1 |
| Taverna, S | 1 |
| Morari, M | 1 |
| Sassone, J | 1 |
| Gopalai, AA | 1 |
| Lim, SY | 1 |
| Aziz, ZA | 1 |
| Lim, SK | 1 |
| Tan, LP | 1 |
| Chong, YB | 1 |
| Tan, CT | 1 |
| Puvanarajah, S | 1 |
| Viswanathan, S | 1 |
| Kuppusamy, R | 1 |
| Tan, AH | 1 |
| Lim, TT | 1 |
| Eow, GB | 1 |
| Norlinah, MI | 1 |
| Li, HH | 1 |
| Zhao, Y | 1 |
| Ahmad-Annuar, A | 1 |
| Woitalla, D | 1 |
| Kuhn, W | 1 |
| Müller, T | 1 |
| Hong, CJ | 1 |
| Liu, HC | 1 |
| Liu, TY | 1 |
| Liao, DL | 1 |
| Tsai, SJ | 1 |
| Golbe, LI | 1 |
| Di Iorio, G | 1 |
| Markopoulou, K | 1 |
| Athanassiadou, A | 1 |
| Papapetropoulos, S | 1 |
| Watts, RL | 1 |
| Vance, JM | 1 |
| Bonifati, V | 2 |
| Williams, TA | 1 |
| Spychala, JR | 1 |
| Stenroos, ES | 1 |
| Johnson, WG | 1 |
| Grünewald, A | 1 |
| Breedveld, GJ | 1 |
| Lohmann-Hedrich, K | 1 |
| Rohé, CF | 1 |
| König, IR | 1 |
| Hagenah, J | 1 |
| Vanacore, N | 1 |
| Meco, G | 1 |
| Antonini, A | 1 |
| Goldwurm, S | 1 |
| Lesage, S | 1 |
| Dürr, A | 1 |
| Binkofski, F | 1 |
| Siebner, H | 1 |
| Münchau, A | 1 |
| Brice, A | 1 |
| Oostra, BA | 1 |
| Klein, C | 1 |
| Lücking, CB | 1 |
| Kösel, S | 1 |
| Mehraein, P | 1 |
| Graeber, MB | 1 |
| Barbieri, S | 1 |
| Hofele, K | 1 |
| Wiederhold, KH | 1 |
| Probst, A | 1 |
| Mistl, C | 1 |
| Danner, S | 1 |
| Kauffmann, S | 1 |
| Sommer, B | 1 |
| Spooren, W | 1 |
| Tolnay, M | 1 |
| Bilbe, G | 1 |
| van der Putten, H | 1 |
3 reviews available for thymine and Parkinson Disease
| Article | Year |
|---|---|
X-linked hydrocephalus genes: Their proximity to telomeres and high A + T content compared to Parkinson's disease.
Topics: Animals; Genes, X-Linked; Humans; Hydrocephalus; Mice; Mutation; Parkinson Disease; Rats; Telomere; | 2023 |
Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositions.
Topics: Adenine; Alzheimer Disease; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes; Databases, G | 2021 |
Mouse models of alpha-synucleinopathy and Lewy pathology. Alpha-synuclein expression in transgenic mice.
Topics: Adenine; alpha-Synuclein; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Humans; Lewy Bo | 2001 |
7 other studies available for thymine and Parkinson Disease
| Article | Year |
|---|---|
Pharmacological antagonism of kainate receptor rescues dysfunction and loss of dopamine neurons in a mouse model of human parkin-induced toxicity.
Topics: Alanine; Animals; Disease Models, Animal; Dopaminergic Neurons; Down-Regulation; Female; GluK2 Kaina | 2020 |
Lack of association between the LRRK2 A419V variant and Asian Parkinson's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Case-Control Studies; China; Cohort Studies; Cy | 2013 |
MTHFR C677T polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patients with Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Cytosine; Female; Folic Acid; Humans; Hyperhom | 2004 |
Association studies of the adenosine A2a receptor (1976T > C) genetic polymorphism in Parkinson's disease and schizophrenia.
Topics: Age Distribution; Age of Onset; Aged; Asian People; Base Sequence; Brain; Brain Chemistry; Cytosine; | 2005 |
Glutathione S-transferase polymorphisms and onset age in alpha-synuclein A53T mutant Parkinson's disease.
Topics: Adenine; Adult; Age of Onset; Aged; Aged, 80 and over; Alleles; alpha-Synuclein; Glutathione Transfe | 2007 |
Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis.
Topics: Base Sequence; Cytosine; DNA, Complementary; Family; Female; Genetic Carrier Screening; Homozygote; | 2007 |
Absence of the mitochondrial A7237T mutation in Parkinson's disease.
Topics: Adenine; Base Sequence; DNA Primers; DNA, Mitochondrial; Electron Transport Complex IV; Frontal Lobe | 1995 |