thymine has been researched along with Melanoma in 9 studies
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mutations in sunlight-induced melanoma arise from cyclobutane pyrimidine dimers (CPDs), DNA photoproducts that are typically created picoseconds after an ultraviolet (UV) photon is absorbed at thymine or cytosine." | 3.81 | Photochemistry. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure. ( Bacchiocchi, A; Bechara, EJ; Brash, DE; Douki, T; Halaban, R; Mano, CM; Premi, S; Wakamatsu, K; Wallisch, S; Weiner, AB, 2015) |
| "We tested 17 malignant mucosal melanomas of the head and neck for the thymine (T)-->adenine (A) missense mutation at nucleotide 1796 in the BRAF gene using direct sequencing and a newly developed assay that uses a novel primer extension method (Mutector assay)." | 3.72 | Exon 15 BRAF mutations are uncommon in melanomas arising in nonsun-exposed sites. ( Begum, S; Cohen, Y; Esche, C; Goldenberg, D; Lavie, O; Rosenbaum, E; Sidransky, D; Westra, WH, 2004) |
| "Following exposure to ultraviolet irradiation (UV), two of three human fibroblast strains and one of three melanoma cell lines showed lower rates of thymine dimer excision during 24 h at 40 degrees C than at 36 degrees C." | 3.65 | Temperature-sensitive DNA repair of ultraviolet damage in human cell lines. ( Goss, P; Parsons, PG, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, KH | 1 |
| Wu, YS | 1 |
| Hall, IH | 1 |
| Premi, S | 1 |
| Wallisch, S | 1 |
| Mano, CM | 1 |
| Weiner, AB | 1 |
| Bacchiocchi, A | 1 |
| Wakamatsu, K | 1 |
| Bechara, EJ | 1 |
| Halaban, R | 1 |
| Douki, T | 1 |
| Brash, DE | 1 |
| Cohen, Y | 1 |
| Rosenbaum, E | 1 |
| Begum, S | 1 |
| Goldenberg, D | 1 |
| Esche, C | 1 |
| Lavie, O | 1 |
| Sidransky, D | 1 |
| Westra, WH | 1 |
| Liu, L | 1 |
| Dilworth, D | 1 |
| Gao, L | 1 |
| Monzon, J | 1 |
| Summers, A | 1 |
| Lassam, N | 1 |
| Hogg, D | 1 |
| Harland, M | 1 |
| Holland, EA | 1 |
| Ghiorzo, P | 1 |
| Mantelli, M | 1 |
| Bianchi-Scarrà, G | 1 |
| Goldstein, AM | 1 |
| Tucker, MA | 1 |
| Ponder, BA | 1 |
| Mann, GJ | 1 |
| Bishop, DT | 1 |
| Newton Bishop, J | 1 |
| Goss, P | 1 |
| Parsons, PG | 1 |
| Chalmers, AH | 1 |
| Lavin, M | 1 |
| Atisoontornkul, S | 1 |
| Mansbridge, J | 1 |
| Kidson, C | 1 |
| Lockshin, A | 1 |
| Giovanella, BC | 1 |
| Stehlin, JS | 1 |
| Kozielski, T | 1 |
| Quian, C | 1 |
| Apperson, RW | 1 |
| Fedorov, NA | 1 |
| Matveenko, VN | 1 |
| Tikhonova, EF | 1 |
9 other studies available for thymine and Melanoma
| Article | Year |
|---|---|
Antitumor agents. 25. Synthesis and antitumor activity of uracil and thymine alpha-methylene-gamma-lactones and related derivatives.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Lactones; Leukemia, Experimental; Male; Melan | 1977 |
Photochemistry. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure.
Topics: Animals; Cells, Cultured; Cytosine; DNA; DNA Damage; Energy Transfer; Humans; Melanins; Melanocytes; | 2015 |
Exon 15 BRAF mutations are uncommon in melanomas arising in nonsun-exposed sites.
Topics: Adenine; DNA; Exons; Head and Neck Neoplasms; Humans; Melanocytes; Melanoma; Models, Genetic; Mutage | 2004 |
Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma.
Topics: 5' Untranslated Regions; Alleles; Cell Line, Transformed; Codon, Initiator; Cyclin-Dependent Kinase | 1999 |
Mutation screening of the CDKN2A promoter in melanoma families.
Topics: Adolescent; Adult; Aged; Cyclin-Dependent Kinase Inhibitor p16; DNA, Neoplasm; Genetic Predispositio | 2000 |
Temperature-sensitive DNA repair of ultraviolet damage in human cell lines.
Topics: Autoradiography; Cell Line; DNA; DNA Repair; Fibroblasts; Humans; Melanoma; Radiation Effects; Tempe | 1976 |
Resistance of human melanoma cells to ultraviolet radiation.
Topics: Cell Line; Cell Survival; Cells, Cultured; Clone Cells; DNA; DNA Repair; Melanins; Melanoma; Radiati | 1976 |
Antitumor activity and minimal toxicity of concentrated thymidine infused in nude mice.
Topics: Animals; Antineoplastic Agents; Male; Melanoma; Mice; Mice, Nude; Solubility; Thymidine; Thymine | 1985 |
[Utilization of pyrimidine precursors in the tumor and liver of mice with Ehrlich ascites carcinoma].
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cytosine; DNA; DNA, Neoplasm; Liver; Male; Melan | 1970 |