thymine has been researched along with MELAS Syndrome in 3 studies
MELAS Syndrome: A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The majority of patients with MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes) have an A-->G mutation at nucleotide 3243 in mitochondrial transfer (t)RNA." | 1.30 | Clinical, physiological, and histological features in a kindred with the T3271C melas mutation. ( Applegarth, D; Maguire, J; Myint, T; Robinson, BH; Tarnopolsky, MA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Park, H | 1 |
| Davidson, E | 1 |
| King, MP | 1 |
| Tarnopolsky, MA | 1 |
| Maguire, J | 1 |
| Myint, T | 1 |
| Applegarth, D | 1 |
| Robinson, BH | 1 |
| Gill-Randall, R | 1 |
| Sherratt, EJ | 1 |
| Thomas, AW | 1 |
| Gagg, JW | 1 |
| Lee, A | 1 |
| Alcolado, JC | 1 |
3 other studies available for thymine and MELAS Syndrome
| Article | Year |
|---|---|
The pathogenic A3243G mutation in human mitochondrial tRNALeu(UUR) decreases the efficiency of aminoacylation.
Topics: Acylation; Adenine; Base Sequence; Cell Line; Cytosine; Guanine; Humans; Leucine-tRNA Ligase; MELAS | 2003 |
Clinical, physiological, and histological features in a kindred with the T3271C melas mutation.
Topics: Adenine; Adult; Biopsy, Needle; Child, Preschool; Cytosine; DNA; DNA, Mitochondrial; Female; Forearm | 1998 |
Analysis of a polycytosine tract and heteroplasmic length variation in the mitochondrial DNA D-loop of patients with diabetes, MELAS syndrome and race-matched controls.
Topics: Adult; Cytosine; Diabetes Mellitus, Type 2; DNA, Mitochondrial; Genetic Variation; Humans; Leukocyte | 2001 |