Page last updated: 2024-10-20

thymine and Hypertension

thymine has been researched along with Hypertension in 16 studies

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"Patients with mild-to-moderate primary hypertension and left ventricular hypertrophy were randomized in a double-blind study to receive treatment with either the angiotensin II type 1 (AT1) receptor antagonist irbesartan (n = 43), or the beta1-adrenergic receptor blocker atenolol (n = 43)."9.10Aldosterone synthase (CYP11B2) -344 C/T polymorphism is related to antihypertensive response: result from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial. ( Hägg, A; Kahan, T; Karlsson, J; Kurland, L; Lind, L; Malmqvist, K; Melhus, H; Nyström, F; Ohman, P, 2002)
"Patients with mild-to-moderate primary hypertension and left ventricular hypertrophy were randomized in a double-blind study to receive treatment with either the angiotensin II type 1 (AT1) receptor antagonist irbesartan (n = 43), or the beta1-adrenergic receptor blocker atenolol (n = 43)."5.10Aldosterone synthase (CYP11B2) -344 C/T polymorphism is related to antihypertensive response: result from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial. ( Hägg, A; Kahan, T; Karlsson, J; Kurland, L; Lind, L; Malmqvist, K; Melhus, H; Nyström, F; Ohman, P, 2002)
"The etiology of preeclampsia (PE) is unknown, but endothelial cell injury plays a pivotal role."1.33Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension. ( Chen, M; Shan, K; Yuan, Z, 2005)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's15 (93.75)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gómez-Zamudio, JH1
Villalobos-Molina, R1
Pigossi, SC1
Alvim-Pereira, F1
Montes, CC1
Finoti, LS1
Secolin, R1
Trevilatto, PC1
Scarel-Caminaga, RM1
Beige, J1
Kreutz, R1
Tscherkaschina, I1
Scherer, S1
Sharma, AM1
Zidek, W1
Offermann, G1
Zhu, H1
Sagnella, GA1
Dong, Y1
Miller, MA1
Onipinla, A1
Markandu, ND1
MacGregor, GA1
Huang, G1
Niu, T1
Peng, S1
Ling, D1
Liu, J1
Zhang, X1
Xu, X1
Haketa, A1
Soma, M1
Nakayama, T1
Sato, M1
Kosuge, K1
Aoi, N1
Matsumoto, K1
Zhang, L1
Rao, F1
Wessel, J1
Kennedy, BP1
Rana, BK1
Taupenot, L1
Lillie, EO1
Cockburn, M1
Schork, NJ1
Ziegler, MG1
O'Connor, DT1
Wojciechowska, W1
Staessen, JA1
Stolarz, K1
Nawrot, T1
Filipovský, J1
Tichá, M1
Bianchi, G2
Brand, E1
Cwynar, M1
Grodzicki, T1
Kuznetsova, T1
Struijker-Boudier, HA1
Svobodová, V1
Thijs, L1
Van Bortel, LM1
Kawecka-Jaszcz, K1
Renner, W1
Grammer, T1
Hoffmann, MM1
Nauck, MS1
Winkelmann, BR1
Boehm, BO1
März, W1
Chen, M1
Yuan, Z1
Shan, K1
Rubattu, S1
Bigatti, G1
Evangelista, A1
Lanzani, C1
Stanzione, R1
Zagato, L1
Manunta, P1
Marchitti, S1
Venturelli, V1
Volpe, M1
Stella, P1
Sookoian, S1
Gianotti, TF1
González, CD1
Pirola, CJ1
Markan, S1
Sachdeva, M1
Sehrawat, BS1
Kumari, S1
Jain, S1
Khullar, M1
Qian, X1
Lu, Z1
Tan, M1
Liu, H1
Lu, D1
Hu, BC1
Chu, SL1
Wang, GL1
Gao, PJ1
Zhu, DL1
Wang, JG1
Kurland, L1
Melhus, H1
Karlsson, J1
Kahan, T1
Malmqvist, K1
Ohman, P1
Nyström, F1
Hägg, A1
Lind, L1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery: a Randomized, Placebo Controlled Trial[NCT02734238]Phase 453 participants (Actual)Interventional2016-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Body Composition at the End of Each Study Phase

Height was measured using a stadiometer. Weight was measured using a calibrated digital scale. Body composition was determined using dual-energy X-ray absorptiometry. These data were used to calculate fat-free body mass, fat mass, and total body tissue mass. (NCT02734238)
Timeframe: end of each study phase: Day 11 for Phase 1, Day 39 for Phase 2, up to Day 85 for Phase 3

,
Interventionkilograms (Least Squares Mean)
Total Body Mass at end of Phase 1Total Body Mass at end of Phase 2Total Body Mass at end of Phase 3Fat-free Mass at end of Phase 1Fat-free Mass at end of Phase 2Fat-free Mass at end of Phase 3Fat Mass at end of Phase 1Fat Mass at end of Phase 2Fat Mass at end of Phase 3
Energy Deficit78.373.376.558.358.060.516.812.212.8
Energy Deficit + Testosterone78.075.879.357.960.463.116.812.012.8

Reviews

2 reviews available for thymine and Hypertension

ArticleYear
Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis.
    Journal of hypertension, 2007, Volume: 25, Issue:1

    Topics: Aldosterone; Blood Pressure; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Cytochro

2007
A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension.
    European journal of human genetics : EJHG, 2007, Volume: 15, Issue:12

    Topics: Asian People; Bias; Cytosine; Genetic Predisposition to Disease; Heterozygote; Humans; Hypertension;

2007

Trials

2 trials available for thymine and Hypertension

ArticleYear
MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians.
    Molecular and cellular biochemistry, 2007, Volume: 302, Issue:1-2

    Topics: Asian People; Case-Control Studies; Cytosine; Female; Folic Acid; Gene Frequency; Genetic Predisposi

2007
Aldosterone synthase (CYP11B2) -344 C/T polymorphism is related to antihypertensive response: result from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial.
    American journal of hypertension, 2002, Volume: 15, Issue:5

    Topics: Adrenergic beta-Antagonists; Aldosterone; Angiotensin Receptor Antagonists; Antihypertensive Agents;

2002

Other Studies

12 other studies available for thymine and Hypertension

ArticleYear
Adventitia removal does not modify the alphaID-adrenoceptors response in aorta during hypertension and ageing.
    Autonomic & autacoid pharmacology, 2009, Volume: 29, Issue:3

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Aging; Animals; Endothelium,

2009
Genetic association study between Interleukin 10 gene and dental implant loss.
    Archives of oral biology, 2012, Volume: 57, Issue:9

    Topics: Adenine; Alleles; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular

2012
Matrix analysis for the dissection of interactions of G-protein beta3 subunit C825T genotype, allograft function, and posttransplant hypertension in kidney transplantation.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 40, Issue:6

    Topics: Adult; Cytosine; Female; Follow-Up Studies; Genotype; Graft Survival; Heterotrimeric GTP-Binding Pro

2002
Contrasting associations between aldosterone synthase gene polymorphisms and essential hypertension in blacks and in whites.
    Journal of hypertension, 2003, Volume: 21, Issue:1

    Topics: Adenine; Adult; Alleles; Black People; Case-Control Studies; Cytochrome P-450 CYP11B2; Female; Gene

2003
Association between the interleukin-1beta C(-511)T polymorphism and blood pressure in a Chinese hypertensive population.
    Immunology letters, 2004, Feb-15, Volume: 91, Issue:2-3

    Topics: Asian People; Blood Pressure; Cytosine; Female; Genetic Predisposition to Disease; Humans; Hypertens

2004
Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension.
    Journal of hypertension, 2004, Volume: 22, Issue:10

    Topics: Adenine; Alleles; Asian People; Case-Control Studies; Cholesterol, HDL; Coenzyme A Ligases; Female;

2004
Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins.
    Physiological genomics, 2004, Nov-17, Volume: 19, Issue:3

    Topics: Adenine; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alleles; Autonomic Nervous System;

2004
Association of peripheral and central arterial wave reflections with the CYP11B2 -344C allele and sodium excretion.
    Journal of hypertension, 2004, Volume: 22, Issue:12

    Topics: Adult; Alleles; Arteries; Blood Pressure; Cytochrome P-450 CYP11B2; Cytosine; DNA Transposable Eleme

2004
Association analysis of the polymorphism T1128C in the signal peptide of neuropeptide Y in a Swedish hypertensive population.
    Journal of hypertension, 2004, Volume: 22, Issue:12

    Topics: Cytosine; Humans; Hypertension; Neuropeptide Y; Polymorphism, Genetic; Protein Sorting Signals; Swed

2004
Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension.
    Gynecologic and obstetric investigation, 2005, Volume: 60, Issue:3

    Topics: Adult; Amino Acid Sequence; Case-Control Studies; China; Clusterin; Cytosine; DNA Mutational Analysi

2005
Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension.
    Journal of the American College of Cardiology, 2006, Aug-01, Volume: 48, Issue:3

    Topics: Adenine; Adult; Alleles; Atrial Natriuretic Factor; Cytosine; Echocardiography; Female; Genetic Vari

2006
Association between genetic variation in transforming growth factors beta1 and beta3 and renal dysfunction in non-diabetic Chinese.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2008, Volume: 30, Issue:2

    Topics: Adenine; Adult; Aged; Aged, 80 and over; Albuminuria; Asian People; Creatinine; Cytosine; Female; Ge

2008