thymine has been researched along with Dihydropyrimidine Dehydrogenase Deficiency in 10 studies
Dihydropyrimidine Dehydrogenase Deficiency: An autosomal recessive disorder affecting DIHYDROPYRIMIDINE DEHYDROGENASE and causing familial pyrimidinemia. It is characterized by thymine-uraciluria in homozygous deficient patients. Even a partial deficiency in the enzyme leaves individuals at risk for developing severe 5-FLUOROURACIL-associated toxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thus, DPD deficiency may feature prominent brain abnormalities involving the cerebral white matter and brainstem." | 1.32 | Head imaging abnormalities in dihydropyrimidine dehydrogenase deficiency. ( Barkovich, AJ; Enns, GM; Manning, M; Sanger, T; van Gennip, AH; van Kuilenburg, AB; Witt, DR, 2004) |
| "In addition to this study we analyzed a DPD deficiency case and a DHPuria case." | 1.30 | Possible prediction of adverse reactions to fluorouracil by the measurement of urinary dihydrothymine and thymine. ( Dobashi, K; Hayashi, K; Kidouchi, K; Kondou, M; Kouwaki, M; Sumi, S; Togari, H; Wada, Y, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schouten, JF | 1 |
| Willems, J | 1 |
| Sanders, SJWJ | 1 |
| Creemers, GJ | 1 |
| Deenen, MJ | 1 |
| Liu, N | 1 |
| Sun, Q | 1 |
| Bolzacchini, E | 1 |
| Luchena, G | 1 |
| Giordano, M | 1 |
| Milano, G | 1 |
| Weidensee, S | 1 |
| Goettig, P | 1 |
| Bertone, M | 1 |
| Haas, D | 1 |
| Magdolen, V | 1 |
| Kiechle, M | 1 |
| Meindl, A | 1 |
| van Kuilenburg, AB | 4 |
| Gross, E | 1 |
| Stroomer, AE | 1 |
| Van Lenthe, H | 1 |
| Abeling, NG | 1 |
| Van Gennip, AH | 3 |
| Enns, GM | 1 |
| Barkovich, AJ | 1 |
| Manning, M | 1 |
| Sanger, T | 1 |
| Witt, DR | 1 |
| Al-Sanna'a, NA | 1 |
| Atrak, TM | 1 |
| Abdul-Jabbar, MA | 1 |
| Schmidt, C | 1 |
| Hofmann, U | 1 |
| Kohlmüller, D | 1 |
| Mürdter, T | 1 |
| Zanger, UM | 1 |
| Schwab, M | 1 |
| Hoffmann, GF | 1 |
| Sumi, S | 1 |
| Kidouchi, K | 1 |
| Kondou, M | 1 |
| Hayashi, K | 1 |
| Dobashi, K | 1 |
| Kouwaki, M | 1 |
| Togari, H | 1 |
| Wada, Y | 1 |
10 other studies available for thymine and Dihydropyrimidine Dehydrogenase Deficiency
| Article | Year |
|---|---|
Standard-Dose Trifluridine/Tipiracil as Safe Treatment Alternative in Metastatic Colorectal Cancer Patients With DPD Deficiency.
Topics: Colonic Neoplasms; Dihydropyrimidine Dehydrogenase Deficiency; Humans; Pyrrolidines; Rectal Neoplasm | 2021 |
Quantitation of Pyrimidine in Urine by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry.
Topics: Biomarkers; Chromatography, Liquid; Dihydropyrimidine Dehydrogenase Deficiency; Humans; Pyrimidines; | 2022 |
Safety Report of TAS-102 in a Patient With Reduced DPD Activity.
Topics: Aged; Antineoplastic Agents; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase | 2019 |
Fluoropyrimidines and DPD testing: is there truly an inexorable link?
Topics: Antineoplastic Agents; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP | 2019 |
A mild phenotype of dihydropyrimidine dehydrogenase deficiency and developmental retardation associated with a missense mutation affecting cofactor binding.
Topics: Amino Acid Sequence; Child; Creatinine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil De | 2011 |
New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?
Topics: Aminoisobutyric Acids; beta-Alanine; Brain Diseases, Metabolic, Inborn; Dihydropyrimidine Dehydrogen | 2004 |
Head imaging abnormalities in dihydropyrimidine dehydrogenase deficiency.
Topics: Brain; Dihydropyrimidine Dehydrogenase Deficiency; Fatal Outcome; Female; Humans; Infant; Magnetic R | 2004 |
Dihydropyrimidine dehydrogenase deficiency presenting at birth.
Topics: Age of Onset; Antimetabolites; Binding Sites; Digestive System Abnormalities; Dihydropyrimidine Dehy | 2005 |
Comprehensive analysis of pyrimidine metabolism in 450 children with unspecific neurological symptoms using high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry.
Topics: Adolescent; beta-Alanine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dihydropyri | 2005 |
Possible prediction of adverse reactions to fluorouracil by the measurement of urinary dihydrothymine and thymine.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dihydropyrimidine Dehyd | 1998 |