thymidine has been researched along with Sarcoma, Kaposi in 12 studies
Sarcoma, Kaposi: A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a double-blind, placebo-controlled trial of the efficacy of oral azidothymidine (AZT) in 282 patients with the acquired immunodeficiency syndrome (AIDS) manifested by Pneumocystis carinii pneumonia alone, or with advanced AIDS-related complex." | 9.06 | The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. ( Fischl, MA; Gottlieb, MS; Grieco, MH; Groopman, JE; Laskin, OL; Leedom, JM; Mildvan, D; Richman, DD; Schooley, RT; Volberding, PA, 1987) |
| "We evaluated the development of anemia as part of a trial of zidovudine therapy in patients with the acquired immunodeficiency syndrome (AIDS) with Kaposi sarcoma." | 9.06 | Anemia and erythropoiesis in patients with the acquired immunodeficiency syndrome (AIDS) and Kaposi sarcoma treated with zidovudine. ( Carleton, S; Fauci, AS; Gralnick, HR; Kirk, LE; Kovacs, JA; Lane, HC; Masur, H; Parker, RI; Walker, RE, 1988) |
| "In a 6-week clinical trial 4 dose regimens of 3'-azido-3'-deoxythymidine (AZT), a thymidine analogue with potent anti-viral activity against HTLV-III in vitro, were examined in 19 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)." | 5.06 | Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex. ( Barry, DW; Blum, RM; Durack, DT; Gelmann, E; Klecker, RW; Lehrman, SN; Lyerly, HK; Markham, PD; Weinhold, KJ; Yarchoan, R, 1986) |
| "We conducted a double-blind, placebo-controlled trial of the efficacy of oral azidothymidine (AZT) in 282 patients with the acquired immunodeficiency syndrome (AIDS) manifested by Pneumocystis carinii pneumonia alone, or with advanced AIDS-related complex." | 5.06 | The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. ( Fischl, MA; Gottlieb, MS; Grieco, MH; Groopman, JE; Laskin, OL; Leedom, JM; Mildvan, D; Richman, DD; Schooley, RT; Volberding, PA, 1987) |
| "We evaluated the development of anemia as part of a trial of zidovudine therapy in patients with the acquired immunodeficiency syndrome (AIDS) with Kaposi sarcoma." | 5.06 | Anemia and erythropoiesis in patients with the acquired immunodeficiency syndrome (AIDS) and Kaposi sarcoma treated with zidovudine. ( Carleton, S; Fauci, AS; Gralnick, HR; Kirk, LE; Kovacs, JA; Lane, HC; Masur, H; Parker, RI; Walker, RE, 1988) |
| "We have shown that AIDS-KS spindle cells express IL-1 beta and that IL-1ra inhibits KS-spindle cell growth." | 1.29 | Effects of interleukin-1 and interleukin-1 receptor antagonist in AIDS-Kaposi's sarcoma. ( Cai, J; Gill, P; Jung, B; Law, R; Lin, G; Louie, S; Lunardi-Iskandar, Y; Masood, R, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, W | 1 |
| Burnette, A | 1 |
| Dorjsuren, D | 1 |
| Roberts, PE | 1 |
| Huleihel, M | 1 |
| Shoemaker, RH | 1 |
| Marquez, VE | 1 |
| Agbaria, R | 1 |
| Sei, S | 1 |
| Amaral, MC | 1 |
| Miles, S | 1 |
| Kumar, G | 1 |
| Nel, AE | 1 |
| Louie, S | 1 |
| Cai, J | 1 |
| Law, R | 1 |
| Lin, G | 1 |
| Lunardi-Iskandar, Y | 1 |
| Jung, B | 1 |
| Masood, R | 2 |
| Gill, P | 2 |
| Guo, WX | 1 |
| Antakly, T | 1 |
| Liu, J | 1 |
| Modrell, B | 1 |
| Aruffo, A | 1 |
| Scharnowske, S | 1 |
| Shoyab, M | 1 |
| Husain, SR | 1 |
| Rahman, A | 1 |
| Medveczky, MM | 1 |
| Horvath, E | 1 |
| Lund, T | 1 |
| Medveczky, PG | 1 |
| Yarchoan, R | 1 |
| Klecker, RW | 1 |
| Weinhold, KJ | 1 |
| Markham, PD | 1 |
| Lyerly, HK | 1 |
| Durack, DT | 1 |
| Gelmann, E | 1 |
| Lehrman, SN | 1 |
| Blum, RM | 1 |
| Barry, DW | 1 |
| Fischl, MA | 1 |
| Richman, DD | 1 |
| Grieco, MH | 1 |
| Gottlieb, MS | 1 |
| Volberding, PA | 1 |
| Laskin, OL | 1 |
| Leedom, JM | 1 |
| Groopman, JE | 2 |
| Mildvan, D | 1 |
| Schooley, RT | 1 |
| Korneeva, MN | 1 |
| Novokhatskiĭ, AS | 1 |
| Grebeniuk, VN | 1 |
| Kerimov, SG | 1 |
| Walker, RE | 1 |
| Parker, RI | 1 |
| Kovacs, JA | 1 |
| Masur, H | 1 |
| Lane, HC | 1 |
| Carleton, S | 1 |
| Kirk, LE | 1 |
| Gralnick, HR | 1 |
| Fauci, AS | 1 |
1 review available for thymidine and Sarcoma, Kaposi
| Article | Year |
|---|---|
AIDS-related Kaposi's sarcoma: therapeutic modalities.
Topics: Acquired Immunodeficiency Syndrome; Bone Marrow Transplantation; Combined Modality Therapy; Doxorubi | 1987 |
3 trials available for thymidine and Sarcoma, Kaposi
| Article | Year |
|---|---|
Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Body Weight; Clinical Trials as Topic; Del | 1986 |
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Clinical Trials as Topic | 1987 |
Anemia and erythropoiesis in patients with the acquired immunodeficiency syndrome (AIDS) and Kaposi sarcoma treated with zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anemia; Antiviral Agents; Drug Evaluation; Erythrocyte In | 1988 |
8 other studies available for thymidine and Sarcoma, Kaposi
| Article | Year |
|---|---|
Potent antiviral activity of north-methanocarbathymidine against Kaposi's sarcoma-associated herpesvirus.
Topics: Antiviral Agents; Herpesvirus 8, Human; Humans; Inhibitory Concentration 50; Sarcoma, Kaposi; Thymid | 2005 |
Oncostatin-M stimulates tyrosine protein phosphorylation in parallel with the activation of p42MAPK/ERK-2 in Kaposi's cells. Evidence that this pathway is important in Kaposi cell growth.
Topics: Acquired Immunodeficiency Syndrome; Benzoquinones; Blotting, Western; Calcium-Calmodulin-Dependent P | 1993 |
Effects of interleukin-1 and interleukin-1 receptor antagonist in AIDS-Kaposi's sarcoma.
Topics: Acquired Immunodeficiency Syndrome; Blotting, Northern; Cell Division; Cell Line; Endothelium, Vascu | 1995 |
AIDS-related Kaposi's sarcoma: evidence for direct stimulatory effect of glucocorticoid on cell proliferation.
Topics: Acquired Immunodeficiency Syndrome; Dexamethasone; Drug Synergism; Growth Substances; Humans; Mifepr | 1995 |
Interactions between oncostatin M and the IL-6 signal transducer, gp130.
Topics: Animals; Antigens, CD; Cell Line; Chlorocebus aethiops; Cytokine Receptor gp130; Cytokines; DNA; DNA | 1994 |
Potentiation of cytotoxicity of Kaposi's sarcoma related to immunodeficiency syndrome (AIDS) by liposome-encapsulated doxorubicin.
Topics: Acquired Immunodeficiency Syndrome; Cell Division; Cell Survival; Doxorubicin; Drug Carriers; Humans | 1993 |
In vitro antiviral drug sensitivity of the Kaposi's sarcoma-associated herpesvirus.
Topics: Acyclovir; Antiviral Agents; Carcinogens; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; DNA, Vir | 1997 |
[Functional activity of the lymphocytes in patients with Kaposi's sarcoma].
Topics: Chronic Disease; DNA, Neoplasm; Humans; Lymphocyte Activation; Lymphocytes; Mitogens; Sarcoma, Kapos | 1988 |