Page last updated: 2024-11-06

thymidine and Recrudescence

thymidine has been researched along with Recrudescence in 37 studies

Research Excerpts

ExcerptRelevanceReference
"To investigate the therapeutic benefit of sequential interferon alpha-1b (IFNa-1b) in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) who showed early complete response to telbivudine (LdT) treatment, and to explore the clinical value of serum hepatitis B surface antigen (HBsAg) for predicting sustained virological response (SVR)."9.17[Clinical observations of sequential interferon therapy following complete response to telbivudine treatment in chronic hepatitis B patients]. ( Guo, SH; Sandeep, KK; Zhang, DZ; Zhang, QF; Zhang, W, 2013)
"Treatment of the acute disease with N-methanocarbathymidine significantly reduced the severity of acute disease and decreased acute vaginal virus shedding more effectively than acyclovir."7.81Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs. ( Bernstein, DI; Bravo, FJ; Cardin, RD; Glazer, RI; Pullum, DA; Rahman, A; Shen, H; Wang, M, 2015)
"In vitro and in vivo studies were done on a herpes simplex virus type 2 strain recovered from a patient on acyclovir (ACV) which was ACV resistant but expressed thymidine (dThd) kinase (EC 2."7.67Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity. ( Barry, DW; Ellis, MN; Fyfe, JA; Keller, PM; Lehrman, SN; Martin, JL; Rooney, JF; Straus, SE, 1987)
"In 3,800 node-negative breast cancers recruited between 1972 and 1991, the consistency of information provided by the 3H-thymidine labelling index (TLI), in terms of basic relations with other clinico-pathological and biological variables and clinical predictivity, was evaluated using a combined analysis of results previously published by our group for distinct series of patients."5.30Cell proliferation in 3,800 node-negative breast cancers: consistency over time of biological and clinical information provided by 3H-thymidine labelling index. ( Daidone, MG; Leutner, M; Luisi, A; Mastore, M; Salvadori, B; Silvestrini, R, 1997)
"To investigate the therapeutic benefit of sequential interferon alpha-1b (IFNa-1b) in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) who showed early complete response to telbivudine (LdT) treatment, and to explore the clinical value of serum hepatitis B surface antigen (HBsAg) for predicting sustained virological response (SVR)."5.17[Clinical observations of sequential interferon therapy following complete response to telbivudine treatment in chronic hepatitis B patients]. ( Guo, SH; Sandeep, KK; Zhang, DZ; Zhang, QF; Zhang, W, 2013)
"Treatment of the acute disease with N-methanocarbathymidine significantly reduced the severity of acute disease and decreased acute vaginal virus shedding more effectively than acyclovir."3.81Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs. ( Bernstein, DI; Bravo, FJ; Cardin, RD; Glazer, RI; Pullum, DA; Rahman, A; Shen, H; Wang, M, 2015)
"We investigated thymidine kinase (tk) mutants isolated during multiple episodes of recurrent bilateral acyclovir resistant herpes simplex keratitis in an immunocompetent patient."3.80Common and new acyclovir resistant herpes simplex virus-1 mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient. ( Coen, DM; Hart, IJ; Hopkins, M; Kaye, SB; Kirwan, R; Pan, D, 2014)
"In vitro and in vivo studies were done on a herpes simplex virus type 2 strain recovered from a patient on acyclovir (ACV) which was ACV resistant but expressed thymidine (dThd) kinase (EC 2."3.67Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity. ( Barry, DW; Ellis, MN; Fyfe, JA; Keller, PM; Lehrman, SN; Martin, JL; Rooney, JF; Straus, SE, 1987)
"DNA synthesis time (Ts) and 3H thymidine (TdR) labelling index (LI) of bone marrow (BM) myelomatous plasma cells (PC) and of the residual haemopoietic cell population (RHCP) were measured by in vitro quantitative 14C-TdR autoradiography in five patients with multiple myeloma (MM) in different phases of disease (three at presentation and two at relapse) and in one patient with solitary extra-osseous myeloma."3.67Proliferation kinetics of plasma cells and of normal haemopoietic cells in multiple myeloma. ( Ciotti, R; Danova, M; Dörmer, P; Girino, M; Luoni, R; Montecucco, CM; Riccardi, A; Ucci, G, 1987)
"Thirty-eight patients with advanced HNSCC underwent 11C-4DST PET/CT and 18F-FDG PET/CT before treatment."1.42Volumetric comparison of positron emission tomography/computed tomography using 4'-[methyl-¹¹C]-thiothymidine with 2-deoxy-2-¹⁸F-fluoro-D-glucose in patients with advanced head and neck squamous cell carcinoma. ( Ishiwata, K; Ito, K; Kubota, K; Minamimoto, R; Miyata, Y; Morooka, M; Okasaki, M; Toyohara, J; Yokoyama, J, 2015)
"Lamivudine was switched to telbivudine."1.42Telbivudine in liver transplant recipients: Renal protection does not overcome the risk of polyneuropathy and myopathy. ( Akarca, US; Bademkiran, F; Duman, S; Ersoz, G; Gunsar, F; Karasu, Z; Kose, T; Ozutemiz, O; Sozbilen, M; Turan, I; Yapali, S, 2015)
"Hepatitis B virus (HBV) recurrence after orthotopic liver transplantation (OLT) represents a severe condition that requires prophylaxis with specific immunoglobulin and lamivudine."1.38Telbivudin as prophylaxis for hepatitis B virus recurrence after liver transplantation: a case series in single-center experience. ( Amato, G; Calise, F; Cuomo, O; Dicostanzo, G; Lanza, AG; Marcos, A; Perrella, A; Pisaniello, D; Santaniello, W, 2012)
"In 3,800 node-negative breast cancers recruited between 1972 and 1991, the consistency of information provided by the 3H-thymidine labelling index (TLI), in terms of basic relations with other clinico-pathological and biological variables and clinical predictivity, was evaluated using a combined analysis of results previously published by our group for distinct series of patients."1.30Cell proliferation in 3,800 node-negative breast cancers: consistency over time of biological and clinical information provided by 3H-thymidine labelling index. ( Daidone, MG; Leutner, M; Luisi, A; Mastore, M; Salvadori, B; Silvestrini, R, 1997)
"This hypertriglyceridemia was found to be due to the absence of serum apolipoprotein C-II (apo C-II) which was identified by Western blotting using polyclonal anti-apo C-II antiserum."1.30A thymidine to cytosine substitution for codon 26 of exon 3 of apolipoprotein C-II gene in a patient with apolipoprotein C-II deficiency. ( Fuku, H; Kuniyoshi, A; Matsuyama, Y; Okamoto, Y; Tamagawa, T, 1999)
"We describe a patient with acute myelogenous leukemia (AML) who received his second autologous blood stem cell transplantation (ABSCT) following a G-CSF-combined pre-transplant conditioning regimen."1.29Successful second autologous blood stem cell transplantation after G-CSF-combined conditioning for the treatment of high-risk acute myelogenous leukemia. ( Akashi, K; Harada, M; Inaba, S; Niho, Y; Takamatsu, Y; Teshima, T, 1994)
"Spontaneous ocular recurrences were reduced during therapy, compared to saline-treated controls."1.28Suppression of ocular herpes recurrences by a thymidine kinase inhibitor in squirrel monkeys. ( Bobek, M; Cheng, YC; Dutschman, GE; Kaufman, HE; Thompson, HW; Varnell, ED, 1991)
"This result is - compared with 53% recurrences of previous own cases before the use of a specific virostatic-considerably better."1.26[Herpetic recurrence prophylaxis with trifluorothymidine after keratoplasty (author's transl)]. ( Sie, SH, 1980)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199021 (56.76)18.7374
1990's4 (10.81)18.2507
2000's1 (2.70)29.6817
2010's11 (29.73)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Salpini, R1
Alteri, C1
Cento, V1
Pollicita, M1
Micheli, V1
Gubertini, G1
De Sanctis, GM1
Visca, M1
Romano, S1
Sarrecchia, C1
Andreoni, M1
Angelico, M1
Parruti, G1
Svicher, V1
Perno, CF2
Wong, GL1
Chan, HL1
Lo, AO1
Chan, HY1
Tse, CH1
Chim, AM1
Wong, VW1
Pan, D1
Kaye, SB1
Hopkins, M1
Kirwan, R1
Hart, IJ1
Coen, DM1
Zhang, W1
Sandeep, KK1
Zhang, QF1
Guo, SH1
Zhang, DZ1
Chen, DB1
Chen, YM1
Liu, J1
Xie, DY1
Lu, CR1
Huang, ZL1
Zhu, RH1
Gao, ZL1
Perrella, A2
Lanza, AG2
Pisaniello, D2
DiCostanzo, G2
Calise, F2
Cuomo, O2
Ito, K1
Yokoyama, J1
Miyata, Y1
Toyohara, J1
Okasaki, M1
Minamimoto, R1
Morooka, M1
Ishiwata, K1
Kubota, K1
Turan, I1
Yapali, S1
Bademkiran, F1
Kose, T1
Duman, S1
Sozbilen, M1
Gunsar, F1
Ersoz, G1
Akarca, US1
Ozutemiz, O1
Karasu, Z1
Bernstein, DI1
Bravo, FJ1
Pullum, DA1
Shen, H1
Wang, M1
Rahman, A1
Glazer, RI1
Cardin, RD1
Pan, HY2
Chen, L1
Yang, DH1
Huang, HJ1
Tong, YX1
Chen, CR1
Yan, J1
Santaniello, W1
Amato, G1
Marcos, A1
Violin, M1
Cozzi-Lepri, A1
Velleca, R1
Vincenti, A1
D'Elia, S1
Chiodo, F1
Ghinelli, F1
Bertoli, A1
d'Arminio Monforte, A1
Moroni, M1
Balotta, C1
Sie, SH1
Peavy, DL1
Nelms, DC1
Mackler, BF1
Knight, SC1
Harding, B1
Burman, S1
Mertin, J1
Drewinko, B2
Alexanian, R2
Boyer, H1
Barlogie, B1
Rubinow, SI1
Takamatsu, Y1
Teshima, T1
Akashi, K1
Inaba, S1
Harada, M1
Niho, Y1
Silvestrini, R1
Daidone, MG1
Luisi, A1
Mastore, M1
Leutner, M1
Salvadori, B1
Kuniyoshi, A1
Okamoto, Y1
Tamagawa, T1
Matsuyama, Y1
Fuku, H1
Bigar, F1
Meyer, JS1
Hixon, B1
Sassa, S1
Zalar, GL1
Kappas, A1
Coster, DJ1
McKinnon, JR1
McGill, JI1
Jones, BR1
Fraunfelder, FT1
Hoelzer, D1
Schmücker, H1
Kurrle, E1
Kaufman, HE1
Varnell, ED1
Cheng, YC1
Bobek, M1
Thompson, HW1
Dutschman, GE1
Ellis, MN1
Keller, PM1
Fyfe, JA1
Martin, JL1
Rooney, JF1
Straus, SE1
Lehrman, SN1
Barry, DW1
Ucci, G1
Riccardi, A1
Dörmer, P1
Danova, M1
Luoni, R1
Montecucco, CM1
Ciotti, R1
Girino, M1
Colin, J1
Chastel, C1
Donovan, R1
Soothill, JF1
O'Grady, FW1
Rasmussen, LE1
Jordan, GW1
Stevens, DA1
Merigan, TC1
Han, T1
Wang, J1
Folb, PI1
Ramot, B1
Dannenberg, AM1
Ando, M1
Shima, K1
Rich, RR1
Kirkpatrick, CH1
Rosenthal, AS1

Trials

4 trials available for thymidine and Recrudescence

ArticleYear
[Clinical observations of sequential interferon therapy following complete response to telbivudine treatment in chronic hepatitis B patients].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2013, Volume: 21, Issue:8

    Topics: Adult; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; I

2013
Trifluridine (viroptic) for herpetic keratitis.
    The Medical letter on drugs and therapeutics, 1980, May-30, Volume: 22, Issue:11

    Topics: Antiviral Agents; Clinical Trials as Topic; Corneal Ulcer; Humans; Keratitis, Dendritic; Recurrence;

1980
Cell number requirements for lymphocyte stimulation in vitro: changes during the course of multiple sclerosis and the effects of immunosuppression.
    Clinical and experimental immunology, 1981, Volume: 46, Issue:1

    Topics: Adult; Azathioprine; Cells, Cultured; Clinical Trials as Topic; Humans; Immunosuppressive Agents; Le

1981
Clinical evaluation of adenine arabinoside and trifluorothymidine in the treatment of corneal ulcers caused by herpes simplex virus.
    The Journal of infectious diseases, 1976, Volume: 133 Suppl

    Topics: Administration, Topical; Clinical Trials as Topic; Corneal Ulcer; Drug Evaluation; Humans; Keratitis

1976

Other Studies

33 other studies available for thymidine and Recrudescence

ArticleYear
Snapshot on drug-resistance rate and profiles in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practice.
    Journal of medical virology, 2013, Volume: 85, Issue:6

    Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Guanin

2013
Serum hepatitis B surface antigen kinetics in severe reactivation of hepatitis B e antigen negative chronic hepatitis B patients receiving nucleoside/nucleotide analogues.
    Antiviral therapy, 2013, Volume: 18, Issue:8

    Topics: Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B e Anti

2013
Common and new acyclovir resistant herpes simplex virus-1 mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient.
    The Journal of infectious diseases, 2014, Feb-01, Volume: 209, Issue:3

    Topics: Acyclovir; Adult; Amino Acid Substitution; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Her

2014
Durability of efficacy after telbivudine off-treatment in chronic hepatitis B patients.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2014, Volume: 59, Issue:1

    Topics: Adolescent; Adult; Aged; Antiviral Agents; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans;

2014
Telbivudine prophylaxis for hepatitis B virus recurrence after liver transplantation improves renal function.
    Transplantation proceedings, 2014, Volume: 46, Issue:7

    Topics: Adult; Antiviral Agents; Creatinine; Female; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transpl

2014
Volumetric comparison of positron emission tomography/computed tomography using 4'-[methyl-¹¹C]-thiothymidine with 2-deoxy-2-¹⁸F-fluoro-D-glucose in patients with advanced head and neck squamous cell carcinoma.
    Nuclear medicine communications, 2015, Volume: 36, Issue:3

    Topics: Aged; Carcinoma, Squamous Cell; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Ki-

2015
Telbivudine in liver transplant recipients: Renal protection does not overcome the risk of polyneuropathy and myopathy.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2015, Volume: 21, Issue:8

    Topics: Aged; Antiviral Agents; Diabetes Mellitus; Drug Substitution; End Stage Liver Disease; Female; Glome

2015
Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs.
    Antiviral chemistry & chemotherapy, 2015, Volume: 24, Issue:1

    Topics: Acute Disease; Animals; Antiviral Agents; Disease Models, Animal; Female; Guinea Pigs; Herpes Genita

2015
Ten-year follow-up of hepatitis B relapse after cessation of lamivudine or telbivudine treatment in chronic hepatitis B patients.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2015, Volume: 21, Issue:12

    Topics: Adolescent; Adult; Antiviral Agents; DNA, Viral; Feasibility Studies; Female; Follow-Up Studies; Hep

2015
Telbivudin as prophylaxis for hepatitis B virus recurrence after liver transplantation: a case series in single-center experience.
    Transplantation proceedings, 2012, Volume: 44, Issue:7

    Topics: Adult; Case-Control Studies; Female; Hepatitis B; Humans; Liver Transplantation; Male; Middle Aged;

2012
Risk of failure in patients with 215 HIV-1 revertants starting their first thymidine analog-containing highly active antiretroviral therapy.
    AIDS (London, England), 2004, Jan-23, Volume: 18, Issue:2

    Topics: Adult; Aged; Antiretroviral Therapy, Highly Active; Chronic Disease; Cohort Studies; Drug Resistance

2004
[Herpetic recurrence prophylaxis with trifluorothymidine after keratoplasty (author's transl)].
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1980, Volume: 180, Issue:1

    Topics: Adolescent; Adult; Aged; Corneal Transplantation; Female; Humans; Keratitis, Dendritic; Male; Middle

1980
Failure of autologous oral epithelia to activate RAS lymphocytes.
    Clinical immunology and immunopathology, 1982, Volume: 22, Issue:2

    Topics: Behcet Syndrome; Epithelial Cells; Epithelium; Humans; Lymphocyte Activation; Mitomycin; Mitomycins;

1982
The growth fraction of human myeloma cells.
    Blood, 1981, Volume: 57, Issue:2

    Topics: Female; Humans; Kinetics; Male; Melphalan; Middle Aged; Multiple Myeloma; Prednisone; Recurrence; Th

1981
Successful second autologous blood stem cell transplantation after G-CSF-combined conditioning for the treatment of high-risk acute myelogenous leukemia.
    Bone marrow transplantation, 1994, Volume: 13, Issue:3

    Topics: Adult; Blood Transfusion, Autologous; Combined Modality Therapy; Cytarabine; DNA, Neoplasm; Drug The

1994
Cell proliferation in 3,800 node-negative breast cancers: consistency over time of biological and clinical information provided by 3H-thymidine labelling index.
    International journal of cancer, 1997, Feb-20, Volume: 74, Issue:1

    Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Cell Division; Confidence Intervals; DNA, Neoplasm

1997
A thymidine to cytosine substitution for codon 26 of exon 3 of apolipoprotein C-II gene in a patient with apolipoprotein C-II deficiency.
    Internal medicine (Tokyo, Japan), 1999, Volume: 38, Issue:2

    Topics: Apolipoprotein C-II; Apolipoproteins C; Blotting, Western; Codon; Cytosine; DNA; DNA Primers; Exons;

1999
Clinical experiences with trifluorothymidine in herpes simplex keratitis.
    Advances in ophthalmology = Fortschritte der Augenheilkunde = Progres en ophtalmologie, 1979, Volume: 38

    Topics: Animals; Corneal Transplantation; Deoxycytidine; Female; Humans; Idoxuridine; Keratitis, Dendritic;

1979
Advanced stage and early relapse of breast carcinomas associated with high thymidine labeling indices.
    Cancer research, 1979, Volume: 39, Issue:10

    Topics: Age Factors; Aged; Breast Neoplasms; DNA, Neoplasm; Female; Humans; Lymphatic Metastasis; Middle Age

1979
Studies in porphyria. VII. Induction of uroporphyrinogen-I synthase and expression of the gene defect of acute intermittent porphyria in mitogen-stimulated human lymphocytes.
    The Journal of clinical investigation, 1978, Volume: 61, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aged; Ammonia-Lyases; Cells, Cultured; Child; Child, Preschool; En

1978
Growth kinetics of plasma cell myeloma.
    Journal of the National Cancer Institute, 1977, Volume: 58, Issue:5

    Topics: Bone Marrow; Bone Marrow Cells; Cell Division; Female; Humans; In Vitro Techniques; Infusions, Paren

1977
Re-entry of resting leukaemic blood cells into proliferation in human acute leukaemia during diffusion chamber culture.
    Blut, 1976, Volume: 33, Issue:5

    Topics: Acute Disease; Cell Division; Cells, Cultured; Humans; Leukemia; Recurrence; Thymidine; Tritium

1976
Suppression of ocular herpes recurrences by a thymidine kinase inhibitor in squirrel monkeys.
    Antiviral research, 1991, Volume: 16, Issue:3

    Topics: Animals; Keratitis, Herpetic; Recurrence; Saimiri; Simplexvirus; Thymidine; Thymidine Kinase; Viral

1991
Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:7

    Topics: Acyclovir; Adult; Animals; Antiviral Agents; Arabinonucleosides; Cloning, Molecular; DNA Restriction

1987
Proliferation kinetics of plasma cells and of normal haemopoietic cells in multiple myeloma.
    Cell and tissue kinetics, 1987, Volume: 20, Issue:3

    Topics: Aged; Bone Marrow; Cell Division; DNA; Female; Hematopoietic Stem Cells; Humans; Kinetics; Leukemia,

1987
[Early treatment of ocular herpes simplex. Apropos of 6 cases of herpetic conjunctivitis].
    Journal francais d'ophtalmologie, 1985, Volume: 8, Issue:12

    Topics: Adult; Conjunctivitis, Viral; Female; Humans; Keratitis, Dendritic; Male; Middle Aged; Ophthalmic So

1985
Immunological studies in children undergoing tonsillectomy.
    Clinical and experimental immunology, 1973, Volume: 14, Issue:3

    Topics: Animals; Antistreptolysin; Cells, Cultured; Child; Child, Preschool; Female; Haemophilus influenzae;

1973
Co-trimaxazole therapy: place and prospects.
    The Medical journal of Australia, 1973, Jun-30, Volume: 1, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacteriuria; Drug Combinations; Drug Resistance, Microbial

1973
Lymphocyte interferon production and transformation after Herpes simplex infections in humans.
    Journal of immunology (Baltimore, Md. : 1950), 1974, Volume: 112, Issue:2

    Topics: Antibodies, Viral; Antigens, Viral; Cells, Cultured; Cytopathogenic Effect, Viral; Fibroblasts; HeLa

1974
'Antigenic' disparity between leukaemic lymphoblasts and normal lymphocytes in identical twins.
    Clinical and experimental immunology, 1972, Volume: 12, Issue:2

    Topics: Acute Disease; Antigens, Neoplasm; Child, Preschool; Diseases in Twins; Histocompatibility Testing;

1972
Autoradiography of activated lymphocytes in the blood in Hodgkin's disease.
    Israel journal of medical sciences, 1973, Volume: 9, Issue:7

    Topics: Adolescent; Adult; Age Factors; Antigens; Autoradiography; DNA; Female; Hodgkin Disease; Humans; Lym

1973
Macrophage accumulation, division, maturation, and digestive and microbicidal capacities in tuberculous lesions. 3. The turnover of macrophages and its relation to their activation and antimicrobial immunity in primary BCG lesions and those of reinfection
    Journal of immunology (Baltimore, Md. : 1950), 1972, Volume: 109, Issue:5

    Topics: Animals; Autoradiography; Cell Division; Cell Survival; Galactosidases; Hypersensitivity, Delayed; I

1972
Photosensitive cheilitis. Clinical and pathogenetic considerations.
    Annals of internal medicine, 1971, Volume: 75, Issue:6

    Topics: Adult; Biopsy; Black People; Cheilitis; Chronic Disease; Cytoplasmic Granules; Diagnosis, Differenti

1971