thymidine has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 20 studies
Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To further investigate this possible therapeutic approach we used a whole blood assay to characterize the proliferative responsiveness (3H-thymidine incorporation) of circulating T cells from AML patients with severe treatment-induced leukopenia, i." | 3.72 | Functional characterization of T lymphocytes derived from patients with acute myelogenous leukemia and chemotherapy-induced leukopenia. ( Bruserud, Ø; Ernst, P; Nesthus, I; Paulsen, K; Sjo, M; Wendelbo, Ø, 2004) |
| "Twenty patients who received high-dose methotrexate for osteosarcoma (n = 11), lymphoid cancers (n = 8), and gastric cancer (n = 1) developed nephrotoxicity (median serum creatinine, 3." | 3.69 | Carboxypeptidase-G2, thymidine, and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction. ( Adamson, PC; Balis, FM; Montello, MJ; Murphy, RF; O'Brien, M; Sorensen, JM; Widemann, BC, 1997) |
| "It is uncertain if acute lymphoblastic leukemia (ALL) cells expressing myeloid makers can respond to granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF)." | 2.68 | Heterogeneous effects of G-CSF and GM-CSF on cell growth and ara-C cytotoxicity in childhood leukemias which express myeloid markers. ( Cao, DC; Higashigawa, M; Hori, H; Ido, M; Kawasaki, H; Komada, Y; Kuwabara, H; Ohkubo, T; Sakurai, M, 1996) |
| "Acute lymphoblastic leukemia (ALL) with mixed lineage leukemia (MLL) gene rearrangements (MLL+ALL) has a dismal prognosis and is characterized by high surface CD44 expression." | 1.46 | Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression. ( Abe, M; Ando, N; Furuichi, Y; Goi, K; Inukai, T; Kagami, K; Kasai, S; Nagano, O; Nakane, T; Ohno, S; Okazaki, S; Saitoh, S; Saya, H; Sugita, K, 2017) |
| "We show that acute lymphoblastic leukemia (ALL) cells avoid lethal replication stress after thymidine (dT)-induced inhibition of DNP dCTP synthesis by switching to NSP-mediated dCTP production." | 1.40 | Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. ( Armijo, AL; Austin, WR; Boulos, N; Campbell, DO; Czernin, J; Darvish, R; Dimitrova, E; Faull, KF; Gordin, A; Herschman, HR; Jung, ME; Lavie, A; Le, TM; Lee, JT; Li, Z; Liao, HI; Martin, C; Murphy, JM; Nathanson, DA; Nomme, J; Phelps, ME; Radu, CG; Sadeghi, S; Ta, L; Tom, M; Wei, L; Wilks, M, 2014) |
| "Neoplastic cells of childhood acute lymphoblastic leukemia (ALL) with natural killer (NK) cell properties were studied for the expression of p75 interleukin-2 receptors (IL-2R) and the receptor functions." | 1.28 | Functional p75 interleukin-2 receptor expression on the fresh blast cells in childhood acute lymphoblastic leukemia with natural killer cell properties. ( Ichikawa, M; Kawai, H; Kinoshita, A; Komiyama, A; Miyasaka, M; Nakazawa, S; Tsudo, M, 1991) |
| "Using JM and MOLT3, two human T-cell acute lymphoblastic leukemia cell lines, we investigated the ability of 24-h thymidine exposures to enhance the cytotoxicity of cis-diammine-1,1-cyclobutane dicarboxylate platinum (II) (carboplatin)." | 1.28 | Interactions of thymidine, hyperthermia, and cis-diammine-1,1-cyclobutane dicarboxylate platinum (II) in human T-cell leukemia. ( Cohen, JD; Robins, HI; Schmitt, CL; Tanner, MA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 12 (60.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kasai, S | 1 |
| Furuichi, Y | 1 |
| Ando, N | 1 |
| Kagami, K | 1 |
| Abe, M | 1 |
| Nakane, T | 1 |
| Goi, K | 1 |
| Inukai, T | 1 |
| Saitoh, S | 1 |
| Ohno, S | 1 |
| Okazaki, S | 1 |
| Nagano, O | 1 |
| Saya, H | 1 |
| Sugita, K | 1 |
| Nathanson, DA | 1 |
| Armijo, AL | 1 |
| Tom, M | 1 |
| Li, Z | 1 |
| Dimitrova, E | 1 |
| Austin, WR | 1 |
| Nomme, J | 1 |
| Campbell, DO | 1 |
| Ta, L | 1 |
| Le, TM | 1 |
| Lee, JT | 1 |
| Darvish, R | 1 |
| Gordin, A | 1 |
| Wei, L | 1 |
| Liao, HI | 1 |
| Wilks, M | 1 |
| Martin, C | 1 |
| Sadeghi, S | 1 |
| Murphy, JM | 1 |
| Boulos, N | 1 |
| Phelps, ME | 1 |
| Faull, KF | 1 |
| Herschman, HR | 1 |
| Jung, ME | 1 |
| Czernin, J | 1 |
| Lavie, A | 1 |
| Radu, CG | 1 |
| Hegazy, AN | 1 |
| Klein, C | 1 |
| Wendelbo, Ø | 1 |
| Nesthus, I | 1 |
| Sjo, M | 1 |
| Paulsen, K | 1 |
| Ernst, P | 1 |
| Bruserud, Ø | 1 |
| Roychowdhury, S | 1 |
| Baiocchi, RA | 1 |
| Vourganti, S | 1 |
| Bhatt, D | 1 |
| Blaser, BW | 1 |
| Freud, AG | 1 |
| Chou, J | 1 |
| Chen, CS | 2 |
| Xiao, JJ | 1 |
| Parthun, M | 1 |
| Chan, KK | 1 |
| Eisenbeis, CF | 1 |
| Ferketich, AK | 1 |
| Grever, MR | 1 |
| Caligiuri, MA | 1 |
| Gangjee, A | 1 |
| Devraj, R | 1 |
| McGuire, JJ | 1 |
| Kisliuk, RL | 1 |
| Haber, M | 1 |
| Norris, MD | 1 |
| Kavallaris, M | 1 |
| Camacho, M | 1 |
| Madafiglio, J | 1 |
| Baker, CJ | 1 |
| White, L | 1 |
| Stewart, BW | 2 |
| Taskén, K | 2 |
| Andersson, KB | 2 |
| Erikstein, BK | 1 |
| Hansson, V | 1 |
| Jahnsen, T | 1 |
| Blomhoff, HK | 2 |
| Christoffersen, J | 1 |
| Smeland, EB | 1 |
| Stokke, T | 1 |
| van der Plas, DC | 1 |
| Smiers, F | 1 |
| Pouwels, K | 2 |
| Hoefsloot, LH | 1 |
| Löwenberg, B | 2 |
| Touw, IP | 2 |
| Higashigawa, M | 1 |
| Kuwabara, H | 1 |
| Cao, DC | 1 |
| Hori, H | 1 |
| Ohkubo, T | 1 |
| Kawasaki, H | 1 |
| Ido, M | 1 |
| Komada, Y | 1 |
| Sakurai, M | 1 |
| Widemann, BC | 1 |
| Balis, FM | 1 |
| Murphy, RF | 1 |
| Sorensen, JM | 1 |
| Montello, MJ | 1 |
| O'Brien, M | 1 |
| Adamson, PC | 1 |
| Sackey, FN | 1 |
| Watson, CS | 1 |
| Gametchu, B | 1 |
| Barnes, MJ | 1 |
| Taylor, GA | 1 |
| Newell, DR | 1 |
| Jeanteur, P | 1 |
| Ichikawa, M | 1 |
| Kawai, H | 1 |
| Komiyama, A | 1 |
| Tsudo, M | 1 |
| Miyasaka, M | 1 |
| Kinoshita, A | 1 |
| Nakazawa, S | 1 |
| Catchpoole, D | 1 |
| Bökkerink, JP | 1 |
| Damen, FJ | 1 |
| Hulscher, MW | 1 |
| Bakker, MA | 1 |
| De Abreu, RA | 1 |
| van Agthoven, AJ | 1 |
| van Gurp, R | 1 |
| Delwel, R | 1 |
| Hagemeijer, A | 1 |
| Hählen, K | 1 |
| Cohen, JD | 1 |
| Robins, HI | 1 |
| Schmitt, CL | 1 |
| Tanner, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Trial of Carboxypeptidase-G2 (CPDG2) and Thymidine for the Management of Patients With Methotrexate Toxicity and Renal Dysfunction[NCT00001298] | Phase 1 | 10 participants | Interventional | 1992-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for thymidine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Heterogeneous effects of G-CSF and GM-CSF on cell growth and ara-C cytotoxicity in childhood leukemias which express myeloid markers.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; C | 1996 |
19 other studies available for thymidine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression.
Topics: Biological Transport; Cell Line, Tumor; Cell Survival; Child; Child, Preschool; Female; Gene Express | 2017 |
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
Topics: Animals; Biosynthetic Pathways; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Disease Eradication | 2014 |
Ex vivo priming of CD4 T cells converts immunological tolerance into effective antitumor immunity in a murine model of acute lymphoblastic leukemia.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Proliferation; Dendritic Cells; Disease Models, Animal; Fe | 2008 |
Functional characterization of T lymphocytes derived from patients with acute myelogenous leukemia and chemotherapy-induced leukopenia.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; CD28 Antigen | 2004 |
Selective efficacy of depsipeptide in a xenograft model of Epstein-Barr virus-positive lymphoproliferative disorder.
Topics: Animals; Antineoplastic Agents; Apoptosis; Burkitt Lymphoma; Caspase Inhibitors; Cell Division; Cell | 2004 |
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypo | 1995 |
An assay for the determination of reduced methotrexate accumulation in cells displaying limited viability in vitro.
Topics: Animals; Cryopreservation; Freezing; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Precu | 1995 |
Regulation of growth in a neoplastic B cell line by transfected subunits of 3',5'-cyclic adenosine monophosphate-dependent protein kinase.
Topics: B-Lymphocytes; Blotting, Northern; Cell Division; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protei | 1994 |
Retinoblastoma protein is rapidly dephosphorylated by elevated cyclic adenosine monophosphate levels in human B-lymphoid cells.
Topics: B-Lymphocytes; Cell Cycle; Cell Division; Cell Line; Cell Nucleus; Colforsin; Cyclic AMP; Humans; Mi | 1994 |
Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain.
Topics: Animals; Antigens, CD; B-Lymphocytes; Base Sequence; Burkitt Lymphoma; Cell Line; DNA Primers; DNA-B | 1996 |
Carboxypeptidase-G2, thymidine, and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction.
Topics: Adolescent; Adult; Antidotes; Antimetabolites, Antineoplastic; Carboxypeptidases; Child; Child, Pres | 1997 |
Cell cycle regulation of membrane glucocorticoid receptor in CCRF-CEM human ALL cells: correlation to apoptosis.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Membrane; Demecolcine; DNA, Neoplasm; G1 Phase; Gene | 1997 |
Development of a whole cell assay to measure methotrexate-induced inhibition of thymidylate synthase and de novo purine synthesis in leukaemia cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Child; Guanine; Humans; Inosine; Leukemia; Methotrexate; P | 2000 |
[Nutrition, genetic polymorphism, and cancer].
Topics: Colorectal Neoplasms; DNA; DNA Repair; Folic Acid; Genotype; Humans; Methylenetetrahydrofolate Reduc | 2000 |
Functional p75 interleukin-2 receptor expression on the fresh blast cells in childhood acute lymphoblastic leukemia with natural killer cell properties.
Topics: Adolescent; Antibodies, Monoclonal; Antigens, CD; Blast Crisis; Cell Division; Histocytochemistry; H | 1991 |
Structural analysis of replicating DNA following exposure to cytotoxic drugs: implications for current models of DNA synthesis in mammalian cells.
Topics: Antineoplastic Agents; Cell Line; Chromatography, DEAE-Cellulose; DNA; DNA Replication; DNA, Single- | 1990 |
Biochemical evidence for synergistic combination treatment with methotrexate and 6-mercaptopurine in acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; DNA, Neoplasm; Drug Synergism; Humans; Lymphocytes; | 1990 |
Role of interleukin-7 in the growth of acute lymphoblastic leukemia.
Topics: Cell Division; DNA, Neoplasm; Humans; Interleukin-7; Precursor Cell Lymphoblastic Leukemia-Lymphoma; | 1990 |
Interactions of thymidine, hyperthermia, and cis-diammine-1,1-cyclobutane dicarboxylate platinum (II) in human T-cell leukemia.
Topics: Antineoplastic Agents; Carboplatin; Cell Line; Cell Survival; Drug Synergism; Heart; Humans; Organop | 1989 |