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thymidine and Nervous System Disorders

thymidine has been researched along with Nervous System Disorders in 19 studies

Research Excerpts

ExcerptRelevanceReference
"On the basis of observation that acyclovir potentiates the in-vitro antiviral activity of 3-azido-2',3'-dideoxythymidine (also known as azidothymidine or zidovudine) against human immunodeficiency virus (HIV), we administered a regimen of azidothymidine and acyclovir to eight patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex."7.67Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study. ( Allain, JP; Blum, MR; Lehrman, SN; Leuther, M; Maha, M; McAtee, N; Mitsuya, H; Surbone, A; Thomas, RV; Yarchoan, R, 1988)
"On the basis of observation that acyclovir potentiates the in-vitro antiviral activity of 3-azido-2',3'-dideoxythymidine (also known as azidothymidine or zidovudine) against human immunodeficiency virus (HIV), we administered a regimen of azidothymidine and acyclovir to eight patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex."3.67Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study. ( Allain, JP; Blum, MR; Lehrman, SN; Leuther, M; Maha, M; McAtee, N; Mitsuya, H; Surbone, A; Thomas, RV; Yarchoan, R, 1988)
"Increased risk of lactic acidosis has also been described for those with impaired liver and renal function taking entecavir."2.50Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment. ( Fung, J; Lai, CL; Seto, WK; Yuen, MF, 2014)
"Telbivudine has also been reported to be associated with myopathy and neuropathy, particularly when used in combination with pegylated interferon."2.45Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B. ( Fleischer, RD; Lok, AS, 2009)
" 5-Fluorouracil at high dosage may cause cerebellar ataxia, but may also do so at low dosage when combined with thymidine infusions."2.37Neurological complications of antineoplastic therapy. ( Shapiro, WR; Young, DF, 1984)
"Mental disturbances associated with acquired immunodeficiency syndrome (AIDS) are related not only to profound psychosocial stress, systemic diseases, and neoplasms or opportunistic infections within the central nervous system (CNS); they are also related to the direct neurotoxicity of the etiologic human immunodeficiency virus (HIV), producing an array of both insidious and acute affective, cognitive, and behavioral dysfunction that can mimic many neuropsychiatric disorders."2.37AIDS dementia: a review of the literature. ( Marotta, RF; Perry, S, 1987)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199012 (63.16)18.7374
1990's1 (5.26)18.2507
2000's3 (15.79)29.6817
2010's3 (15.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fung, J1
Seto, WK1
Lai, CL1
Yuen, MF1
Fleischer, RD1
Lok, AS1
Kim, SK1
Im, HJ1
Kim, W1
Kim, TS1
Hwangbo, B1
Kim, HJ1
El-Hattab, AW1
Scaglia, F1
Pontarin, G1
Ferraro, P1
Valentino, ML2
Hirano, M2
Reichard, P1
Bianchi, V1
Lara, MC1
Weiss, B1
Illa, I1
Madoz, P1
Massuet, L1
Andreu, AL1
Anikster, Y1
Martí, R1
Shapiro, WR1
Young, DF1
Graham, DG1
Krieger, C1
Perry, TL1
Ziltener, HJ1
Yarchoan, R3
Berg, G1
Brouwers, P1
Fischl, MA1
Spitzer, AR1
Wichman, A1
Grafman, J1
Thomas, RV2
Safai, B1
Brunetti, A1
Surbone, A1
McAtee, N1
Blum, MR1
Maha, M1
Allain, JP1
Mitsuya, H1
Lehrman, SN1
Leuther, M1
Dalakas, MC1
Spitzer, R1
Elder, G1
Sever, JL1
Perry, S1
Marotta, RF1
Knowles, M2
Hughes, D2
Caspary, EA2
Field, EJ3
Saunders, M1
Rezai, Z1
Yoon, CH1
Frick, E1
Stickl, H1
Zinn, KH1
Kozik, M1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 1 Double-Blinded Study for Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ATI-2173 in Healthy Subjects and Subjects With Chronic Hepatitis B Virus Infection[NCT04248426]Phase 188 participants (Actual)Interventional2020-02-05Completed
Nutritional Assessment in Patients Affected by Mitochondrial Cytopathy[NCT02375438]26 participants (Actual)Observational2014-12-31Completed
A Phase II, Monocenter, Single Arm Study To Assess The Safety and Efficacy Of Combination Deoxycytidine and Deoxythymidine For Mitochondrial Depletion Disorders[NCT04802707]Phase 250 participants (Anticipated)Interventional2021-10-18Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for thymidine and Nervous System Disorders

ArticleYear
Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:3

    Topics: Acidosis, Lactic; Adenine; Administration, Oral; Antiviral Agents; Arabinofuranosyluracil; Dose-Resp

2014
Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B.
    Journal of hepatology, 2009, Volume: 51, Issue:4

    Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Creatine Kinase; Drug Discovery; Early Terminatio

2009
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2013, Volume: 10, Issue:2

    Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon

2013
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2013, Volume: 10, Issue:2

    Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon

2013
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2013, Volume: 10, Issue:2

    Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon

2013
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2013, Volume: 10, Issue:2

    Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon

2013
Neurological complications of antineoplastic therapy.
    Acta neurologica Scandinavica. Supplementum, 1984, Volume: 100

    Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Antineoplastic Combined Chemother

1984
AIDS dementia: a review of the literature.
    Alzheimer disease and associated disorders, 1987, Volume: 1, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Brain; Counseling; Dementia; Humans; Nervous S

1987

Other Studies

14 other studies available for thymidine and Nervous System Disorders

ArticleYear
F-18 fluorodeoxyglucose and F-18 fluorothymidine positron emission tomography/computed tomography imaging in a case of neurosarcoidosis.
    Clinical nuclear medicine, 2010, Volume: 35, Issue:2

    Topics: Adult; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Ner

2010
Mitochondrial DNA depletion and thymidine phosphate pool dynamics in a cellular model of mitochondrial neurogastrointestinal encephalomyopathy.
    The Journal of biological chemistry, 2006, Aug-11, Volume: 281, Issue:32

    Topics: Adenosine Triphosphate; Cytosol; DNA, Mitochondrial; Fibroblasts; Gastrointestinal Diseases; Humans;

2006
Infusion of platelets transiently reduces nucleoside overload in MNGIE.
    Neurology, 2006, Oct-24, Volume: 67, Issue:8

    Topics: Adolescent; Adult; Deoxyuridine; Female; Gastrointestinal Diseases; Humans; Male; Mitochondrial Ence

2006
Catecholamine toxicity: a proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinson's disease.
    Neurotoxicology, 1984,Spring, Volume: 5, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Catecholamines; Child; DNA Polymerase II; Female; Humans; Male; Mang

1984
Amyotrophic lateral sclerosis: interleukin-6 levels in cerebrospinal fluid.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1992, Volume: 19, Issue:3

    Topics: Amyotrophic Lateral Sclerosis; Humans; Interleukin-6; Mental Disorders; Monocytes; Nervous System Di

1992
Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine.
    Lancet (London, England), 1987, Jan-17, Volume: 1, Issue:8525

    Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Diseases; Humans; Male; Middle Aged; Nervous System

1987
Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study.
    Annals of internal medicine, 1988, Volume: 108, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; AIDS-Related Complex; Antiviral Agents; Drug I

1988
Treatment of human immunodeficiency virus-related polyneuropathy with 3'-azido-2',3'-dideoxythymidine.
    Annals of neurology, 1988, Volume: 23 Suppl

    Topics: Acquired Immunodeficiency Syndrome; Aged; Female; Humans; Leg; Nervous System Diseases; Neural Condu

1988
Lymphocyte transformation in multiple sclerosis. Inhibition of unstimulated thymidine uptake by a serum factor.
    Lancet (London, England), 1968, Dec-07, Volume: 2, Issue:7580

    Topics: Acute Disease; Blood Group Antigens; Culture Techniques; Humans; Lymphocytes; Multiple Sclerosis; Ne

1968
Lymphocyte trnsformation induced by encephalitogenic factor in multiple sclerosis and other neurological diseases.
    Lancet (London, England), 1968, Dec-07, Volume: 2, Issue:7580

    Topics: Culture Techniques; Encephalitis; Humans; Lymphocytes; Multiple Sclerosis; Nervous System Diseases;

1968
Lymphocyte stimulation with phytohaemagglutinin in multiple sclerosis.
    Lancet (London, England), 1969, Mar-29, Volume: 1, Issue:7596

    Topics: Culture Techniques; Humans; Lectins; Lymphocytes; Multiple Sclerosis; Nervous System Diseases; Thymi

1969
Abnormal rate of granule cell migration in the cerebellum of "Weaver" mutant mice.
    Developmental biology, 1972, Volume: 29, Issue:1

    Topics: Animals; Autoradiography; Cell Division; Cell Movement; Cerebellum; Crosses, Genetic; Genes, Dominan

1972
[Lymphocyte transformation in multiple sclerosis. Demonstration of cell sensitivity to basic myelin protein (author's transl)].
    Klinische Wochenschrift, 1974, Mar-01, Volume: 52, Issue:5

    Topics: Acute Disease; Antigens; Carbon Radioisotopes; Cerebrovascular Disorders; Chronic Disease; Female; H

1974
Degenerative changes of neurocytes in the light of autoradiographic investigations.
    Pathologia Europaea, 1971, Volume: 6, Issue:2

    Topics: Adenine; Amino Acids; Animals; Autoradiography; Brain; Carbon Isotopes; Cerebral Cortex; Disease Mod

1971