thymidine has been researched along with Nervous System Disorders in 19 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "On the basis of observation that acyclovir potentiates the in-vitro antiviral activity of 3-azido-2',3'-dideoxythymidine (also known as azidothymidine or zidovudine) against human immunodeficiency virus (HIV), we administered a regimen of azidothymidine and acyclovir to eight patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex." | 7.67 | Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study. ( Allain, JP; Blum, MR; Lehrman, SN; Leuther, M; Maha, M; McAtee, N; Mitsuya, H; Surbone, A; Thomas, RV; Yarchoan, R, 1988) |
| "On the basis of observation that acyclovir potentiates the in-vitro antiviral activity of 3-azido-2',3'-dideoxythymidine (also known as azidothymidine or zidovudine) against human immunodeficiency virus (HIV), we administered a regimen of azidothymidine and acyclovir to eight patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex." | 3.67 | Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study. ( Allain, JP; Blum, MR; Lehrman, SN; Leuther, M; Maha, M; McAtee, N; Mitsuya, H; Surbone, A; Thomas, RV; Yarchoan, R, 1988) |
| "Increased risk of lactic acidosis has also been described for those with impaired liver and renal function taking entecavir." | 2.50 | Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment. ( Fung, J; Lai, CL; Seto, WK; Yuen, MF, 2014) |
| "Telbivudine has also been reported to be associated with myopathy and neuropathy, particularly when used in combination with pegylated interferon." | 2.45 | Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B. ( Fleischer, RD; Lok, AS, 2009) |
| " 5-Fluorouracil at high dosage may cause cerebellar ataxia, but may also do so at low dosage when combined with thymidine infusions." | 2.37 | Neurological complications of antineoplastic therapy. ( Shapiro, WR; Young, DF, 1984) |
| "Mental disturbances associated with acquired immunodeficiency syndrome (AIDS) are related not only to profound psychosocial stress, systemic diseases, and neoplasms or opportunistic infections within the central nervous system (CNS); they are also related to the direct neurotoxicity of the etiologic human immunodeficiency virus (HIV), producing an array of both insidious and acute affective, cognitive, and behavioral dysfunction that can mimic many neuropsychiatric disorders." | 2.37 | AIDS dementia: a review of the literature. ( Marotta, RF; Perry, S, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (63.16) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fung, J | 1 |
| Seto, WK | 1 |
| Lai, CL | 1 |
| Yuen, MF | 1 |
| Fleischer, RD | 1 |
| Lok, AS | 1 |
| Kim, SK | 1 |
| Im, HJ | 1 |
| Kim, W | 1 |
| Kim, TS | 1 |
| Hwangbo, B | 1 |
| Kim, HJ | 1 |
| El-Hattab, AW | 1 |
| Scaglia, F | 1 |
| Pontarin, G | 1 |
| Ferraro, P | 1 |
| Valentino, ML | 2 |
| Hirano, M | 2 |
| Reichard, P | 1 |
| Bianchi, V | 1 |
| Lara, MC | 1 |
| Weiss, B | 1 |
| Illa, I | 1 |
| Madoz, P | 1 |
| Massuet, L | 1 |
| Andreu, AL | 1 |
| Anikster, Y | 1 |
| MartÃ, R | 1 |
| Shapiro, WR | 1 |
| Young, DF | 1 |
| Graham, DG | 1 |
| Krieger, C | 1 |
| Perry, TL | 1 |
| Ziltener, HJ | 1 |
| Yarchoan, R | 3 |
| Berg, G | 1 |
| Brouwers, P | 1 |
| Fischl, MA | 1 |
| Spitzer, AR | 1 |
| Wichman, A | 1 |
| Grafman, J | 1 |
| Thomas, RV | 2 |
| Safai, B | 1 |
| Brunetti, A | 1 |
| Surbone, A | 1 |
| McAtee, N | 1 |
| Blum, MR | 1 |
| Maha, M | 1 |
| Allain, JP | 1 |
| Mitsuya, H | 1 |
| Lehrman, SN | 1 |
| Leuther, M | 1 |
| Dalakas, MC | 1 |
| Spitzer, R | 1 |
| Elder, G | 1 |
| Sever, JL | 1 |
| Perry, S | 1 |
| Marotta, RF | 1 |
| Knowles, M | 2 |
| Hughes, D | 2 |
| Caspary, EA | 2 |
| Field, EJ | 3 |
| Saunders, M | 1 |
| Rezai, Z | 1 |
| Yoon, CH | 1 |
| Frick, E | 1 |
| Stickl, H | 1 |
| Zinn, KH | 1 |
| Kozik, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1 Double-Blinded Study for Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ATI-2173 in Healthy Subjects and Subjects With Chronic Hepatitis B Virus Infection[NCT04248426] | Phase 1 | 88 participants (Actual) | Interventional | 2020-02-05 | Completed | ||
| Nutritional Assessment in Patients Affected by Mitochondrial Cytopathy[NCT02375438] | 26 participants (Actual) | Observational | 2014-12-31 | Completed | |||
| A Phase II, Monocenter, Single Arm Study To Assess The Safety and Efficacy Of Combination Deoxycytidine and Deoxythymidine For Mitochondrial Depletion Disorders[NCT04802707] | Phase 2 | 50 participants (Anticipated) | Interventional | 2021-10-18 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for thymidine and Nervous System Disorders
| Article | Year |
|---|---|
Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment.
Topics: Acidosis, Lactic; Adenine; Administration, Oral; Antiviral Agents; Arabinofuranosyluracil; Dose-Resp | 2014 |
Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Creatine Kinase; Drug Discovery; Early Terminatio | 2009 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Neurological complications of antineoplastic therapy.
Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Antineoplastic Combined Chemother | 1984 |
AIDS dementia: a review of the literature.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Brain; Counseling; Dementia; Humans; Nervous S | 1987 |
14 other studies available for thymidine and Nervous System Disorders
| Article | Year |
|---|---|
F-18 fluorodeoxyglucose and F-18 fluorothymidine positron emission tomography/computed tomography imaging in a case of neurosarcoidosis.
Topics: Adult; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Ner | 2010 |
Mitochondrial DNA depletion and thymidine phosphate pool dynamics in a cellular model of mitochondrial neurogastrointestinal encephalomyopathy.
Topics: Adenosine Triphosphate; Cytosol; DNA, Mitochondrial; Fibroblasts; Gastrointestinal Diseases; Humans; | 2006 |
Infusion of platelets transiently reduces nucleoside overload in MNGIE.
Topics: Adolescent; Adult; Deoxyuridine; Female; Gastrointestinal Diseases; Humans; Male; Mitochondrial Ence | 2006 |
Catecholamine toxicity: a proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinson's disease.
Topics: Adolescent; Adult; Aged; Aging; Catecholamines; Child; DNA Polymerase II; Female; Humans; Male; Mang | 1984 |
Amyotrophic lateral sclerosis: interleukin-6 levels in cerebrospinal fluid.
Topics: Amyotrophic Lateral Sclerosis; Humans; Interleukin-6; Mental Disorders; Monocytes; Nervous System Di | 1992 |
Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Diseases; Humans; Male; Middle Aged; Nervous System | 1987 |
Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; AIDS-Related Complex; Antiviral Agents; Drug I | 1988 |
Treatment of human immunodeficiency virus-related polyneuropathy with 3'-azido-2',3'-dideoxythymidine.
Topics: Acquired Immunodeficiency Syndrome; Aged; Female; Humans; Leg; Nervous System Diseases; Neural Condu | 1988 |
Lymphocyte transformation in multiple sclerosis. Inhibition of unstimulated thymidine uptake by a serum factor.
Topics: Acute Disease; Blood Group Antigens; Culture Techniques; Humans; Lymphocytes; Multiple Sclerosis; Ne | 1968 |
Lymphocyte trnsformation induced by encephalitogenic factor in multiple sclerosis and other neurological diseases.
Topics: Culture Techniques; Encephalitis; Humans; Lymphocytes; Multiple Sclerosis; Nervous System Diseases; | 1968 |
Lymphocyte stimulation with phytohaemagglutinin in multiple sclerosis.
Topics: Culture Techniques; Humans; Lectins; Lymphocytes; Multiple Sclerosis; Nervous System Diseases; Thymi | 1969 |
Abnormal rate of granule cell migration in the cerebellum of "Weaver" mutant mice.
Topics: Animals; Autoradiography; Cell Division; Cell Movement; Cerebellum; Crosses, Genetic; Genes, Dominan | 1972 |
[Lymphocyte transformation in multiple sclerosis. Demonstration of cell sensitivity to basic myelin protein (author's transl)].
Topics: Acute Disease; Antigens; Carbon Radioisotopes; Cerebrovascular Disorders; Chronic Disease; Female; H | 1974 |
Degenerative changes of neurocytes in the light of autoradiographic investigations.
Topics: Adenine; Amino Acids; Animals; Autoradiography; Brain; Carbon Isotopes; Cerebral Cortex; Disease Mod | 1971 |