Page last updated: 2024-11-06

thymidine and Muscular Diseases

thymidine has been researched along with Muscular Diseases in 23 studies

Muscular Diseases: Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.

Research Excerpts

ExcerptRelevanceReference
"All oral nucleoside analogues against hepatitis B virus, with an exception of telbivudine, have been reported causing lactic acidosis (LA)."8.89Lactic acidosis during telbivudine treatment for HBV: a case report and literature review. ( Hu, P; Huang, XY; Jin, JL; Lu, JH; Luo, SS; Weng, XH; Zhang, JM, 2013)
"Telbivudine is an L-nucleoside analogue with potent antiviral activity against hepatitis B virus (HBV)."5.39Two cases of telbivudine-induced myopathy in siblings with chronic hepatitis B. ( Ahn, SH; Han, KH; Kim, EH; Kim, SM; Lee, KH; Park, H, 2013)
"All oral nucleoside analogues against hepatitis B virus, with an exception of telbivudine, have been reported causing lactic acidosis (LA)."4.89Lactic acidosis during telbivudine treatment for HBV: a case report and literature review. ( Hu, P; Huang, XY; Jin, JL; Lu, JH; Luo, SS; Weng, XH; Zhang, JM, 2013)
"Myopathy or neuropathy has been associated with lamivudine/telbivudine therapy in hepatitis B patients."3.80Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion. ( Jin, S; Lv, H; Wang, Z; Xu, H; Yuan, Y; Zhang, W; Zheng, L, 2014)
"Telbivudine (beta-l-2'-deoxythymidine) is an orally administered nucleoside analog drug approved for the treatment of patients with chronic hepatitis B since 2006."3.77Rhabdomyolysis in a 48-year-old man with hepatitis B-induced cirrhosis. ( Dang, S; Gao, N; Jia, X; Zhang, X, 2011)
"A 27 yo male of African origin received telbivudine for hepatitis B during 3 months."3.76Myotoxicity of telbivudine in pre-existing muscle damage. ( Ay, L; Finsterer, J, 2010)
"Increased risk of lactic acidosis has also been described for those with impaired liver and renal function taking entecavir."2.50Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment. ( Fung, J; Lai, CL; Seto, WK; Yuen, MF, 2014)
"Successful treatment of chronic hepatitis B (CHB) often requires long-term oral nucleoside/nucleotide agents which can be associated with viral resistance, patient non-compliance and adverse effects."2.46Safety evaluation of telbivudine. ( But, DY; Fung, J; Lai, CL; Yuen, MF, 2010)
"Telbivudine has also been reported to be associated with myopathy and neuropathy, particularly when used in combination with pegylated interferon."2.45Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B. ( Fleischer, RD; Lok, AS, 2009)
"Lamivudine was switched to telbivudine."1.42Telbivudine in liver transplant recipients: Renal protection does not overcome the risk of polyneuropathy and myopathy. ( Akarca, US; Bademkiran, F; Duman, S; Ersoz, G; Gunsar, F; Karasu, Z; Kose, T; Ozutemiz, O; Sozbilen, M; Turan, I; Yapali, S, 2015)
"Telbivudine is an L-nucleoside analogue with potent antiviral activity against hepatitis B virus (HBV)."1.39Two cases of telbivudine-induced myopathy in siblings with chronic hepatitis B. ( Ahn, SH; Han, KH; Kim, EH; Kim, SM; Lee, KH; Park, H, 2013)
"6-Mercaptopurine (6-MP) is an adenine antagonist which has been shown to cause skeletal muscle atrophy in neonatal rats."1.27Investigating the myopathic effects of 6-mercaptopurine on developing skeletal muscle cells in vitro. ( Kaji, H; Yander, G, 1984)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19908 (34.78)18.7374
1990's0 (0.00)18.2507
2000's3 (13.04)29.6817
2010's12 (52.17)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kim, EH1
Park, H1
Lee, KH1
Ahn, SH1
Kim, SM1
Han, KH1
Lee, SW1
Jang, JH1
Kim, BJ1
Jin, JL1
Hu, P1
Lu, JH1
Luo, SS1
Huang, XY1
Weng, XH1
Zhang, JM1
Fung, J2
Seto, WK1
Lai, CL2
Yuen, MF2
Xu, H1
Wang, Z1
Zheng, L1
Zhang, W1
Lv, H1
Jin, S1
Yuan, Y1
Turan, I1
Yapali, S1
Bademkiran, F1
Kose, T1
Duman, S1
Sozbilen, M1
Gunsar, F1
Ersoz, G1
Akarca, US1
Ozutemiz, O1
Karasu, Z1
Ambang, T1
Tan, JS1
Ong, S1
Wong, KT1
Goh, KJ1
Fleischer, RD1
Lok, AS1
But, DY1
Finsterer, J1
Ay, L1
Dang, S1
Gao, N1
Zhang, X1
Jia, X1
Zou, XJ1
Jiang, XQ1
Tian, DY1
Wang, M1
Da, Y1
Cai, H1
Lu, Y1
Wu, L1
Jia, J1
Hirano, M1
Martí, R1
Spinazzola, A1
Nishino, I1
Nishigaki, Y1
Butí, MA1
Yander, G1
Kaji, H1
Mohr, W1
Bock, G1
Lossnitzer, K1
Helbert, M1
Fletcher, T1
Peddle, B1
Harris, JR1
Pinching, AJ1
Schiaffino, S1
Bormioli, SP1
Aloisi, M1
Ofeigsson, OJ1
Mitchell, R1
Patrick, RS1
Currie, S2
Saunders, M2
Knowles, M2
Brown, AE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 1 Double-Blinded Study for Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ATI-2173 in Healthy Subjects and Subjects With Chronic Hepatitis B Virus Infection[NCT04248426]Phase 188 participants (Actual)Interventional2020-02-05Completed
The Effect of Telbivudine on Renal Function and Proteinuria in Patients With Chronic Hepatitis B Infection and Chronic Kidney Diseases[NCT02049736]0 participants (Actual)Interventional2013-12-31Withdrawn (stopped due to unable to recruit patients)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for thymidine and Muscular Diseases

ArticleYear
Lactic acidosis during telbivudine treatment for HBV: a case report and literature review.
    World journal of gastroenterology, 2013, Sep-07, Volume: 19, Issue:33

    Topics: Acidosis, Lactic; Adult; Antiviral Agents; Hepatitis B, Chronic; Humans; Male; Mitochondrial Disease

2013
Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:3

    Topics: Acidosis, Lactic; Adenine; Administration, Oral; Antiviral Agents; Arabinofuranosyluracil; Dose-Resp

2014
Myopathy and neuropathy associated with nucleos(t)ide analog therapy for hepatitis B.
    Journal of hepatology, 2009, Volume: 51, Issue:4

    Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Creatine Kinase; Drug Discovery; Early Terminatio

2009
Safety evaluation of telbivudine.
    Expert opinion on drug safety, 2010, Volume: 9, Issue:5

    Topics: Adult; Antiviral Agents; Biomarkers; Creatine Kinase; Double-Blind Method; Drug Resistance, Viral; F

2010
[Telbivudine in the treatment of the chronic B hepatitis].
    Gastroenterologia y hepatologia, 2008, Volume: 31, Issue:4

    Topics: Adolescent; Adult; Aged; Antiviral Agents; Biomarkers, Pharmacological; Biotransformation; Clinical

2008

Other Studies

18 other studies available for thymidine and Muscular Diseases

ArticleYear
Two cases of telbivudine-induced myopathy in siblings with chronic hepatitis B.
    Clinical and molecular hepatology, 2013, Volume: 19, Issue:1

    Topics: Adult; Antiviral Agents; Creatine Kinase; Electromyography; Hepatitis B, Chronic; Humans; Male; Musc

2013
Dysphagia could be the first presenting symptom of telbivudine-induced myopathy.
    Internal medicine journal, 2013, Volume: 43, Issue:9

    Topics: Aged; Antiviral Agents; Deglutition Disorders; Female; Humans; Muscular Diseases; Telbivudine; Thymi

2013
Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion.
    Journal of clinical pathology, 2014, Volume: 67, Issue:11

    Topics: Adult; Aged, 80 and over; Antiviral Agents; Biopsy; DNA, Mitochondrial; Female; Hepatitis B; Humans;

2014
Telbivudine in liver transplant recipients: Renal protection does not overcome the risk of polyneuropathy and myopathy.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2015, Volume: 21, Issue:8

    Topics: Aged; Antiviral Agents; Diabetes Mellitus; Drug Substitution; End Stage Liver Disease; Female; Glome

2015
Clinicopathological Features of Telbivudine-Associated Myopathy.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Aged; Female; Humans; Male; Middle Aged; Muscular Diseases; Telbivudine; Thymidine

2016
Myotoxicity of telbivudine in pre-existing muscle damage.
    Virology journal, 2010, Nov-17, Volume: 7

    Topics: Adult; Antiviral Agents; Creatine Kinase; Hepatitis B; Humans; Male; Muscle, Skeletal; Muscular Dise

2010
Rhabdomyolysis in a 48-year-old man with hepatitis B-induced cirrhosis.
    The American journal of the medical sciences, 2011, Volume: 342, Issue:1

    Topics: Acute Kidney Injury; Antiviral Agents; Fatal Outcome; Fibrosis; Hepatitis B; Humans; Male; Middle Ag

2011
Clinical features and risk factors of creatine kinase elevations and myopathy associated with telbivudine.
    Journal of viral hepatitis, 2011, Volume: 18, Issue:12

    Topics: Adolescent; Adult; Age Distribution; Aged; Antiviral Agents; Creatine Kinase; Female; Hepatitis B, C

2011
Telbivudine myopathy in a patient with chronic hepatitis B.
    International journal of clinical pharmacy, 2012, Volume: 34, Issue:3

    Topics: Adult; Antiviral Agents; Hepatitis B, Chronic; Humans; Male; Muscular Diseases; Telbivudine; Thymidi

2012
Thymidine phosphorylase deficiency causes MNGIE: an autosomal recessive mitochondrial disorder.
    Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:8-9

    Topics: Blotting, Southern; Brain Diseases; Chromatography, High Pressure Liquid; Genes, Recessive; Genetic

2004
Investigating the myopathic effects of 6-mercaptopurine on developing skeletal muscle cells in vitro.
    Drug and chemical toxicology, 1984, Volume: 7, Issue:2

    Topics: Animals; Cell Survival; Chick Embryo; DNA; In Vitro Techniques; Leucine; Mercaptopurine; Microtubule

1984
Skeletal muscle regeneration in myopathic hamsters of strain BIO 8262.
    Virchows Archiv. B, Cell pathology, 1976, Jul-21, Issue:1

    Topics: Animals; Autoradiography; Cricetinae; Muscles; Muscular Diseases; Necrosis; Regeneration; Thymidine;

1976
Necrotising myopathy and zidovudine.
    Lancet (London, England), 1988, May-07, Volume: 1, Issue:8593

    Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Humans; Male; Muscular Diseases; Necrosis; Thymid

1988
Zidovudine-associated myopathy.
    Lancet (London, England), 1988, Sep-17, Volume: 2, Issue:8612

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Humans; Muscular Diseases; Thymidine; Zidovudi

1988
Cell proliferation in rat skeletal muscle during early stages of compensatory hypertrophy.
    Virchows Archiv. B, Cell pathology, 1972, Volume: 11, Issue:3

    Topics: Animals; Autoradiography; Cell Count; Cell Division; Cell Nucleus; Epithelial Cells; Fibroblasts; Hy

1972
Observations on the cold water treatment of cutaneous burns.
    The Journal of pathology, 1972, Volume: 108, Issue:2

    Topics: Animals; Back; Burns; Cell Nucleus; Collagen; Connective Tissue; Connective Tissue Cells; Cryosurger

1972
Immunological aspects of polymyositis. The in vitro activity of lymphocytes on incubation with muscle antigen and with muscle cultures.
    The Quarterly journal of medicine, 1971, Volume: 40, Issue:157

    Topics: Adolescent; Adult; Aged; Animals; Antigens; Antilymphocyte Serum; Child, Preschool; Culture Techniqu

1971
Immunological aspects of systemic sclerosis in vitro activity of lymphocytes from patients with the disorder.
    The British journal of dermatology, 1971, Volume: 84, Issue:5

    Topics: Adult; Animals; Antigens; Biopsy; Collagen; Culture Techniques; Cytotoxicity Tests, Immunologic; Der

1971