thymidine has been researched along with Multiple Sclerosis in 35 studies
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitoxantrone is an anti-neoplastic anthracenedione derivative that, based on its immunosuppressive properties, is approved for the treatment of severe forms of relapsing-remitting or secondary progressive multiple sclerosis (MS)." | 7.73 | Multiple sclerosis: Mitoxantrone promotes differential effects on immunocompetent cells in vitro. ( Archelos, JJ; Hartung, HP; Hemmer, B; Kieseier, BC; Neuhaus, O; Stüve, O; Wiendl, H, 2005) |
| "The human T cell response to the myelin basic protein (MBP) has been studied with respect to T cell receptor (TCR) usage, HLA class II restriction elements, and epitope specificity using a total of 215 long-term MBP-specific T cell lines (TCL) isolated from the peripheral blood of 13 patients with multiple sclerosis (MS) and 10 healthy donors." | 7.68 | Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones. ( Drexler, K; Ertl, B; Giegerich, G; Goebels, N; Jechart, G; Meinl, E; Morelle, C; Ott, M; Saruhan-Direskeneli, G; Weber, F, 1993) |
| "The effects of factors secreted by polymorphonuclear leucocytes (PMNL) incubated with multiple sclerosis (MS) and control brain antigens (MSG2 and KG2 respectively) were evaluated by assay of thymidine uptake by lymphocytes from normal individuals and MS patients." | 7.66 | Thymidine uptake by lymphocytes in the presence of supernatants of polymorphonuclear leucocytes incubated with multiple sclerosis brain antigens. ( Clausen, J; Rastogi, SC, 1983) |
| " Our results indicate that, in healthy individuals, CD4(+) T cell responses against the multiple sclerosis (MS) auto-antigens, myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG), were increased in Treg depleted CD4(+) T cells as compared to total CD4(+) T cells." | 3.74 | A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses. ( Hellings, N; Hensen, K; Rummens, JL; Somers, V; Stinissen, P; Thewissen, M; Venken, K, 2007) |
| "Mitoxantrone is an anti-neoplastic anthracenedione derivative that, based on its immunosuppressive properties, is approved for the treatment of severe forms of relapsing-remitting or secondary progressive multiple sclerosis (MS)." | 3.73 | Multiple sclerosis: Mitoxantrone promotes differential effects on immunocompetent cells in vitro. ( Archelos, JJ; Hartung, HP; Hemmer, B; Kieseier, BC; Neuhaus, O; Stüve, O; Wiendl, H, 2005) |
| "The human T cell response to the myelin basic protein (MBP) has been studied with respect to T cell receptor (TCR) usage, HLA class II restriction elements, and epitope specificity using a total of 215 long-term MBP-specific T cell lines (TCL) isolated from the peripheral blood of 13 patients with multiple sclerosis (MS) and 10 healthy donors." | 3.68 | Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones. ( Drexler, K; Ertl, B; Giegerich, G; Goebels, N; Jechart, G; Meinl, E; Morelle, C; Ott, M; Saruhan-Direskeneli, G; Weber, F, 1993) |
| "In 128 patients with multiple sclerosis (MS) and 204 blood donors (control persons) the in vitro activation of 'Ficoll-purified' peripheral blood T lymphocytes was measured using the 3H-thymidine incorporation rate without (spontaneous proliferation) and with mitogen addition (concanavalin A, phytohemagglutinin)." | 3.67 | Age-associated T-lymphocyte activation through mitogens in patients with multiple sclerosis and blood donors. ( Bauer, HJ; Bushart, W; Hierholzer, E; Kreuzfelder, E; Scheiermann, N; Trenn, G, 1988) |
| "The effects of factors secreted by polymorphonuclear leucocytes (PMNL) incubated with multiple sclerosis (MS) and control brain antigens (MSG2 and KG2 respectively) were evaluated by assay of thymidine uptake by lymphocytes from normal individuals and MS patients." | 3.66 | Thymidine uptake by lymphocytes in the presence of supernatants of polymorphonuclear leucocytes incubated with multiple sclerosis brain antigens. ( Clausen, J; Rastogi, SC, 1983) |
| "Mice were immunized to induce experimental autoimmune encephalomyelitis (EAE) and treated with AP for seven days during different phases of disease." | 1.38 | Endotoxin- and ATP-neutralizing activity of alkaline phosphatase as a strategy to limit neuroinflammation. ( Boonstra, JG; Brands, R; Hintzen, RQ; Huizinga, R; Kreft, KL; Laman, JD; Onderwater, S, 2012) |
| "Adoptive transfer experimental autoimmune encephalomyelitis (AT-EAE), a disease resembling multiple sclerosis, is induced in rats by myelin basic protein (MBP)-activated CD4(+) T lymphocytes." | 1.31 | Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. ( Barbaria, J; Beeton, C; Béraud, E; Bernard, D; Cahalan, MD; Chandy, KG; Clot-Faybesse, O; Pennington, M; Wulff, H, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (68.57) | 18.7374 |
| 1990's | 4 (11.43) | 18.2507 |
| 2000's | 5 (14.29) | 29.6817 |
| 2010's | 2 (5.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chawla, PS | 1 |
| Kochar, MS | 1 |
| Huizinga, R | 1 |
| Kreft, KL | 1 |
| Onderwater, S | 1 |
| Boonstra, JG | 1 |
| Brands, R | 1 |
| Hintzen, RQ | 1 |
| Laman, JD | 1 |
| Watzlawik, JO | 1 |
| Warrington, AE | 1 |
| Rodriguez, M | 2 |
| Neuhaus, O | 1 |
| Wiendl, H | 1 |
| Kieseier, BC | 1 |
| Archelos, JJ | 1 |
| Hemmer, B | 1 |
| Stüve, O | 1 |
| Hartung, HP | 1 |
| Venken, K | 1 |
| Thewissen, M | 1 |
| Hellings, N | 1 |
| Somers, V | 1 |
| Hensen, K | 1 |
| Rummens, JL | 1 |
| Stinissen, P | 1 |
| Rastogi, SC | 2 |
| Clausen, J | 3 |
| Knight, SC | 1 |
| Harding, B | 1 |
| Burman, S | 1 |
| Mertin, J | 1 |
| Mogensen, JT | 1 |
| Zeeberg, IE | 1 |
| Meinl, E | 1 |
| Weber, F | 1 |
| Drexler, K | 1 |
| Morelle, C | 1 |
| Ott, M | 1 |
| Saruhan-Direskeneli, G | 1 |
| Goebels, N | 1 |
| Ertl, B | 1 |
| Jechart, G | 1 |
| Giegerich, G | 1 |
| Cross, AH | 1 |
| O'Mara, T | 1 |
| Raine, CS | 1 |
| Scholz, C | 1 |
| Patton, KT | 1 |
| Anderson, DE | 1 |
| Freeman, GJ | 1 |
| Hafler, DA | 1 |
| Beeton, C | 1 |
| Wulff, H | 1 |
| Barbaria, J | 1 |
| Clot-Faybesse, O | 1 |
| Pennington, M | 1 |
| Bernard, D | 1 |
| Cahalan, MD | 1 |
| Chandy, KG | 1 |
| Béraud, E | 1 |
| Karandikar, NJ | 1 |
| Crawford, MP | 1 |
| Yan, X | 1 |
| Ratts, RB | 1 |
| Brenchley, JM | 1 |
| Ambrozak, DR | 1 |
| Lovett-Racke, AE | 1 |
| Frohman, EM | 1 |
| Stastny, P | 1 |
| Douek, DC | 1 |
| Koup, RA | 1 |
| Racke, MK | 1 |
| Koh, DR | 1 |
| Fung-Leung, WP | 1 |
| Ho, A | 1 |
| Gray, D | 1 |
| Acha-Orbea, H | 1 |
| Mak, TW | 1 |
| Lennon, VA | 1 |
| Benveniste, EN | 1 |
| Merrill, JE | 1 |
| Konttinen, YT | 1 |
| Bergroth, V | 1 |
| Kinnunen, E | 1 |
| Nordström, D | 1 |
| Kouri, T | 1 |
| Trenn, G | 1 |
| Kreuzfelder, E | 1 |
| Hierholzer, E | 1 |
| Scheiermann, N | 1 |
| Bauer, HJ | 1 |
| Bushart, W | 1 |
| Ferraro, D | 1 |
| Salemi, G | 1 |
| Cestelli, A | 1 |
| Chiarini, A | 1 |
| Savettieri, G | 1 |
| Knowles, M | 3 |
| Hughes, D | 2 |
| Caspary, EA | 3 |
| Field, EJ | 3 |
| Saunders, M | 2 |
| Hedberg, H | 2 |
| Källén, B | 4 |
| Löw, B | 2 |
| Nilsson, O | 4 |
| Traeger, J | 1 |
| Carraz, M | 1 |
| Fries, D | 1 |
| Perrin, J | 1 |
| Saubier, E | 1 |
| Bernhardt, JP | 1 |
| Revillard, JP | 1 |
| Bonnet, P | 1 |
| Archimbaud, JP | 1 |
| Brochier, J | 1 |
| Frick, E | 1 |
| Stickl, H | 1 |
| Zinn, KH | 1 |
| Bell, TM | 1 |
| Koulischer, L | 1 |
| Stenuit, J | 1 |
| Zweiman, B | 1 |
| Silberberg, DH | 1 |
| Kibler, RF | 1 |
| Paty, DW | 1 |
| Sherr, V | 1 |
| Brody, JA | 1 |
| Harlem, MM | 1 |
| Kurtzke, JF | 1 |
| White, LR | 1 |
| Jensen, MK | 1 |
1 review available for thymidine and Multiple Sclerosis
| Article | Year |
|---|---|
What's new in clinical pharmacology and therapeutics.
Topics: Abatacept; Acetanilides; Amides; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antipark | 2008 |
1 trial available for thymidine and Multiple Sclerosis
| Article | Year |
|---|---|
Cell number requirements for lymphocyte stimulation in vitro: changes during the course of multiple sclerosis and the effects of immunosuppression.
Topics: Adult; Azathioprine; Cells, Cultured; Clinical Trials as Topic; Humans; Immunosuppressive Agents; Le | 1981 |
33 other studies available for thymidine and Multiple Sclerosis
| Article | Year |
|---|---|
Endotoxin- and ATP-neutralizing activity of alkaline phosphatase as a strategy to limit neuroinflammation.
Topics: Adenosine Triphosphate; Adult; Alkaline Phosphatase; Animals; Antigens, CD; Blood Vessels; Brain; Ce | 2012 |
PDGF is required for remyelination-promoting IgM stimulation of oligodendrocyte progenitor cell proliferation.
Topics: Analysis of Variance; Animals; Blotting, Western; Bromodeoxyuridine; Cell Proliferation; Humans; Imm | 2013 |
Multiple sclerosis: Mitoxantrone promotes differential effects on immunocompetent cells in vitro.
Topics: Adult; Annexin A5; Blood Cells; Cell Death; Cell Differentiation; Cells, Cultured; Cytokines; Dendri | 2005 |
A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses.
Topics: Autoantigens; CD4 Antigens; Clonal Anergy; Female; Flow Cytometry; Fluoresceins; Fluorescent Dyes; H | 2007 |
In vitro stimulation of multiple sclerosis (MS) T and B lymphocytes by autologous monokines generated in the presence of MS-specific brain antigens.
Topics: Adult; Antigens; B-Lymphocytes; Brain; Epitopes; Humans; Lymphocyte Activation; Monokines; Multiple | 1982 |
Thymidine uptake by lymphocytes in the presence of supernatants of polymorphonuclear leucocytes incubated with multiple sclerosis brain antigens.
Topics: Adult; Antigens; Brain; Cells, Cultured; Humans; Lymphocytes; Multiple Sclerosis; Neutrophils; Thymi | 1983 |
Impaired inhibition of mitogenic response of peripheral blood mononuclear cells by serum from patients with multiple sclerosis.
Topics: Adult; Blood; Cells, Cultured; Central Nervous System Diseases; Concanavalin A; Female; Humans; Male | 1981 |
Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.
Topics: Adult; Amino Acid Sequence; Base Sequence; Brain Chemistry; DNA; DNA Primers; Epitopes; Female; HLA | 1993 |
Chronologic localization of myelin-reactive cells in the lesions of relapsing EAE: implications for the study of multiple sclerosis.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Encephalomyelitis, Autoimmune, Experimental; | 1993 |
Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation.
Topics: Abatacept; Antigens, CD; Antigens, Differentiation; Autoantigens; B7-1 Antigen; B7-2 Antigen; Clone | 1998 |
Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis.
Topics: Animals; Calcium Channel Blockers; CD4-Positive T-Lymphocytes; Cells, Cultured; Cnidarian Venoms; Di | 2001 |
Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis.
Topics: Adjuvants, Immunologic; Adult; Case-Control Studies; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymp | 2002 |
Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice.
Topics: Animals; CD8 Antigens; Crosses, Genetic; Death; Disease Models, Animal; DNA Replication; Encephalomy | 1992 |
Remyelination by oligodendrocytes stimulated by antiserum to spinal cord.
Topics: Animals; Cell Division; Demyelinating Diseases; Female; Fluorescent Antibody Technique; Immunization | 1987 |
Activated T lymphocytes in patients with multiple sclerosis in clinical remission.
Topics: Autoradiography; Cell Division; Female; Histocompatibility Antigens Class II; Humans; Immunohistoche | 1987 |
Age-associated T-lymphocyte activation through mitogens in patients with multiple sclerosis and blood donors.
Topics: Adolescent; Adult; Aged; Aging; Blood Donors; Child; Female; Humans; Immune Tolerance; Lymphocyte Ac | 1988 |
Inhibition of glial proliferation in vitro by serum from patients with multiple sclerosis.
Topics: Adult; Animals; Cell Division; Cells, Cultured; Female; Humans; Male; Middle Aged; Multiple Sclerosi | 1987 |
Lymphocyte transformation in multiple sclerosis. Inhibition of unstimulated thymidine uptake by a serum factor.
Topics: Acute Disease; Blood Group Antigens; Culture Techniques; Humans; Lymphocytes; Multiple Sclerosis; Ne | 1968 |
Lymphocyte trnsformation induced by encephalitogenic factor in multiple sclerosis and other neurological diseases.
Topics: Culture Techniques; Encephalitis; Humans; Lymphocytes; Multiple Sclerosis; Nervous System Diseases; | 1968 |
Lymphocyte stimulation with phytohaemagglutinin in multiple sclerosis.
Topics: Culture Techniques; Humans; Lectins; Lymphocytes; Multiple Sclerosis; Nervous System Diseases; Thymi | 1969 |
Further studies on the mixed leukocyte reaction in multiple sclerosis and various arthritides.
Topics: Arthritis; Arthritis, Rheumatoid; Cell Survival; Cells, Cultured; Humans; Leukocytes; Lymphocyte Cul | 1973 |
Studies of anti-lymphocyte globulins made from thoracic duct lymphocytes.
Topics: ABO Blood-Group System; Animals; Antigens; Antigens, Viral; Antilymphocyte Serum; Cells, Cultured; C | 1969 |
[Lymphocyte transformation in multiple sclerosis. Demonstration of cell sensitivity to basic myelin protein (author's transl)].
Topics: Acute Disease; Antigens; Carbon Radioisotopes; Cerebrovascular Disorders; Chronic Disease; Female; H | 1974 |
Growth potential of scrapie mouse brain in vitro.
Topics: Animals; Brain; Culture Techniques; DNA; Mice; Multiple Sclerosis; Nerve Tissue Proteins; RNA; Scrap | 1971 |
[Recent results apropos of the growth in vitro of lymphocytes from patients with multiple sclerosis. Radioautographic study].
Topics: Autoradiography; Cerebrospinal Fluid; Humans; In Vitro Techniques; Lectins; Lymphocytes; Multiple Sc | 1968 |
In vitro lymphocyte responsiveness of human subjects receiving azathioprine.
Topics: Antigens; Azathioprine; Blood Cell Count; Candida; Culture Techniques; Humans; Hypersensitivity, Del | 1971 |
Immunology of multiple sclerosis.
Topics: Amino Acid Sequence; Animals; Antigens; Cattle; Cerebrospinal Fluid; Encephalomyelitis, Autoimmune, | 1971 |
Mixed leucocyte reaction in multiple sclerosis.
Topics: Arthritis, Rheumatoid; Humans; In Vitro Techniques; Leukocytes; Mitomycins; Multiple Sclerosis; Thym | 1971 |
Lymphocyte stimulation with measles antigen in multiple sclerosis.
Topics: Complement Fixation Tests; Humans; Lymphocyte Activation; Lymphocytes; Measles virus; Multiple Scler | 1970 |
Effects of cerebrospinal fluid on cultured blood leukocytes from patients with multiple sclerosis.
Topics: Aged; Cerebrospinal Fluid; Culture Techniques; DNA; Female; Humans; Lectins; Leukocytes; Lymphocyte | 1971 |
Impaired mixed leucocyte reaction in some different diseases, notably multiple sclerosis and various arthritides.
Topics: Arthritis; Arthritis, Rheumatoid; Culture Techniques; Humans; Leukocytes; Lymphocyte Activation; Mit | 1971 |
Unsuccessful attempt to induce transformation by cerebrospinal fluid in cultured lymphocytes from patients with multiple sclerosis.
Topics: Autoradiography; Cerebrospinal Fluid; Culture Techniques; Humans; Lectins; Lymphocytes; Multiple Scl | 1968 |
Lymphocyte transformation in multiple sclerosis.
Topics: Cell Differentiation; DNA; Humans; Lectins; Lymphocytes; Multiple Sclerosis; Thymidine; Tritium | 1968 |