thymidine has been researched along with Mitochondrial Diseases in 10 studies
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "All oral nucleoside analogues against hepatitis B virus, with an exception of telbivudine, have been reported causing lactic acidosis (LA)." | 8.89 | Lactic acidosis during telbivudine treatment for HBV: a case report and literature review. ( Hu, P; Huang, XY; Jin, JL; Lu, JH; Luo, SS; Weng, XH; Zhang, JM, 2013) |
| "All oral nucleoside analogues against hepatitis B virus, with an exception of telbivudine, have been reported causing lactic acidosis (LA)." | 4.89 | Lactic acidosis during telbivudine treatment for HBV: a case report and literature review. ( Hu, P; Huang, XY; Jin, JL; Lu, JH; Luo, SS; Weng, XH; Zhang, JM, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, L | 2 |
| Eriksson, S | 1 |
| Stamp, C | 1 |
| Whitehall, JC | 1 |
| Smith, ALM | 1 |
| Houghton, D | 1 |
| Bradshaw, C | 1 |
| Stoll, EA | 1 |
| Blain, AP | 1 |
| Turnbull, DM | 1 |
| Greaves, LC | 1 |
| Lopez-Gomez, C | 1 |
| Levy, RJ | 1 |
| Sanchez-Quintero, MJ | 1 |
| Juanola-Falgarona, M | 1 |
| Barca, E | 2 |
| Garcia-Diaz, B | 2 |
| Tadesse, S | 1 |
| Garone, C | 2 |
| Hirano, M | 3 |
| Jin, JL | 1 |
| Hu, P | 1 |
| Lu, JH | 1 |
| Luo, SS | 1 |
| Huang, XY | 1 |
| Weng, XH | 1 |
| Zhang, JM | 1 |
| Mojahed, H | 1 |
| Gutierrez, P | 1 |
| Pizzorno, G | 1 |
| Tanji, K | 1 |
| Arias-Mendoza, F | 1 |
| Quinzii, CM | 1 |
| Sun, R | 1 |
| Moran, NF | 2 |
| Bain, MD | 1 |
| Muqit, MM | 1 |
| Bax, BE | 2 |
| Baine, M | 1 |
| El-Hattab, AW | 1 |
| Scaglia, F | 1 |
| MartÃ, R | 1 |
| Spinazzola, A | 1 |
| Nishino, I | 1 |
| Nishigaki, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Deoxythymidine and Deoxycytidine Treatment for Thymidine Kinase 2 (TK2) Deficiency[NCT03639701] | Phase 1/Phase 2 | 23 participants (Actual) | Interventional | 2017-05-16 | Active, not recruiting | ||
| The Safety, Tolerability, Pharmacodynamics, and Efficacy of Erythrocyte Encapsulated Thymidine Phosphorylase (EE-TP) in Patients With MNGIE[NCT03866954] | Phase 2 | 0 participants (Actual) | Interventional | 2024-11-30 | Withdrawn (stopped due to Change of circumstances with Commercial partner) | ||
| Nutritional Assessment in Patients Affected by Mitochondrial Cytopathy[NCT02375438] | 26 participants (Actual) | Observational | 2014-12-31 | Completed | |||
| A Phase II, Monocenter, Single Arm Study To Assess The Safety and Efficacy Of Combination Deoxycytidine and Deoxythymidine For Mitochondrial Depletion Disorders[NCT04802707] | Phase 2 | 50 participants (Anticipated) | Interventional | 2021-10-18 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for thymidine and Mitochondrial Diseases
| Article | Year |
|---|---|
Lactic acidosis during telbivudine treatment for HBV: a case report and literature review.
Topics: Acidosis, Lactic; Adult; Antiviral Agents; Hepatitis B, Chronic; Humans; Male; Mitochondrial Disease | 2013 |
Thymidine kinase 2 enzyme kinetics elucidate the mechanism of thymidine-induced mitochondrial DNA depletion.
Topics: Deoxycytidine; DNA, Mitochondrial; Humans; Kinetics; Mitochondrial Diseases; Mitochondrial Proteins; | 2014 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
7 other studies available for thymidine and Mitochondrial Diseases
| Article | Year |
|---|---|
Mutational analyses of human thymidine kinase 2 reveal key residues in ATP-Mg
Topics: Adenosine Triphosphate; Catalysis; Humans; Mitochondrial Diseases; Thymidine; Thymidine Kinase | 2022 |
Age-associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon.
Topics: Aging; Animals; Cell Proliferation; Colon; Electron Transport Complex I; Female; Mice, Inbred C57BL; | 2021 |
Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency.
Topics: Animals; Antimetabolites; Deoxycytidine Monophosphate; Disease Models, Animal; DNA, Mitochondrial; D | 2017 |
Deoxynucleoside stress exacerbates the phenotype of a mouse model of mitochondrial neurogastrointestinal encephalopathy.
Topics: Age Factors; Animals; Body Weight; Brain; Deoxyribonucleosides; Disease Models, Animal; Intestinal P | 2014 |
Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIE.
Topics: Adult; Deoxyuridine; Drug Delivery Systems; Erythrocyte Transfusion; Erythrocytes; Fatal Outcome; Fe | 2008 |
Mitochondrial neurogastrointestinal encephalopathy without elevated thymidine levels.
Topics: Biomarkers; Bone Marrow Transplantation; Brain Diseases, Metabolic; Enzyme Replacement Therapy; Gast | 2010 |
Thymidine phosphorylase deficiency causes MNGIE: an autosomal recessive mitochondrial disorder.
Topics: Blotting, Southern; Brain Diseases; Chromatography, High Pressure Liquid; Genes, Recessive; Genetic | 2004 |