thymidine and Liver Dysfunction studies

Research Excerpts

Excerpt	Relevance	Reference
"Telbivudine was well tolerated by all subjects."	2.72	Pharmacokinetics of telbivudine in subjects with various degrees of hepatic impairment. ( Alcorn, HW; Brown, NA; Chao, GC; Dubuc Patrick, G; Marbury, TC; Smith, WB; Zhou, XJ, 2006)
" Tissue injury was measured during the dosing regimen (0, 1, 7, 14, and 30 days) and over a time course of 24-96h after the last dose (30 days)."	1.34	Impact of repeated exposure on toxicity of perchloroethylene in Swiss Webster mice. ( Latendresse, JR; Mehendale, HM; Mumtaz, MM; Philip, BK, 2007)
" Prior to HAART, long-term use of high-dosage AZT caused myopathy, cardiomyopathy, and hepatotoxicity, associated with mitochondrial DNA depletion."	1.33	3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity. ( Bentley, AT; Lynx, MD; McKee, EE, 2006)
"Colchicine was administered 2 h prior to CCl4 or corn oil injection."	1.29	Effect of antimitotic agent colchicine on carbon tetrachloride toxicity. ( Mehendale, HM; Rao, VC, 1993)
"3H-thymidine incorporation was studied using peripheral blood mononuclear cells (PBMC) from 41 Egyptians with Schistosoma mansoni infection."	1.26	Dichotomies in the reactivity to worm antigen in human schistosomiasis mansoni. ( El Kholy, A; Ellner, JJ; Mahmoud, AA; Olds, GR; Osman, GS, 1981)

Timeframe	Studies, this research(%)	All Research%
pre-1990	40 (76.92)	18.7374
1990's	6 (11.54)	18.2507
2000's	6 (11.54)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Moran, NF	1
Bain, MD	1
Muqit, MM	1
Bax, BE	1
Ribera Pascuet, E	1
Curran, A	1
Yasuchika, K	1
Hirose, T	1
Fujii, H	1
Oe, S	1
Hasegawa, K	1
Fujikawa, T	1
Azuma, H	1
Yamaoka, Y	1
BOND, VP	1
FLIEDNER, TM	1
CRONKITE, EP	1
RUBINI, JR	1
BRECHER, G	1
SCHORK, PK	1
GOUTIER, R	1
BAUGNET-MAHIEU, L	1
SEMAL, M	1
BRYANT, BJ	1
NAKAMURA, RM	1
MIYADA, DS	1
MOYER, DL	1
GUZEK, JW	1
BUCHER, NL	2
SWAFFIELD, MN	2
DITROIA, JF	1
LEHNERT, SM	1
HOLLAND, P	1
MAUER, AM	1
MESCHAN, I	1
CASTELLS, J	1
FAUSTO, N	1
UCHIYAMA, T	1
VANLANCKER, JL	1
WARAVDEKAR, VS	1
SASLAW, LD	1
JONES, WA	1
BEHKI, RM	1
MORGAN, WS	1
LEEVY, CM	1
TEN-HOVE, W	1
FRANK, O	1
BAKER, H	1
LAHTIHARJU, A	1
SIGEL, B	1
PECHET, G	1
QUE, MY	1
MACDONALD, RA	2
PETERSON, JE	1
CRONE, M	1
ITZHAKI, S	1
SCHMID, R	1
MALLORY, GK	1
Lynx, MD	1
Bentley, AT	1
McKee, EE	1
Zhou, XJ	1
Marbury, TC	1
Alcorn, HW	1
Smith, WB	1
Dubuc Patrick, G	1
Chao, GC	1
Brown, NA	1
Philip, BK	1
Mumtaz, MM	1
Latendresse, JR	1
Mehendale, HM	3
Makowka, L	1
Rotstein, LE	1
Falk, RE	1
Falk, JA	1
Zuk, R	1
Langer, B	1
Blendis, LM	1
Phillips, MJ	1
Nishimura, M	1
Epstein, WL	1
Fukuyama, K	1
Charters, AC	1
Oakes, DD	1
Froehlich, JP	1
Ellner, JJ	1
Olds, GR	1
Osman, GS	1
El Kholy, A	1
Mahmoud, AA	1
Rao, VC	1
Kim, HP	1
Kim, SY	1
Lee, EJ	1
Kim, YC	2
Zolotnitskaia, RP	1
Sorokin, AV	1
Watanabe, A	1
Miyazaki, M	1
Taketa, K	1
Karp, JE	1
Schacter, LP	1
Burke, PJ	1
Nostrant, TT	1
Miller, DL	1
Appelman, HD	1
Gumucio, JJ	1
Grasso, P	1
Gray, TJ	1
Pappas, A	1
Starzl, TE	1
Porter, KA	1
Kashiwagi, N	1
Kodavanti, PR	1
Kodavanti, UP	1
Faroon, OM	1
Kashani, SA	2
Chang, TM	2
Nishiguchi, S	1
Kuroki, T	1
Takeda, T	1
Nakajima, S	1
Shiomi, S	1
Seki, S	1
Matsui-Yuasa, I	2
Otani, S	2
Kobayashi, K	1
Kubo, S	1
Morisawa, S	1
Kinoshita, H	1
Sakai, K	1
Kissling, M	1
Speck, B	1
Wickramasinghe, SN	1
Longland, JE	1
Goerttler, K	1
Arnold, HP	1
Michalk, DV	1
Rabes, HM	1
Scholze, P	1
Jantsch, B	1
Newberry, WM	1
Shorey, JW	1
Sanford, JP	1
Combes, B	1
Dupuy, JM	1
Lafforet, D	1
Rachman, F	1
Svoboda, D	1
Reddy, J	1
Bunyaratvej, S	1
Helpap, B	1
Cremer, H	1
Grouls, V	1
Rocklin, RE	1
David, JR	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Safety, Tolerability, Pharmacodynamics, and Efficacy of Erythrocyte Encapsulated Thymidine Phosphorylase (EE-TP) in Patients With MNGIE[NCT03866954]			Phase 2	0 participants (Actual)	Interventional	2024-11-30	Withdrawn (stopped due to Change of circumstances with Commercial partner)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Current role of tenofovir in clinical medicine]. Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 8 Topics: Adenine; Anti-HIV Agents; Antimetabolites; Antiretroviral Therapy, Highly Active; Chemical and Drug	2008
[Lymphocyte transformation in liver diseases (review of the literature)]. Laboratornoe delo, 1975, Issue:2 Topics: Antigens; Chronic Disease; Glucocorticoids; Hepatitis; Humans; Liver; Liver Cirrhosis; Liver Disease	1975
[Lymphocyte culture. Methods and clinical application]. Annales Universitatis Saraviensis. Medizin, 1975, Volume: 22, Issue:4 Topics: B-Lymphocytes; Cell Migration Inhibition; Cells, Cultured; Culture Media; Cytological Techniques; DN	1975

Article	Year
Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIE. Neurology, 2008, Aug-26, Volume: 71, Issue:9 Topics: Adult; Deoxyuridine; Drug Delivery Systems; Erythrocyte Transfusion; Erythrocytes; Fatal Outcome; Fe	2008
Establishment of a highly efficient gene transfer system for mouse fetal hepatic progenitor cells. Hepatology (Baltimore, Md.), 2002, Volume: 36, Issue:6 Topics: Animals; Fetal Tissue Transplantation; Fetus; Gene Expression; Gene Transfer Techniques; Genetic The	2002
Proliferative potentials of bone marrow and blood cells studied by in vitro uptake of H3-thymidine. Acta haematologica, 1959, Volume: 21, Issue:1 Topics: Blood; Blood Cells; Bone Marrow; In Vitro Techniques; Liver Diseases; Nucleosides; Nucleotides; Thym	1959
[The effect of total irradiation and of AET on the activity of thymidine kinases in the regenerating liver]. Archives internationales de physiologie et de biochimie, 1963, Volume: 71 Topics: beta-Aminoethyl Isothiourea; Liver; Liver Diseases; Liver Regeneration; Phosphotransferases; Radiati	1963
REUTILIZATION OF LYMPHOCYTE DNA BY CELLS OF INTESTINAL CRYPTS AND REGENERATING LIVER. The Journal of cell biology, 1963, Volume: 18 Topics: Animals; Autoradiography; DNA; Intestine, Small; Intestines; Liver Diseases; Liver Regeneration; Lym	1963
EFFECT OF LIVER REGENERATION FOLLOWING PARTIAL HEPATECTOMY ON THE UPTAKE OF TRITIATED THYMIDINE IN THE PITUITARY GLAND OF THE RAT. Nature, 1963, Aug-17, Volume: 199 Topics: Hepatectomy; Liver Diseases; Liver Regeneration; Metabolism; Pituitary Gland; Rats; Research; Thymid	1963
EFFECT OF ADRENOCORTICOTROPHIC HORMONE AND CORTISONE ON THE UPTAKE OF TRITIATED THYMIDINE BY REGENERATING LIVER TISSUE IN THE WHITE RAT. Nature, 1964, Feb-29, Volume: 201 Topics: Adrenocorticotropic Hormone; Autoradiography; Cortisone; Hepatectomy; Hyperplasia; Liver Diseases; L	1964
THE INFLUENCE OF AGE UPON THE INCORPORATION OF THYMIDINE-2-C14 INTO THE DNA OF REGENERATING RAT LIVER. Cancer research, 1964, Volume: 24 Topics: Carbon Isotopes; DNA; Liver Diseases; Liver Regeneration; Metabolism; Rats; Research; Thymidine	1964
THE INHIBITION OF DNA SYNTHESIS BY NUCLEAR PROTEINS. Biochimica et biophysica acta, 1964, Feb-17, Volume: 80 Topics: Antimetabolites; DNA; DNA Replication; Liver; Liver Diseases; Liver Regeneration; Nuclear Proteins;	1964
DRUG-INDUCED IN-VITRO STIMULATION OF PERIPHERAL LYMPHOCYTES. Lancet (London, England), 1964, Jun-20, Volume: 1, Issue:7347 Topics: Antigen-Antibody Reactions; Child; Dermatitis; Drug Hypersensitivity; Epilepsy; Fever; Hepatomegaly;	1964
THE UTILIZATION OF METHOTREXATE, AMINOPTERIN, SPLEEN HEMOGENATE, THYMUS HEMOGENATE, AND DNA AS TEST AGENTS FOR SUPPRESSION OF DNA SYNTHESIS IN REGENERATING RAT LIVER. Radiology, 1964, Volume: 83 Topics: Aminopterin; DNA; Hepatectomy; Liver Diseases; Liver Regeneration; Metabolism; Methotrexate; Pharmac	1964
METABOLIC ALTERATIONS AFTER TOTAL BODY DOSES OF X-RADIATION. EFFECT OF IRRADIATION OF NORMAL LIVER ON DNA SYNTHESIS AFTER PARTIAL HEPATECTOMY. Archives of biochemistry and biophysics, 1964, Jul-20, Volume: 106 Topics: Carbon Isotopes; DNA; Hepatectomy; Liver Diseases; Liver Regeneration; Metabolism; Nucleotidyltransf	1964
THE RATE OF INCORPORATION OF LABELED THYMIDINE INTO THE DEOXYRIBONUCLEIC ACID OF REGENERATING RAT LIVER IN RELATION TO THE AMOUNT OF LIVER EXCISED. Cancer research, 1964, Volume: 24 Topics: Autoradiography; Cell Nucleus; DNA; Hepatectomy; Liver Diseases; Liver Regeneration; Rats; Research;	1964
HEPATIC CHANGES INDUCED BY AN AQUEOUS EXTRACT OF ULTRAVIOLET-IRRADIATED LINOLENIC ACID. The American journal of pathology, 1964, Volume: 45 Topics: alpha-Linolenic Acid; Autoradiography; Chemical and Drug Induced Liver Injury; Fatty Acids; Fatty Ac	1964
STUDIES ON THE PHOSPHORYLATION OF THYMIDINE IN REGENERATING RAT LIVER. Archives of biochemistry and biophysics, 1964, Volume: 107 Topics: Cytosine; DNA; Fluorides; Liver Diseases; Liver Regeneration; Nucleosides; Nucleotidases; Oxidative	1964
FOLIC ACID DEFICIENCY AND HEPATIC DNA SYNTHESIS. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1964, Volume: 117 Topics: Avitaminosis; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; DNA; Folic Aci	1964
[THE REGENERATIVE REACTION TO A SINGLE ADMINISTRATION OF CARBON TETRACHLORIDE IN DIFFERENT TISSUES]. Virchows Archiv fur pathologische Anatomie und Physiologie und fur klinische Medizin, 1964, Jul-21, Volume: 337 Topics: Animals; Autoradiography; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Division; Hyper	1964
TRITIATED THYMIDINE AUTORADIOGRAPHY IN THE REGENERATING LIVER OF THE DOG. The Journal of surgical research, 1965, Volume: 5 Topics: Autoradiography; Body Weight; DNA; Dogs; Hepatectomy; Hyperplasia; Liver Diseases; Liver Regeneratio	1965
EFFECTS OF THE PYRROLIZIDINE ALKALOID, LASIOCARPINE N-OXIDE, ON NUCLEAR AND CELL DIVISION IN THE LIVER RATS. The Journal of pathology and bacteriology, 1965, Volume: 89 Topics: Alkaloids; Autoradiography; Cell Division; Colchicine; DNA; Hepatectomy; Liver; Liver Diseases; Live	1965
ON THE RELATIVE FUNCTIONING OF THE PATHWAYS FOR FORMATION OF THYMIDINE NUCLEOTIDES IN THE REGNERATING LIVER AND SPLEEN OF THE RAT. Biochimica et biophysica acta, 1965, Jan-11, Volume: 95 Topics: Carbon Isotopes; DNA; Liver Diseases; Liver Regeneration; Metabolism; Nucleosides; Nucleotides; Orot	1965
Regeneration in fatty liver and cirrhosis: autoradiographic study using tritiated thymidine. Archives of pathology, 1960, Volume: 69 Topics: Animals; Fatty Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Liver Diseases; Nucleosides; N	1960
3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity. Biochemical pharmacology, 2006, Apr-28, Volume: 71, Issue:9 Topics: Animals; Anti-HIV Agents; Chemical and Drug Induced Liver Injury; In Vitro Techniques; Kinetics; Liv	2006
Impact of repeated exposure on toxicity of perchloroethylene in Swiss Webster mice. Toxicology, 2007, Mar-22, Volume: 232, Issue:1-2 Topics: Alanine Transaminase; Animals; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Cytochro	2007
Studies into the mechanism of reversal of experimental acute hepatic failure by hepatocyte transplantation. 1. Canadian journal of surgery. Journal canadien de chirurgie, 1981, Volume: 24, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cytosol; Female; Galactosamine; Graft Enhancement,	1981
Autotransplantation of hepatic granulomas into the skin of mice with Schistosoma mansoni infection. The Journal of investigative dermatology, 1982, Volume: 79, Issue:3 Topics: Animals; Autoradiography; Cytoplasm; Dermatologic Surgical Procedures; Disease Models, Animal; DNA;	1982
Effect of hepatectomy on mitotic activity in the rat spleen. The Journal of surgical research, 1980, Volume: 29, Issue:4 Topics: Animals; Autoradiography; DNA; Hepatectomy; Liver Diseases; Liver Regeneration; Male; Mitosis; Monon	1980
Dichotomies in the reactivity to worm antigen in human schistosomiasis mansoni. Journal of immunology (Baltimore, Md. : 1950), 1981, Volume: 126, Issue:1 Topics: Adolescent; Adult; Antigens; Child; DNA; Female; Humans; Liver Diseases; Male; Middle Aged; Ovum; Sc	1981
Effect of antimitotic agent colchicine on carbon tetrachloride toxicity. Archives of toxicology, 1993, Volume: 67, Issue:6 Topics: Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Biotransformation	1993
Zeaxanthin dipalmitate from Lycium chinense has hepatoprotective activity. Research communications in molecular pathology and pharmacology, 1997, Volume: 97, Issue:3 Topics: Animals; beta Carotene; Carbon Tetrachloride; Cell Division; Cells, Cultured; Chemical and Drug Indu	1997
Mechanisms of increased alpha1-fetoprotein production in hepatic injury. Experientia, 1976, Apr-15, Volume: 32, Issue:4 Topics: Adenosine Triphosphate; Alanine Transaminase; alpha-Fetoproteins; Animals; DNA; Ethionine; Female; F	1976
Humoral factors in aplastic anemia: relationship of liver dysfunction to lack of serum stimulation of bone marrow growth in vitro. Blood, 1978, Volume: 51, Issue:3 Topics: ABO Blood-Group System; Adolescent; Adult; Anemia, Aplastic; Bone Marrow; Bone Marrow Cells; Cell Co	1978
Acinar distribution of liver cell regeneration after selective zonal injury in the rat. Gastroenterology, 1978, Volume: 75, Issue:2 Topics: Allyl Compounds; Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Female; Liver; Live	1978
Long-term studies on chemically induced liver enlargement in the rat. III. Structure and behaviour of the hepatic nodular lesions induced by Ponceau MX. Toxicology, 1977, Volume: 7, Issue:3 Topics: Animals; Azo Compounds; Chemical and Drug Induced Liver Injury; Diet; Female; Food Coloring Agents;	1977
Portal hepatotrophic factors, diabetes mellitus and acute liver atrophy, hypertrophy and regeneration. Surgery, gynecology & obstetrics, 1975, Volume: 141, Issue:6 Topics: Animals; Atrophy; Autoradiography; Diabetes Mellitus, Experimental; DNA; Dogs; Glucagon; Hepatectomy	1975
Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone-, mirex-, or phenobarbital-pretreated rats. Toxicologic pathology, 1992, Volume: 20, Issue:4 Topics: Animals; Autoradiography; Carbon Tetrachloride; Cell Size; Chemical and Drug Induced Liver Injury; C	1992
Effects of hepatic stimulatory factor released from free or microencapsulated hepatocytes on galactosamine induced fulminant hepatic failure animal model. Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology, 1991, Volume: 19, Issue:3 Topics: Animals; Cell-Free System; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models,	1991
Physicochemical characteristics of hepatic stimulatory factor prepared from cell free supernatant of hepatocyte cultures. Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology, 1991, Volume: 19, Issue:3 Topics: Acrylic Resins; Autoradiography; Calibration; Cell-Free System; Cells, Cultured; Chemical and Drug I	1991
Effects of putrescine on D-galactosamine-induced acute liver failure in rats. Hepatology (Baltimore, Md.), 1990, Volume: 12, Issue:2 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liv	1990
Characterization of liver regeneration stimulatory factor in human portal serum. The American journal of gastroenterology, 1988, Volume: 83, Issue:10 Topics: Animals; Cells, Cultured; Chromatography, Gel; DNA; Growth Substances; Hepatectomy; Humans; Liver; L	1988
Lymphocyte transforming activity in the serum of patients with hepatic disease. Vox sanguinis, 1971, Volume: 21, Issue:3 Topics: Autoradiography; Cholestasis; Culture Techniques; Cytidine; DNA Replication; Globulins; Hepatitis; H	1971
Rate of incorporation of tritiated thymidine into DNA of normoblastic and megaloblastic bone marrow cells in vitro. Acta haematologica, 1974, Volume: 52, Issue:1 Topics: Alcoholism; Anemia, Hypochromic; Anemia, Macrocytic; Bone Marrow; Bone Marrow Cells; Deoxyuridine; D	1974
[Carcinogen-induced diaplacental effects in the rat. (Histological findings and the kinetics of DNA metabolism following the application of aflatoxin B1, methylazoxymethanol-acetate, and ethylnitrosourea)]. Zeitschrift fur Krebsforschung, 1970, Volume: 74, Issue:4 Topics: Acetates; Aflatoxins; Animals; Azo Compounds; Brain; Brain Diseases; Carcinogens; Chemical and Drug	1970
Growth kinetics of diethylnitrosamine-induced, enzyme-deficient "preneoplastic" liver cell populations in vivo and in vitro. Cancer research, 1972, Volume: 32, Issue:11 Topics: Adenosine Triphosphatases; Animals; Autoradiography; Carcinogens; Cell Division; Cell Transformation	1972
Depression of lymphocyte reactivity to phytohemagglutinin by serum from patients with liver disease. Cellular immunology, 1973, Volume: 6, Issue:1 Topics: Bile Acids and Salts; Carrier State; Chemical and Drug Induced Liver Injury; Cholelithiasis; Halotha	1973
Xeroderma pigmentosum with liver involvement. Helvetica paediatrica acta, 1974, Volume: 29, Issue:3 Topics: Autoradiography; Biopsy; Cell Count; Cell Survival; Child; Cholestasis; Female; Fibroblasts; Humans;	1974
Hepatic megalocytosis in chronic lasiocarpine poisoning. Some functional studies. The American journal of pathology, 1971, Volume: 65, Issue:2 Topics: Alkaloids; Animals; Autoradiography; Cell Division; Cell Nucleus; Chemical and Drug Induced Liver In	1971
[Reutilization of labeled DNA building blocks in wound healing]. Die Naturwissenschaften, 1971, Volume: 58, Issue:11 Topics: Animals; Autoradiography; DNA; Granulation Tissue; Liver Diseases; Liver Regeneration; Mice; Necrosi	1971
Detection in vitro of cellular hypersensitivity to drugs. The Journal of allergy and clinical immunology, 1971, Volume: 48, Issue:5 Topics: Adult; Aged; Antigen-Antibody Complex; Antigens; Cell Migration Inhibition; Child; Culture Technique	1971

thymidine and Liver Dysfunction

Research Excerpts

Research

Studies (52)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies