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thymidine and Leukemia P388

thymidine has been researched along with Leukemia P388 in 39 studies

Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.

Research Excerpts

ExcerptRelevanceReference
"Experiments were carried out in vitro on adriamycin (ADR) accumulation and cytotoxicity alone and in combination with calcium channel antagonist, verapamil (VRP), in ascites murine tumour models of Ehrlich carcinoma (EAC), sarcoma 180 (S180) and P388 lymphocytic leukaemia (P388)."7.67Modulation of in vitro response to adriamycin by verapamil in murine P388 leukaemia, Ehrlich ascites carcinoma and sarcoma 180. ( Basrur, VS; Chitnis, MP; Pradhan, SG; Tantri, SK, 1987)
"Experiments were carried out in vitro on adriamycin (ADR) accumulation and cytotoxicity alone and in combination with calcium channel antagonist, verapamil (VRP), in ascites murine tumour models of Ehrlich carcinoma (EAC), sarcoma 180 (S180) and P388 lymphocytic leukaemia (P388)."3.67Modulation of in vitro response to adriamycin by verapamil in murine P388 leukaemia, Ehrlich ascites carcinoma and sarcoma 180. ( Basrur, VS; Chitnis, MP; Pradhan, SG; Tantri, SK, 1987)
"The treatment with cepharanthine potentiated these blocking effects induced by doxorubicin in cells."1.28[Assay of flow cytometry for the effect of cepharanthine on resistance to doxorubicin]. ( Furusawa, S; Hayashi, A; Kisara, S; Maekawa, I; Sasaki, K; Takayanagi, Y, 1992)
"Pentoxifylline (PTX) is a methylxanthine used clinically in the treatment of intermittent claudication."1.28Inhibition of DNA biosynthesis by vincristine and pentoxifylline in murine P388 leukemia cells resistant to doxorubicin. ( Chitnis, MP; Juvekar, AS; Viladkar, AB, 1990)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199024 (61.54)18.7374
1990's14 (35.90)18.2507
2000's1 (2.56)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liao, ZY1
Sordet, O1
Zhang, HL1
Kohlhagen, G1
Antony, S1
Gmeiner, WH1
Pommier, Y1
Grossie, VB1
Valdivieso, M1
Drewinko, B1
Loo, TL1
Plagemann, PG1
Wohlhueter, RM1
Uitendaal, MP1
Schornagel, JH1
Leyva, A1
Pinedo, HM1
Lin, TS2
Fischer, PH2
Prusoff, WH2
Marsh, JC1
Kessel, D1
Butler, WB1
Iyer, VK1
Horwitz, JP1
Shealy, YF1
Frye, JL1
DuBois, NF1
Shaddix, SC1
Brockman, RW1
Hall, IH1
Lee, KH1
Okano, M1
Sims, D1
Ibuka, T1
Liou, YF1
Imakura, Y1
Kubasova, T1
Horváth, M1
Kocsis, K1
Fenyö, M1
Cafaggi, S1
Esposito, M1
Parodi, B1
Viale, M1
Ng, TB1
Liu, WK1
Sze, SF1
Yeung, HW1
Galimberti, S1
Bianchi, F1
Bernardini, N1
Mattii, L1
Dolfi, A1
Lupetti, M1
Petrini, M1
Kirshenbaum, MR1
Chen, SF1
Behrens, CH1
Papp, LM1
Stafford, MM1
Sun, JH1
Behrens, DL1
Fredericks, JR1
Polkus, ST1
Sipple, P1
Neil, GL1
Berger, AE1
Bhuyan, BK1
Blowers, CL1
Kuentzel, SL1
Kisara, S1
Hayashi, A1
Maekawa, I1
Furusawa, S1
Takayanagi, Y1
Sasaki, K1
Stenberg, K1
Skog, S1
Tribukait, B1
Borg, AL1
Kawato, Y1
Aonuma, M1
Hirota, Y1
Kuga, H1
Sato, K1
Zhen, Y1
Cao, S1
Xue, Y1
Wu, S1
Miko, M2
Krepelka, J2
Melka, M2
Duh, CY1
Kinghorn, AD1
Pezzuto, JM1
Juvekar, AS2
Chitnis, MP6
Kazmin, SD1
Danko, IM1
Kolosov, EV1
Pinchouk, VG1
Viladkar, AB1
Averbuch, SD1
Clawson, RE1
Bachur, NR1
Felsted, RL1
Spiridonidis, C2
Raza, A2
Zhao, SC1
Preisler, HD2
Riva, CM1
Rustum, YM1
Miller, B1
Tenenholz, T1
Egorin, MJ1
Sosnovsky, G1
Rao, NU1
Gutierrez, PL1
Satyamoorthy, K2
Kamath, NS1
Archer, S1
Ross, BS1
Pica-Mattoccia, L1
Cioli, D1
Pradhan, SG1
Basrur, VS1
Tantri, SK1
Adwankar, MK1
Fuska, J1
Fusková, A1
Proksa, B1
Plunkett, W1
Desgranges, C1
Razaka, G1
De Clercq, E1
Herdewijn, P1
Balzarini, J1
Drouillet, F1
Bricaud, H1
Ucar, K1
Mayers, G1
Bankert, R1
Chitnis, M1
Menon, R1
Adwankar, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase Ib/II Study of Ramucirumab (Cyramza®), Nal-IRI (ONIVYDE®) and Trifluridine/Tipiracil (Lonsurf®) in Second Line Metastatic Gastric Cancer (COOL Study).[NCT05927857]Phase 1/Phase 245 participants (Anticipated)Interventional2023-09-01Not yet recruiting
Randomized Phase II Trial of Fluorouracil and Folinic Acid With or Without Liposomal Irinotecan (ONIVYDE) for Patients With Metastatic Biliary Tract Cancer Which Progressed Following Gemcitabine Plus Cisplatin[NCT03524508]Phase 2178 participants (Actual)Interventional2018-09-04Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for thymidine and Leukemia P388

ArticleYear
Inhibition of adenosine deaminase to increase the antitumor activity of adenine nucleoside analogues.
    Annals of the New York Academy of Sciences, 1985, Volume: 451

    Topics: Adenine; Adenosine Deaminase Inhibitors; Adult; Animals; Carcinoma, Ehrlich Tumor; Clinical Trials a

1985

Other Studies

38 other studies available for thymidine and Leukemia P388

ArticleYear
A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
    Cancer research, 2005, Jun-01, Volume: 65, Issue:11

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Death; DNA Damage; DNA Topoisomerases, Type I; DN

2005
Effect of thymidine on the toxicity and antitumor activity of cis-diamminedichloroplatinum (II).
    Cancer chemotherapy and pharmacology, 1984, Volume: 13, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cisplatin; Drug Interactions;

1984
Effect of sulfhydryl reagents on nucleoside transport in cultured mammalian cells.
    Archives of biochemistry and biophysics, 1984, Volume: 233, Issue:2

    Topics: Animals; Binding Sites; Biological Transport; Cells, Cultured; Cricetinae; Cricetulus; Female; Hydro

1984
Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.
    European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:12

    Topics: Animals; Drug Synergism; Female; Infusions, Parenteral; Inosine; Leukemia L1210; Leukemia P388; Leuk

1984
Effect of 3'-amino-3'-deoxythymidine on L1210 and P388 leukemias in mice.
    Biochemical pharmacology, 1982, Jan-01, Volume: 31, Issue:1

    Topics: Animals; Antineoplastic Agents; Dideoxynucleosides; Drug Administration Schedule; Female; Leukemia L

1982
Antitumor activity of the 3'-chloroethylnitrosourea analog of thymidine and the prevention by co-administered thymidine of lethality but not of anticancer activity.
    Cancer research, 1982, Volume: 42, Issue:5

    Topics: Animals; Antineoplastic Agents; Body Weight; Bone Marrow; Dideoxynucleosides; Drug Interactions; Fem

1982
Estrogen-bridged purines: a new series of anti-tumor agents which alter cell membrane properties.
    Biochemical and biophysical research communications, 1982, Nov-16, Volume: 109, Issue:1

    Topics: Animals; Biological Transport; Cell Membrane; Cycloleucine; DNA Replication; Doxorubicin; Drug Evalu

1982
Carbocyclic analogues of 5-fluorouracil nucleosides.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:9

    Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Leukemia P388; Mice; Nucleosides; Thym

1981
Antitumor agents XLII: Comparison of antileukemic activity of helenalin, brusatol, and bruceantin and their esters on different strains of P-388 lymphocytic leukemic cells.
    Journal of pharmaceutical sciences, 1981, Volume: 70, Issue:10

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cells, Cultured; DNA, Neoplasm; Glaucarubin; Leukemia P3

1981
Effect of visible light on some cellular and immune parameters.
    Immunology and cell biology, 1995, Volume: 73, Issue:3

    Topics: Adult; Animals; Cells, Cultured; Humans; Immunity, Cellular; Leukemia P388; Light; Lymphocyte Activa

1995
A water-soluble 1,2-diaminocyclohexaneplatinum(II) complex containing procaine hydrochloride: synthesis and antiproliferative activity in vitro.
    Die Pharmazie, 1994, Volume: 49, Issue:8

    Topics: Animals; Antineoplastic Agents; Blood Urea Nitrogen; DNA, Neoplasm; Female; Leukemia P388; Mice; Mic

1994
Action of alpha-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines.
    General pharmacology, 1994, Volume: 25, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Leucine; Leuke

1994
Scanning electron microscopy of multidrug resistant cells in haematological and mammary malignancies.
    Cellular and molecular biology (Noisy-le-Grand, France), 1993, Volume: 39, Issue:5

    Topics: Acute Disease; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Breas

1993
(R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]- bis[5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione] dimethanesulfonate (DMP 840), a novel bis-naphthalimide with potent nonselective tumoricidal activity in vitro.
    Cancer research, 1994, Apr-15, Volume: 54, Issue:8

    Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Division; Clinical Trials, Phase I as Topic; Colonic

1994
Studies of the biochemical pharmacology of the fermentation-derived antitumor agent, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
    Advances in enzyme regulation, 1978, Volume: 17

    Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line; Cell Survival; Female; Glutamine; Gl

1978
[Assay of flow cytometry for the effect of cepharanthine on resistance to doxorubicin].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1992, Volume: 112, Issue:11

    Topics: Alkaloids; Animals; Benzylisoquinolines; DNA Damage; DNA, Neoplasm; Doxorubicin; Drug Resistance; Dr

1992
Comparative studies of galactose-6-mustard and L-phenylalanine mustard on cell growth and cell cycle kinetics in vitro.
    Anti-cancer drugs, 1992, Volume: 3, Issue:2

    Topics: Alkylating Agents; Animals; Cell Cycle; Cell Division; CHO Cells; Cricetinae; DNA, Neoplasm; Fibrobl

1992
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.
    Cancer research, 1991, Aug-15, Volume: 51, Issue:16

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Survival; DNA Damage; DNA Replication

1991
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.
    Cancer research, 1991, Aug-15, Volume: 51, Issue:16

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Survival; DNA Damage; DNA Replication

1991
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.
    Cancer research, 1991, Aug-15, Volume: 51, Issue:16

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Survival; DNA Damage; DNA Replication

1991
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.
    Cancer research, 1991, Aug-15, Volume: 51, Issue:16

    Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Survival; DNA Damage; DNA Replication

1991
Green tea extract inhibits nucleoside transport and potentiates the antitumor effect of antimetabolites.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 1991, Volume: 6, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Cytarabine; Drug Synergism; Female; Humans; Leukemia L12

1991
9-Hydroxybenfluron: cytostatic effects and inhibition of macromolecular biosynthesis in Ehrlich ascites and P388 murine leukemia cells.
    Anti-cancer drugs, 1991, Volume: 2, Issue:3

    Topics: Adenine; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Fluorenes; Leukemi

1991
Cell-cycle specific cytotoxicity mediated by stizophyllin (2 alpha,3 beta,12 beta-trihydroxypregna-4,7,16-trien-20-one), a novel electrophilic pregnane isolated from Stizophyllum riparium.
    Chemico-biological interactions, 1991, Volume: 80, Issue:1

    Topics: Animals; Astrocytoma; Cell Cycle; Cell Survival; CHO Cells; Cricetinae; DNA; DNA Replication; Kineti

1991
Circumvention of drug resistance of P388/R cells by the combination of adriamycin and mitoxantrone with hyperthermia (42 degrees C).
    Neoplasma, 1991, Volume: 38, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Doxorubicin; Dru

1991
Ascitic tumor cell cycle metabolism and energetics.
    Neoplasma, 1991, Volume: 38, Issue:2

    Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Cycle; Cholesterol; Energy Met

1991
Inhibition of DNA biosynthesis by vincristine and pentoxifylline in murine P388 leukemia cells resistant to doxorubicin.
    Neoplasma, 1990, Volume: 37, Issue:6

    Topics: Animals; Cell Survival; DNA Replication; Doxorubicin; Drug Resistance; Leukemia P388; Mice; Mice, In

1990
Cellular pharmacology and antitumor activity of N-(p-azidobenzoyl)-daunorubicin, a photoactive anthracycline analogue.
    Cancer chemotherapy and pharmacology, 1986, Volume: 16, Issue:3

    Topics: Affinity Labels; Animals; Antibiotics, Antineoplastic; Cells, Cultured; Daunorubicin; DNA; Humans; L

1986
Improved rapid autoradiography with elimination of background.
    Cell biochemistry and function, 1985, Volume: 3, Issue:2

    Topics: Animals; Autoradiography; Floxuridine; Leukemia P388; Mice; Thymidine; Tritium

1985
1-beta-D-arabinofuranosylcytosine metabolism and incorporation into DNA as determinants of in vivo murine tumor cell response.
    Cancer research, 1985, Volume: 45, Issue:12 Pt 1

    Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Bone Marrow; Deoxycytidine Kinas

1985
Cellular pharmacology of N,N',N''-triethylene thiophosphoramide.
    Cancer letters, 1988, Aug-15, Volume: 41, Issue:2

    Topics: Animals; Cell Division; Cell Survival; DNA Replication; DNA, Neoplasm; Kinetics; Leucine; Leukemia P

1988
Inhibition of biosynthetic processes in P388 and Ehrlich ascites cells by cloturin.
    Drugs under experimental and clinical research, 1988, Volume: 14, Issue:9

    Topics: Adenine; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Kinetics; Leukemia

1988
Hyperthermia blocks reversibility of hydroxyurea and bipyridine induced synergistic inhibition of DNA biosynthesis in P388 murine leukemia cells.
    Neoplasma, 1988, Volume: 35, Issue:2

    Topics: 2,2'-Dipyridyl; Animals; DNA Replication; Drug Synergism; Hot Temperature; Hydroxyurea; Kinetics; Le

1988
Restoration of doxorubicin responsiveness in doxorubicin-resistant P388 murine leukaemia cells by dipyrone.
    Oncology, 1987, Volume: 44, Issue:1

    Topics: Aminopyrine; Animals; Dipyrone; DNA; Doxorubicin; Drug Resistance; Drug Synergism; Leukemia P388; Le

1987
Synthesis and biological properties of some 6H-pyrido[4,3-b]carbazoles.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:7

    Topics: Alkaloids; Animals; Antineoplastic Agents; Carbazoles; Ellipticines; Leukemia P388; Mice; Thymidine;

1987
Modulation of in vitro response to adriamycin by verapamil in murine P388 leukaemia, Ehrlich ascites carcinoma and sarcoma 180.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:4

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cell Survival; Depression, Chemical; DNA, Neoplasm; Do

1987
Modification of tumor cell sensitivity to antineoplastic agents lonidamine and bouvardin (NSC 259968) at elevated temperatures.
    Neoplasma, 1986, Volume: 33, Issue:2

    Topics: Animals; Antineoplastic Agents; DNA; Drug Resistance; Hyperthermia, Induced; Indazoles; Leukemia P38

1986
New cytotoxic and antitumor agents. VII. Derivatives of 1-benzylidenisoindolin-3-one and 5,6-dihydro-8H-isoquinolo(2,3-a)phthalasin-5-one.
    Neoplasma, 1985, Volume: 32, Issue:4

    Topics: Adenine; Animals; Antineoplastic Agents; Benzylidene Compounds; Cell Division; Chemical Phenomena; C

1985
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.
    Cancer research, 1986, Volume: 46, Issue:3

    Topics: Animals; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Fluorouracil; Leukemia P38

1986
Double labeling of S-phase murine cells with bromodeoxyuridine and a second DNA-specific probe.
    Cancer research, 1985, Volume: 45, Issue:5

    Topics: Animals; Antibodies, Monoclonal; Autoradiography; Bromodeoxyuridine; Cell Cycle; Cytarabine; DNA; Le

1985
Inhibition of macromolecular synthesis in P388 mouse leukemia ascites cells by bouvardin (NSC 259968).
    Tumori, 1985, Jun-30, Volume: 71, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Depression, Chemical; DNA, Neoplasm; Dose-Response Relat

1985