thymidine has been researched along with Leukemia L 1210 in 278 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The toxicity and metabolism of a thymidine analogue, 5-hydroxymethyl-2'-deoxyuridine (5HmdUrd) were studied with human leukemia cells (HL-60) and with human platelets." | 3.67 | In vitro and in vivo studies of a promising antileukemic thymidine analogue, 5-hydroxymethyl-2' deoxyuridine. ( Bergstrom, D; Kahilainen, L; Kangas, L; Vilpo, JA, 1986) |
| " Virtually non toxic concentrations of dThd potentiated the cytotoxicity of MNNG more than 10-fold but that of MMS was potentiated only about 2-fold showing that O-alkylation of DNA was associated not only with the facilitation of mutagenesis but also with the potentiation of cytotoxicity." | 2.37 | Deoxyribonucleoside-induced selective modulation of cytotoxicity and mutagenesis. ( Danenberg, PV; Ibric, LL; Peterson, AR; Peterson, H, 1985) |
| "Thymidine has been demonstrated to alter the pharmacokinetic parameters of 5-FU in man and in mice, but a selective modification of the antitumor activity of 5-FU has not yet been unequivocally demonstrated." | 2.36 | Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites. ( Au, JL; Danhauser, L; Luccioni, C; Rustum, YM, 1981) |
| "Dipyridamole has been shown to enhance the in vitro activity of antimetabolite anticancer drugs through the inhibition of nucleoside transport." | 1.30 | Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding. ( Bowman, KJ; Calvert, AH; Curtin, NJ; Golding, BT; Griffin, RJ; Huang, B; Loughlin, PJ; Newell, DR; Turner, RN, 1999) |
| "Thymidine incorporation has also shown that DNA synthesis is occurring until this blockade is achieved." | 1.29 | A non-characteristic response of L1210 cells to lovastatin. ( Engelke, KJ; Hacker, MP, 1994) |
| " Because of the potentially large antigen load released by such a cell kill, the immune modulator pyran copolymer was also tested in combination with DAC." | 1.27 | Effects of 5-aza-2'-deoxycytidine in combination with the biochemical modulator thymidine or the immune modulator pyran copolymer on L1210 leukemia-bearing mice. ( Covey, JM; Zaharko, DS, 1984) |
| "Trimetrexate is a novel lipophilic folate antagonist that causes growth inhibition, inhibition of nucleic acid biosynthesis, and cytotoxicity at nanomolar concentrations in tissue cultures." | 1.27 | Biochemical pharmacology of the lipophilic antifolate, trimetrexate. ( Besserer, JA; Boritzki, TJ; Elslager, EF; Fry, DW; Jackson, RC; Leopold, WR; Sloan, BJ, 1984) |
| " Stearylamine, a synthetic lipid which continued to dominate the preparation of cationic liposome was the most toxic of the lipids tested." | 1.27 | Toxicity of some charged lipids used in liposome preparations. ( Campbell, PI, 1983) |
| " Different dosing regimens of BSO were found to potentiate L-PAM toxicity in a manner that depended upon the degree of GSH depletion." | 1.27 | Chemosensitization of L-phenylalanine mustard by the thiol-modulating agent buthionine sulfoximine. ( Ahmad, S; Greene, K; Kramer, RA; Vistica, DT, 1987) |
| " Forty-eight hours after MTX dosage the level of 7-hydroxymethotrexate exceeded that of MTX by ten to one." | 1.26 | Methotrexate cytotoxicity: studies on its reversal by folates and nucleosides. ( Lankelma, J; Leyva, A; Nederbragt, H; Pinedo, HM, 1981) |
| "Cytidine was partially able to reverse the delayed repopulation of LCFU when given 1 day after aza-CR, but it was unable to reverse the phenomenon 2 days after aza-CR." | 1.26 | Biological characterization of a prolonged antileukemic effect of 5-azacytidine. ( Presant, CA; Valeriote, F; Vietti, TJ, 1977) |
| " Ultrastructural studies revealed a very close correlation between the dose-response curve for mitochondrial damage and that for MGBG inhibition of mitochondrial DNA synthesis." | 1.26 | A selective effect of methylglyoxal-bis(guanylhydrazone) on the synthesis of mitochondrial DNA of cultured L1210 leukemia cells. ( Dave, C; Feuerstein, B; Porter, CW, 1979) |
| "Chartreusin was lethal to both L1210 and P388 cells in culture with 90% of the cells being killed after a 24-hr exposure to 1." | 1.26 | Effects of chartreusin on cell survival and cell cycle progression. ( Bhuyan, BK; Bono, VH; Dion, RL; Robinson, MI; Shugars, KD, 1978) |
| "Single intrafemoral injection of NMU in the dosage of 80 mg/Kh in mice with ascites leucemia L1210 induced considerable disorders in the tumor cell cycle." | 1.26 | [Effect of N-nitroso-N'-methylurea on the cellular kinetics in tumors]. ( Frankfurt, OS; Ostrovskaia, LA, 1977) |
| " When animals were dosed on consecutive days with delta9-tetrahydrocannabinol and killed on the third day, thymidine-3H incorporation was increased while delta8-tetrahydrocannabinol retained its inhibitory activity under the same conditions." | 1.26 | Effects of cannabinoids on L1210 murine leukemia. 1. Inhibition of DNA synthesis. ( Friedman, MA; Tucker, AN, 1977) |
| "Thymidine uptake was affected most and preceded parallel changes in viable cell numbers." | 1.25 | The effects of arginine deficiency on lymphoma cells. ( Burton, AF; Storr, JM, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 251 (90.29) | 18.7374 |
| 1990's | 20 (7.19) | 18.2507 |
| 2000's | 7 (2.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schinazi, RF | 2 |
| Chen, MS | 4 |
| Prusoff, WH | 12 |
| Patil, VD | 1 |
| Wise, DS | 1 |
| Wotring, LL | 2 |
| Bloomer, LC | 1 |
| Townsend, LB | 2 |
| De Clercq, E | 6 |
| Descamps, J | 2 |
| Balzarini, J | 8 |
| Giziewicz, J | 1 |
| Barr, PJ | 1 |
| Robins, MJ | 2 |
| Thomas, HD | 1 |
| Saravanan, K | 1 |
| Wang, LZ | 1 |
| Lin, MJ | 1 |
| Northen, JS | 1 |
| Barlow, H | 1 |
| Barton, M | 1 |
| Newell, DR | 3 |
| Griffin, RJ | 3 |
| Golding, BT | 3 |
| Curtin, NJ | 3 |
| Kiyomiya, K | 1 |
| Satoh, J | 1 |
| Horie, H | 1 |
| Kurebe, M | 1 |
| Nakagawa, H | 1 |
| Matsuo, S | 1 |
| Nenortas, E | 1 |
| Kulikowicz, T | 1 |
| Burri, C | 1 |
| Shapiro, TA | 1 |
| Barlow, HC | 1 |
| Bowman, KJ | 2 |
| Calvert, AH | 4 |
| Davison, R | 1 |
| Huang, B | 2 |
| Loughlin, PJ | 2 |
| Smith, PG | 1 |
| Celen, S | 1 |
| Karlsson, A | 1 |
| de Groot, T | 1 |
| Verbruggen, A | 1 |
| Bormans, G | 1 |
| Cooper, S | 1 |
| Chen, KZ | 1 |
| Ravi, S | 1 |
| Dollinger, MR | 1 |
| Burchenal, JH | 2 |
| Kreis, W | 1 |
| Fox, JJ | 2 |
| Skipper, HE | 2 |
| Schabel, FM | 2 |
| Wilcox, WS | 1 |
| Yankee, RA | 1 |
| De Vita, VT | 1 |
| Perry, S | 4 |
| Zaharko, DS | 4 |
| Covey, JM | 3 |
| Hatfield, PW | 1 |
| Grant, S | 2 |
| Rauscher, F | 1 |
| Margolin, J | 1 |
| Cadman, E | 2 |
| Leyva, A | 4 |
| Nederbragt, H | 2 |
| Lankelma, J | 1 |
| Pinedo, HM | 4 |
| Jackson, RC | 4 |
| Fry, DW | 1 |
| Boritzki, TJ | 1 |
| Besserer, JA | 1 |
| Leopold, WR | 1 |
| Sloan, BJ | 1 |
| Elslager, EF | 1 |
| Shiau, GT | 2 |
| Gray, DA | 1 |
| Durkacz, BW | 1 |
| Shall, S | 3 |
| Klohs, WD | 1 |
| Wilson, JR | 1 |
| Weiser, MM | 1 |
| Frankfurt, O | 1 |
| Bernacki, RJ | 1 |
| Ishitsuka, H | 1 |
| Miwa, M | 1 |
| Takemoto, K | 1 |
| Fukuoka, K | 1 |
| Itoga, A | 1 |
| Maruyama, HB | 1 |
| Ali-Osman, F | 1 |
| Maurer, HR | 1 |
| Jackman, AL | 1 |
| Taylor, GA | 6 |
| Harrap, KR | 9 |
| Darzynkiewicz, Z | 1 |
| Carter, S | 1 |
| Kimmel, M | 1 |
| Wachsmuth, ED | 1 |
| Becker, M | 1 |
| Grieve, AP | 1 |
| Maurer-Schultze, B | 3 |
| Trentesaux, C | 1 |
| Jeannesson, P | 1 |
| Carpentier, Y | 1 |
| Kouamouo, J | 1 |
| Jardillier, JC | 1 |
| Plagemann, PG | 1 |
| Wohlhueter, RM | 1 |
| Uitendaal, MP | 2 |
| Schornagel, JH | 1 |
| Samuels, LL | 1 |
| Straw, JA | 2 |
| Piper, AA | 1 |
| Nott, SE | 1 |
| Mackinnon, WB | 1 |
| Tattersall, MH | 6 |
| Hunston, RN | 1 |
| Jones, AS | 1 |
| McGuigan, C | 1 |
| Walker, RT | 1 |
| Woods, KL | 1 |
| Wakayama, K | 1 |
| Besa, EC | 1 |
| Baskin, SI | 1 |
| Barrie, SE | 2 |
| Davies, LC | 3 |
| Stock, JA | 3 |
| Schultze, B | 2 |
| Jellinghaus, W | 1 |
| Weis, G | 1 |
| Müller, V | 1 |
| Maurer, W | 2 |
| Campbell, PI | 1 |
| Karle, JM | 1 |
| Hoerauf, RM | 1 |
| Cysyk, RL | 2 |
| Ramonas, LM | 1 |
| DuVernay, VH | 1 |
| Eubanks, D | 1 |
| Perales, R | 1 |
| Prestayko, AW | 1 |
| Crooke, ST | 1 |
| van der Grint, L | 1 |
| Browman, GP | 3 |
| Hart, LI | 1 |
| Krishan, A | 1 |
| Dutt, K | 1 |
| Israel, M | 1 |
| Ganapathi, R | 1 |
| Firestone, RA | 1 |
| Pisano, JM | 1 |
| Bailey, PJ | 1 |
| Sturm, A | 1 |
| Bonney, RJ | 1 |
| Wightman, P | 1 |
| Devlin, R | 1 |
| Lin, CS | 1 |
| Keller, DL | 1 |
| Tway, PC | 1 |
| Rustum, YM | 5 |
| Danhauser, L | 2 |
| Luccioni, C | 1 |
| Au, JL | 1 |
| Lin, TS | 7 |
| Fischer, PH | 5 |
| Marsh, JC | 1 |
| Chou, TC | 2 |
| Schmid, FA | 2 |
| Braun, TJ | 1 |
| Su, TL | 1 |
| Watanabe, KA | 1 |
| Philips, FS | 2 |
| Appel, H | 1 |
| Csullog, GW | 1 |
| Layton, D | 1 |
| Luckenbach, GA | 1 |
| Andreesen, R | 1 |
| Munder, PG | 1 |
| Laurent, G | 1 |
| Laduron, C | 1 |
| Ruysschaert, JM | 1 |
| Deleers, M | 1 |
| Shealy, YF | 1 |
| Frye, JL | 1 |
| DuBois, NF | 1 |
| Shaddix, SC | 2 |
| Brockman, RW | 3 |
| Major, PP | 1 |
| Sargent, L | 1 |
| Egan, EM | 1 |
| Kufe, DW | 1 |
| Lehman, C | 1 |
| Akiyama, SI | 1 |
| Kuwano, M | 1 |
| Komiyama, S | 1 |
| Saneyoshi, M | 1 |
| Eckstein, F | 1 |
| Kinahan, JJ | 2 |
| Kowal, EP | 1 |
| Grindey, GB | 6 |
| Parker, WB | 2 |
| Rose, LM | 1 |
| Tiwari, KN | 2 |
| Montogmery, JA | 1 |
| Secrist, JA | 2 |
| Bennett, LL | 1 |
| Xu, ZQ | 1 |
| Qiu, YL | 1 |
| Chokekijchai, S | 1 |
| Mitsuya, H | 1 |
| Zemlicka, J | 1 |
| Engelke, KJ | 1 |
| Hacker, MP | 1 |
| Kirshenbaum, MR | 1 |
| Chen, SF | 1 |
| Behrens, CH | 1 |
| Papp, LM | 1 |
| Stafford, MM | 1 |
| Sun, JH | 1 |
| Behrens, DL | 1 |
| Fredericks, JR | 1 |
| Polkus, ST | 1 |
| Sipple, P | 1 |
| Gorneva, GA | 1 |
| Grancharov, KC | 1 |
| Spassovska, NC | 1 |
| Hogue, DL | 1 |
| Ellison, MJ | 1 |
| Young, JD | 1 |
| Cass, CE | 2 |
| Darmon, AJ | 1 |
| Bleackley, RC | 1 |
| Turner, RN | 1 |
| Jiang, L | 1 |
| Lee, PC | 1 |
| White, J | 1 |
| Rathod, PK | 1 |
| Waxman, S | 1 |
| Schreiber, C | 1 |
| Presant, CA | 1 |
| Valeriote, F | 3 |
| Vietti, TJ | 1 |
| Voytek, P | 1 |
| Beisler, JA | 1 |
| Abbasi, MM | 1 |
| Wolpert-DeFilippes, MK | 2 |
| Veselý, J | 2 |
| Cihák, A | 1 |
| Anderson, T | 1 |
| McMenamin, MG | 1 |
| Schein, PS | 2 |
| Bhuyan, BK | 5 |
| Fraser, TJ | 1 |
| Day, KJ | 1 |
| Wang, G | 1 |
| Foa, P | 1 |
| Paile, W | 1 |
| Yuen, TL | 1 |
| Jones, WA | 1 |
| Jänne, J | 1 |
| Rytömaa, T | 1 |
| Mungall, WS | 1 |
| Lemmen, LJ | 1 |
| Lemmen, KL | 1 |
| Dethmers, JK | 1 |
| Norling, LL | 1 |
| Goodwin, PM | 2 |
| Lewis, PJ | 2 |
| Davies, MI | 2 |
| Skidmore, CJ | 2 |
| Halldorsson, H | 1 |
| Zia'ee, AA | 1 |
| Burns, CP | 1 |
| Luttenegger, DG | 1 |
| Spector, AA | 1 |
| Santelli, G | 2 |
| Talbot, DC | 1 |
| Brouty-Boyé, D | 3 |
| Tovey, MG | 1 |
| Semon, JH | 2 |
| Pavelic, ZP | 2 |
| Bobek, M | 1 |
| Boch, A | 1 |
| Berkowitz, P | 1 |
| Bardos, JT | 1 |
| Lee, KC | 1 |
| Berry, D | 1 |
| Tashima, M | 1 |
| Sawada, H | 2 |
| Tatsumi, K | 3 |
| Nakamura, T | 3 |
| Uchino, H | 1 |
| Johnson, RK | 1 |
| Zee-Cheng, RK | 1 |
| Lee, WW | 1 |
| Acton, EM | 1 |
| Henry, DW | 1 |
| Cheng, CC | 1 |
| Desoize, B | 1 |
| Léger, C | 1 |
| Nahas, G | 1 |
| Ensminger, WD | 1 |
| Rosowsky, A | 2 |
| Feuerstein, B | 1 |
| Porter, CW | 2 |
| Dave, C | 3 |
| Otten, M | 1 |
| Beardsley, GP | 1 |
| McCaffrey, RP | 1 |
| Abelson, HT | 1 |
| Egorin, MJ | 1 |
| Odders, RN | 1 |
| Sanel, FT | 1 |
| Felsted, RL | 1 |
| Bachur, NR | 3 |
| Wallenbrock, MA | 1 |
| Killion, JJ | 1 |
| Robinson, MI | 1 |
| Shugars, KD | 1 |
| Bono, VH | 2 |
| Dion, RL | 2 |
| Kondrat'eva, NA | 1 |
| Dobrynin, IaV | 1 |
| Merkulov, MF | 1 |
| Paul, MA | 1 |
| Neil, GL | 4 |
| Berger, AE | 1 |
| Blowers, CL | 1 |
| Kuentzel, SL | 1 |
| Frei, E | 5 |
| Vogel, FS | 1 |
| Kemper, LA | 1 |
| McGarry, SJ | 1 |
| Graham, DG | 1 |
| Ostrovskaia, LA | 2 |
| Frankfurt, OS | 4 |
| Camplejohn, RS | 1 |
| Kessel, D | 8 |
| Volm, M | 2 |
| Hummel, H | 1 |
| Mattern, J | 2 |
| Tucker, AN | 1 |
| Friedman, MA | 2 |
| Goncharova, SA | 2 |
| Lee, DJ | 1 |
| Prensky, W | 2 |
| Krause, G | 1 |
| Hughes, WL | 2 |
| Sokolova, IS | 1 |
| Bunto, TV | 1 |
| Gorbacheva, LB | 1 |
| Tovey, M | 1 |
| Gresser, I | 2 |
| Broome, JD | 2 |
| Jayaram, HN | 1 |
| Brown, B | 1 |
| Jaffe, N | 1 |
| Pitman, S | 1 |
| Parker, L | 1 |
| Brown, BL | 1 |
| McElhinney, RS | 2 |
| Hutchinson, DJ | 1 |
| Opitz, HG | 2 |
| Niethammer, D | 2 |
| Lemke, H | 2 |
| Flad, HD | 2 |
| Huget, R | 2 |
| Adamson, RH | 3 |
| Johns, DG | 2 |
| Wilson, RG | 1 |
| Bodner, RH | 1 |
| Macwhorter, GE | 1 |
| Moran, RG | 1 |
| Munson, AE | 1 |
| Harris, LS | 1 |
| Dewey, WL | 1 |
| Carchman, RA | 1 |
| Gale, GR | 3 |
| Smith, AB | 3 |
| Atkins, LM | 2 |
| Belton, JG | 1 |
| Berger, NA | 1 |
| Johnson, ES | 1 |
| Skinner, AM | 1 |
| Steele, M | 1 |
| Meriwether, WD | 2 |
| Hildebrand, RC | 1 |
| Young, RC | 7 |
| Goldberg, D | 2 |
| Grotzinger, KR | 1 |
| Filipcík, P | 1 |
| Brtko, J | 1 |
| Rauová, L | 1 |
| Sedláková, V | 1 |
| Vijayalakshmi, D | 1 |
| Dagnino, L | 1 |
| Belt, JA | 3 |
| Gati, WP | 1 |
| Paterson, AR | 2 |
| Riordan, JM | 1 |
| Montgomery, JA | 3 |
| Pommerenke, EW | 1 |
| Traugott, U | 1 |
| Zhen, Y | 1 |
| Cao, S | 1 |
| Xue, Y | 1 |
| Wu, S | 1 |
| August, EM | 2 |
| Cooper, DL | 1 |
| Crawford, CR | 1 |
| Ng, CY | 1 |
| Kazmin, SD | 1 |
| Danko, IM | 1 |
| Kolosov, EV | 1 |
| Pinchouk, VG | 1 |
| Leonce, S | 1 |
| Anstett, M | 1 |
| Combe-Perez, V | 1 |
| Pierre, A | 1 |
| Oreshkin, AE | 1 |
| Miasishcheva, NV | 1 |
| Walzel, H | 1 |
| Jonas, L | 1 |
| Rosin, T | 1 |
| Brock, J | 1 |
| Jones, LM | 1 |
| Borysko, KZ | 1 |
| Gildersleeve, DL | 1 |
| Pískala, A | 1 |
| Chabot, GG | 1 |
| Momparler, RL | 1 |
| Trave, F | 1 |
| Zakrzewski, SF | 1 |
| Petrelli, N | 1 |
| Herrera, L | 1 |
| Mittelman, A | 1 |
| Arbuck, SG | 1 |
| Creaven, PJ | 2 |
| Nakajima, S | 1 |
| Fukuyasu, H | 1 |
| Sato, Y | 1 |
| Kazuno, Y | 1 |
| Yoshida, M | 2 |
| Hoshi, A | 3 |
| Matherly, LH | 2 |
| Schuetz, JD | 1 |
| Westin, E | 1 |
| Goldman, ID | 2 |
| Thompson, DP | 1 |
| Carter, GL | 2 |
| Cory, JG | 3 |
| Swinnen, LJ | 1 |
| Fisher, SG | 1 |
| Erickson, LC | 1 |
| Cooney, DA | 1 |
| Dalal, M | 1 |
| Kang, GJ | 1 |
| Cupp, JE | 1 |
| DeClercq, E | 1 |
| Broder, S | 1 |
| Orr, RM | 2 |
| Powles, RL | 1 |
| Hartmann, HR | 1 |
| Bollag, W | 1 |
| Barlowe, CK | 1 |
| Phillips, VM | 1 |
| Xu, J | 1 |
| Noel, LD | 1 |
| Riva, CM | 1 |
| Patt, LM | 1 |
| Houck, JC | 1 |
| Peterson, AR | 1 |
| Danenberg, PV | 1 |
| Ibric, LL | 1 |
| Peterson, H | 1 |
| Kondziella, U | 1 |
| Böswald, M | 1 |
| Siebert, M | 1 |
| Bassukas, ID | 1 |
| Rhee, HM | 1 |
| Hanusovská, E | 1 |
| Ujházy, V | 1 |
| Gray, GD | 2 |
| Ohlmann, GM | 1 |
| Darnowski, JW | 1 |
| Holdridge, C | 1 |
| Handschumacher, RE | 1 |
| Belanger, K | 1 |
| Collins, JM | 1 |
| Klecker, RW | 1 |
| Vilpo, JA | 2 |
| Suvanto, E | 1 |
| Kangas, L | 2 |
| Kahilainen, L | 1 |
| Bergstrom, D | 1 |
| Kramer, RA | 1 |
| Greene, K | 1 |
| Ahmad, S | 1 |
| Vistica, DT | 1 |
| Hibbs, JB | 1 |
| Taintor, RR | 1 |
| Kelley, JA | 1 |
| Sato, A | 1 |
| Bacon, PE | 1 |
| Brown, NC | 1 |
| Rode, W | 1 |
| Jastreboff, MM | 1 |
| Bertino, JR | 4 |
| Agar, NS | 1 |
| Sadrzadeh, SM | 1 |
| Hallaway, PE | 1 |
| Eaton, JW | 1 |
| Sani, BP | 1 |
| Vaid, A | 1 |
| Elliott, RD | 1 |
| Cavanaugh, PF | 1 |
| Tukalo, D | 1 |
| Bergeron, RJ | 1 |
| Meldrum, JB | 1 |
| Gupta, VS | 1 |
| Lowes, NR | 1 |
| Ranney, DF | 1 |
| Gordon, RO | 1 |
| Pincus, JH | 1 |
| Oppenheim, JJ | 1 |
| Gerzon, K | 1 |
| Kau, D | 1 |
| Glick, JL | 2 |
| Sahler, C | 1 |
| Crystal, HA | 1 |
| Hildebrand, J | 1 |
| Thys, O | 1 |
| Atassi, G | 1 |
| Debusscher, L | 1 |
| Tagnon, HJ | 1 |
| Durham, JP | 1 |
| Ives, DH | 1 |
| Hughes, RG | 1 |
| Kimball, AP | 2 |
| Li, LH | 3 |
| Cowie, CH | 1 |
| Sirotnak, FM | 1 |
| Donsbach, RC | 1 |
| Hill, DL | 1 |
| Wingo, R | 1 |
| Rosenoff, SH | 1 |
| Bostick, F | 2 |
| Kohn, KW | 1 |
| Friedman, CA | 1 |
| Ewig, RA | 1 |
| Iqbal, ZM | 1 |
| Lee, YC | 4 |
| Byfield, JE | 4 |
| Bennett, LR | 4 |
| Chan, YM | 1 |
| McPartland, RP | 1 |
| Wang, MC | 1 |
| Bloch, A | 1 |
| Weinfeld, H | 1 |
| Sasada, M | 1 |
| Shirakawa, S | 2 |
| Wakisaka, G | 1 |
| Storr, JM | 1 |
| Burton, AF | 2 |
| Thomas, DB | 1 |
| Jackson, ST | 1 |
| Tannenberg, WJ | 1 |
| Jehn, UW | 1 |
| Hartmann, NR | 2 |
| Dombernowsky, P | 2 |
| Counsilman, AC | 1 |
| Cain, BF | 1 |
| Baguley, BC | 1 |
| Macieira-Coelho, A | 2 |
| Avrameas, S | 1 |
| DeVita, VT | 6 |
| Bray, DA | 2 |
| Bagley, CM | 1 |
| Scheufens, EE | 1 |
| Kanzawa, F | 2 |
| Kuretani, K | 2 |
| Kanai, T | 2 |
| Walker, EM | 2 |
| Meischen, SJ | 1 |
| Homan, ER | 1 |
| Chabner, BA | 2 |
| Jeng, MW | 1 |
| Ehrke, J | 1 |
| Mihich, E | 3 |
| Ichino, M | 1 |
| Chang, JC | 1 |
| Hall, TC | 1 |
| Allen, LM | 1 |
| Ho, DH | 1 |
| Nevalainen, DE | 1 |
| Woolley, PV | 1 |
| Turnell, RW | 1 |
| Benckhuijsen, C | 1 |
| Reusser, F | 1 |
| Nichol, FR | 1 |
| Mickelson, MM | 1 |
| Camiener, GW | 2 |
| Gish, DT | 2 |
| Kelly, RC | 2 |
| Wechter, WJ | 2 |
| Moxley, TE | 1 |
| LePage, GA | 1 |
| Hersh, EM | 1 |
| Rustum, Y | 1 |
| Wilkoff, LJ | 1 |
| Dulmadge, EA | 1 |
| Lloyd, HH | 2 |
| Wang, JJ | 1 |
| Chervinsky, DS | 1 |
| Rosen, JM | 1 |
| Bosmann, HB | 1 |
| Lohr, K | 1 |
| Spataro, A | 1 |
| Dent, PB | 1 |
| Hillcoat, BL | 1 |
| Chello, PL | 1 |
| Wallerstein, H | 1 |
| Slater, LM | 1 |
| Eng, B | 1 |
| Calman, N | 1 |
| Oliverio, VT | 2 |
| Smith, CG | 1 |
| Olin, EJ | 2 |
| Hryniuk, WM | 1 |
| O'Brien, P | 1 |
| McCullough, JL | 1 |
| Mizuno, NS | 1 |
| Humphrey, EW | 1 |
| Cooper, EH | 1 |
| Velde, GV | 1 |
| Loy, PR | 1 |
| Soucek, J | 1 |
| Ehrke, MJ | 1 |
| Wheeler, GP | 2 |
| Bowdon, BJ | 2 |
| Adamson, DJ | 1 |
| Vail, MH | 1 |
| Shaddix, S | 1 |
| Laster, WR | 1 |
| Buskirk, HH | 1 |
| Reineke, LM | 1 |
| Simpson-Herren, L | 1 |
| Thomas, MT | 1 |
| Hofer, KG | 2 |
| Hofer, M | 1 |
| Stone, AE | 1 |
| Saslaw, LD | 1 |
| Kline, I | 1 |
| Waravdekar, VS | 1 |
| Hart, LG | 1 |
| Shrecker, AW | 1 |
| Urshel, MJ | 1 |
| Roberts, D | 1 |
| Wodinsky, I | 2 |
| Himmelfarb, P | 1 |
| Thayer, PS | 1 |
| Martin, HE | 1 |
| Bach, MK | 1 |
| Denham, C | 1 |
| Myers, M | 1 |
| Sartorelli, AC | 1 |
| Booth, BA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Optimizing and Personalising Azacitidine Combination Therapy for Treating Solid Tumours Using the Quadratic Phenotypic Optimization Platform (QPOP) and an Artificial Intelligence-based Platform (CURATE.AI)[NCT05381038] | Phase 1/Phase 2 | 10 participants (Anticipated) | Interventional | 2022-06-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for thymidine and Leukemia L 1210
| Article | Year |
|---|---|
Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA, Neoplasm; Fluorodeoxyuridylate; Fluoroura | 1981 |
Functional heterogeneity in macrophages activated by Corynebacterium parvum: characterization of subpopulations with different activities in promoting immune responses and suppressing tumor cell growth.
Topics: Animals; Ascitic Fluid; Cell Division; Cell Separation; Cells, Cultured; Erythrocytes; Female; Immun | 1977 |
Methotrexate revisited.
Topics: Adolescent; Adult; Alkalies; Aminopterin; Animals; Bone Marrow; Bone Neoplasms; Drug Therapy, Combin | 1976 |
Deoxyribonucleoside-induced selective modulation of cytotoxicity and mutagenesis.
Topics: Alkylating Agents; Animals; Azaguanine; Cell Line; Cell Survival; Cricetinae; Deoxyadenosines; Deoxy | 1985 |
Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.
Topics: Anilides; Animals; Cell Division; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans; | 1969 |
Kinetics of normal and leukemic leukocyte populations and relevance to chemotherapy.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Division; Cytarabine; Hem | 1970 |
1 trial available for thymidine and Leukemia L 1210
| Article | Year |
|---|---|
Current studies of methotrexate and 5-fluorouracil and their interaction in human tumor cells.
Topics: Animals; Cells, Cultured; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug The | 1983 |
271 other studies available for thymidine and Leukemia L 1210
| Article | Year |
|---|---|
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Kinetics; Leukemia L1210; Mice; P | 1979 |
Synthesis and biological activity of a novel adenosine analogue, 3-beta-D-ribofuranosylthieno[2,3-d]pyrimidin-4-one.
Topics: Adenosine; Adenosine Kinase; Animals; Antineoplastic Agents; Biotransformation; In Vitro Techniques; | 1985 |
Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
Topics: Alkynes; Animals; Cell Survival; Idoxuridine; Leukemia L1210; Mice; Rabbits; Simplexvirus; Substrate | 1983 |
Preclinical evaluation of a novel pyrimidopyrimidine for the prevention of nucleoside and nucleobase reversal of antifolate cytotoxicity.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Proliferation; Dipyridamole; Drug Synergism; Female; | 2009 |
Correlation between nuclear action of anthracycline anticancer agents and their binding affinity to the proteasome.
Topics: Active Transport, Cell Nucleus; Animals; Antibiotics, Antineoplastic; Cell Nucleus; Cysteine Endopep | 2002 |
Antitrypanosomal activities of fluoroquinolones with pyrrolidinyl substitutions.
Topics: Animals; Anti-Infective Agents; DNA; Fluoroquinolones; Leukemia L1210; Mice; Pyrrolidines; Structure | 2003 |
Resistance-modifying agents. 11.(1) Pyrimido[5,4-d]pyrimidine modulators of antitumor drug activity. Synthesis and structure-activity relationships for nucleoside transport inhibition and binding to alpha1-acid glycoprotein.
Topics: Animals; Antimetabolites, Antineoplastic; Biochemistry; Biological Transport; Dipyridamole; Drug Res | 2004 |
The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinonucleosides; Chlorocebus aethiops; Enzyme I | 2006 |
Thymidine block does not synchronize L1210 mouse leukaemic cells: implications for cell cycle control, cell cycle analysis and whole-culture synchronization.
Topics: Animals; Cell Cycle; Cell Division; Cell Line, Tumor; DNA, Neoplasm; Leukemia L1210; Mice; Thymidine | 2008 |
Analogs of 1-beta-D-arabinofuranosylcytosine. Studies on mechanisms of action in Burkitt's cell culture and mouse leukemia, and in vitro deamination studies.
Topics: Animals; Burkitt Lymphoma; Chromatography, Paper; Culture Techniques; Cytarabine; Cytosine Nucleotid | 1967 |
Experimental evaluation of potential anticancer agents. XXI. Scheduling of arabinosylcytosine to take advantage of its S-phase specificity against leukemia cells.
Topics: Animals; Antimetabolites; Cell Division; Cytarabine; DNA, Neoplasm; Leukemia L1210; Mice; Thymidine; | 1967 |
The cell cycle of leukemia L1210 cells in vivo.
Topics: Animals; Ascitic Fluid; Autoradiography; Cell Division; DNA; In Vitro Techniques; Leukemia L1210; Mi | 1967 |
Effects of 5-aza-2'-deoxycytidine in combination with the biochemical modulator thymidine or the immune modulator pyran copolymer on L1210 leukemia-bearing mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Body Weight; Decitabine; Leuke | 1984 |
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Cell Line; Kidney; Leukemia L1210; Mice; | 1984 |
Dose- and schedule-dependent activation and drug synergism between thymidine and 5-aza-2'-deoxycytidine in a human promyelocytic leukemia cell line.
Topics: Animals; Antineoplastic Agents; Azacitidine; Biological Transport; Cell Line; Cell Survival; Chromat | 1982 |
Methotrexate cytotoxicity: studies on its reversal by folates and nucleosides.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Cells, Cultured; Head and Neck Neoplasms; | 1981 |
Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
Topics: Animals; Cell Line; Culture Techniques; Deoxyuridine; Drug Resistance; Folic Acid; Folic Acid Antago | 1984 |
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Deoxyribonucleosides; Female; Kin | 1980 |
Inhibitors of nuclear ADP-ribosyl transferase retard DNA repair after N-methyl-N-nitroso-urea. Further evidence for the involvement of (ADP-ribose)n in DNA repair.
Topics: Adenosine Diphosphate Ribose; Animals; Cell Division; Centrifugation, Density Gradient; Deoxycytidin | 1981 |
Galactosyltransferase activity and cell growth: uridine diphosphate (UDP)galactose inhibition of murine leukemic L1210 cells.
Topics: Animals; Cell Cycle; Cell Division; Galactosyltransferases; Leukemia L1210; Mice; Thymidine; Uridine | 1984 |
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransfera | 1980 |
Comparison of cytostatic sensitivities of L 1210 cells and human stimulated lymphocytes in three cell proliferation assays.
Topics: Animals; Antimetabolites, Antineoplastic; Azathioprine; Cell Division; Cells, Cultured; Cytarabine; | 1980 |
Modulation of anti-metabolite effects. Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB3717.
Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Deoxyuridine; Folic Acid; Leukemia L1210; | 1984 |
Effects of [3H]UdR on the cell-cycle progression of L1210 cells.
Topics: Animals; Cell Cycle; Flow Cytometry; Kinetics; Leukemia L1210; Mathematics; Mice; Models, Biological | 1984 |
Fully automated and fast image analysis of autoradiographs with a TAS-Leitz. Determination of size, Feulgen fluorescence and grain counts of individual nuclei and their evaluation by a simplified cluster analysis.
Topics: Animals; Autoradiography; Cell Nucleus; Coloring Agents; Jejunum; Leukemia L1210; Mice; Rosaniline D | 1984 |
Effects of a new antitumor compound, mopidamol, on thymidine and 2-deoxyglucose transport in leukaemic L 1210 cells.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Deoxy Sugars; Deoxyglucose; Kinetics; Leukemia L121 | 1984 |
Effect of sulfhydryl reagents on nucleoside transport in cultured mammalian cells.
Topics: Animals; Binding Sites; Biological Transport; Cells, Cultured; Cricetinae; Cricetulus; Female; Hydro | 1984 |
Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.
Topics: Animals; Drug Synergism; Female; Infusions, Parenteral; Inosine; Leukemia L1210; Leukemia P388; Leuk | 1984 |
Modulation of deoxycytidine metabolism in vivo with high-dose thymidine in mice.
Topics: Animals; Bone Marrow; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Deoxycyti | 1983 |
Improved therapeutic index with high-dose methotrexate: comparison of thymidine-purine rescue with citrovorum factor rescue in mice.
Topics: Animals; Brain Neoplasms; Deoxycytidine; DNA Replication; Dose-Response Relationship, Drug; Hypoxant | 1984 |
Critical modulation by thymidine and hypoxanthine of sequential methotrexate-5-fluorouracil synergism in murine L1210 cells.
Topics: Animals; Cell Survival; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hypoxanthine; Hypox | 1983 |
Strategies for the measurement of the inhibitory effects of thymidine analogs on the activity of thymidylate synthase in intact murine leukemia L1210 cells.
Topics: Animals; Deoxycytidine; Deoxyuridine; DNA; Leukemia L1210; Methyltransferases; Mice; Thymidine; Thym | 1984 |
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.
Topics: Animals; Antimetabolites, Antineoplastic; Bromodeoxyuridine; Deoxycytidine; Deoxyuridine; Drug Resis | 1984 |
Molecular basis of the antineoplastic activity of 3'-amino-3'-deoxythymidine.
Topics: Animals; Antimetabolites, Antineoplastic; Dideoxynucleosides; DNA Polymerase II; DNA Replication; Ki | 1984 |
Two components in L1210 cells and their growth characterization.
Topics: Animals; Cell Count; Cell Division; Cell Separation; DNA, Neoplasm; Leukemia L1210; Mice; Mice, Inbr | 1984 |
A reappraisal of the effect upon thymidine kinase of thymidine derivatives carrying large groups at the 5'-position.
Topics: Animals; Chromatography, High Pressure Liquid; Leukemia L1210; Mice; Thymidine; Thymidine Kinase; Th | 1984 |
Comparing cell kinetic studies of the effect of ftorafur and 5-fluorouracil on the L 1210 ascites tumor.
Topics: Animals; Cell Division; Female; Fluorouracil; Kinetics; Leukemia L1210; Mice; Mitosis; Neoplasm Tran | 1981 |
Toxicity of some charged lipids used in liposome preparations.
Topics: Animals; Cell Division; Cholesterol; DNA; Leukemia L1210; Lipids; Liposomes; Mice; Phosphatidic Acid | 1983 |
Labelling of the thymidine and deoxycytidine bases of DNA by [2-14C]deoxycytidine in cultured L1210 cells.
Topics: 3-Deazauridine; Animals; Carbon Radioisotopes; Cytarabine; Cytidine; Deoxycytidine; DNA; Leukemia L1 | 1983 |
Comparison of in vitro and in vivo effects of thymidine on L1210 leukemia in mice.
Topics: Animals; Cell Survival; Chromatography, High Pressure Liquid; Clone Cells; Deoxycytidine; Dose-Respo | 1982 |
The antitumor effects of anthracyclines. II. The stereospecificity of the carbomethoxy group at position 10 of the class II anthracycline molecule.
Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; DNA, Neoplasm; Leukemia L1210; Mice; Molecula | 1982 |
Reversal of methotrexate inhibition of colony growth of L1210 leukemia cells in semisolid medium.
Topics: Animals; Bone Marrow; Cell Division; Clone Cells; Culture Media; Inosine; Leucovorin; Leukemia L1210 | 1981 |
The intracellular mechanism of action of metoprine (DDMP).
Topics: Animals; Cell Survival; Cells, Cultured; Deoxyuridine; Dose-Response Relationship, Drug; Drug Resist | 1980 |
Comparative effects of adriamycin and N-trifluoroacetyladriamycin-14-valerate on cell kinetics, chromosomal damage, and macromolecular synthesis in vitro.
Topics: Animals; B-Lymphocytes; Cell Cycle; Cell Division; Cell Line; Chromosome Aberrations; Doxorubicin; H | 1981 |
Lysosomotropic agents. 4. Carbobenzoxyglycylphenylalanyl, a new protease-sensitive masking group for introduction into cells.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Detergents; Dipeptides; Hydrogen-Ion Concentration; | 1982 |
Effect of 3'-amino-3'-deoxythymidine on L1210 and P388 leukemias in mice.
Topics: Animals; Antineoplastic Agents; Dideoxynucleosides; Drug Administration Schedule; Female; Leukemia L | 1982 |
Antitumor activity of the 3'-chloroethylnitrosourea analog of thymidine and the prevention by co-administered thymidine of lethality but not of anticancer activity.
Topics: Animals; Antineoplastic Agents; Body Weight; Bone Marrow; Dideoxynucleosides; Drug Interactions; Fem | 1982 |
Biochemical effects of 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil and 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mouse leukemic cells sensitive and resistant to 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Arabinofuranosyluracil; Cell Survival; Cytarabine; Deoxycytidine; DNA Replication; Kinetics | 1982 |
Purine modulation of thymidine activity in L1210 leukemia cells in vitro.
Topics: Adenine; Animals; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxyribonuc | 1982 |
Modification of in vivo methotrexate antitumor effect in L1210 leukemia by induced impairment of purine salvage.
Topics: Animals; Cell Line; Cell Survival; Drug Resistance; Leukemia L1210; Male; Mercaptopurine; Methotrexa | 1981 |
The interaction of liposomes with cells: the relation of cell specific toxicity to lipid composition.
Topics: Animals; Cell Survival; Cells, Cultured; Chemical Phenomena; Chemistry; Fibroblasts; Leukemia L1210; | 1980 |
Inhibition of cationic liposomes of [3H]thymidine incorporation into DNA of L1210 cells.
Topics: Adsorption; Animals; Cations; DNA; In Vitro Techniques; Leukemia L1210; Liposomes; Mice; Thymidine; | 1981 |
Carbocyclic analogues of 5-fluorouracil nucleosides.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Leukemia P388; Mice; Nucleosides; Thym | 1981 |
Correlation of thymidine-enhanced incorporation of ara-C in deoxyribonucleic acid with increased cell kill.
Topics: Animals; Cell Survival; Cells, Cultured; Cytarabine; DNA; Kinetics; Leukemia L1210; Mice; Thymidine | 1981 |
Enhancement of 1-beta-D-arabinofuranosylcytosine accumulation within L1210 cells and increased cytotoxicity following thymidine exposure.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine; Deoxyribonucleotides; DNA | 1980 |
Antitumor effect of a combination of 6-methylthioinosine and amphotericin B on mouse leukemia L1210.
Topics: Adjuvants, Immunologic; Amphotericin B; Animals; Drug Synergism; Inosine; Leukemia L1210; Male; Meth | 1980 |
Antiviral, antimetabolic and antineoplastic activities of 2'- or 3'-amino or -azido-substituted deoxyribonucleosides.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Antiviral Agents; Cell Division; Cells, Cultured; D | 1980 |
Biochemical and antitumor effects of the combination of thymidine and 1-beta-D-arabinofuranosylcytosine against leukemia L1210.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Aspartic Acid; Cells, Cultured; Cytarabine; Cytidine | 1981 |
Metabolism and metabolic actions of 4'-thiothymidine in L1210 cells.
Topics: Animals; Antineoplastic Agents; Cell Division; DNA Replication; DNA, Neoplasm; Leukemia L1210; Mice; | 1995 |
Unsaturated acyclic analogues of 2'-deoxyadenosine and thymidine containing fluorine: synthesis and biological activity.
Topics: Adenine; Animals; Antineoplastic Agents; Antiviral Agents; Cattle; Deoxyadenosines; HIV; Humans; Hyd | 1995 |
A non-characteristic response of L1210 cells to lovastatin.
Topics: Animals; Cell Cycle; DNA, Neoplasm; G1 Phase; G2 Phase; Kinetics; Leukemia L1210; Lovastatin; Mevalo | 1994 |
(R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]- bis[5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione] dimethanesulfonate (DMP 840), a novel bis-naphthalimide with potent nonselective tumoricidal activity in vitro.
Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Division; Clinical Trials, Phase I as Topic; Colonic | 1994 |
Inhibition of DNA synthesis in different tissues of L1210-leukemia-bearing mice by new platinum (II) complexes.
Topics: Animals; Cisplatin; DNA, Neoplasm; Leukemia L1210; Mice; Organoplatinum Compounds; Thymidine | 1993 |
Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae.
Topics: Adenosine; Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Carrier Proteins; Cell | 1996 |
An interleukin-1beta converting enzyme-like protease is a key component of Fas-mediated apoptosis.
Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Apoptosis; Caenorhabditis elegans Proteins; Caspase 1 | 1996 |
Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Division; Cell Survival; Dipyridamole; Dr | 1999 |
Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum.
Topics: Animals; Cell Division; Enzyme Inhibitors; Erythrocytes; Folic Acid Antagonists; Indoles; Isoindoles | 2000 |
Varying effects of deoxynucleosides on the incorporation of thymidine into the DNA of monolayer and suspension cultures.
Topics: Animals; Ascites; Bone Marrow; Bone Marrow Cells; Cell Survival; Cells, Cultured; Deoxycytidine; Deo | 1977 |
Biological characterization of a prolonged antileukemic effect of 5-azacytidine.
Topics: Animals; Azacitidine; Bone Marrow; Bone Marrow Cells; Cell Division; Cell Survival; Cytidine; Dose-R | 1977 |
Comparative studies of the cytostatic action and metabolism of 5-azacytidine and 5,6-dihydro-5-azacytidine.
Topics: Animals; Azacitidine; Cell Division; Cells, Cultured; Cytidine; Cytidine Deaminase; Deoxycytidine; D | 1977 |
Incorporation of a potent antileukemic agent, 5-aza-2'-deoxycytidine, into DNA of cells from leukemic mice.
Topics: Animals; Azacitidine; Deoxycytidine; Epithelium; Female; Leukemia L1210; Leukemia, Experimental; Liv | 1977 |
Chlorozotocin, 2-(3-(2-chloroethyl)-3-nitrosoureido)-D-glucopyranose, an antitumor agent with modified bone marrow toxicity.
Topics: Animals; Antineoplastic Agents; Blood Cell Count; Bone Marrow; Carmustine; DNA, Neoplasm; Ethyl Chlo | 1975 |
Cell proliferation kinetics and drug sensitivity of exponential and stationary populations of cultured L1210 cells.
Topics: Amino Acids; Animals; Antineoplastic Agents; Carmustine; Cell Division; Cell Survival; Cells, Cultur | 1977 |
Selectivity of action of 5-FU: biochemical basis.
Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans | 1979 |
Granulocytic chalone is not a polyamine complex.
Topics: Animals; Bone Marrow; Granulocytes; Growth Inhibitors; Humans; Leukemia L1210; Leukemia, Experimenta | 1979 |
Nucleoside 5'-monophosphate analogues. Synthesis of 5'-sulfamino-5'-deoxynucleosides.
Topics: Adenosine; Animals; Cells, Cultured; Deoxyadenosines; Enterococcus faecalis; Escherichia coli; Leuke | 1978 |
The effect of gamma radiation and neocarzinostatin on NAD and ATP levels in mouse leukaemia cells.
Topics: Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Dose-Response Relationship, Drug; Gamm | 1978 |
The involvement of poly(ADP-ribose) polymerase in the degradation of NAD caused by gamma-radiation and N-methyl-N-nitrosourea.
Topics: Animals; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Kinetics; Leukemia | 1979 |
Effect of dietary fat saturation on survival of mice with L1210 leukemia.
Topics: Animals; Cell Division; Dietary Fats; Fats, Unsaturated; Leukemia L1210; Male; Mice; Nutritional Phy | 1978 |
In vivo enhancement of 5-fluorouracil cytotoxicity to AKR leukemia cells by thymidine in mice.
Topics: Animals; Cell Survival; Colony-Forming Units Assay; Drug Synergism; Drug Therapy, Combination; Femal | 1978 |
Some observations on the reversibility of methotrexate toxicity in normal proliferating tissues.
Topics: Animals; Bone Marrow; Bone Marrow Cells; DNA; Drug Interactions; Drug Therapy, Combination; Hypoxant | 1977 |
Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidines.
Topics: Allopurinol; Animals; Drug Synergism; Female; Hypoxanthines; Inosine; Leucovorin; Leukemia L1210; Ma | 1977 |
Inhibition by interferon of thymidine uptake in chemostat cultures of L1210 cells.
Topics: Animals; Cell Division; Cell Membrane; Deoxyadenosines; Deoxyglucose; DNA, Neoplasm; Glucose; Interf | 1978 |
Modulation versus rescue of antimetabolite toxicity by salvage metabolites administered by continuous infusion.
Topics: Animals; Drug Therapy, Combination; Duodenal Diseases; Female; Infusions, Parenteral; Inosine; Letha | 1978 |
Synthesis and antitumor activity of 1,2-dihydro-1-(2-deosy-beta-D-erythro-pentofuranosyl)-2-oxo-5-methylpyrazine 4-oxide, a structural analogue of thymidine.
Topics: Animals; Antineoplastic Agents; Escherichia coli; In Vitro Techniques; Leukemia L1210; Methods; Mice | 1977 |
Effect of 1,3-bis(2-chloroethyl)-1-nitrosourea on newly synthesized DNA in L-1210 cells.
Topics: Animals; Carmustine; Cells, Cultured; DNA Replication; DNA, Neoplasm; Kinetics; Leukemia L1210; Mice | 1979 |
Experimental antitumor activity of aminoanthraquinones.
Topics: Animals; Anthraquinones; Antineoplastic Agents; DNA; Drug Administration Schedule; Female; Leukemia | 1979 |
Plasma membrane inhibition of macromolecular precursor transport by THC.
Topics: Aminoisobutyric Acids; Animals; Cannabinoids; Cell Membrane; Dronabinol; Humans; In Vitro Techniques | 1979 |
Reversal of the cytotoxicity of 3'-amino-3'-deoxythymidine by pyrimidine deoxyribonucleosides.
Topics: Animals; Cell Count; Cell Division; Deoxyribonucleosides; Dideoxynucleosides; DNA, Neoplasm; In Vitr | 1979 |
Thymidine 5'-O-pivaloate. A prodrug derivative of thymidine with potential applications in high-dose methotrexate therapy.
Topics: Animals; DNA; Drug Therapy, Combination; Kinetics; Leukemia L1210; Male; Methotrexate; Mice; Pentano | 1979 |
A selective effect of methylglyoxal-bis(guanylhydrazone) on the synthesis of mitochondrial DNA of cultured L1210 leukemia cells.
Topics: Animals; Cells, Cultured; DNA, Mitochondrial; DNA, Neoplasm; Dose-Response Relationship, Drug; Guani | 1979 |
Evaluation of ribonucleoside and deoxyribonucleoside triphosphate pools in cultured leukemia cells during exposure to methotrexate or methotrexate plus thymidine.
Topics: Animals; Cell Division; Cell Line; Cells, Cultured; Deoxyribonucleotides; Dose-Response Relationship | 1979 |
Specific protection against the cytotoxicity of a new class of nitrosoureas by pyrimidine deoxyribonucleosides.
Topics: Animals; Cell Survival; Cells, Cultured; Deoxyribonucleosides; Leukemia L1210; Melanoma; Mice; Neopl | 1979 |
Methotrexate di-n-butyl ester effects on thymidine metabolism.
Topics: Animals; Biological Transport; Cells, Cultured; DNA-Directed DNA Polymerase; Kinetics; Leukemia L121 | 1979 |
Synthesis and biological activity of several amino analogues of thymidine.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Cells, Cultured; Leukemia L1210; Sa | 1978 |
Antineoplastic agents. 1. Synthesis and antineoplastic activities of chloroethyl- and methylnitrosourea analogues of thymidine.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carbamates; Cell Division; Cells, Cultured; Chemi | 1978 |
Inhibitory effects of phytohemagglutinin isolectins L4 and E4 on L1210 cells.
Topics: Animals; Cell Aggregation; Cell Division; Cells, Cultured; DNA, Neoplasm; Glucose; Lectins; Leukemia | 1978 |
Isolation of high-rate DNA synthetic cells by con A chromatography.
Topics: Animals; Autoradiography; Cell Line; Cell Separation; Chromatography, Affinity; Concanavalin A; DNA, | 1978 |
Effects of chartreusin on cell survival and cell cycle progression.
Topics: Animals; Antibiotics, Antineoplastic; Benzopyrans; Cell Cycle; Cell Survival; Cells, Cultured; Demec | 1978 |
[Cellular test system for studying the biological properties of preparations with L-asparaginase activity].
Topics: Animals; Antineoplastic Agents; Asparaginase; Biological Assay; Burkitt Lymphoma; Cells, Cultured; C | 1977 |
Studies on the selective toxicity of guanazole in mice.
Topics: Animals; Depression, Chemical; DNA; Female; Guanazole; In Vitro Techniques; Leukemia L1210; Mice; Mi | 1978 |
Potentiation of the antitumor activity of methotrexate by concurrent infusion of thymidine.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; Female; Infusions, Parenteral; Inosine; Leukemia | 1978 |
Studies of the biochemical pharmacology of the fermentation-derived antitumor agent, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line; Cell Survival; Female; Glutamine; Gl | 1978 |
Cytostatic, cytocidal and potential antitumor properties of a class of quinoid compounds, initiators of the dormant state in the spores of Agaricus bisporus.
Topics: Amino Acids; Animals; Antineoplastic Agents; Autoradiography; Basidiomycota; Carcinoma, Ehrlich Tumo | 1975 |
[Effect of N-nitroso-N'-methylurea on the cellular kinetics in tumors].
Topics: Animals; Cell Count; DNA, Neoplasm; Female; Kinetics; Leukemia L1210; Mammary Neoplasms, Experimenta | 1977 |
In vivo cell synchrony in the L1210 mouse leukaemia studied with 5-fluorouracil or 5-fluorouracil followed by cold thymidine infusion.
Topics: Animals; Cell Division; DNA; Female; Fluorouracil; Leukemia L1210; Mice; Mitotic Index; Neoplasm Tra | 1977 |
Effects of acronycine on cell-surface properties of murine leukemia cells.
Topics: Acronine; Alkaloids; Amino Acids; Anilino Naphthalenesulfonates; Animals; Cadaverine; Cell Membrane; | 1977 |
[Correlation between the effects of cytostatic agents on leukemia L 1210 in vivo and in the short term test in vitro (author's transl)].
Topics: Animals; Cell Count; Culture Techniques; Deoxyuridine; Doxorubicin; Female; Leucine; Leukemia L1210; | 1977 |
Effects of cannabinoids on L1210 murine leukemia. 1. Inhibition of DNA synthesis.
Topics: Animals; Cannabinoids; Depression, Chemical; DNA, Neoplasm; Dronabinol; Leukemia L1210; Mice; Mice, | 1977 |
Effect of methotrexate on the cell cycle of L1210 leukemia.
Topics: Animals; Cell Division; DNA, Neoplasm; Leukemia L1210; Methotrexate; Mitotic Index; Thymidine | 1976 |
Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets.
Topics: Animals; Binding, Competitive; Cell Division; Cell Survival; DNA; DNA, Neoplasm; Drug Implants; Fema | 1976 |
[Effect of N-nitroso-N-methylurea on DNA and RNA synthesis in cells of liver and spleen tumors in leucosis L-1210].
Topics: Animals; DNA, Neoplasm; Leukemia L1210; Leukopenia; Liver Neoplasms; Methylnitrosourea; Mice; Mice, | 1976 |
Early effect of interferon on mouse leukemia cells cultivated in a chemostat.
Topics: Amino Acids; Animals; Cell Division; Cells, Cultured; Culture Media; DNA, Neoplasm; Interferons; Kin | 1975 |
Studies of the mechanism of growth promotion of lymphoma cells by 2-mercaptoethanol in vitro.
Topics: Animals; Autoradiography; Cell Division; Cells, Cultured; Culture Media; Disulfides; Growth Substanc | 1975 |
The reversal of methotrexate toxicity by thymidine with maintenance of antitumour effects.
Topics: Allopurinol; Animals; Drug Therapy, Combination; Leucovorin; Leukemia L1210; Male; Methotrexate; Mic | 1975 |
New approaches to cancer chemotherapy with methotrexate.
Topics: Adult; Animals; Biological Transport; Bone Marrow; Creatinine; DNA, Neoplasm; Doxorubicin; Drug Ther | 1975 |
Aspects of the biochemical pharmacology of cytembena.
Topics: Acrylates; Animals; Cell Division; DNA Nucleotidyltransferases; DNA, Neoplasm; Dose-Response Relatio | 1975 |
Methotrexate-thymidine treatment of murine leukemia.
Topics: Allopurinol; Animals; Drug Evaluation, Preclinical; Leucovorin; Leukemia L1210; Methotrexate; Mice; | 1975 |
Antitumor effects of bis-thiosemicarbazones--inhibition of deoxyribonucleic acid synthesis in vitro.
Topics: Animals; Antineoplastic Agents; Bacterial Proteins; Carbon Radioisotopes; Cells, Cultured; Chelating | 1975 |
Metabolism and selective effects of 1-beta-D-arabinofuranosylcytosine in L1210 and Host tissues in vivo.
Topics: Animals; Ascitic Fluid; Cytarabine; DNA, Neoplasm; Idoxuridine; Intestine, Small; Leukemia L1210; Li | 1975 |
Inhibition of 3H-thymidine incorporation of lymphocytes by a soluble factor from macrophages.
Topics: Animals; Ascitic Fluid; Bone Marrow; Bone Marrow Cells; Cell Line; Cell Separation; Cells, Cultured; | 1975 |
Initial studies on the cytotoxic action of maytansine, a novel ansa macrolide.
Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; Leucine; Leukemia L1210; Leukemia, Experiment | 1975 |
Inhibition of macromolecular synthesis in L1210 mouse leukemia ascites cells by hycanthone.
Topics: Animals; DNA, Neoplasm; Ethylenediamines; Leukemia L1210; Mice; Neoplasm Proteins; Protein Biosynthe | 1975 |
Effects of allopurinol on the therapeutic efficacy of methotrexate.
Topics: Allopurinol; Animals; Chick Embryo; Female; Hypoxanthines; Leukemia L1210; Leukemia, Experimental; M | 1975 |
Biochemical characterization of a factor released by macrophages.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chromatography, Paper; Chromatography, Th | 1975 |
Antineoplastic activity of cannabinoids.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cannabidiol; C | 1975 |
[Effect of methotrexate on the leukemic cell cycle in mouse ascitic leukemia L1210].
Topics: Animals; Ascitic Fluid; Cell Transformation, Neoplastic; Drug Resistance; Drug Synergism; Female; Le | 1975 |
The role of metals in the antitumor action of 1,5-bisthiosemicarbazones.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chelating Agents; Copper; DNA, Neoplasm; Kinetics; | 1975 |
Comparative effects of Yoshi-864 and busulfan on certain transplantable murine tumors.
Topics: Alkylating Agents; Animals; Busulfan; Carcinoma, Ehrlich Tumor; Cell Survival; Chick Embryo; DNA Rep | 1975 |
Effects of 4-nitrobenzofurazans and their N-oxides on synthesis of protein and nucleic acid by murine leukemia cells.
Topics: Animals; Benzoxazoles; Cells, Cultured; Cyclic N-Oxides; DNA, Neoplasm; Leukemia L1210; Leukemia, Ex | 1975 |
Ortho-phenanthroline inhibition of DNA synthesis in mammalian cells.
Topics: Animals; Binding Sites; Cobalt; Cycloheximide; Dactinomycin; DNA Replication; Lectins; Leukemia L121 | 1975 |
Cellular pharmocodynamics of several anthrocycline antibiotics.
Topics: Animals; Cells, Cultured; Daunorubicin; DNA, Neoplasm; Doxorubicin; In Vitro Techniques; Leukemia L1 | 1976 |
Alterations in 3H-thymidine incorporation into DNA induced by methyl CCNU (1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea) in normal and tumorous tissues in vivo.
Topics: Animals; Bone Marrow; DNA; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Intesti | 1976 |
Distribution of triiodothyronine nuclear receptors during the cell cycle in mouse leukemia cells.
Topics: Animals; Cell Cycle; Cell Nucleus; Demecolcine; G1 Phase; Leukemia L1210; Mice; Receptors, Thyroid H | 1992 |
L1210/B23.1 cells express equilibrative, inhibitor-sensitive nucleoside transport activity and lack two parental nucleoside transport activities.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Biological Transport; Carrier Proteins; Cell Membrane | 1992 |
Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Carcinoma, Squamous Cell; Chemical Phenomena; Chem | 1991 |
[Reversal of multidrug resistance with (R)-verapamil in vitro and in vivo].
Topics: Animals; Antineoplastic Agents; Cytarabine; Doxorubicin; Drug Resistance; Female; Leukemia L1210; Mi | 1991 |
Green tea extract inhibits nucleoside transport and potentiates the antitumor effect of antimetabolites.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cytarabine; Drug Synergism; Female; Humans; Leukemia L12 | 1991 |
Inhibition of poly(adenosine diphosphate-ribose) polymerase by thymidine and thymidine analogues in L1210 cells and its relationship to the potentiation of the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea but not of 3'-[3-(2-chloroethyl)-3-n
Topics: Animals; Antineoplastic Agents; Carmustine; Dideoxynucleosides; DNA; DNA Damage; Drug Synergism; Enz | 1991 |
Isolation and characterization of an L1210 cell line retaining the sodium-dependent carrier cif as its sole nucleoside transport activity.
Topics: 2-Chloroadenosine; Affinity Labels; Animals; Carrier Proteins; Cell Division; Cell Membrane; Cell Su | 1990 |
Ascitic tumor cell cycle metabolism and energetics.
Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Cycle; Cholesterol; Energy Met | 1991 |
Flow cytometric evaluation of the cell cycle perturbations induced by S12363, a new vinca alkaloid derivative.
Topics: Acridine Orange; Animals; Benzimidazoles; Cell Cycle; Chromatin; Flow Cytometry; Leukemia L1210; Mic | 1990 |
[Active transport of cobalamins in leukemic cells of L-1210 mice].
Topics: Animals; Biological Transport, Active; Cobalt Radioisotopes; DNA, Neoplasm; Endocytosis; Leukemia L1 | 1990 |
Relationship between internalization kinetics and cytotoxicity of mistletoe lectin I to L1210 leukaemia cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Endocytosis; Leucine; Leukemia L1210; Mice; Mice, Inbred | 1990 |
Dual mechanisms of inhibition of DNA synthesis by triciribine.
Topics: Animals; Antineoplastic Agents; DNA Polymerase I; DNA Primase; DNA Replication; DNA, Neoplasm; Kinet | 1990 |
Mechanism of action of 1-beta-D-arabinofuranosyl-5-azacytosine and its effects in L1210 mouse leukemia cells.
Topics: Animals; Antineoplastic Agents; Azacitidine; Bone Marrow; Bone Marrow Cells; Cell Division; Cell Lin | 1986 |
Effects of 5-aza-2'-deoxycytidine on survival and cell cycle progression of L1210 leukemia cells.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Cycle; Cell Survival; Cells, Cultured; Decitabine; | 1986 |
Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.
Topics: Animals; Biotransformation; Cell Division; Colonic Neoplasms; DNA; Drug Synergism; Fluorouracil; Fol | 1987 |
A simple method for predicting modes of actions of antitumor agents.
Topics: Adenosine; Animals; Antineoplastic Agents; DNA Replication; Guanosine; Leukemia L1210; Mitosis; Nucl | 1988 |
A method for the synchronization of cultured cells with aphidicolin: application to the large-scale synchronization of L1210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase.
Topics: Animals; Aphidicolin; Cell Cycle; Cytological Techniques; Diterpenes; DNA Polymerase II; Flow Cytome | 1989 |
Changes in messenger RNA levels for the subunits of ribonucleotide reductase during the cell cycle of leukemia L1210 cells.
Topics: Animals; Blotting, Northern; Calcium; Cell Cycle; DNA Replication; Kinetics; Leukemia L1210; Macromo | 1989 |
Ultraviolet irradiation produces cytotoxic synergy and increased DNA interstrand crosslinking with cis- and trans-diamminedichloroplatinum(II).
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cisplatin; Colonic Neoplasms; DNA Replicat | 1989 |
Differential affinities of pyrimidine nucleoside analogues for deoxythymidine and deoxycytidine kinase determine their incorporation into murine leukemia L1210 cells.
Topics: Animals; Cells, Cultured; Deoxycytidine; Deoxycytidine Kinase; Leukemia L1210; Mice; Nucleic Acids; | 1987 |
2',3'-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis.
Topics: Animals; Antiviral Agents; Deoxycytidine; Deoxycytosine Nucleotides; HIV; Humans; Leukemia L1210; Mi | 1987 |
Inhibition of human leukaemic thymidylate kinase and L1210 ribonucleotide reductase by dinucleotides of adenosine and thymidine and their phosphonate analogues.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Humans; Kinetics; Leukemia L1210; Leukemia, My | 1988 |
Dinucleotide analogues as inhibitors of thymidine kinase, thymidylate kinase, and ribonucleotide reductase.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Chemical Phenomena; Chemistry; Dinucleoside Ph | 1988 |
Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine.
Topics: Animals; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Leukemia L1210; Lung N | 1986 |
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
Topics: Adenosine; Animals; Cell Division; Floxuridine; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Mi | 1987 |
[Inhibitory effect of poriatin on murine leukemia 1210 cells].
Topics: Animals; Antineoplastic Agents; DNA-Directed DNA Polymerase; DNA, Neoplasm; Drugs, Chinese Herbal; L | 1988 |
Isolation and characterization of a mutant of L1210 murine leukemia deficient in nitrobenzylthioinosine-insensitive nucleoside transport.
Topics: Animals; Biological Transport; Carrier Proteins; Cytarabine; Floxuridine; Inosine; Leukemia L1210; M | 1988 |
1-beta-D-arabinofuranosylcytosine metabolism and incorporation into DNA as determinants of in vivo murine tumor cell response.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Bone Marrow; Deoxycytidine Kinas | 1985 |
Opposing effects of the polycation hexadimethrine (polybrene) on normal and leukemic lymphocytes.
Topics: Animals; Cell Division; Female; Hexadimethrine Bromide; In Vitro Techniques; Leukemia L1210; Lymphoc | 1985 |
Tumour cell recruitment of the JB-1 and L 1210 ascites tumour determined directly by double labelling with [14C]- and [3H]-thymidine.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Cell Cycle; Cell Division; Cell Line; Female; Leukem | 1988 |
An in vivo study on the synchronizing effect of hydroxyurea.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Cell Cycle; Cell Division; DNA Replication; Female; | 1988 |
Parallelism between transport inhibition and L1210 cell growth by ouabain.
Topics: Animals; Biological Transport; Cell Division; Cell Survival; Digitoxin; Digoxin; DNA Replication; Ki | 1988 |
Effect of thymidine on uptake, DNA alkylation, and DNA repair in L1210 cells treated with 1,3-bis(2-chloroethyl)-1-nitrosourea or 3'-[3-(2-chloroethyl)-3-nitrosoureido]-3'-deoxythymidine.
Topics: Alkylation; Animals; Carmustine; Cell Line; Dideoxynucleosides; DNA; DNA Repair; Drug Synergism; Leu | 1988 |
DNA synthesis, protein synthesis and platinum content following drug administration in cis-diamminedichloroplatinum(II) -sensitive and -resistant L1210 cells transferred from in vitro to in vivo conditions.
Topics: Animals; Cell Line; Cisplatin; DNA, Neoplasm; Drug Resistance; Leukemia L1210; Mice; Mice, Inbred DB | 1987 |
Antibiotic binding to human polymorphonuclear neutrophils, mouse leukemia L1210 cells and mouse thymocytes.
Topics: Animals; Anti-Bacterial Agents; Clindamycin; Doxycycline; Fusidic Acid; Humans; Leukemia L1210; Mice | 1986 |
Concentrative uridine transport by murine splenocytes: kinetics, substrate specificity, and sodium dependency.
Topics: Animals; Biological Transport, Active; Kinetics; Leukemia L1210; Mice; Mice, Inbred C57BL; Sodium; S | 1987 |
Technique for detection of DNA nucleobases by reversed-phase high-performance liquid chromatography optimized for quantitative determination of thymidine substitution by iododeoxyuridine.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; DNA; DNA, Neoplasm; Humans; Hydrolysis; Id | 1987 |
Antileukemic activity against L1210 leukemia, pharmacokinetics and hematological side effects of 5-hydroxymethyl-2'-deoxyuridine.
Topics: Animals; Antineoplastic Agents; Blood Cells; Female; Leukemia L1210; Male; Mice; Mice, Inbred BALB C | 1987 |
In vitro and in vivo studies of a promising antileukemic thymidine analogue, 5-hydroxymethyl-2' deoxyuridine.
Topics: Animals; Antineoplastic Agents; Blood Platelets; Cell Line; Deoxycytidine; Humans; Leukemia; Leukemi | 1986 |
Enhancement of the anticancer activity of bis(2-chloroethyl)nitrosourea in mice by coadministration of 2'-deoxyuridine, 2'-deoxycytidine, or thymidine.
Topics: Animals; Carmustine; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; Drug Synergism; Leukemia L12 | 1987 |
Schedule-dependent antitumor and toxic effects of thymidine and 5-fluorouracil in AKR and L1210 leukemias.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Female; F | 1986 |
Chemosensitization of L-phenylalanine mustard by the thiol-modulating agent buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Drug Synergism; Glutathione; Leukemia L1210; Male; Melphalan; Methi | 1987 |
Activated macrophage-mediated cytotoxicity: use of the in vitro cytotoxicity assay for study of bioenergetic and biochemical changes that develop in tumor target cells.
Topics: Animals; Cells, Cultured; Cytotoxicity, Immunologic; Guinea Pigs; Leukemia L1210; Liver Neoplasms, E | 1986 |
Plasma kinetics and effects of 5,6-dihydro-5-azacytidine in mice and L1210 tumor.
Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Chromatography, High Pressure Liquid; Drug Evaluati | 1985 |
The utility of combinations of drugs directed at specific sites of the same target enzyme--ribonucleotide reductase as the model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Cells, Cultured; Deoxyadenos | 1985 |
Thymidylate synthase inhibition in cells with arrested DNA synthesis is not due to an allosteric interaction in the replitase complex.
Topics: Animals; Aphidicolin; Cell Line; Diterpenes; DNA Replication; Humans; Leukemia L1210; Methyltransfer | 1985 |
Erythrocyte catalase. A somatic oxidant defense?
Topics: Animals; Catalase; Erythrocytes; Humans; Hydrogen Peroxide; Leukemia L1210; Mice; Oxygen Consumption | 1986 |
5'-Haloacetamido-5'-deoxythymidines: novel inhibitors of thymidylate synthase.
Topics: Animals; Chromatography, Gel; Kinetics; Leukemia L1210; Mice; Thymidine; Thymidylate Synthase | 1986 |
Characterization of L1210 cell growth inhibition by the bacterial iron chelators parabactin and compound II.
Topics: Animals; Cell Cycle; DNA; Iron Chelating Agents; Leukemia L1210; Mice; Oxazoles; Ribonucleoside Diph | 1985 |
Toxicologic and antitumor studies on 5-hydroxymethyldeoxyuridine.
Topics: Animals; Antineoplastic Agents; Body Weight; Humans; Intestine, Small; Leukemia L1210; Leukemia L517 | 1985 |
Biological effects of murine histocompatibility antigen solubilized with 3 M potassium chloride.
Topics: Animals; Antibody Formation; Cytotoxicity Tests, Immunologic; DNA; Epitopes; Female; Graft Rejection | 1973 |
The adamantyl group in medicinal agents. 3. Nucleoside 5'-adamantoates. The adamantoyl function as a protecting group.
Topics: Adenocarcinoma; Aminohydrolases; Animals; Antibody Formation; Chemistry, Organic; Culture Techniques | 1967 |
Specific metabolic changes in DNA-treated L1210 leukemia cells.
Topics: Animals; Carbon Isotopes; Culture Techniques; Dactinomycin; DNA; DNA, Bacterial; DNA, Neoplasm; Esch | 1967 |
The influence of partial synchronization of cell growth on the inhibition of L1210 cell viability by mouse thymus DNA.
Topics: Animals; Antineoplastic Agents; Culture Techniques; Depression, Chemical; DNA; DNA, Neoplasm; Floxur | 1968 |
Effect of AC-3579, a diazafluoranthen derivative, on murine leukemia P388 and L1210--I. In vivo study.
Topics: Adenosine Triphosphatases; Animals; Aza Compounds; Fluorenes; Injections, Intraperitoneal; Leukemia | 1973 |
Deoxycytidine kinase. I. Distribution in normal and neoplastic tissues and interrelationships of deoxycytidine and 1-beta-D-arabinofuranosylcytosine phosphorylation.
Topics: Adenocarcinoma; Animals; Carcinoma, Hepatocellular; Cattle; Chick Embryo; Chromatography, Ion Exchan | 1969 |
Metabolic effects of cyclic 9- -D-arabinofuranosyladenine 3',5'-monophosphate in L1210 cells.
Topics: Adenosine Triphosphate; Animals; Arabinose; Cells, Cultured; Culture Media; Cyclic AMP; DNA Nucleoti | 1972 |
Biochemical effects of ellipticine on leukemia L1210 cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; Carbazoles; Carbon Radioisotopes; Depression, Chemical; D | 1974 |
The intracellular concentration dependence of antifolate inhibition of DNA synthesis in L1210 leukemia cells.
Topics: Animals; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Dose-Response Relationship, Drug; Leu | 1974 |
Nonspecific inhibition of precursor uptake by alkyl-substituted purines and prednisolone.
Topics: Acetates; Adenine; Adenocarcinoma; Animals; Carbon Radioisotopes; Cell Division; Cell Line; Choline; | 1974 |
Alterations induced by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in deoxyribonucleic acid synthesis in normal and tumorous tissues. Implications for optimal chemotherapy.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Carmustine; DNA; DNA, Neoplasm; Dose-Response Relations | 1974 |
DNA chain growth during replication of asynchronous L1210 cells. Alkaline elution of large DNA segments from cells lysed on filters.
Topics: Animals; Carbon Radioisotopes; Cell Division; Cells, Cultured; Centrifugation, Density Gradient; DNA | 1974 |
X-ray repair replication in L1210 leukemia cells.
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; Cytarabine; Daunorubicin; DNA Repair; Dose-Response Rel | 1974 |
Cytidine 5'-triphosphate synthetase as a target for inhibition by the antitumor agent 3-deazauridine.
Topics: Animals; Cells, Cultured; Cytidine; Cytosine Nucleotides; Deoxycytidine; Deoxyuridine; Enzyme Inhibi | 1974 |
Effect of neocarzinostatin on DNA synthesis in L1210 cells.
Topics: Animals; Antibiotics, Antineoplastic; Bacterial Proteins; Carbon Radioisotopes; Centrifugation, Dens | 1974 |
Damage of mammalian cell DNA in vivo and in vitro induced by neocarzinostatin.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Bacterial Proteins; Cattle; Cells, Cult | 1974 |
The effects of arginine deficiency on lymphoma cells.
Topics: Animals; Arginase; Arginine; Carbon Radioisotopes; Cell Count; Cell Line; Cell Survival; Cells, Cult | 1974 |
The restriction of the release of migration inhibitory factor to certain phases of the cell cycle of murine leukemia, L1210.
Topics: Animals; B-Lymphocytes; Cell Division; Cell Line; Cell Migration Inhibition; Cells, Cultured; Chroma | 1972 |
Factors determining cell sensitivity to methotrexate: studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines.
Topics: Animals; Biological Assay; Cell Count; Cell Line; Cells, Cultured; Deoxyadenosines; Deoxyribonucleot | 1974 |
The life cycle of antibody-forming cells. II. Evidence for steady state proliferation of direct haemolytic plaque-forming cells during the primary and secondary responses.
Topics: Animals; Antibody Formation; Antibody-Producing Cells; Ascitic Fluid; Autoradiography; Carbon Isotop | 1972 |
Autoradiographic and cytophotometric analyses of the resting stages of the L1210 ascites tumor.
Topics: Animals; Ascitic Fluid; Autoradiography; Cell Division; Computers; Cytological Techniques; DNA, Neop | 1974 |
Selective inhibition of the growth of bacteriophage lambda by experimental antileukaemic bisquaternary salts.
Topics: Animals; Antineoplastic Agents; Coliphages; DNA; DNA Viruses; Dose-Response Relationship, Drug; Esch | 1974 |
Modulation of cell behavior in vitro by the substratum in fibroblastic and leukemic mouse cell lines.
Topics: Aldehydes; Animals; Buffers; Cattle; Cell Division; Chemical Phenomena; Chemistry; Contact Inhibitio | 1972 |
The effect of chemotherapy on the growth of leukemia L1210. II. Persistence of a nitrosourea-induced change in the growth characteristics of transplant generations.
Topics: Animals; Ascites; Autoradiography; Cells; DNA, Neoplasm; Growth; Leukemia L1210; Male; Mice; Mice, I | 1972 |
Inhibition of repair of DNA single strand breaks in mouse leukemia cells by actinomycin D.
Topics: Animals; Cell Line; Centrifugation, Density Gradient; Cobalt Isotopes; Cold Temperature; Cytarabine; | 1972 |
Use of gamma distributed transit times and the Laplace transform method in theoretical cell kinetics.
Topics: Animals; Computers; Female; Kinetics; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Mitosis | 1972 |
Specific inhibition of DNA synthesis by cyclocytidine.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Cells, Cultured; Cyclization; Cytidine; Depression, | 1972 |
The effect of methyl CCNU (NSC-95441) on the cellular kinetics of normal and leukemic murine tissues in vivo.
Topics: Animals; Ascitic Fluid; Bone Marrow; Bone Marrow Cells; Cell Division; DNA; DNA, Neoplasm; Gastric M | 1973 |
Antitumor action of dichloro(4,5-dimethyl-0-phenylenediamine-N',N')platinum(II).
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Chlorine; DNA; In Vitro | 1973 |
The effect of dose interval on the survival of L1210 leukemic mice treated with DNA synthesis inhibitors.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Division; Cell Survival; Cytarabine; DNA, Neoplas | 1973 |
Threshold methotrexate concentration for in vivo inhibition of DNA synthesis in normal and tumorous target tissues.
Topics: Animals; Ascites; Ascitic Fluid; Bone Marrow; Deoxyuridine; Depression, Chemical; DNA Replication; D | 1973 |
Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro. Effects on mouse lymphoma cells in comparison with splenic lymphocytes.
Topics: Animals; Cell Line; Cells, Cultured; Cysteine; Disulfides; Half-Life; Leukemia L1210; Lymphocytes; L | 1973 |
Mechanism of the inhibition of DNA biosynthesis by 4,4'-diacetyldiphenylurea-bis(guanylhydrazone) in leukemia L1210 cells.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Cell-Free System; Cells, Cultured; DNA Nucleotidylt | 1973 |
Effect of phosphorylated cyclocytidine on deoxyribonucleic acid polymerase.
Topics: Anhydrides; Animals; Antineoplastic Agents; Carbon Radioisotopes; Cytarabine; Cytosine Nucleotides; | 1973 |
Enhanced antitumor effect of cytosine arabinoside given in a schedule dictated by kinetic studies in vivo.
Topics: Animals; Antineoplastic Agents; Cytarabine; DNA, Neoplasm; Kinetics; Leukemia L1210; Male; Mice; Mic | 1973 |
In vitro effect of sodium warfarin on DNA and RNA synthesis of mouse L1210 leukemic cells and Walker tumor cells.
Topics: Animals; Carcinoma 256, Walker; Cells, Cultured; DNA, Neoplasm; Leukemia L1210; Mice; Rats; RNA, Neo | 1973 |
Inhibition of macromolecular biosynthesis in cultured L1210 mouse leukemia cells by thalicarpine (NSC 68075).
Topics: Alkaloids; Animals; Antineoplastic Agents; Cells, Cultured; Centrifugation, Density Gradient; Chroma | 1973 |
Biochemical studies of a new antitumor agent, O2,2'-cyclocytidine.
Topics: Anhydrides; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Carbon Radioisotopes; Ce | 1974 |
The response of C3H mice to an L1210 tumor allograft.
Topics: Animals; Ascitic Fluid; Autoradiography; Bone Marrow; Graft Rejection; Histocompatibility; Leukemia | 1974 |
Effects of tryptophan deprivation on L1210 cells in culture.
Topics: Animals; Cell Division; Cell Nucleus; Cell Survival; Cells, Cultured; DNA, Neoplasm; Histones; Leuke | 1974 |
Studies on the mechanism of resistance to lymphocytolysis induced by corticosteroids.
Topics: Animals; Carnitine; Cell Line; Cell Nucleus; Drug Resistance; Fatty Acids, Nonesterified; Glucose; H | 1974 |
Similarity of Tetrahymeana and mammalian RNA polymerases based on rifampicin resistance.
Topics: Animals; Cell Nucleus; Depression, Chemical; Escherichia coli; Leukemia L1210; Mice; Rifampin; RNA N | 1970 |
Comparative biological activity of nogalamycin and its analogs.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Binding Sites; Cell Line; Cell-Free System; Chemical Pheno | 1970 |
Immunosuppressive, antiviral and antitumor activities of cytarabine derivatives.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cricetinae; Cytarabine; DNA; Esters; Graft Rejecti | 1972 |
Cyclic nucleotide analogs as carcinostatic agents.
Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Arabinose; Carcinoma, Ehrlich Tumor; Cell Line; | 1972 |
Inhibition of DNA and RNA metabolism by daunorubicin and adriamycin in L1210 mouse leukemia.
Topics: Amino Sugars; Animals; Antibiotics, Antineoplastic; Carbon Isotopes; Cells, Cultured; Daunorubicin; | 1972 |
Tissue-specific effects of N 6 -( 2 -isopentenyl) adenosine on the incorporation of precursors into nucleic acids and protein in rats and mice.
Topics: Adenosine; Alkenes; Animals; Cell Division; DNA; Female; Intestinal Mucosa; Leukemia L1210; Liver; M | 1972 |
Kinetics of effect of 1-beta-D-arabinofuranosylcytosine, its 5'-palmitoyl ester, 1-beta-D-arabinofuranosyluracil, and tritiated thymidine on the viability of cultured leukemia L1210 cells.
Topics: Animals; Arabinose; Cell Survival; Cells, Cultured; Depression, Chemical; Esters; Half-Life; In Vitr | 1972 |
Comparative biochemical studies of adriamycin and daunomycin in leukemic cells.
Topics: Animals; Antibiotics, Antineoplastic; Daunorubicin; Depression, Chemical; DNA Nucleotidyltransferase | 1972 |
A direct in vitro assay for studying radiosensitization in mammalian cells.
Topics: Animals; Biopsy; Cells, Cultured; Dactinomycin; DNA Repair; DNA Replication; DNA, Neoplasm; Evaluati | 1972 |
Camptothecin effects on DNA synthesis in murine leukemia cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; Carbon Isotopes; Cell Division; Cell Line; Cells, Culture | 1972 |
Studies on camptothecin-induced degradation and apparent reaggregation of DNA from L1210 cells.
Topics: Acridines; Alkaloids; Animals; Antineoplastic Agents; Carbon Isotopes; Cell Line; Centrifugation, De | 1972 |
Interaction of phytohemagglutinin and concanavalin A with transplantable mouse lymphomas of differing malignant potential.
Topics: Animals; Concanavalin A; DNA; Lectins; Leukemia L1210; Lymphoma; Mice; Neoplasm Transplantation; Neo | 1972 |
Antitumor activity of a folate-cleaving enzyme, carboxypeptidase G 1 .
Topics: Animals; Antineoplastic Agents; Carboxypeptidases; Carcinoma 256, Walker; Cell Division; Cell Line; | 1972 |
The proliferation kinetics of L 1210 ascites tumour.
Topics: Animals; Autoradiography; Carcinoma, Ehrlich Tumor; Cell Count; Cell Division; DNA, Neoplasm; Leukem | 1972 |
Reversal of resistance to methotrexate in L1210 murine leukemia by uracil.
Topics: Animals; DNA; Drug Resistance; Leukemia L1210; Mercaptopurine; Methotrexate; Nucleic Acids; Tetrahyd | 1971 |
Effects of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; NSC-79037) and its degradation products on progression of L1210 cells through the cell cycle.
Topics: Animals; Antineoplastic Agents; Autoradiography; Carbon Isotopes; Cyanates; Cyclohexanes; Cyclohexyl | 1971 |
Nucleic acids. 11. Synthesis of 5'-esters of 1-beta-D-arabinofuranosylcytosine possessing antileukemic and immunosuppressive activity.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cytarabine; DNA; Esters; Humans; Immunosuppressive | 1971 |
Some determinants of camptothecin responsiveness in leukemia L1210 cells.
Topics: Alkaloids; Animals; Antineoplastic Agents; Cell Line; Cells, Cultured; Dactinomycin; Depression, Che | 1971 |
Biological and biochemical differences between tubercidin (7-deazaadenosine) and its 5'-phosphate methyl ester.
Topics: Animals; Antineoplastic Agents; Blood; Carcinoma; Cell Line; Chromatography, Paper; Culture Media; D | 1971 |
Automated image analysis in autoradiography.
Topics: Analysis of Variance; Animals; Autoradiography; Computers; Data Display; Leukemia L1210; Mice; Micro | 1971 |
Growth rate and cell kill.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactio | 1971 |
Inhibition of growth of leukemia cells by enzymic folate depletion.
Topics: Animals; Carboxypeptidases; Carcinoma 256, Walker; Cell Line; Culture Media; Depression, Chemical; F | 1971 |
Effect of combined therapy with cytosine arabinoside (NSC-63878) and l,3-bis-(2-chloroethyl)-1-nitrosourea (NSC-409962) on sarcoma 180 and L1210 in vivo.
Topics: Animals; Cytarabine; DNA, Neoplasm; Drug Synergism; Female; Leukemia L1210; Mice; Neoplasms, Experim | 1969 |
The rationale of the chemotherapeutic regimes relative to present knowledge of cell and population kinetics.
Topics: Animals; Cell Differentiation; Cell Division; DNA; Humans; Kinetics; Leukemia; Leukemia L1210; Leuke | 1970 |
Dimethyladenosine dialdehyde: inhibition of leukemia 1210 DNA polymerase.
Topics: Aldehydes; Animals; Carbon Isotopes; DNA Nucleotidyltransferases; In Vitro Techniques; Leukemia L121 | 1970 |
The effect of chemotherapy on the growth characteristics and cellular kinetics of leukemia L1210.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Cell Division; Cyclophosphamide; DNA, Neop | 1970 |
Comparative effects of the antitumor agents 5-(Dimethyltriazeno)-imidazole-4-carboxamide and 1,3-bis(2-chloroethyl)-1-nitrosourea on cell cycle of L1210 leukemia cells in vivo.
Topics: Amides; Animals; Antineoplastic Agents; Autoradiography; Biological Assay; DNA, Neoplasm; Imidazoles | 1970 |
Effects of 4,4'-diacetyldiphenylurea-bis-(guanylhydrazone) on the incorporation of precursors into nucleic acid and protein of leukemia L1210.
Topics: Animals; Carbon Isotopes; Culture Techniques; Depression, Chemical; DNA Nucleotidyltransferases; DNA | 1970 |
Effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and some chemically related compounds upon the progression of cultured H.Ep. no. 2 cells through the cell cycle.
Topics: Animals; Benzocycloheptenes; Carcinoma; Cell Division; Cell Line; Culture Techniques; Cyanates; Ethy | 1970 |
Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole.
Topics: Adenine; Animals; Azaguanine; Carbon Isotopes; Carcinoma, Squamous Cell; Culture Techniques; DNA, Ne | 1970 |
Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia.
Topics: Animals; Cell Line; Chromatography, Paper; Culture Techniques; DNA Nucleotidyltransferases; DNA, Neo | 1970 |
Kinetic parameters and growth curves for experimental tumor systems.
Topics: Adenocarcinoma; Animals; Autoradiography; Benz(a)Anthracenes; Carcinoma, Ehrlich Tumor; Female; Kine | 1970 |
Interferon and cell division. 3. Effect of interferon on the division cycle of L1210 cells in vitro.
Topics: Autoradiography; Benzocycloheptenes; Cell Count; Cell Division; Culture Techniques; DNA; Interferons | 1971 |
Kinetics of proliferation, migration, and death of L1210 ascites cells.
Topics: Animals; Ascitic Fluid; Autoradiography; Cell Count; Cell Division; Cell Movement; Cell Survival; DN | 1971 |
Antitumor and antimitogenic properties of the photochemical reaction product of ammonium hexachloroiridate (IV).
Topics: Animals; Antineoplastic Agents; Blood Proteins; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Culture T | 1971 |
Radiotoxicity of intranuclear tritium, 125 iodine and 131 iodine.
Topics: Animals; Cell Count; Cell Nucleus; Cell Survival; DNA, Neoplasm; Female; Half-Life; Idoxuridine; Iod | 1971 |
Sparing action of uridine on the activity of arabinosylcytosine with normal and leukemic mice.
Topics: Animals; Chromatography; Cytarabine; Cytosine; Drug Synergism; Leukemia L1210; Male; Mice; Nucleosid | 1968 |
Effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds upon the synthesis of DNA by cell-free systems.
Topics: Animals; Cell-Free System; DNA, Neoplasm; Histocytochemistry; Leukemia L1210; Mice; Neoplasm Transpl | 1968 |
Antitumor activity and some pharmacologic properties of anthramycin methyl ether.
Topics: Animals; Antibiotics, Antineoplastic; Blood Pressure; Culture Techniques; Dactinomycin; DNA; Dogs; E | 1968 |
Metabolism of 1-beta-D-arabinofuranosylcytosine in leukemia L1210: studies with intact cells.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Chromatography, Ion Exchange; Cytarabine; Cytosine | 1968 |
On the poor correlation between the inhibition by methotrexate of dihydrofolate reductase and of deoxynucleoside incorporation into DNA.
Topics: Animals; Deoxyuridine; DNA, Neoplasm; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; L | 1968 |
Spin filter culture: the propagation of mammalian cells in suspension.
Topics: Animals; Cell Line; Culture Techniques; Deoxyuridine; Filtration; Kinetics; Leukemia L1210; Ligases; | 1969 |
Biochemical and genetic studies of a mutant strain of mouse leukemia L1210 resistant to 1-beta-D-arabinofuranosylcytosine (Cytarabine).
Topics: Animals; Culture Techniques; Cytarabine; Leukemia L1210; Mice; Mutation; Nucleosides; Nucleotides; P | 1969 |
Relationship of normal CDF1 mouse leukocyte kinetics to growth characteristics of leukemia L1210.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Hematopoiesis; Kinetics; Leukemia L1210; Leu | 1969 |
The thymidine-14C and -3H double-labeling technic in the study of the cell cycle of L1210 leukemia ascites tumor in vivo.
Topics: Animals; Autoradiography; Carbon Isotopes; DNA; Kinetics; Leukemia L1210; Mathematics; Methods; Mice | 1969 |
Accumulation of two alkylating agents, nitrogen mustard and busulfan, by murine leukemia cells in vitro.
Topics: Amines; Animals; Busulfan; In Vitro Techniques; Leukemia L1210; Leukemia, Experimental; Mechloretham | 1969 |
The synergistic anti-neoplastic activity of combinations of mitomycins with either 6-thioguanine or 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; DNA, Neoplasm; Drug Synergism; Female; Fluorouracil; In Vitro Techni | 1965 |