thymidine has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 26 studies
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " By contrast, methanol fixation followed by a brief treatment with the detergent Triton X-100 and immunostaining with either 19F4 or PC10 (but not with 19A2) combined a high sensitivity and specificity scores of the recognition of the 3H-thymidine-labeled cells: PC10 gave a more intense and, hence, more readable reaction." | 3.69 | PCNA immunopositivity index as a substitute to 3H-thymidine pulse-labeling index (TLI) in methanol-fixed human lymphocytes. ( Capel, P; Degraef, C; Del Bino, G; Feremans, W; Fokan, D; Galand, P; Morret, M, 1995) |
| "Leukemic blast cells isolated from chronic myeloid leukemia (CML) patients showed significant cell growth inhibition within twentyfour hours." | 1.31 | Boron compounds against human leukemic cells. ( Bhattacharya, M; Bhattacharya, S; Biswas, J; Das, M; Ghosh, M; Ghosh, P; Gomes, A; Mitra, S; Murmu, N; Sur, P; Vedasiromoni, JR, 2001) |
| "The response of normal and chronic myeloid leukemia (CML), CD34+ cells to human macrophage inflammatory protein-1 alpha (MIP-1 alpha or LD78) was assessed." | 1.29 | Macrophage inflammatory protein-1 alpha receptors are present on cells enriched for CD34 expression from patients with chronic myeloid leukemia. ( Chasty, RC; Lucas, GS; Owen-Lynch, PJ; Pierce, A; Whetton, AD, 1995) |
| "The cobalamin metabolism in chronic myelogenous leukemia (CML) was evaluated in 18 newly diagnosed and untreated patients by formiminoglutamic acid (FiGlu) and methyl malonic acid excretion (MMA) tests." | 1.29 | Cobalamin-dependent metabolism in chronic myelogenous leukemia determined by deoxyuridine suppression test and the formiminoglutamic acid and methylmalonate excretion in urine. ( Gimsing, P; Hippe, E, 1995) |
| "We cultured chronic myelogenous leukemia cells from the peripheral blood of several patients in blast crisis with three inhibitors of lipoxygenases: ETYA, and the more selective A63162 (Abbott) or SC41661A (Searle)." | 1.29 | Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase. ( Anderson, KM; Harris, JE; Jajeh, A; Levin, J; Seed, T, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (15.38) | 18.7374 |
| 1990's | 16 (61.54) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naud, JS | 1 |
| Ghani, K | 1 |
| de Campos-Lima, PO | 1 |
| Caruso, M | 1 |
| Murmu, N | 2 |
| Ghosh, P | 2 |
| Gomes, A | 2 |
| Mitra, S | 2 |
| Das, M | 2 |
| Besra, SE | 1 |
| Majumdar, J | 1 |
| Bhattacharya, S | 2 |
| Sur, P | 2 |
| Vedasiromoni, JR | 2 |
| Gambacorti-Passerini, C | 1 |
| Zucchetti, M | 1 |
| Russo, D | 1 |
| Frapolli, R | 1 |
| Verga, M | 1 |
| Bungaro, S | 1 |
| Tornaghi, L | 1 |
| Rossi, F | 1 |
| Pioltelli, P | 1 |
| Pogliani, E | 1 |
| Alberti, D | 1 |
| Corneo, G | 1 |
| D'Incalci, M | 1 |
| van der Hoorn, MA | 1 |
| van Luxemburg-Heijs, SA | 1 |
| van Bergen, CA | 1 |
| Bongaerts, R | 1 |
| Willemze, R | 1 |
| Falkenburg, JH | 1 |
| HAMMOUDA, F | 1 |
| QUAGLINO, D | 1 |
| HAYHOE, FG | 1 |
| HAMPEL, KE | 1 |
| PALME, G | 1 |
| Chasty, RC | 1 |
| Lucas, GS | 1 |
| Owen-Lynch, PJ | 1 |
| Pierce, A | 1 |
| Whetton, AD | 2 |
| Walter, H | 1 |
| Galand, P | 1 |
| Del Bino, G | 1 |
| Morret, M | 1 |
| Capel, P | 1 |
| Degraef, C | 1 |
| Fokan, D | 1 |
| Feremans, W | 1 |
| Gimsing, P | 1 |
| Hippe, E | 1 |
| Cashman, JD | 2 |
| Eaves, AC | 3 |
| Eaves, CJ | 3 |
| Tosi, P | 1 |
| Visani, G | 1 |
| Ottaviani, E | 1 |
| Gamberi, B | 1 |
| Cenacchi, A | 1 |
| Tura, S | 1 |
| Wolpe, SD | 1 |
| Berczi, A | 1 |
| Barabas, K | 1 |
| Sizensky, JA | 1 |
| Faulk, WP | 1 |
| Anderson, KM | 1 |
| Levin, J | 1 |
| Jajeh, A | 1 |
| Seed, T | 1 |
| Harris, JE | 1 |
| Alama, A | 1 |
| Meazza, R | 1 |
| Barbieri, F | 1 |
| Biassoni, R | 1 |
| Mazzei, M | 1 |
| Nicolin, A | 1 |
| Szczylik, C | 1 |
| Skórski, T | 1 |
| Malaguarnera, L | 1 |
| Hetman, J | 1 |
| Chen, ST | 1 |
| Calabretta, B | 1 |
| Wark, G | 1 |
| Heyworth, CM | 1 |
| Spooncer, E | 1 |
| Czaplewski, L | 1 |
| Francis, JM | 1 |
| Dexter, TM | 1 |
| Benthin, M | 1 |
| Dallmann, I | 1 |
| Atzpodien, J | 1 |
| Ghosh, M | 1 |
| Bhattacharya, M | 1 |
| Biswas, J | 1 |
| Malik, F | 1 |
| Delgado, C | 1 |
| Knüsli, C | 1 |
| Irvine, AE | 1 |
| Fisher, D | 1 |
| Francis, GE | 1 |
| Otsuka, T | 1 |
| Humphries, RK | 1 |
| Hogge, DE | 1 |
| Chitnis, MP | 2 |
| Kamath, NS | 1 |
| Parekh, HK | 2 |
| Advani, SH | 2 |
| Callea, V | 1 |
| Morabito, F | 1 |
| Lista, P | 1 |
| Pegoraro, L | 1 |
| Cambrin, GR | 1 |
| Guerrasio, A | 1 |
| Saglio, G | 1 |
| Tassinari, A | 1 |
| Fierro, MT | 1 |
| Iacopino, P | 1 |
| Sokal, JE | 1 |
| Pauly, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label Randomized Clinical Trial to Compare the Toxicities and Efficacy of Pharmacokinetically-guided and BSA Fixed Dosing Strategy of Docetaxel and Paclitaxel in Chinese Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma, and Breast Cancer Patie[NCT01891123] | 300 participants (Anticipated) | Interventional | 2013-06-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for thymidine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Benzamides; Blast Crisis; Cell Division; Female; H | 2003 |
25 other studies available for thymidine and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Nilotinib and imatinib inhibit cytarabine cellular uptake: implications for combination therapy.
Topics: Benzamides; Cytarabine; Drug Therapy, Combination; Humans; Imatinib Mesylate; Leukemia, Myelogenous, | 2012 |
Antineoplastic effect of new boron compounds against leukemic cell lines and cells from leukemic patients.
Topics: Acute Disease; Antineoplastic Agents; Apoptosis; Boron Compounds; Cell Division; Guanidines; HL-60 C | 2002 |
The progenitor cell inhibition assay to measure the anti-leukemic reactivity of T cell clones against acute and chronic myeloid leukemia.
Topics: Acute Disease; Antigens, CD34; Cell Division; Clone Cells; Colony-Forming Units Assay; Cytokines; Cy | 2003 |
BLASTIC CRISIS IN CHRONIC GRANULOCYTIC LEUKAEMIA. CYTOCHEMICAL, CYTOGENETIC, AND AUTORADIOGRAPHIC STUDIES IN FOUR CASES.
Topics: Adolescent; Alkaline Phosphatase; Autoradiography; Bone Marrow Examination; Busulfan; Chromosome Abe | 1964 |
[CHROMOSOME STUDIES IN ACUTE AND CHRONIC MYELOCYTIC LEUKEMIA].
Topics: Autoradiography; Chromosome Aberrations; Chromosomes; DNA; Humans; Leukemia, Myelogenous, Chronic, B | 1964 |
Macrophage inflammatory protein-1 alpha receptors are present on cells enriched for CD34 expression from patients with chronic myeloid leukemia.
Topics: Antigens, CD34; Base Sequence; Cell Cycle; Chemokine CCL4; Colony-Forming Units Assay; Cytokines; DN | 1995 |
Analytical applications of partitioning: detection of differences or changes in surface properties of mammalian cell populations.
Topics: Animals; Carbon Radioisotopes; Cell Cycle; Cell Differentiation; Cell Membrane; Cell Separation; Cel | 1994 |
PCNA immunopositivity index as a substitute to 3H-thymidine pulse-labeling index (TLI) in methanol-fixed human lymphocytes.
Topics: Autoradiography; Cell Line; Histological Techniques; Humans; Immunohistochemistry; Ki-67 Antigen; Le | 1995 |
Cobalamin-dependent metabolism in chronic myelogenous leukemia determined by deoxyuridine suppression test and the formiminoglutamic acid and methylmalonate excretion in urine.
Topics: Adolescent; Adult; Aged; Bone Marrow; Bone Marrow Cells; Deoxyuridine; Female; Formiminoglutamic Aci | 1995 |
The tetrapeptide AcSDKP specifically blocks the cycling of primitive normal but not leukemic progenitors in long-term culture: evidence for an indirect mechanism.
Topics: Amino Acid Sequence; Bone Marrow; Bone Marrow Cells; Cell Adhesion; Cell Cycle; Chemokine CCL4; Colo | 1994 |
Synergistic cytotoxicity of AZT plus alpha and gamma interferon in chronic myeloid leukemia cell line K562.
Topics: Cell Division; Cell Line; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Syner | 1993 |
Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; CHO Cells; Cricetinae; | 1993 |
Adriamycin conjugates of human transferrin bind transferrin receptors and kill K562 and HL60 cells.
Topics: Cell Survival; DNA Replication; Doxorubicin; Humans; Iodine Radioisotopes; Kinetics; Leukemia, Myelo | 1993 |
Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetamides; Amides; Apoptosis; Base Sequence; Blast Crisis; Blood C | 1993 |
Antiproliferative effect of DNA polymerase alpha antisense oligodeoxynucleotides on breast cancer cells.
Topics: Adenocarcinoma; Base Sequence; Breast Neoplasms; Cell Division; DNA Polymerase II; DNA Replication; | 1993 |
Inhibition of in vitro proliferation of chronic myelogenous leukemia progenitor cells by c-myb antisense oligodeoxynucleotides.
Topics: Antigens, CD34; beta 2-Microglobulin; Blast Crisis; Cell Division; DNA Primers; Down-Regulation; Hem | 1996 |
Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 alpha.
Topics: Calcium; Chemokine CCL3; Chemokine CCL4; DNA Replication; Growth Inhibitors; Hematopoietic Stem Cell | 1998 |
13cis- and all-trans retinoic acid have antiproliferative effects on CML cells and render IFN alpha antiproliferative potency after combined treatment in vitro.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Drug Synergism | 2001 |
Boron compounds against human leukemic cells.
Topics: Apoptosis; Boron Compounds; Cell Division; DNA, Neoplasm; Guanidines; Humans; Leukemia, Myelogenous, | 2001 |
Polyethylene glycol (PEG)-modified granulocyte-macrophage colony-stimulating factor (GM-CSF) with conserved biological activity.
Topics: Animals; Biological Availability; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Chromatography, L | 1992 |
Lack of evidence for abnormal autocrine or paracrine mechanisms underlying the uncontrolled proliferation of primitive chronic myeloid leukemia progenitor cells.
Topics: Bone Marrow; Bone Marrow Cells; Cell Adhesion; Cell Cycle; Cell Division; Cells, Cultured; Hematopoi | 1991 |
Dipyrone enhances intracellular accumulation and cytotoxicity of adriamycin in human chronic myeloid leukemia cells.
Topics: Cell Survival; Dipyrone; DNA; Doxorubicin; Drug Evaluation, Preclinical; Drug Synergism; Humans; Leu | 1991 |
Abrogation of human chronic myeloid leukemia cells insensitivity to adriamycin and mitoxanthrone cytotoxicity by quinidine.
Topics: Cell Survival; DNA Replication; DNA, Neoplasm; Doxorubicin; Humans; Kinetics; Leukemia, Myelogenous, | 1990 |
Multilineage cell involvement in Ph1-negative, bcr-negative chronic myeloid leukemia.
Topics: Aged; Antigens, Differentiation, T-Lymphocyte; Biomarkers, Tumor; Cell Differentiation; Chromosome A | 1988 |
In vitro thymidine uptake by circulating leukocytes.
Topics: Adult; Biological Transport; Cells, Cultured; Hematologic Diseases; Humans; Leukemia; Leukemia, Lymp | 1974 |