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thymidine and Koch's Disease

thymidine has been researched along with Koch's Disease in 26 studies

Research Excerpts

ExcerptRelevanceReference
"We report the synthesis of 5'-modified thymidines (16, 18, 21, 23) and 5,5'-bis-substituted 2'-deoxyuridine analogues (30, 47) as inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt)."7.79Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors. ( Frecer, V; Munier-Lehmann, H; Risseeuw, MD; Toti, KS; Van Calenbergh, S; Verbeke, F, 2013)
"Thymidine monophosphate kinase (TMPK(mt)) is an essential enzyme for nucleotide metabolism in Mycobacterium tuberculosis, and thus an attractive target for novel antituberculosis agents."7.77Computer-assisted combinatorial design of bicyclic thymidine analogs as inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. ( Frecer, V; Miertus, S; Seneci, P, 2011)
"We report on Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) inhibitory activities of a series of new 3'- and 5'-modified thymidine analogues including α- and β-derivatives."7.77Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase. ( Froeyen, M; Helynck, O; Munier-Lehmann, H; Van Calenbergh, S; Van Poecke, S, 2011)
"We report the synthesis of 5'-modified thymidines (16, 18, 21, 23) and 5,5'-bis-substituted 2'-deoxyuridine analogues (30, 47) as inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt)."3.79Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors. ( Frecer, V; Munier-Lehmann, H; Risseeuw, MD; Toti, KS; Van Calenbergh, S; Verbeke, F, 2013)
"Thymidine monophosphate kinase (TMPK(mt)) is an essential enzyme for nucleotide metabolism in Mycobacterium tuberculosis, and thus an attractive target for novel antituberculosis agents."3.77Computer-assisted combinatorial design of bicyclic thymidine analogs as inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. ( Frecer, V; Miertus, S; Seneci, P, 2011)
"We report on Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) inhibitory activities of a series of new 3'- and 5'-modified thymidine analogues including α- and β-derivatives."3.77Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase. ( Froeyen, M; Helynck, O; Munier-Lehmann, H; Van Calenbergh, S; Van Poecke, S, 2011)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199020 (76.92)18.7374
1990's1 (3.85)18.2507
2000's1 (3.85)29.6817
2010's4 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrade, CH1
Pasqualoto, KF1
Ferreira, EI1
Hopfinger, AJ1
Frecer, V2
Seneci, P1
Miertus, S1
Van Poecke, S1
Munier-Lehmann, H2
Helynck, O1
Froeyen, M1
Van Calenbergh, S2
Toti, KS1
Verbeke, F1
Risseeuw, MD1
WOLFART, W1
Sellam, J1
Hamdi, H1
Roy, C1
Baron, G1
Lemann, M1
Puéchal, X1
Breban, M1
Berenbaum, F1
Humbert, M1
Weldingh, K1
Salmon, D1
Ravaud, P1
Emilie, D1
Mariette, X1
Watson, SR1
Collins, FM1
Lefford, MJ2
Muscoplat, CC1
Thoen, CO1
Chen, AW1
Rakich, PM1
Johnson, DW1
Kutsukake, H1
Nagao, S1
Tanaka, A1
Nilsson, BS2
Vischer, TL1
Baram, P2
Soltysik, L1
Condoulis, W1
Condoulis, WV1
Soltysik, LM1
North, RJ1
Ando, M1
McGregor, DD1
Mackaness, GB1
Averbakh, MM4
Puzik, VI1
Salvo, VF1
Litvinov, VI4
Moroz, AM2
Gogebashvili, NV1
Chaparas, SD2
Hedrick, SR2
Clark, RG1
Garman, R1
Dove, JT1
Kerby, GR1
Thurmon, TF1
LaPolla, JJ1
Kent, DC1

Other Studies

26 other studies available for thymidine and Koch's Disease

ArticleYear
3D-Pharmacophore mapping of thymidine-based inhibitors of TMPK as potential antituberculosis agents.
    Journal of computer-aided molecular design, 2010, Volume: 24, Issue:2

    Topics: Algorithms; Antitubercular Agents; Binding Sites; Computer Simulation; Enzyme Inhibitors; Molecular

2010
Computer-assisted combinatorial design of bicyclic thymidine analogs as inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
    Journal of computer-aided molecular design, 2011, Volume: 25, Issue:1

    Topics: Antitubercular Agents; Binding Sites; Drug Design; Humans; Models, Molecular; Mycobacterium tubercul

2011
Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase.
    Bioorganic & medicinal chemistry, 2011, Dec-15, Volume: 19, Issue:24

    Topics: Humans; Models, Molecular; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Protein Kinase I

2011
Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.
    Bioorganic & medicinal chemistry, 2013, Jan-01, Volume: 21, Issue:1

    Topics: Antitubercular Agents; Humans; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Thymidine; T

2013
[HISTOAUTORADIOGRAPHIC STUDIES ON THE METABOLISM AND GENESIS OF TUBERCULOUS GRANULATION TISSUE. (DETERMINED WITH RADIOACTIVE LABELLED H3-THYMIDINE, H3-CYTIDINE AND H3-PHENYLALANINE)].
    Beitrage zur pathologischen Anatomie und zur allgemeinen Pathologie, 1964, Volume: 129

    Topics: Autoradiography; Cell Division; Cytidine; DNA; Granulation Tissue; Guinea Pigs; Nucleosides; Phenyla

1964
Comparison of in vitro-specific blood tests with tuberculin skin test for diagnosis of latent tuberculosis before anti-TNF therapy.
    Annals of the rheumatic diseases, 2007, Volume: 66, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, Bacterial; Antitubercular Agents; Bacterial Pr

2007
Development of suppressor T cells in mice heavily infected with mycobacteria.
    Immunology, 1980, Volume: 39, Issue:3

    Topics: Animals; Hypersensitivity, Delayed; Lymphocyte Activation; Mice; Mycobacterium bovis; Mycobacterium

1980
Properties of peritoneal exudate lymphocytes that mediate tuberculin delayed-type hypersensitivity and anti-tuberculosis immunity. I. The effect of cytotoxic agents.
    Immunology, 1980, Volume: 41, Issue:3

    Topics: Animals; Ascitic Fluid; BCG Vaccine; Bromodeoxyuridine; Female; Hypersensitivity, Delayed; Immunity,

1980
Development of specific lymphocyte immunostimulation and tuberculin skin reactivity in swine infected with Mycobacterium bovis and Mycobacterium avium.
    American journal of veterinary research, 1975, Volume: 36, Issue:08

    Topics: Administration, Oral; Animals; Female; Lymph Nodes; Lymphocyte Activation; Mycobacterium; Mycobacter

1975
Arrest of DNA replication of macrophages in BCG granuloma and peritoneal exudates by bacteria.
    Microbiology and immunology, 1990, Volume: 34, Issue:2

    Topics: Animals; DNA Replication; Female; Glucosamine; Granuloma; Guinea Pigs; Kinetics; Macrophages; Male;

1990
Rifampicin: an immunosuppressant?
    Lancet (London, England), 1971, Aug-14, Volume: 2, Issue:7720

    Topics: Culture Techniques; DNA; Humans; Immune Tolerance; Immunosuppression Therapy; Immunosuppressive Agen

1971
Lymphocyte cultures in drug hypersensitivity.
    Lancet (London, England), 1966, Aug-27, Volume: 2, Issue:7461

    Topics: Culture Media; DNA; Drug Hypersensitivity; Humans; In Vitro Techniques; Lymphocytes; Penicillin G; T

1966
The in vitro assay of tuberculin hypersensitivity in Macaca mulatta sensitized with bacille Calmette Guerin cell wall vaccine and-or infected with virulent Mycobacterium tuberculosis.
    Laboratory animal science, 1971, Volume: 21, Issue:5

    Topics: Animals; BCG Vaccine; Haplorhini; Hypersensitivity, Delayed; Lymphocytes; Macaca; Monkey Diseases; M

1971
The in vitro assay of tuberculin hypersensitivity in Macaca mulatta. II. A modified assay requiring 1 milliliter of blood.
    Journal of medical primatology, 1974, Volume: 3, Issue:4

    Topics: Animals; BCG Vaccine; Blood; Cell Separation; Female; Freund's Adjuvant; Hypersensitivity, Delayed;

1974
Importance of thymus-derived lymphocytes in cell-mediated immunity to infection.
    Cellular immunology, 1973, Volume: 7, Issue:1

    Topics: Animals; Antilymphocyte Serum; Autoradiography; Cell Division; Female; Immunity, Cellular; Immunizat

1973
Macrophage activation in tuberculin reactions of rabbits with primary BCG infection and reinfection.
    Journal of the Reticuloendothelial Society, 1973, Volume: 14, Issue:2

    Topics: Animals; Biopsy; Bone Marrow; Cell Division; Female; Galactosidases; Hypersensitivity, Delayed; Lyso

1973
Properties of lymphocytes which confer adoptive immunity to tuberculosis in rats.
    Immunology, 1973, Volume: 25, Issue:4

    Topics: Animals; BCG Vaccine; Female; Immunization, Passive; Lymphocytes; Rats; Rifampin; Thymidine; Tritium

1973
[Immunomorphology of elevated delayed-type sensitivity in tuberculosis].
    Arkhiv patologii, 1973, Volume: 35, Issue:3

    Topics: Animals; Antilymphocyte Serum; Autoradiography; BCG Vaccine; Guinea Pigs; Hypersensitivity, Delayed;

1973
[The effect of antilymphocytic serum on the increased sensitivity of the delayed type in tuberculosis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1973, Volume: 75, Issue:1

    Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Antigen-Antibody Reactions; Antilymphocyte Serum; B

1973
[The effect of antilymphocyte serum on the increased sensitivity of the delayed type in tuberculosis].
    Biulleten' eksperimental'noi biologii i meditsiny, 1973, Volume: 75, Issue:3

    Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Antilymphocyte Serum; Autoradiography; BCG Vaccine;

1973
[Nucleic acid content and antibody synthesis in tuberculosis].
    Arkhiv patologii, 1971, Volume: 33, Issue:9

    Topics: Animals; Antibody Formation; Autoradiography; BCG Vaccine; DNA; Fluorescent Antibody Technique; Guin

1971
Comparison of the lymphocyte transformation test with the tuberculin test in rhesus monkeys and chimpanzees.
    American journal of veterinary research, 1970, Volume: 31, Issue:8

    Topics: Animals; Antigens; BCG Vaccine; Haplorhini; Hominidae; Lymphocyte Activation; Lymphocytes; Monkey Di

1970
Failure to demonstrate transformation of lymphocytes of patients with isoniazid-associated hepatitis.
    The American review of respiratory disease, 1972, Volume: 106, Issue:3

    Topics: Aspartate Aminotransferases; Autoradiography; Cells, Cultured; Chemical and Drug Induced Liver Injur

1972
In vitro lymphocyte reactivity to PPD and phytohaemagglutinin in relation to PPD skin reactivity and age.
    Scandinavian journal of respiratory diseases, 1971, Volume: 52, Issue:1

    Topics: Adult; Age Factors; Aged; Antigens; Carbon Isotopes; Cell Count; Female; Humans; Immune Sera; In Vit

1971
Correlation of tuberculin skin reaction with in vitro lymphocyte transformation.
    The American review of respiratory disease, 1968, Volume: 97, Issue:5

    Topics: Antigen-Antibody Reactions; Autoradiography; Culture Techniques; Humans; Hypersensitivity, Delayed;

1968
In vivo responses of human lymphocytes to PPD. The use of a liquid scintillation technique.
    The American review of respiratory disease, 1968, Volume: 98, Issue:3

    Topics: Antigen-Antibody Reactions; DNA; Humans; Lymphocytes; Male; Methods; Radiometry; Thymidine; Tritium;

1968