Page last updated: 2024-11-06

thymidine and Kidney Calculi

thymidine has been researched along with Kidney Calculi in 2 studies

Kidney Calculi: Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Schepers, MS	2
van Ballegooijen, ES	2
Bangma, CH	2
Verkoelen, CF	2

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 DiabetesL a Open-label Trial[NCT02502071]			Phase 4	45 participants (Actual)	Interventional	2017-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Number of Participants With Urine Uric Acid Precipitation by Polarized Microscopy

Urine uric acid crystals were identified by polarized microscopy (Polarized light imaging Zeiss Axiovert 135; 0.3NA objective), and pictures were captured from each urine sample. UA crystals were defined dichotomously as being present or absent. (NCT02502071)
Timeframe: Day 1 (pre-therapy) and Day 2 (post-therapy)

Intervention	participants (Number)
	Day 1 (pre-therapy)	Day 2 (post-therapy)
Sodium Bicarbonate	14	3

Change in Urine Uric Acid Concentration (Increased Solubility) by Assay

Urine uric acid were evaluated using a QuantiChrom UA kit assay (DIUA-250) with quantitative colorimetric UA determination at 590 nm (BioAssay System, California, USA). (NCT02502071)
Timeframe: Day 1 (pre-therapy) and Day 2 (post-therapy)

Intervention	mg/dl (Geometric Mean)
	Day 1 (pre-therapy)	Day 2 (post-therapy)
Sodium Bicarbonate	23.81	22.30

Other Studies

2 other studies available for thymidine and Kidney Calculi

Article	Year
Crystals cause acute necrotic cell death in renal proximal tubule cells, but not in collecting tubule cells. Kidney international, 2005, Volume: 68, Issue:4 Topics: Animals; Apoptosis; Calcium Oxalate; Crystallization; Culture Media; Dinoprostone; Dogs; Humans; Hyd	2005
Oxalate is toxic to renal tubular cells only at supraphysiologic concentrations. Kidney international, 2005, Volume: 68, Issue:4 Topics: Animals; Apoptosis; Calcium Oxalate; Cell Count; Cell Line; Crystallization; Dinoprostone; Dogs; Dos	2005