Page last updated: 2024-11-06

thymidine and Kernicterus

thymidine has been researched along with Kernicterus in 2 studies

Kernicterus: A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)

Research Excerpts

ExcerptRelevanceReference
"Clinical studies have suggested that the early stages of bilirubin encephalopathy are reversible."7.67Bilirubin toxicity in a neuroblastoma cell line N-115: II. Delayed effects and recovery. ( Amit, Y; Poznansky, MJ; Schiff, D, 1989)
"Though bilirubin is reported to affect a variety of cellular functions, the primary target of its toxic effect is still not known."5.28Bilirubin toxicity in a neuroblastoma cell line N-115: I. Effects on Na+K+ ATPase, [3H]-thymidine uptake, L-[35S]-methionine incorporation, and mitochondrial function. ( Amit, Y; Chan, G; Fedunec, S; Poznansky, MJ; Schiff, D, 1989)
"Clinical studies have suggested that the early stages of bilirubin encephalopathy are reversible."3.67Bilirubin toxicity in a neuroblastoma cell line N-115: II. Delayed effects and recovery. ( Amit, Y; Poznansky, MJ; Schiff, D, 1989)
"Though bilirubin is reported to affect a variety of cellular functions, the primary target of its toxic effect is still not known."1.28Bilirubin toxicity in a neuroblastoma cell line N-115: I. Effects on Na+K+ ATPase, [3H]-thymidine uptake, L-[35S]-methionine incorporation, and mitochondrial function. ( Amit, Y; Chan, G; Fedunec, S; Poznansky, MJ; Schiff, D, 1989)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Amit, Y2
Chan, G1
Fedunec, S1
Poznansky, MJ2
Schiff, D2

Other Studies

2 other studies available for thymidine and Kernicterus

ArticleYear
Bilirubin toxicity in a neuroblastoma cell line N-115: I. Effects on Na+K+ ATPase, [3H]-thymidine uptake, L-[35S]-methionine incorporation, and mitochondrial function.
    Pediatric research, 1989, Volume: 25, Issue:4

    Topics: Albumins; Bilirubin; Kernicterus; Methionine; Mitochondria; Neuroblastoma; Neurons; Potassium; Sodiu

1989
Bilirubin toxicity in a neuroblastoma cell line N-115: II. Delayed effects and recovery.
    Pediatric research, 1989, Volume: 25, Issue:4

    Topics: Albumins; Animals; Bilirubin; Dose-Response Relationship, Drug; Kernicterus; Methionine; Mice; Mitoc

1989