thymidine has been researched along with Kernicterus in 2 studies
Kernicterus: A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clinical studies have suggested that the early stages of bilirubin encephalopathy are reversible." | 7.67 | Bilirubin toxicity in a neuroblastoma cell line N-115: II. Delayed effects and recovery. ( Amit, Y; Poznansky, MJ; Schiff, D, 1989) |
| "Though bilirubin is reported to affect a variety of cellular functions, the primary target of its toxic effect is still not known." | 5.28 | Bilirubin toxicity in a neuroblastoma cell line N-115: I. Effects on Na+K+ ATPase, [3H]-thymidine uptake, L-[35S]-methionine incorporation, and mitochondrial function. ( Amit, Y; Chan, G; Fedunec, S; Poznansky, MJ; Schiff, D, 1989) |
| "Clinical studies have suggested that the early stages of bilirubin encephalopathy are reversible." | 3.67 | Bilirubin toxicity in a neuroblastoma cell line N-115: II. Delayed effects and recovery. ( Amit, Y; Poznansky, MJ; Schiff, D, 1989) |
| "Though bilirubin is reported to affect a variety of cellular functions, the primary target of its toxic effect is still not known." | 1.28 | Bilirubin toxicity in a neuroblastoma cell line N-115: I. Effects on Na+K+ ATPase, [3H]-thymidine uptake, L-[35S]-methionine incorporation, and mitochondrial function. ( Amit, Y; Chan, G; Fedunec, S; Poznansky, MJ; Schiff, D, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amit, Y | 2 |
| Chan, G | 1 |
| Fedunec, S | 1 |
| Poznansky, MJ | 2 |
| Schiff, D | 2 |
2 other studies available for thymidine and Kernicterus
| Article | Year |
|---|---|
Bilirubin toxicity in a neuroblastoma cell line N-115: I. Effects on Na+K+ ATPase, [3H]-thymidine uptake, L-[35S]-methionine incorporation, and mitochondrial function.
Topics: Albumins; Bilirubin; Kernicterus; Methionine; Mitochondria; Neuroblastoma; Neurons; Potassium; Sodiu | 1989 |
Bilirubin toxicity in a neuroblastoma cell line N-115: II. Delayed effects and recovery.
Topics: Albumins; Animals; Bilirubin; Dose-Response Relationship, Drug; Kernicterus; Methionine; Mice; Mitoc | 1989 |