thymidine has been researched along with Kahler Disease in 92 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aims of this study were to evaluate the possibility of using (11)C-methionine ((11)C-MET) and (11)C-4'-thiothymidine ((11)C-4DST) whole-body PET/CT for the imaging of amino acid metabolism and DNA synthesis, respectively, when searching for bone marrow involvement in patients with multiple myeloma (MM) and to compare these findings with those for (18)F-FDG PET/CT and aspiration cytology." | 7.81 | Comparison of (11)C-4'-thiothymidine, (11)C-methionine, and (18)F-FDG PET/CT for the detection of active lesions of multiple myeloma. ( Hagiwara, S; Hirai, R; Inoue, T; Ishiwata, K; Ito, K; Kubota, K; Minamimoto, R; Miwa, A; Miyata, Y; Morooka, M; Okasaki, M; Toyohara, J, 2015) |
| "The effect of IFN alpha-2b on thymidine, uridine, and leucine uptake was examined on peripheral blood mononuclear cells (PBMC) of healthy donors and 15 patients with multiple myeloma (MM)." | 7.68 | The effect of alpha-interferon on thymidine, uridine, and leucine uptake and ultrastructure of peripheral blood mononuclear cells from multiple myeloma patients. ( Cohen, AM; Djaldetti, M; Fishman, P; Winder, A, 1993) |
| "The aims of this study were to evaluate the possibility of using (11)C-methionine ((11)C-MET) and (11)C-4'-thiothymidine ((11)C-4DST) whole-body PET/CT for the imaging of amino acid metabolism and DNA synthesis, respectively, when searching for bone marrow involvement in patients with multiple myeloma (MM) and to compare these findings with those for (18)F-FDG PET/CT and aspiration cytology." | 3.81 | Comparison of (11)C-4'-thiothymidine, (11)C-methionine, and (18)F-FDG PET/CT for the detection of active lesions of multiple myeloma. ( Hagiwara, S; Hirai, R; Inoue, T; Ishiwata, K; Ito, K; Kubota, K; Minamimoto, R; Miwa, A; Miyata, Y; Morooka, M; Okasaki, M; Toyohara, J, 2015) |
| "This study found that oridonin, a natural diterpenoid purified from Rabdosia rubescens, inhibited growth of multiple myeloma (MM; U266, RPMI8226), acute lymphoblastic T-cell leukemia (Jurkat), and adult T-cell leukemia (MT-1) cells with an effective dose that inhibited 50% of target cells (ED50) ranging from 0." | 3.73 | Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. ( Bandobashi, K; Ikezoe, T; Koeffler, HP; Machida, H; Saito, T; Taguchi, H; Takemoto, S; Togitani, K; Yang, Y, 2005) |
| "The effect of IFN alpha-2b on thymidine, uridine, and leucine uptake was examined on peripheral blood mononuclear cells (PBMC) of healthy donors and 15 patients with multiple myeloma (MM)." | 3.68 | The effect of alpha-interferon on thymidine, uridine, and leucine uptake and ultrastructure of peripheral blood mononuclear cells from multiple myeloma patients. ( Cohen, AM; Djaldetti, M; Fishman, P; Winder, A, 1993) |
| "Simultaneous evaluation of bone marrow plasma cell thymidine labelling index (LI) and serum beta-2-microglobulin (SB2M) was performed in 146 patients with multiple myeloma (MM) or monoclonal gammopathy of undetermined significance (MGUS)." | 3.67 | Lack of correlation between plasma cell thymidine labelling index and serum beta-2-microglobulin in monoclonal gammopathies. ( Boccadoro, M; D'Alberto, M; Durie, BG; Frutiger, Y; Gallamini, A; Gavarotti, P; Marmont, F; Massaia, M; Redoglia, V; Tribalto, M, 1987) |
| "DNA synthesis time (Ts) and 3H thymidine (TdR) labelling index (LI) of bone marrow (BM) myelomatous plasma cells (PC) and of the residual haemopoietic cell population (RHCP) were measured by in vitro quantitative 14C-TdR autoradiography in five patients with multiple myeloma (MM) in different phases of disease (three at presentation and two at relapse) and in one patient with solitary extra-osseous myeloma." | 3.67 | Proliferation kinetics of plasma cells and of normal haemopoietic cells in multiple myeloma. ( Ciotti, R; Danova, M; Dörmer, P; Girino, M; Luoni, R; Montecucco, CM; Riccardi, A; Ucci, G, 1987) |
| "Tritiated thymidine labeling indices (LI), although useful in diagnosis and prognosis of multiple myeloma, have not found wide-spread application because autoradiographic analysis is difficult and time consuming." | 3.67 | Immunofluorescent plasma cell labeling indices (LI) using a monoclonal antibody (BU-1). ( Gonchoroff, NJ; Greipp, PR; Witzig, TE, 1985) |
| "Ninety-seven patients with multiple myeloma evaluated serially had both a tritiated thymidine labeling index of bone marrow plasma cells (LI%) and in vitro myeloma stem cell culture performed." | 3.66 | Human myeloma in vitro colony growth: interrelationships between drug sensitivity, cell kinetics, and patient survival duration. ( Durie, BG; Salmon, SE; Young, LA, 1983) |
| "Sequential sera from 45 patients with multiple myeloma (MM) and from 6 patients with solid tumors but normal bone marrows who received cyclophosphamide, 15 mg/kg/day for 4 days, were assayed for their effects on tritiated thymidine (3H-TdR) incorporation by normal bone marrow cells and malignant plasma cells." | 3.65 | Induction of serum stimulation and plasma cell proliferation during chemotherapy of multiple myeloma. ( Burke, PJ; Humphrey, RL; Karp, JE, 1977) |
| "Thymidine was purified to homogeneity (4mg purified from 3l of culture medium) and identified as such by nuclear magnetic resonance spectroscopy." | 1.33 | Thymidine secretion by hybridoma and myeloma cells. ( Nissen-Meyer, J; Petersen, D; Rise, F; Spilsberg, B, 2006) |
| "Multiple myeloma is a B-cell cancer characterized by the proliferation of malignant plasma cells in the bone marrow, increased angiogenesis, and the development of osteolytic bone disease." | 1.32 | Multifunctional role of matrix metalloproteinases in multiple myeloma: a study in the 5T2MM mouse model. ( Asosingh, K; Blacher, S; Carron, C; Croucher, PI; De Bruyne, E; De Leenheer, E; De Raeve, H; Devy, L; Noël, A; Van Camp, B; Van Riet, I; Van Valckenborgh, E; Vanderkerken, K, 2004) |
| "CD74 was expressed by most multiple myeloma cell lines, as was CD74 mRNA, at levels mirroring CD74 protein." | 1.32 | CD74 is expressed by multiple myeloma and is a promising target for therapy. ( Burton, JD; Cardillo, TM; Ely, S; Gold, DV; Goldenberg, DM; Reddy, PK; Stein, R, 2004) |
| " We studied cytotoxic effects of selected toxic light chains in further detail." | 1.31 | Cytotoxicity of myeloma light chains in cultured human kidney proximal tubule cells. ( Batuman, V; Meleg-Smith, S; Pote, A; Simon, EE; Zwizinski, C, 2000) |
| "Fifty-three patients had symptomatic multiple myeloma (MM) at diagnosis, nine were in stable remission, six in unstable remission, and 16 in the relapse phase." | 1.27 | Low plasma cell 3(H) thymidine incorporation in monoclonal gammopathy of undetermined significance (MGUS), smouldering myeloma and remission phase myeloma: a reliable indicator of patients not requiring therapy. ( Boccadoro, M; Fossati, G; Gallamini, A; Gavarotti, P; Marmont, F; Neretto, G; Pileri, A; Testa, MG; Tribalto, M; Volta, C, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 72 (78.26) | 18.7374 |
| 1990's | 8 (8.70) | 18.2507 |
| 2000's | 9 (9.78) | 29.6817 |
| 2010's | 3 (3.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Slørdahl, TS | 1 |
| Denayer, T | 1 |
| Moen, SH | 1 |
| Standal, T | 1 |
| Børset, M | 1 |
| Ververken, C | 1 |
| Rø, TB | 1 |
| Okasaki, M | 1 |
| Kubota, K | 1 |
| Minamimoto, R | 1 |
| Miyata, Y | 1 |
| Morooka, M | 1 |
| Ito, K | 1 |
| Ishiwata, K | 1 |
| Toyohara, J | 1 |
| Inoue, T | 1 |
| Hirai, R | 1 |
| Hagiwara, S | 1 |
| Miwa, A | 1 |
| Yu, X | 1 |
| McGraw, PA | 1 |
| House, FS | 1 |
| Crowe, JE | 1 |
| Morgenroth, A | 1 |
| Dinger, C | 1 |
| Zlatopolskiy, BD | 1 |
| Al-Momani, E | 1 |
| Glatting, G | 1 |
| Mottaghy, FM | 1 |
| Reske, SN | 1 |
| KILLMANN, SA | 2 |
| CRONKITE, EP | 2 |
| FLIEDNER, TM | 2 |
| BOND, VP | 2 |
| Van Valckenborgh, E | 1 |
| Croucher, PI | 1 |
| De Raeve, H | 1 |
| Carron, C | 1 |
| De Leenheer, E | 1 |
| Blacher, S | 1 |
| Devy, L | 1 |
| Noël, A | 1 |
| De Bruyne, E | 1 |
| Asosingh, K | 1 |
| Van Riet, I | 1 |
| Van Camp, B | 1 |
| Vanderkerken, K | 1 |
| Burton, JD | 1 |
| Ely, S | 1 |
| Reddy, PK | 1 |
| Stein, R | 1 |
| Gold, DV | 1 |
| Cardillo, TM | 1 |
| Goldenberg, DM | 1 |
| Qian, S | 1 |
| Somlo, G | 1 |
| Zhou, B | 1 |
| Zhu, L | 1 |
| Mi, S | 1 |
| Mo, X | 1 |
| Cheung, EM | 1 |
| Qiu, W | 1 |
| Lin, RJ | 1 |
| Rossi, J | 1 |
| Holtz, M | 1 |
| Chu, P | 1 |
| Yen, Y | 1 |
| Ikezoe, T | 1 |
| Yang, Y | 1 |
| Bandobashi, K | 1 |
| Saito, T | 1 |
| Takemoto, S | 1 |
| Machida, H | 1 |
| Togitani, K | 1 |
| Koeffler, HP | 1 |
| Taguchi, H | 1 |
| Spilsberg, B | 2 |
| Rise, F | 2 |
| Petersen, D | 2 |
| Nissen-Meyer, J | 2 |
| O'Connor, KC | 1 |
| Muhitch, JW | 1 |
| Lacks, DJ | 1 |
| Al-Rubeai, M | 1 |
| McGowan, JJ | 1 |
| Wagner, RR | 1 |
| Greipp, PR | 3 |
| Kyle, RA | 2 |
| Perri, RT | 1 |
| Oken, MM | 1 |
| Kay, NE | 1 |
| Boccadoro, M | 6 |
| Gavarotti, P | 5 |
| Fossati, G | 2 |
| Pileri, A | 6 |
| Marmont, F | 2 |
| Neretto, G | 1 |
| Gallamini, A | 3 |
| Volta, C | 1 |
| Tribalto, M | 2 |
| Testa, MG | 1 |
| Massaia, M | 2 |
| Durie, BG | 5 |
| Karp, JE | 2 |
| Burke, PJ | 2 |
| Saylor, PL | 1 |
| Humphrey, RL | 2 |
| Young, LA | 1 |
| Salmon, SE | 4 |
| Shimizu, T | 1 |
| Motoji, T | 1 |
| Oshimi, K | 1 |
| Mizoguchi, H | 1 |
| Hofmann, V | 1 |
| Wetter, O | 1 |
| Linder, KH | 1 |
| Hossfeld, DK | 1 |
| Lunscken, C | 1 |
| Schmitt-Gräff, A | 1 |
| Drewinko, B | 3 |
| Alexanian, R | 4 |
| Boyer, H | 1 |
| Barlogie, B | 2 |
| Rubinow, SI | 1 |
| Shima, Y | 1 |
| Nishimoto, N | 1 |
| Ogata, A | 1 |
| Fujii, Y | 1 |
| Yoshizaki, K | 1 |
| Kishimoto, T | 2 |
| Anthes, JC | 1 |
| Zhan, Z | 1 |
| Gilchrest, H | 1 |
| Egan, RW | 1 |
| Siegel, MI | 1 |
| Billah, MM | 1 |
| Ahmed, SA | 1 |
| Gogal, RM | 1 |
| Walsh, JE | 1 |
| Winder, A | 1 |
| Fishman, P | 1 |
| Djaldetti, M | 1 |
| Cohen, AM | 1 |
| Diamant, M | 1 |
| Hansen, MB | 1 |
| Rieneck, K | 1 |
| Svenson, M | 1 |
| Yasukawa, K | 1 |
| Bendtzen, K | 1 |
| Villunger, A | 1 |
| Egle, A | 1 |
| Kos, M | 1 |
| Egle, D | 1 |
| Tinhofer, I | 1 |
| Henn, T | 1 |
| Uberall, F | 1 |
| Maly, K | 1 |
| Greil, R | 1 |
| Couturier, O | 1 |
| Faivre-Chauvet, A | 1 |
| Filippovich, IV | 1 |
| Thédrez, P | 1 |
| Saï-Maurel, C | 1 |
| Bardiès, M | 1 |
| Mishra, AK | 1 |
| Gauvrit, M | 1 |
| Blain, G | 1 |
| Apostolidis, C | 1 |
| Molinet, R | 1 |
| Abbe, JC | 1 |
| Bataille, R | 1 |
| Wijdenes, J | 1 |
| Chatal, JF | 1 |
| Chérel, M | 1 |
| Pote, A | 1 |
| Zwizinski, C | 1 |
| Simon, EE | 1 |
| Meleg-Smith, S | 1 |
| Batuman, V | 1 |
| Jentzsch, K | 1 |
| Bernengo, MG | 1 |
| Conte, P | 1 |
| Marinone, C | 1 |
| Masera, P | 2 |
| Brent, JA | 1 |
| Bojko, CH | 1 |
| Hollander, VP | 1 |
| Knapp, W | 1 |
| Baumgartner, G | 1 |
| Warner, TF | 1 |
| Krueger, RG | 1 |
| Kearney, JF | 1 |
| Lawton, AR | 1 |
| Ziegler, JB | 1 |
| Hansen, PJ | 1 |
| Penny, R | 1 |
| Byars, N | 1 |
| Kidson, C | 2 |
| Roe, BA | 1 |
| Chen, EY | 1 |
| Tsen, HY | 1 |
| Gola, A | 1 |
| Kuliczkowski, K | 1 |
| Sedek, K | 1 |
| McGuire, Wl | 1 |
| Meyer, JS | 1 |
| Kute, TE | 1 |
| Ogmundsdóttir, HM | 1 |
| Myoken, Y | 1 |
| Okamoto, T | 1 |
| Osaki, T | 1 |
| Yabumoto, M | 1 |
| Sato, GH | 1 |
| Takada, K | 1 |
| Sato, JD | 1 |
| Evans, CE | 1 |
| Galasko, CS | 1 |
| Ward, C | 1 |
| Fernandez-Pol, JA | 1 |
| Frutiger, Y | 1 |
| Redoglia, V | 3 |
| D'Alberto, M | 1 |
| Asaoku, H | 1 |
| Kawano, M | 1 |
| Iwato, K | 1 |
| Tanabe, O | 1 |
| Tanaka, H | 1 |
| Hirano, T | 1 |
| Kuramoto, A | 1 |
| Ucci, G | 1 |
| Riccardi, A | 1 |
| Dörmer, P | 1 |
| Danova, M | 1 |
| Luoni, R | 1 |
| Montecucco, CM | 1 |
| Ciotti, R | 1 |
| Girino, M | 1 |
| Lokhorst, HM | 1 |
| Boom, SE | 1 |
| Bast, BJ | 1 |
| Ballieux, RE | 1 |
| Jernberg, H | 1 |
| Björklund, G | 1 |
| Nilsson, K | 2 |
| Yabe, N | 1 |
| Matsuya, Y | 1 |
| Yamane, I | 1 |
| Takada, M | 1 |
| Ciaiolo, C | 1 |
| Golzio, F | 1 |
| Omedè, P | 1 |
| Witzig, TE | 1 |
| Gonchoroff, NJ | 1 |
| Raymond, NM | 1 |
| O'Fallon, WM | 1 |
| Bjerrum, OW | 1 |
| Plesner, T | 1 |
| Fruttero, A | 1 |
| Buffa, F | 1 |
| Ruá, S | 1 |
| Namba, Y | 2 |
| Kimmel, CB | 1 |
| Tarocco, RP | 2 |
| Mavligit, GM | 1 |
| Gutterman, JU | 1 |
| Hersh, EM | 1 |
| Quaglino, D | 1 |
| Torelli, U | 1 |
| Sauli, S | 1 |
| Mauri, C | 1 |
| Hanaoka, M | 1 |
| Ralph, P | 1 |
| Hyman, R | 2 |
| Epstein, R | 1 |
| Nakoinz, I | 1 |
| Cohn, M | 1 |
| Alberts, DS | 1 |
| Golde, DW | 2 |
| Rosenberg, SA | 1 |
| Einstein, AB | 1 |
| Stevens, RH | 1 |
| Williamson, AR | 1 |
| Abdou, NI | 1 |
| Abdou, NL | 1 |
| Kozinets, GI | 1 |
| Rapoport, GL | 1 |
| Cline, MJ | 1 |
| Queisser, W | 1 |
| Hoelzer, D | 1 |
| Queisser, U | 1 |
| Cowan, NJ | 1 |
| Milstein, C | 1 |
| Liberti, P | 1 |
| Bagioni, C | 1 |
| Brown, BW | 1 |
| Humphrey, R | 1 |
| Svedmyr, EA | 1 |
| Deinhardt, F | 1 |
| Klein, G | 1 |
| Gandini-Attardi, D | 1 |
| Fleischman, JB | 1 |
| Pettengill, OS | 2 |
| Sorenson, GD | 2 |
| Douglas, SD | 1 |
| Kamin, RM | 1 |
| Fudenberg, HH | 1 |
| Szewczyk, Z | 1 |
| Kopaczynska, K | 1 |
| Catovsky, D | 1 |
| Holt, PJ | 1 |
| Galton, DA | 1 |
| Hara, H | 1 |
| Nakai, K | 1 |
| Nagai, K | 1 |
| McIntyre, OR | 1 |
| Ogawa, M | 1 |
| Benzio, G | 1 |
| Pagliardi, GL | 1 |
| Gabutti, V | 1 |
| Todo, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I/II Study of Immunotherapy With hLL1 Administered Twice Weekly for 4 Consecutive Weeks in Patients With Multiple Myeloma[NCT00421525] | Phase 1/Phase 2 | 25 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| A Phase I/II Study of hLL1-DOX (Milatuzumab-Doxorubicin Antibody-Drug Conjugate) in Patients With Multiple Myeloma[NCT01101594] | Phase 1/Phase 2 | 17 participants (Actual) | Interventional | 2010-07-31 | Terminated (stopped due to Study was terminated due to lack of efficacy) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thymidine and Kahler Disease
| Article | Year |
|---|---|
Cellular kinetics staging, and immunoglobulin synthesis in multiple myeloma.
Topics: Antibody Formation; Cell Count; Cell Movement; Diagnosis, Computer-Assisted; DNA, Neoplasm; Evaluati | 1975 |
[Proliferation of bone marrow and peripheral blood cells in leukemia and under normal conditions (review of the literature)].
Topics: Animals; Autoradiography; Blood Cells; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Dogs; F | 1972 |
1 trial available for thymidine and Kahler Disease
| Article | Year |
|---|---|
Sequential therapy compared with combination therapy in multiple myeloma.
Topics: Autoradiography; Bence Jones Protein; Bone Neoplasms; Cell Count; Drug Therapy, Combination; Humans; | 1975 |
89 other studies available for thymidine and Kahler Disease
| Article | Year |
|---|---|
Anti-c-MET Nanobody - a new potential drug in multiple myeloma treatment.
Topics: Antineoplastic Agents; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expr | 2013 |
Comparison of (11)C-4'-thiothymidine, (11)C-methionine, and (18)F-FDG PET/CT for the detection of active lesions of multiple myeloma.
Topics: Adult; Aged; Aged, 80 and over; Bone Marrow; Carbon Radioisotopes; Disease Progression; Female; Fluo | 2015 |
An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies.
Topics: Aminopterin; Antibodies, Monoclonal; Antibodies, Viral; B-Lymphocytes; Cell Fusion; Cell Line, Tumor | 2008 |
Auger electron emitter against multiple myeloma--targeted endo-radio-therapy with 125I-labeled thymidine analogue 5-iodo-4'-thio-2'-deoxyuridine.
Topics: Apoptosis; Biological Transport; Caspase 3; Cell Differentiation; Cell Line, Tumor; Cell Proliferati | 2011 |
Cell proliferation in multiple myeloma studied with tritiated thymidine in vivo.
Topics: Cell Proliferation; Humans; Multiple Myeloma; Thymidine | 1962 |
GRANULOCYTOPOIESIS. II. EMERGENCE AND PATTERN OF LABELING OF NEUTROPHILIC GRANULOCYTES IN HUMANS.
Topics: Anemia; Anemia, Pernicious; Glioblastoma; Hematopoiesis; Humans; Leukemia; Lymphoma; Lymphoma, Non-H | 1964 |
Multifunctional role of matrix metalloproteinases in multiple myeloma: a study in the 5T2MM mouse model.
Topics: Animals; Annexin A5; Apoptosis; Bone Diseases; Cell Division; Diet; Disease Models, Animal; Enzyme I | 2004 |
CD74 is expressed by multiple myeloma and is a promising target for therapy.
Topics: Animals; Antibodies, Monoclonal; Antigens, Differentiation, B-Lymphocyte; Cell Line, Tumor; Cell Pro | 2004 |
CD74 is expressed by multiple myeloma and is a promising target for therapy.
Topics: Animals; Antibodies, Monoclonal; Antigens, Differentiation, B-Lymphocyte; Cell Line, Tumor; Cell Pro | 2004 |
CD74 is expressed by multiple myeloma and is a promising target for therapy.
Topics: Animals; Antibodies, Monoclonal; Antigens, Differentiation, B-Lymphocyte; Cell Line, Tumor; Cell Pro | 2004 |
CD74 is expressed by multiple myeloma and is a promising target for therapy.
Topics: Animals; Antibodies, Monoclonal; Antigens, Differentiation, B-Lymphocyte; Cell Line, Tumor; Cell Pro | 2004 |
Ribozyme cleavage leads to decreased expression of fibroblast growth factor receptor 3 in human multiple myeloma cells, which is associated with apoptosis and downregulation of vascular endothelial growth factor.
Topics: Apoptosis; Blotting, Western; Catalysis; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation | 2005 |
Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways.
Topics: Adult; Aged; Aged, 80 and over; Animals; Apoptosis; bcl-X Protein; Blotting, Western; Cell Line; Cel | 2005 |
Thymidine secretion by hybridoma and myeloma cells.
Topics: Animals; Cell Line; Cell Proliferation; Humans; Hybridomas; Magnetic Resonance Spectroscopy; Mice; M | 2006 |
Modeling suppression of cell death by Bcl-2 over-expression in myeloma NS0 6A1 cells.
Topics: Apoptosis; Cell Death; Cell Line, Tumor; Cell Survival; Computational Biology; Gene Expression Regul | 2006 |
Inhibition of cellular DNA synthesis by vesicular stomatitis virus.
Topics: Animals; Cell Cycle; Cell Transformation, Viral; Cells, Cultured; DNA; Genes, Viral; Kinetics; L Cel | 1981 |
Clinical, morphological, and cell kinetic differences among multiple myeloma, monoclonal gammopathy of undetermined significance, and smoldering multiple myeloma.
Topics: Aged; Autoradiography; Bone Marrow Cells; Cell Nucleolus; Cell Nucleus; Humans; Hypergammaglobulinem | 1983 |
Enhanced T cell suppression is directed toward sensitive circulating B cells in multiple myeloma.
Topics: B-Lymphocytes; Cell Division; Cell Separation; Humans; Multiple Myeloma; Pokeweed Mitogens; Receptor | 1982 |
Low plasma cell 3(H) thymidine incorporation in monoclonal gammopathy of undetermined significance (MGUS), smouldering myeloma and remission phase myeloma: a reliable indicator of patients not requiring therapy.
Topics: Bone Marrow; Cell Division; Humans; Hypergammaglobulinemia; In Vitro Techniques; Kinetics; Multiple | 1984 |
Kinetics of circulating B lymphocytes in human myeloma.
Topics: B-Lymphocytes; Humans; Kinetics; Multiple Myeloma; Thymidine; Tritium | 1983 |
Correlation of proliferative and clonogenic tumor cells in multiple myeloma.
Topics: Bone Marrow; Cell Division; Cells, Cultured; Clone Cells; DNA Replication; Humans; Kinetics; Multipl | 1984 |
Human myeloma in vitro colony growth: interrelationships between drug sensitivity, cell kinetics, and patient survival duration.
Topics: Bone Marrow; Cell Survival; Cells, Cultured; Clone Cells; Drug Evaluation; Drug Evaluation, Preclini | 1983 |
Proliferative state and radiosensitivity of human myeloma stem cells.
Topics: Aged; Bone Marrow; Cell Count; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Female; H | 1982 |
Drug resistance in multiple myeloma associated with high in vitro incorporation of 3H-thymidine.
Topics: Carmustine; Cell Nucleus; Cell Transformation, Neoplastic; Doxorubicin; Drug Resistance; Drug Therap | 1981 |
Plasma cell dyscrasias--a comparative study of cell surface properties in plasma cell leukemia and myeloma.
Topics: Adult; Cells, Cultured; Concanavalin A; Dactinomycin; Humans; Leucine; Leukemia, Plasma Cell; Lympho | 1980 |
The growth fraction of human myeloma cells.
Topics: Female; Humans; Kinetics; Male; Melphalan; Middle Aged; Multiple Myeloma; Prednisone; Recurrence; Th | 1981 |
Myeloma cells express Fas antigen/APO-1 (CD95) but only some are sensitive to anti-Fas antibody resulting in apoptosis.
Topics: Adult; Antibodies, Monoclonal; Antigens, Surface; Apoptosis; Cell Death; Cell Division; Cell Line; f | 1995 |
Interferon-alpha down-regulates the interleukin-6 receptor in a human multiple myeloma cell line, U266.
Topics: Cell Division; Down-Regulation; Humans; Interferon-alpha; Interleukin-6; Iodine Radioisotopes; Multi | 1995 |
A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay.
Topics: Animals; Antibody Formation; CD3 Complex; Cell Line; Cell Survival; Cells, Cultured; Coloring Agents | 1994 |
The effect of alpha-interferon on thymidine, uridine, and leucine uptake and ultrastructure of peripheral blood mononuclear cells from multiple myeloma patients.
Topics: Aged; Female; Humans; Interferon alpha-2; Interferon-alpha; Leucine; Leukocytes, Mononuclear; Lympho | 1993 |
Differential interleukin-6 (IL-6) responses of three established myeloma cell lines in the presence of soluble human IL-6 receptors.
Topics: Antigens, CD; Cytokine Receptor gp130; Flow Cytometry; Humans; Interleukin-6; Iodine Radioisotopes; | 1996 |
Functional granulocyte/macrophage colony stimulating factor receptor is constitutively expressed on neoplastic plasma cells and mediates tumour cell longevity.
Topics: Aged; Apoptosis; B-Lymphocytes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Female; | 1998 |
Validation of 213Bi-alpha radioimmunotherapy for multiple myeloma.
Topics: Alpha Particles; Apoptosis; Bismuth; Cell Survival; Hematopoietic Stem Cells; Humans; Isotope Labeli | 1999 |
Cytotoxicity of myeloma light chains in cultured human kidney proximal tubule cells.
Topics: Apoptosis; Cell Death; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Immunologic; | 2000 |
Secretion of thymidine by hybridoma cells.
Topics: Animals; Humans; Hybridomas; Multiple Myeloma; Thymidine; Tumor Cells, Cultured | 2000 |
[Cystostatic drug sensitivity testing of primary cultures of human tumours (author's transl)].
Topics: Antibiotics, Antineoplastic; Bleomycin; Cells, Cultured; Dactinomycin; Hodgkin Disease; Humans; Kidn | 1975 |
Early recruitment in the human myeloma cell population after cytostatic treatment.
Topics: Bone Marrow; Bone Marrow Cells; Cyclophosphamide; Dactinomycin; Humans; Leucine; Multiple Myeloma; T | 1976 |
Toxicity of 5-bromo-2'-deoxyuridine to malignant lymphoid cell lines.
Topics: Antineoplastic Agents; Bromodeoxyuridine; Cell Division; Cell Line; Leukemia, Lymphoid; Lymphocytes; | 1977 |
Monocyte-mediated suppression of human B lymphocyte differentiation in vitro.
Topics: B-Lymphocytes; Cell Adhesion; Humans; Immunoglobulin G; Immunoglobulin M; Immunosuppression Therapy; | 1978 |
Effect of plant lectins on murine myeloma cells.
Topics: Animals; Cell Line; Cells, Cultured; Lectins; Mice; Mice, Inbred BALB C; Mitosis; Multiple Myeloma; | 1979 |
B lymphocyte differentiation induced by lipopolysaccharide. II. Response of fetal lymphocytes.
Topics: Animals; Antibodies; Antibody Formation; Antibody Specificity; B-Lymphocytes; Cell Differentiation; | 1975 |
Leucocyte function in paraproteinaemia.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Female; Humans; Hypersensitivity, Delayed; Immunoglob | 1975 |
Growth kinetics of plasma cell myeloma.
Topics: Bone Marrow; Bone Marrow Cells; Cell Division; Female; Humans; In Vitro Techniques; Infusions, Paren | 1977 |
Induction of serum stimulation and plasma cell proliferation during chemotherapy of multiple myeloma.
Topics: Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Cyclophosphamide; Humans; Multiple M | 1977 |
DNA chain termination by 2',3'-dideoxythymidine in replicating mammalian cells.
Topics: Animals; Cell Division; Cell Line; Centrifugation, Density Gradient; Chromatography; Chromatography, | 1975 |
Studies on the ribothymidine content of specific rat and human tRNAs: a postulated role for 5-methyl cytosine in the regulation of ribothymidine biosynthesis.
Topics: Animals; Base Sequence; Binding Sites; Cytosine; Female; Humans; Liver; Mice; Multiple Myeloma; Nucl | 1976 |
Myeloma cell resistance to melphalan, BCNU and epirubicin determined in vitro with the 3H-thymidine incorporation technique prior to chemotherapy.
Topics: Adult; Bone Marrow; Carmustine; Drug Resistance; Epirubicin; Humans; Immunoglobulins; Melphalan; Mid | 1992 |
Impact of flow cytometry on predicting recurrence and survival in breast cancer patients.
Topics: Analysis of Variance; Aneuploidy; Breast Neoplasms; Bromodeoxyuridine; Carcinoma, Small Cell; Cell C | 1985 |
Natural killer cell activity in patients with multiple myeloma.
Topics: Aged; Female; Humans; Interferons; Killer Cells, Natural; Male; Middle Aged; Multiple Myeloma; Thymi | 1988 |
An alternative method for the isolation of NS-1 hybridomas using cholesterol auxotrophy of NS-1 mouse myeloma cells.
Topics: Aminopterin; Animals; Cell Line; Cell Separation; Cell Transformation, Neoplastic; Cholesterol; Cult | 1989 |
Does myeloma secrete an osteoblast inhibiting factor?
Topics: Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Growth Inhibitors; Humans; Multiple M | 1989 |
Epidermal growth factor receptor of A431 cells. Characterization of a monoclonal anti-receptor antibody noncompetitive agonist of epidermal growth factor action.
Topics: Animals; Antibodies, Monoclonal; Cell Line; DNA Replication; Epidermal Growth Factor; ErbB Receptors | 1985 |
Lack of correlation between plasma cell thymidine labelling index and serum beta-2-microglobulin in monoclonal gammopathies.
Topics: beta 2-Microglobulin; Bone Marrow; Humans; Hypergammaglobulinemia; Mitotic Index; Monoclonal Gammopa | 1987 |
Decrease in BSF-2/IL-6 response in advanced cases of multiple myeloma.
Topics: Humans; Interleukin-6; Interleukins; Multiple Myeloma; Neoplasm Staging; Recombinant Proteins; Thymi | 1988 |
Proliferation kinetics of plasma cells and of normal haemopoietic cells in multiple myeloma.
Topics: Aged; Bone Marrow; Cell Division; DNA; Female; Hematopoietic Stem Cells; Humans; Kinetics; Leukemia, | 1987 |
Determination of the plasma cell labelling index with bromodeoxyuridine in a double fluorescence technique.
Topics: Bone Marrow; Bromodeoxyuridine; Cell Cycle; DNA; Fluorescent Antibody Technique; Humans; In Vitro Te | 1986 |
Establishment of a new human myeloma cell line (U-2030) and selection of a hat-sensitive subline.
Topics: Aminopterin; Antigens, Surface; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Drug Resi | 1987 |
Enhanced formation of mouse hybridomas without hat treatment in a serum-free medium.
Topics: Aminopterin; Animals; Cell Division; Cell Fusion; Cell Line; Culture Media; Humans; Hybridomas; Hypo | 1986 |
Cytokinetic studies in human myeloma.
Topics: Autoradiography; Cell Cycle; Humans; Mitotic Index; Multiple Myeloma; Paraproteinemias; Plasma Cells | 1986 |
Immunofluorescent plasma cell labeling indices (LI) using a monoclonal antibody (BU-1).
Topics: Antibodies, Monoclonal; Autoradiography; Bone Marrow; DNA; Fluorescent Antibody Technique; Humans; I | 1985 |
Multiple myeloma: significance of plasmablastic subtype in morphological classification.
Topics: Actuarial Analysis; Age Factors; Blood Protein Electrophoresis; Creatinine; Female; Humans; Immunoel | 1985 |
Prognostic importance of labelling index in myelomatosis.
Topics: Humans; Multiple Myeloma; Prognosis; Thymidine; Tritium | 1985 |
Plasma cell acid phosphatase activity as prognostic factor in multiple myeloma: relationship to the thymidine-labeling index.
Topics: Alkaline Phosphatase; Bone Marrow Cells; Humans; Mitosis; Mitotic Index; Multiple Myeloma; Paraprote | 1985 |
Symposium. Myeloma. g. Fluctuation in immunoglobulin synthesis during the cell cycle in synchronized population of myeloma cells.
Topics: Culture Techniques; gamma-Globulins; Immunoglobulins; Mitosis; Multiple Myeloma; Thymidine; Tritium | 1970 |
Immunoglobun, protein and nucleic acid synthesis in cultured myeloma cells.
Topics: Animals; Biological Transport; Cell Line; Culture Techniques; gamma-Globulins; Histocytochemistry; I | 1971 |
In vivo kinetic studies in human myeloma.
Topics: Autoradiography; Bone Marrow; Bone Marrow Cells; Cell Division; DNA; Humans; Immunoglobulin A; Immun | 1974 |
Cell-mediated immunity to plasma cell myeloma: specific inhibition by a serum factor adhering to effector lymphocytes.
Topics: Antibodies, Neoplasm; Bone Marrow; Bone Marrow Cells; Cell Separation; Humans; Immunity, Cellular; L | 1974 |
Cytochemical and autoradiographic investigations on normal and myelomatous plasma cells.
Topics: Acid Phosphatase; Alkaline Phosphatase; Autoradiography; DNA; Electron Transport Complex IV; Histocy | 1967 |
Immunocytology of cultured IgM-forming cells of mouse. I. Requirement of phagocytic cell factor for the growth of IgM-forming tumor cells in tissue culture.
Topics: Acid Phosphatase; Animals; Antibody Specificity; Antibody-Producing Cells; Cattle; Cell Line; Cyclic | 1972 |
Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.
Topics: Animals; Antigens; Antigens, Neoplasm; Cell Differentiation; Cell Line; Cell Membrane; Cell Survival | 1973 |
DNA synthesis in multiple myeloma cells following cell cycle-nonspecific chemotherapy.
Topics: Alkylating Agents; Autoradiography; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; | 1974 |
Sialic acids on the plasma membrane of cultured human lymphoid cells. Chemical aspects and biosynthesis.
Topics: Burkitt Lymphoma; Cell Count; Cell Division; Cell Line; Cell Membrane; Cells, Cultured; DNA; Humans; | 1972 |
Isolation of nuclear pre-mRNA which codes for immunoglobulin heavy chain.
Topics: Animals; Cell Line; Cell Nucleus; Cytoplasm; Electrophoresis, Polyacrylamide Gel; Female; Immunoglob | 1973 |
Anit-immunoglobulins in multiple myeloma.
Topics: Adult; Aged; Antibodies, Anti-Idiotypic; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultu | 1972 |
Growth of human bone marrow in liquid culture.
Topics: Binding Sites, Antibody; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Culture Techniques; Erythr | 1973 |
[Cytophotometric-autoradiographic studies on cell proliferation in paraproteinaemic haemoblastosis with leukemic blood picture changes].
Topics: Aged; Autoradiography; Blood Cells; Blood Proteins; Bone Marrow; Bone Marrow Cells; Diagnosis, Diffe | 1973 |
Automatic monitoring of biochemical parameters in tissue culture. Studies on synchronously growing mouse myeloma cells.
Topics: Animals; Autoanalysis; Carbon Isotopes; Culture Techniques; DNA; Lysine; Mice; Mitosis; Multiple Mye | 1972 |
Studies on surface antigen variants. Isolation of two complementary variants for Thy 1.2.
Topics: Animals; Antigens, Neoplasm; Antigens, Viral; Antineoplastic Agents; Cell Line; Lymphocytes; Lymphom | 1973 |
Synthesis of immunoglobulin and nuclear protein in synchronized mouse myeloma cells.
Topics: Animals; Cell Division; Cell Line; Cell Nucleus; DNA; Histones; Immunoglobulin G; Mice; Mitosis; Mul | 1973 |
Effect of chemotherapy in the labelling index of myeloma cells.
Topics: Bence Jones Protein; Cell Division; DNA; Female; Humans; Leukemia, Plasma Cell; Male; Middle Aged; M | 1974 |
Sensitivity of different target cells to the killing action of peripheral lymphocytes stimulated by autologous lymphoblastoid cell lines.
Topics: Blood Donors; Burkitt Lymphoma; Cell Line; Chromium Radioisotopes; Culture Media; Cytotoxicity Tests | 1974 |
Analysis of deoxyribonucleic acid structure by partition chromatography.
Topics: Alcohols; Amines; Animals; Carbon Isotopes; Cattle; Cell Line; Centrifugation, Density Gradient; Che | 1969 |
The use of quantitative immunofluorescence to measure immunoglobulin levels in mouse myleoma cells during the cell cycle.
Topics: Animals; Autoradiography; Cell Division; Fluorescent Antibody Technique; Goats; Immune Sera; Immunog | 1971 |
Human lymphocyte response to phytomitogens in vitro: normal, agammaglobulinemic and paraproteinemic individuals.
Topics: Adult; Agammaglobulinemia; Aged; Blood Protein Disorders; Carbon Isotopes; Culture Media; DNA; Femal | 1969 |
Blastic transformation of lymphocytes in some proliferative diseases of the leukocytic system.
Topics: Carbon Isotopes; Cells, Cultured; Hodgkin Disease; Humans; Immune Sera; Lectins; Leukemia; Lymphocyt | 1971 |
Growth characteristics of long-term cultures of mouse myeloma cells.
Topics: Animals; Autoradiography; Cell Count; Cell Line; Cells, Cultured; Chromosomes; Clone Cells; Immunogl | 1972 |
Binucleated blast-cells in lymphocyte cultures from myelomatosis.
Topics: Antibody-Producing Cells; Autoradiography; Bone Marrow; Bone Marrow Cells; Cell Nucleus; Cells, Cult | 1972 |
Synthesis and secretion of IgE by an established human myeloma cell line.
Topics: Autoradiography; Cell Count; Cell Division; Cell Line; Culture Media; Fibroblasts; Humans; Immunoglo | 1971 |
[Kinetic studies on human myeloma cells following melphalan administration].
Topics: Adult; Aged; Bone Marrow; Bone Marrow Cells; Cell Division; Cell Nucleus; Cell Transformation, Neopl | 1971 |
IgE myeloma: total body tumor cell number and synthesis of IgE and DNA.
Topics: Antibody-Producing Cells; Autoradiography; Cell Count; DNA, Neoplasm; Humans; Immunoglobulin E; Immu | 1971 |
[Physiopathological and cytogenetic findings in 2 cases of plasma cell leukemia].
Topics: Aged; Autoradiography; Bence Jones Protein; Blood Cell Count; Blood Coagulation Tests; Blood Protein | 1970 |
Proliferation and differentiation of hematopoietic cells in hematologic disorders. II. In vitro radioautographic study of leukemic cells.
Topics: Adult; Aged; Culture Techniques; Female; Hematopoiesis; Humans; Leucine; Leukemia; Leukemia, Lymphoi | 1968 |