thymidine has been researched along with Hormone-Dependent Neoplasms in 25 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of 17 beta-estradiol on cytoplasmic thymidine kinase activity was studied in MCF-7, a human breast cancer cell line in culture which responds to estrogens with an increase in the rate of growth." | 7.66 | Purification and properties of estrogen-responsive cytoplasmic thymidine kinase from human breast cancer. ( Aitken, S; Bronzert, DA; Lippman, ME; Monaco, ME; Pinkus, L, 1981) |
| "Acetaminophen is a commonly used analgesic/antipyretic that also contains a p-phenol." | 5.30 | Acetaminophen alters estrogenic responses in vitro: stimulation of DNA synthesis in estrogen-responsive human breast cancer cells. ( Harnagea-Theophilus, E; Miller, MR, 1998) |
| "Gossypol is a polyphenolic aldehyde occurring naturally in cottonseed that produces antisteroidogenic activity in vivo, has been extensively investigated as a male contraceptive agent, and has demonstrated anticancer activity." | 5.29 | Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. ( Brueggemeier, RW; Chang, CJ; Gilbert, NE; Lin, YC; O'Reilly, JE, 1995) |
| " The aim of this study was to compare the antiproliferative activity of various concentrations of 13-cis retinoic acid (isotretinoin) and all-trans retinoic acid (tretinoin) in a culture of the estrogen-sensitive human breast cancer cell line MCF-7." | 3.71 | 13-cis retinoic acid and all-trans retinoic acid in the regulation of the proliferation and survival of human breast cancer cell line MCF-7. ( Anchim, T; Czeczuga-Semeniuk, E; Dabrowska, M; Dziecioł, J; Tomaszewska, I; Wolczyński, S, 2001) |
| "The effect of 17 beta-estradiol on cytoplasmic thymidine kinase activity was studied in MCF-7, a human breast cancer cell line in culture which responds to estrogens with an increase in the rate of growth." | 3.66 | Purification and properties of estrogen-responsive cytoplasmic thymidine kinase from human breast cancer. ( Aitken, S; Bronzert, DA; Lippman, ME; Monaco, ME; Pinkus, L, 1981) |
| " Tocopherols and saponins extracted from argan tree and 2-methoxyestradiol exhibit a dose-response cytotoxic effect and an antiproliferative action on the tested cell lines." | 1.33 | Tocopherols and saponins derived from Argania spinosa exert, an antiproliferative effect on human prostate cancer. ( Adlouni, A; Bennani, H; Charrouf, Z; Drissi, A; Fiet, J; Giton, F, 2006) |
| "Prostate cancer is an androgen-dependent disease; metastatic prostate cancer is typically treated by androgen receptor (AR) blockade." | 1.33 | Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer. ( Agoulnik, IU; Alvarado, M; Ayala, GE; Bingman, WE; Erdem, H; Frolov, A; Ittmann, MM; Nakka, M; Smith, CL; Vaid, A; Weigel, NL, 2006) |
| " [3H]Thymidine incorporation displayed a bell-shaped dose-response curve in both strains." | 1.30 | LNCaP prostatic adenocarcinoma cells derived from low and high passage numbers display divergent responses not only to androgens but also to retinoids. ( Esquenet, M; Heyns, W; Swinnen, JV; Verhoeven, G, 1997) |
| "Acetaminophen is a commonly used analgesic/antipyretic that also contains a p-phenol." | 1.30 | Acetaminophen alters estrogenic responses in vitro: stimulation of DNA synthesis in estrogen-responsive human breast cancer cells. ( Harnagea-Theophilus, E; Miller, MR, 1998) |
| "Gossypol is a polyphenolic aldehyde occurring naturally in cottonseed that produces antisteroidogenic activity in vivo, has been extensively investigated as a male contraceptive agent, and has demonstrated anticancer activity." | 1.29 | Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. ( Brueggemeier, RW; Chang, CJ; Gilbert, NE; Lin, YC; O'Reilly, JE, 1995) |
| "Hormonal management of breast cancer is confounded by an almost inevitable progression of cell growth from a steroid-regulated to a steroid-autonomous state." | 1.29 | Alterations in transforming growth factor-alpha and -beta production and cell responsiveness during the progression of MCF-7 human breast cancer cells to estrogen-autonomous growth. ( Herman, ME; Katzenellenbogen, BS, 1994) |
| "In vitro cultures of breast cancer tissue demonstrate that some tumours are hormone-sensitive and others hormone-insensitive, but it cannot be predicted whether cell proliferation is stimulated or inhibited by hormone treatment." | 1.26 | Short-term culture of human breast cancer: in vitro effects of hormones related to patient response. ( Andersen, J; Bichel, P; Poulsen, HS, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (44.00) | 18.7374 |
| 1990's | 8 (32.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Swamy, N | 1 |
| Chen, TC | 1 |
| Peleg, S | 1 |
| Dhawan, P | 1 |
| Christakos, S | 1 |
| Stewart, LV | 1 |
| Weigel, NL | 2 |
| Mehta, RG | 1 |
| Holick, MF | 1 |
| Ray, R | 1 |
| Pandini, G | 1 |
| Mineo, R | 1 |
| Frasca, F | 1 |
| Roberts, CT | 1 |
| Marcelli, M | 1 |
| Vigneri, R | 1 |
| Belfiore, A | 1 |
| Drissi, A | 1 |
| Bennani, H | 1 |
| Giton, F | 1 |
| Charrouf, Z | 1 |
| Fiet, J | 1 |
| Adlouni, A | 1 |
| Agoulnik, IU | 1 |
| Vaid, A | 1 |
| Nakka, M | 1 |
| Alvarado, M | 1 |
| Bingman, WE | 1 |
| Erdem, H | 1 |
| Frolov, A | 1 |
| Smith, CL | 1 |
| Ayala, GE | 1 |
| Ittmann, MM | 1 |
| Tang, FY | 1 |
| Best, I | 1 |
| Tang, LK | 1 |
| Homo, F | 1 |
| Durant, S | 1 |
| Duval, D | 1 |
| Marie, JP | 1 |
| Zittoun, R | 1 |
| Harousseau, JL | 1 |
| Poulsen, HS | 1 |
| Bichel, P | 1 |
| Andersen, J | 1 |
| Leung, BS | 2 |
| Potter, AH | 2 |
| Qureshi, S | 1 |
| Bronzert, DA | 1 |
| Monaco, ME | 1 |
| Pinkus, L | 1 |
| Aitken, S | 1 |
| Lippman, ME | 2 |
| Gilbert, NE | 1 |
| O'Reilly, JE | 1 |
| Chang, CJ | 1 |
| Lin, YC | 1 |
| Brueggemeier, RW | 1 |
| Herman, ME | 1 |
| Katzenellenbogen, BS | 1 |
| Esquenet, M | 1 |
| Swinnen, JV | 1 |
| Heyns, W | 1 |
| Verhoeven, G | 1 |
| Harnagea-Theophilus, E | 1 |
| Miller, MR | 1 |
| Montecchia, MF | 1 |
| Lamb, C | 1 |
| Molinolo, AA | 1 |
| Luthy, IA | 1 |
| Pazos, P | 1 |
| Charreau, E | 1 |
| Vanzulli, S | 1 |
| Lanari, C | 1 |
| Lupowitz, Z | 1 |
| Zisapel, N | 1 |
| Rahman, NA | 1 |
| Huhtaniemi, I | 1 |
| Jeng, MH | 1 |
| Yue, W | 1 |
| Eischeid, A | 1 |
| Wang, JP | 1 |
| Santen, RJ | 1 |
| Czeczuga-Semeniuk, E | 1 |
| Wolczyński, S | 1 |
| Dziecioł, J | 1 |
| Dabrowska, M | 1 |
| Anchim, T | 1 |
| Tomaszewska, I | 1 |
| Lippman, M | 1 |
| Huff, K | 1 |
| Bolan, G | 1 |
| Engel, LW | 1 |
| Young, NA | 1 |
| Tralka, TS | 1 |
| O'Brien, SJ | 1 |
| Joyce, MJ | 1 |
| Pasqualini, JR | 1 |
| Gelly, C | 1 |
| Paciotti, GF | 1 |
| Tamarkin, L | 1 |
| Pasteels, JL | 1 |
| Kiss, R | 1 |
| Paridaens, R | 1 |
| Hennessey, TL | 1 |
| Rubin, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Safety Study of Palbociclib in Combination With Letrozole or Fulvestrant in African American Women With Hormone Receptor Positive HER2 Negative Advanced Breast Cancer[NCT02692755] | Phase 2/Phase 3 | 35 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinical Benefit Rate (CBR), for those with evaluable disease, defined as the percentage of patients who achieved complete response, partial response and stable disease. RECIST 1.1 was used as the standard way to measure response to treatment. The mean (SD) of specific metabolites were calculated at each time point and graphically assess these measures over time with clinical response and hematological toxicity. The mean change in these variables from baseline to each follow-up point was be calculated. Generalized linear model was utilized for the correlative analysis of clinical response and hematologic events. (NCT02692755)
Timeframe: 24 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| Single ARM | 23 |
Number of patients who required dose delays in palbociclib attributed to neutropenia. (NCT02692755)
Timeframe: 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Single ARM | 17 |
Number of patients who required dose reductions in palbociclib therapy (NCT02692755)
Timeframe: 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Single ARM | 13 |
"For study purpose febrile neutropenia will be defined according to the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) v4.0: ANC less than 1000/mm3 with a single temperature of >38.3 degrees Celsius (101 degrees Fahrenheit) or a sustained temperature of 38 degrees Celsius (100.4 degrees Fahrenheit) for more than one hour.~Planned oncology therapy is defined as completion of one year of therapy for advanced breast cancer in the absence of disease progression or cessation of study drug due to progressive disease or non-hematological toxicity." (NCT02692755)
Timeframe: 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Palbociclib + Letrozole or Fulvestrant | 35 |
25 other studies available for thymidine and Hormone-Dependent Neoplasms
| Article | Year |
|---|---|
Inhibition of proliferation and induction of apoptosis by 25-hydroxyvitamin D3-3beta-(2)-Bromoacetate, a nontoxic and vitamin D receptor-alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cells.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Animals; Apoptosis; Calcitriol; Carrier Proteins; Caspases | 2004 |
Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anilides; Cell Line, Tumor; Cell Mov | 2005 |
Tocopherols and saponins derived from Argania spinosa exert, an antiproliferative effect on human prostate cancer.
Topics: 2-Methoxyestradiol; Antioxidants; Cell Proliferation; Estradiol; Humans; Male; Neoplasms, Hormone-De | 2006 |
Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer.
Topics: Androgens; Cell Line, Tumor; Cell Proliferation; Exons; Humans; Immunohistochemistry; Introns; Male; | 2006 |
Hormone regulation of the growth of endometrial hyperplasias and tumors from the aged fischer rat.
Topics: Aging; Animals; Bucladesine; Cells, Cultured; Cyclic AMP; Endometrial Hyperplasia; Estradiol; Female | 1982 |
Glucocorticoid receptors and hormonal responsiveness of human blood and bone-marrow cells in non-lymphocytic leukemia.
Topics: Adult; Bone Marrow; Child, Preschool; Dexamethasone; Dinoprostone; Humans; In Vitro Techniques; Isop | 1981 |
Short-term culture of human breast cancer: in vitro effects of hormones related to patient response.
Topics: Breast Neoplasms; Cells, Cultured; Estradiol; Female; Hormones; Humans; In Vitro Techniques; Menopau | 1982 |
Interaction of prolactin, estrogen and progesterone in a human mammary carcinoma cell line, CAMA-1 - I Cell growth and thymidine uptake.
Topics: Breast Neoplasms; Cell Division; Cell Line; Culture Media; Estradiol; Female; Humans; Neoplasms, Hor | 1981 |
Purification and properties of estrogen-responsive cytoplasmic thymidine kinase from human breast cancer.
Topics: Breast Neoplasms; Cell Line; Estradiol; Female; Humans; Kinetics; Mitochondria; Neoplasms, Hormone-D | 1981 |
Antiproliferative activity of gossypol and gossypolone on human breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Drug Resistance, Multiple; Drug Screening As | 1995 |
Alterations in transforming growth factor-alpha and -beta production and cell responsiveness during the progression of MCF-7 human breast cancer cells to estrogen-autonomous growth.
Topics: Breast Neoplasms; Cell Division; Culture Media; Dose-Response Relationship, Drug; Estradiol; Humans; | 1994 |
LNCaP prostatic adenocarcinoma cells derived from low and high passage numbers display divergent responses not only to androgens but also to retinoids.
Topics: Acid Phosphatase; Calcitriol; Carrier Proteins; Cell Division; Diazepam Binding Inhibitor; ErbB Rece | 1997 |
Acetaminophen alters estrogenic responses in vitro: stimulation of DNA synthesis in estrogen-responsive human breast cancer cells.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Breast Neoplasms; DNA, Neoplasm; Estrogens; Flow Cytometry; | 1998 |
Progesterone receptor involvement in independent tumor growth in MPA-induced murine mammary adenocarcinomas.
Topics: Adenocarcinoma; Androgens; Animals; Binding Sites; Estradiol; Female; Flutamide; Glucocorticoids; Go | 1999 |
Hormonal interactions in human prostate tumor LNCaP cells.
Topics: Androgens; Cell Division; Cell Survival; Drug Interactions; Estradiol; Humans; Male; Melatonin; Neop | 1999 |
Hormonal regulation of proliferation of granulosa and Leydig cell lines derived from gonadal tumors of transgenic mice expressing the inhibin-alpha subunit promoter/simian virus 40 T-antigen fusion gene.
Topics: Activins; Animals; Antigens, Polyomavirus Transforming; Artificial Gene Fusion; DNA, Neoplasm; Femal | 1999 |
Role of MAP kinase in the enhanced cell proliferation of long term estrogen deprived human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Estradiol; | 2000 |
13-cis retinoic acid and all-trans retinoic acid in the regulation of the proliferation and survival of human breast cancer cell line MCF-7.
Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Cell Surviv | 2001 |
Progesterone and glucocorticoid interactions with receptor in breast cancer cells in long-term tissue culture.
Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Dexamethasone; Female; Humans; Hyd | 1977 |
Establishment and characterization of three new continuous cell lines derived from human breast carcinomas.
Topics: Breast Neoplasms; Caseins; Cell Division; Cell Line; Chromosome Aberrations; Female; Humans; Kinetic | 1978 |
Biological response of the anti-estrogen ICI 164,384 in human hormone-dependent and hormone-independent mammary cancer cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; DNA, Neoplasm; Estradiol; Estrogen Antagonis | 1990 |
Interleukin-1 directly regulates hormone-dependent human breast cancer cell proliferation in vitro.
Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Female; Humans; Interleukin-1; Isotope Labeli | 1988 |
[Utilization of the TLI technic (thymidine labeling index) in cancerology].
Topics: Animals; Breast Neoplasms; Female; Humans; Mammary Neoplasms, Experimental; Mice; Neoplasms; Neoplas | 1987 |
Mode of estrogen action on cell proliferation in CAMA-1 cells: II. Sensitivity of G1 phase population.
Topics: Breast Neoplasms; Cell Cycle; Cell Division; Cell Line; Estradiol; Humans; Interphase; Kinetics; Neo | 1987 |
Development and inheritance of osmotic tolerance in a line of spontaneously transformed BALB/3T3 cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Culture Media; Mice; Neoplasms, Hormone-Depende | 1986 |