thymidine has been researched along with Herpes Simplex Virus Infection in 60 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The treatment of herpetic corneal ulcerations with trifluorthymidine (F3T) has been evaluated in a clinical trial." | 9.05 | Trifluorthymidine in the treatment of herpes simplex corneal ulcers. A clinical evaluation. ( Gilbert, P; Work, K, 1980) |
| "The outcome of neonatal herpes simplex (HSV) infection, even after therapy with high dose acyclovir (ACV), is not optimum." | 7.77 | N-Methanocarbathymidine is more effective than acyclovir for treating neonatal herpes simplex virus infection in guinea pigs. ( Bernstein, DI; Bravo, FJ; Cardin, RD; Clark, JR; Earwood, JD; Glazer, R; Rahman, A, 2011) |
| "N-methanocarbathymidine (N-MCT) has previously been shown to be effective against lethal orthopoxvirus and herpes simplex virus type-1 infections in mice." | 7.77 | Efficacy of orally administered low dose N-methanocarbathymidine against lethal herpes simplex virus type-2 infections of mice. ( Collins, DJ; Glazer, R; Quenelle, DC; Rahman, A; Rice, TL, 2011) |
| "N-Methanocarbathymidine [(N)-MCT], a thymidine analogue incorporating a pseudosugar with a fixed Northern conformation, exhibits antiherpetic activity against both herpes simplex virus (HSV) HSV-1 and HSV-2, with a potency greater than that of the reference standard, ganciclovir (GCV)." | 7.71 | Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase. ( Agbaria, R; Ben-Zvi, Z; Candotti, F; Ford, H; Johns, DG; Manor, E; Marquez, VE; Morris, JC; Noy, R, 2002) |
| "Herpes simplex virus (HSV) mutants defective for thymidine kinase expression (TK-) have been reported to establish latent infection of sensory ganglia of mice, in that HSV latency-associated transcript is expressed, but to be defective for reactivation." | 7.69 | Reactivation of thymidine kinase-defective herpes simplex virus is enhanced by nucleoside. ( Gaydos, A; Hay, KA; Tenser, RB, 1996) |
| " Specificity of the hybridization was assessed using a biotinylated cloned subgenomic herpes simplex virus type 1 DNA fragment to localize viral nucleic acids in sections of infected cells." | 7.68 | Ultrastructural localization of defined sequences of viral RNA and DNA by in situ hybridization of biotinylated DNA probes on sections of herpes simplex virus type 1 infected cells. ( Puvion, E; Puvion-Dutilleul, F, 1991) |
| "), and propylene glycol were evaluated for their potential efficacy in the treatment of cutaneous herpes simplex virus infections by in vitro studies of TFT penetration through skin and in vivo studies of therapeutic activity against herpes simplex virus type 1 infections in the dorsal cutaneous guinea pig model." | 7.67 | Effect of azone and propylene glycol on penetration of trifluorothymidine through skin and efficacy of different topical formulations against cutaneous herpes simplex virus infections in guinea pigs. ( Clark, DS; Gaede, P; McKeough, M; Robertson, F; Spruance, SL; Sugibayashi, K, 1984) |
| "The antiviral agent thymine arabinoside (9-beta-D-arabinofuranosyl thymine, Ara-T) was applied topically and by anodal (+) iontophoresis in a NaCl solution to Herpes simplex virus type 1 (HSV-1), and Herpes simplex virus type 2 (HSV-2) skin infections in hairless mice." | 7.67 | Thymine arabinoside (Ara-T) topical and iontophoretic application for herpes simplex virus type 1 and type 2 skin infections in hairless mice. ( Gangarosa, LP; Gentry, GA; Hill, JM; Kwon, BS; Wiggins, CA, 1984) |
| "Herpes simplex virus mutant KG111 contains a nonsense mutation at codon 44 of the viral thymidine kinase (tk) gene and produces low amounts of a truncated tk polypeptide." | 7.67 | Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model. ( Coen, DM; Irmiere, AF; Jacobson, JG; Kerns, KM, 1989) |
| "In vitro and in vivo studies were done on a herpes simplex virus type 2 strain recovered from a patient on acyclovir (ACV) which was ACV resistant but expressed thymidine (dThd) kinase (EC 2." | 7.67 | Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity. ( Barry, DW; Ellis, MN; Fyfe, JA; Keller, PM; Lehrman, SN; Martin, JL; Rooney, JF; Straus, SE, 1987) |
| "Trifluorothymidine (TFT) is known to be concentrated in herpes simplex virus (HSV) infected cells in vitro in the form of phosphorylated derivatives." | 7.67 | Trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19F nuclear magnetic resonance in a murine hepatitis model. ( Bodor, N; Brey, W; el Koussi, A; Houck, HJ; Loftsson, T; Raad, I; Rand, KH; Rocca, J, 1987) |
| "Methoxymethyldeoxyuridine (MMUdR) when used in combination with either trifluorothymidine (F3TdR) or phosphonoformate (PFA) showed synergistic activity against herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) in vitro, whereas MMUdR and acycloguanosine (ACG) combination was antagonistic against herpes viruses." | 7.67 | Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with trifluorothymidine, phosphonoformate and acycloguanosine against herpes simplex viruses. ( Ayisi, NK; Babiuk, LA; Gupta, SV, 1985) |
| "A plaque autoradiography assay to detect and quantitate thymidine kinase (TK) mutants of herpes simplex virus type 1 (HSV-1) and HSV-2 in clinical samples is described." | 7.67 | Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates. ( Barry, DW; Biron, KK; Ellis, MN; Furman, PA; Keller, PM; Lehrman, SN; Martin, JL, 1985) |
| "5,6-Dihydro-5-azathymidine (DHAdT), a nucleoside antibiotic inhibitory for herpes simplex virus (HSV) in cell cultures (H." | 7.66 | Activities of 5,6-dihydro-5-azathymidine against herpes simplex virus infections in mice. ( Eidson, EE; Renis, HE, 1979) |
| "E-5-Propenyl-2'-deoxyuridine (E-5-propenyl-dUrd) inhibited the growth of herpes simplex virus (HSV) types 1 (HSV-1) and 2 in culture." | 7.66 | Anti-herpes simplex virus and anti-human cell growth activity of E-5-propenyl-2'-deoxyuridine and the concept of selective protection in antivirus chemotherapy. ( Bergstrom, DE; Cheng, YC; Grill, S; Ruth, J, 1980) |
| "The treatment of herpetic corneal ulcerations with trifluorthymidine (F3T) has been evaluated in a clinical trial." | 5.05 | Trifluorthymidine in the treatment of herpes simplex corneal ulcers. A clinical evaluation. ( Gilbert, P; Work, K, 1980) |
| "The outcome of neonatal herpes simplex (HSV) infection, even after therapy with high dose acyclovir (ACV), is not optimum." | 3.77 | N-Methanocarbathymidine is more effective than acyclovir for treating neonatal herpes simplex virus infection in guinea pigs. ( Bernstein, DI; Bravo, FJ; Cardin, RD; Clark, JR; Earwood, JD; Glazer, R; Rahman, A, 2011) |
| "N-methanocarbathymidine (N-MCT) has previously been shown to be effective against lethal orthopoxvirus and herpes simplex virus type-1 infections in mice." | 3.77 | Efficacy of orally administered low dose N-methanocarbathymidine against lethal herpes simplex virus type-2 infections of mice. ( Collins, DJ; Glazer, R; Quenelle, DC; Rahman, A; Rice, TL, 2011) |
| " PA317/STK, which constantly shed retroviral vectors, was used to transduce cancer cells with the herpes simplex virus thymidine kinase (HSV-tk) gene." | 3.74 | Entrapment of retroviral vector producer cells in three-dimensional alginate scaffolds for potential use in cancer gene therapy. ( Agbaria, R; Cohen, S; Dvir-Ginzberg, M; Konson, A, 2007) |
| "N-Methanocarbathymidine [(N)-MCT], a thymidine analogue incorporating a pseudosugar with a fixed Northern conformation, exhibits antiherpetic activity against both herpes simplex virus (HSV) HSV-1 and HSV-2, with a potency greater than that of the reference standard, ganciclovir (GCV)." | 3.71 | Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase. ( Agbaria, R; Ben-Zvi, Z; Candotti, F; Ford, H; Johns, DG; Manor, E; Marquez, VE; Morris, JC; Noy, R, 2002) |
| "We have obtained 190 active Herpes simplex virus type 1 thymidine kinase mutants by substituting a 33 nucleotide sequence with 20% degeneracy for a portion of the nucleotide sequence that encodes the putative thymidine binding site [K." | 3.69 | Herpes thymidine kinase mutants with altered catalytic efficiencies obtained by random sequence selection. ( Dube, DK; French, DC; Loeb, LA; Munir, KM, 1994) |
| "Herpes simplex virus (HSV) mutants defective for thymidine kinase expression (TK-) have been reported to establish latent infection of sensory ganglia of mice, in that HSV latency-associated transcript is expressed, but to be defective for reactivation." | 3.69 | Reactivation of thymidine kinase-defective herpes simplex virus is enhanced by nucleoside. ( Gaydos, A; Hay, KA; Tenser, RB, 1996) |
| " Specificity of the hybridization was assessed using a biotinylated cloned subgenomic herpes simplex virus type 1 DNA fragment to localize viral nucleic acids in sections of infected cells." | 3.68 | Ultrastructural localization of defined sequences of viral RNA and DNA by in situ hybridization of biotinylated DNA probes on sections of herpes simplex virus type 1 infected cells. ( Puvion, E; Puvion-Dutilleul, F, 1991) |
| "In vitro and in vivo studies were done on a herpes simplex virus type 2 strain recovered from a patient on acyclovir (ACV) which was ACV resistant but expressed thymidine (dThd) kinase (EC 2." | 3.67 | Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity. ( Barry, DW; Ellis, MN; Fyfe, JA; Keller, PM; Lehrman, SN; Martin, JL; Rooney, JF; Straus, SE, 1987) |
| "), and propylene glycol were evaluated for their potential efficacy in the treatment of cutaneous herpes simplex virus infections by in vitro studies of TFT penetration through skin and in vivo studies of therapeutic activity against herpes simplex virus type 1 infections in the dorsal cutaneous guinea pig model." | 3.67 | Effect of azone and propylene glycol on penetration of trifluorothymidine through skin and efficacy of different topical formulations against cutaneous herpes simplex virus infections in guinea pigs. ( Clark, DS; Gaede, P; McKeough, M; Robertson, F; Spruance, SL; Sugibayashi, K, 1984) |
| "Trifluorothymidine (TFT) is known to be concentrated in herpes simplex virus (HSV) infected cells in vitro in the form of phosphorylated derivatives." | 3.67 | Trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19F nuclear magnetic resonance in a murine hepatitis model. ( Bodor, N; Brey, W; el Koussi, A; Houck, HJ; Loftsson, T; Raad, I; Rand, KH; Rocca, J, 1987) |
| "The antiviral agent thymine arabinoside (9-beta-D-arabinofuranosyl thymine, Ara-T) was applied topically and by anodal (+) iontophoresis in a NaCl solution to Herpes simplex virus type 1 (HSV-1), and Herpes simplex virus type 2 (HSV-2) skin infections in hairless mice." | 3.67 | Thymine arabinoside (Ara-T) topical and iontophoretic application for herpes simplex virus type 1 and type 2 skin infections in hairless mice. ( Gangarosa, LP; Gentry, GA; Hill, JM; Kwon, BS; Wiggins, CA, 1984) |
| "Methoxymethyldeoxyuridine (MMUdR) when used in combination with either trifluorothymidine (F3TdR) or phosphonoformate (PFA) showed synergistic activity against herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) in vitro, whereas MMUdR and acycloguanosine (ACG) combination was antagonistic against herpes viruses." | 3.67 | Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with trifluorothymidine, phosphonoformate and acycloguanosine against herpes simplex viruses. ( Ayisi, NK; Babiuk, LA; Gupta, SV, 1985) |
| "Herpes simplex virus mutant KG111 contains a nonsense mutation at codon 44 of the viral thymidine kinase (tk) gene and produces low amounts of a truncated tk polypeptide." | 3.67 | Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model. ( Coen, DM; Irmiere, AF; Jacobson, JG; Kerns, KM, 1989) |
| "A plaque autoradiography assay to detect and quantitate thymidine kinase (TK) mutants of herpes simplex virus type 1 (HSV-1) and HSV-2 in clinical samples is described." | 3.67 | Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates. ( Barry, DW; Biron, KK; Ellis, MN; Furman, PA; Keller, PM; Lehrman, SN; Martin, JL, 1985) |
| " In vitro data show that FEAU has activity against herpes simplex virus types 1 and 2 comparable to that of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU, 2), 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil (FIAU, 3), and acyclovir (ACV, 12)." | 3.67 | 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent. ( Benigni, DA; Brodfuehrer, PR; Chen, MS; Ghazzouli, I; Howell, HG; Mansuri, MM; Martin, JC, 1987) |
| " Acyclovir has provided successful treatment in AIDS patients suffering from severe herpes simplex and herpes zoster virus infections." | 3.67 | Management of viral infections in AIDS patients. ( Drucker, JL; King, DH, 1987) |
| " Currently, acyclovir is the most effective agent for the treatment of herpes simplex and varicella-zoster virus infections." | 3.67 | Antiviral agents. ( Cockerill, FR; Hermans, PE, 1987) |
| " With cell homogenates of noninfected Vero cells, thymidine (TdR) was phosphorylated about fifty and twenty times more efficiently than FIAC and ara-C, while infection of Vero cells with Herpes Simplex Virus Type 1 (HSV-1) resulted in a 23-fold increase of TdR- and a 1270-fold increase of FIAC phosphorylation." | 3.66 | In vitro metabolism of 1-beta-D-arabinofuranosylcytosine and 1-beta-2'-fluoroarabino-5-iodocytosine in normal and herpes simplex type 1 virus-infected cells. ( Colacino, J; Damin, L; Kreis, W; Lopez, C, 1982) |
| "E-5-Propenyl-2'-deoxyuridine (E-5-propenyl-dUrd) inhibited the growth of herpes simplex virus (HSV) types 1 (HSV-1) and 2 in culture." | 3.66 | Anti-herpes simplex virus and anti-human cell growth activity of E-5-propenyl-2'-deoxyuridine and the concept of selective protection in antivirus chemotherapy. ( Bergstrom, DE; Cheng, YC; Grill, S; Ruth, J, 1980) |
| "Acyclovir is a prototype of this improved process." | 2.37 | Promising new antiviral drugs. ( Bryson, YJ, 1988) |
| "The thymine base has been tethered to a distal triphenylmethoxy moiety through a polymethylene chain (n = 3-8) or through a (2-ethoxy)ethyl spacer." | 1.33 | N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. ( Balzarini, J; Camarasa, MJ; Familiar, O; Gago, F; Hernandez, AI; Karlsson, A; Negri, A; Pérez-Pérez, MJ; Rodríguez-Barrios, F, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (81.67) | 18.7374 |
| 1990's | 4 (6.67) | 18.2507 |
| 2000's | 5 (8.33) | 29.6817 |
| 2010's | 2 (3.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matulic-Adamic, J | 1 |
| Takahashi, K | 1 |
| Chou, TC | 1 |
| Gadler, H | 1 |
| Price, RW | 1 |
| Reddy, AR | 1 |
| Kalman, TI | 1 |
| Watanabe, KA | 1 |
| Mansuri, MM | 1 |
| Ghazzouli, I | 1 |
| Chen, MS | 1 |
| Howell, HG | 1 |
| Brodfuehrer, PR | 1 |
| Benigni, DA | 1 |
| Martin, JC | 2 |
| Jeffrey, GA | 1 |
| McGee, DP | 1 |
| Tippie, MA | 1 |
| Smee, DF | 1 |
| Matthews, TR | 1 |
| Verheyden, JP | 1 |
| Bernstein, DI | 1 |
| Bravo, FJ | 1 |
| Clark, JR | 1 |
| Earwood, JD | 1 |
| Rahman, A | 2 |
| Glazer, R | 2 |
| Cardin, RD | 1 |
| Quenelle, DC | 1 |
| Collins, DJ | 1 |
| Rice, TL | 1 |
| Noy, R | 1 |
| Ben-Zvi, Z | 1 |
| Manor, E | 1 |
| Candotti, F | 1 |
| Morris, JC | 1 |
| Ford, H | 1 |
| Marquez, VE | 2 |
| Johns, DG | 1 |
| Agbaria, R | 3 |
| HANNA, C | 3 |
| WILKINSON, KP | 2 |
| DUBBS, DR | 1 |
| KIT, S | 1 |
| FORCE, EE | 1 |
| STEWART, RC | 1 |
| HAFF, RF | 1 |
| SIMINOFF, P | 1 |
| Choi, Y | 1 |
| Comin, MJ | 1 |
| Russ, P | 1 |
| George, C | 1 |
| Huleihel, M | 1 |
| Ben-Kasus, T | 1 |
| Dvir-Ginzberg, M | 1 |
| Konson, A | 1 |
| Cohen, S | 1 |
| Hernandez, AI | 1 |
| Familiar, O | 1 |
| Negri, A | 1 |
| Rodríguez-Barrios, F | 1 |
| Gago, F | 1 |
| Karlsson, A | 1 |
| Camarasa, MJ | 1 |
| Balzarini, J | 1 |
| Pérez-Pérez, MJ | 1 |
| Poirier, RH | 1 |
| Kingham, JD | 1 |
| de Miranda, P | 1 |
| Annel, M | 1 |
| Burkhardt, U | 1 |
| Wigand, R | 1 |
| Cheng, YC | 1 |
| Grill, S | 1 |
| Ruth, J | 1 |
| Bergstrom, DE | 1 |
| Stening, G | 1 |
| Gotthammar, B | 1 |
| Larsson, A | 1 |
| Alenius, S | 1 |
| Johansson, NG | 1 |
| Oberg, B | 1 |
| Machida, H | 3 |
| Sakata, S | 2 |
| Morozumi, M | 1 |
| Kiyanagi, T | 1 |
| Kuninaka, A | 3 |
| Yoshino, H | 3 |
| Fischer, PH | 1 |
| Murphy, DG | 1 |
| Kawahara, R | 1 |
| Spruance, SL | 1 |
| McKeough, M | 1 |
| Sugibayashi, K | 1 |
| Robertson, F | 1 |
| Gaede, P | 1 |
| Clark, DS | 1 |
| Hill, JM | 1 |
| Wiggins, CA | 1 |
| Kwon, BS | 1 |
| Gentry, GA | 2 |
| Gangarosa, LP | 1 |
| Gilbert, P | 1 |
| Work, K | 1 |
| Kreis, W | 1 |
| Damin, L | 1 |
| Colacino, J | 1 |
| Lopez, C | 1 |
| Ichikawa, M | 1 |
| Saneyoshi, M | 2 |
| Munir, KM | 1 |
| French, DC | 1 |
| Dube, DK | 1 |
| Loeb, LA | 1 |
| Tenser, RB | 1 |
| Gaydos, A | 1 |
| Hay, KA | 1 |
| Summers, BC | 1 |
| Margolis, TP | 1 |
| Leib, DA | 1 |
| Müller, WE | 1 |
| Falke, D | 1 |
| Renis, HE | 1 |
| Eidson, EE | 1 |
| Nakayama, C | 1 |
| Underwood, GE | 1 |
| Weed, SD | 1 |
| Gosling, PH | 2 |
| Puvion-Dutilleul, F | 1 |
| Puvion, E | 1 |
| Reuveni, H | 1 |
| Bull, CO | 1 |
| Landry, ML | 1 |
| Milstone, LM | 1 |
| Schwartz, PM | 1 |
| Bean, B | 1 |
| Bryson, YJ | 1 |
| Lietman, PS | 1 |
| Hayward, A | 1 |
| Laszlo, M | 1 |
| Vafai, A | 1 |
| Coen, DM | 1 |
| Irmiere, AF | 1 |
| Jacobson, JG | 1 |
| Kerns, KM | 1 |
| Ellis, MN | 2 |
| Keller, PM | 2 |
| Fyfe, JA | 1 |
| Martin, JL | 2 |
| Rooney, JF | 1 |
| Straus, SE | 1 |
| Lehrman, SN | 2 |
| Barry, DW | 2 |
| Rand, KH | 2 |
| Raad, I | 2 |
| el Koussi, A | 1 |
| Houck, HJ | 1 |
| Brey, W | 1 |
| Rocca, J | 1 |
| Loftsson, T | 1 |
| Bodor, N | 2 |
| Palù, G | 1 |
| Valisena, S | 1 |
| Cristalli, G | 1 |
| Cusinato, R | 1 |
| Peracchi, M | 1 |
| Stefanelli, S | 1 |
| Bonora, GM | 1 |
| Griengl, H | 1 |
| Hayden, W | 1 |
| Penn, G | 1 |
| De Clercq, E | 1 |
| Rosenwirth, B | 1 |
| Ayisi, NK | 1 |
| Gupta, SV | 1 |
| Babiuk, LA | 1 |
| Lawrence, N | 1 |
| Lushbaugh, W | 1 |
| Biron, KK | 1 |
| Furman, PA | 1 |
| el Koussi, AA | 1 |
| Miyake, A | 1 |
| Houck, H | 1 |
| Gildersleeve, N | 1 |
| Drucker, JL | 1 |
| King, DH | 1 |
| Harmenberg, J | 1 |
| Abele, G | 1 |
| Wahren, B | 1 |
| Coldiron, BM | 1 |
| Orcutt, VL | 1 |
| Barbaro, DJ | 1 |
| Bach, MC | 1 |
| Hermans, PE | 1 |
| Cockerill, FR | 1 |
| Hütteroth, TH | 1 |
| Litwin, SD | 1 |
| Cleve, H | 1 |
| Rasmussen, LE | 1 |
| Jordan, GW | 1 |
| Stevens, DA | 1 |
| Merigan, TC | 1 |
| Allen, LB | 1 |
| Sidwell, RW | 1 |
| Gray, GD | 1 |
| Nichol, FR | 1 |
| Mickelson, MM | 1 |
| Camiener, GW | 1 |
| Gish, DT | 1 |
| Kelly, RC | 1 |
| Wechter, WJ | 1 |
| Moxley, TE | 1 |
| Neil, GL | 1 |
1 review available for thymidine and Herpes Simplex Virus Infection
| Article | Year |
|---|---|
Promising new antiviral drugs.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Cytomegalovirus Infections; Foscarnet; Ganc | 1988 |
1 trial available for thymidine and Herpes Simplex Virus Infection
| Article | Year |
|---|---|
Trifluorthymidine in the treatment of herpes simplex corneal ulcers. A clinical evaluation.
Topics: Chemical Phenomena; Chemistry; Clinical Trials as Topic; Corneal Ulcer; Herpes Simplex; Humans; Idox | 1980 |
58 other studies available for thymidine and Herpes Simplex Virus Infection
| Article | Year |
|---|---|
Nucleosides. 150. Synthesis and some biological properties of 5-monofluoromethyl, 5-difluoromethyl, and 5-trifluoromethyl derivatives of 2'-deoxyuridine and 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyluracil.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Cell Division; Chemical Phenomena; Chemistry; Deo | 1988 |
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent.
Topics: Acyclovir; Animals; Arabinofuranosyluracil; Cell Line; Chemical Phenomena; Chemistry; Encephalitis; | 1987 |
Acyclic analogues of 2'-deoxynucleosides related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine as potential antiviral agents.
Topics: Acyclovir; Animals; Antiviral Agents; Female; Ganciclovir; Herpes Simplex; Mice; Phosphorylation; St | 1985 |
N-Methanocarbathymidine is more effective than acyclovir for treating neonatal herpes simplex virus infection in guinea pigs.
Topics: Acyclovir; Animals; Animals, Newborn; Antiviral Agents; Disease Models, Animal; Guinea Pigs; Herpes | 2011 |
Efficacy of orally administered low dose N-methanocarbathymidine against lethal herpes simplex virus type-2 infections of mice.
Topics: Administration, Oral; Animals; Antiviral Agents; Disease Models, Animal; Dose-Response Relationship, | 2011 |
Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Chromatography, High Pressure Liqui | 2002 |
UPTAKE OF TRITIUM-LABELED THYMIDINE IN THE RABBIT CORNEA INFECTED WITH HERPES SIMPLEX.
Topics: Animals; Cornea; DNA; Epithelium; Herpes Simplex; Keratitis; Keratitis, Dendritic; Metabolism; Rabbi | 1964 |
MUTANT STRAINS OF HERPES SIMPLEX DEFICIENT IN THYMIDINE KINASE-INDUCING ACTIVITY.
Topics: Animals; Herpes Simplex; Metabolism; Mice; Mutation; Nucleotides; Pharmacology; Phosphorylation; Pho | 1964 |
HERPES SIMPLEX SKIN INFECTION IN RABBITS. I. EFFECT OF 5-IODO-2'-DEOXYURIDINE.
Topics: Antiviral Agents; Deoxyuridine; Herpes Simplex; Hyaluronoglucosaminidase; Idoxuridine; Pharmacology; | 1964 |
THE EFFECT OF 5-BROMODEOXYURIDINE ON HERPES SIMPLEX INFECTION OF HELA CELLS.
Topics: Antigens; Antiviral Agents; Bromodeoxyuridine; DNA; DNA, Viral; HeLa Cells; Herpes Simplex; Humans; | 1964 |
EFFECT OF IDOXURIDINE ON THE UPTAKE OF TRITIUM-LABELED THYMIDINE IN THE RABBIT CORNEA INFECTED WITH HERPES SIMPLEX.
Topics: Animals; Cornea; Corneal Ulcer; DNA; DNA, Viral; Epithelium; Herpes Simplex; Idoxuridine; Keratitis; | 1965 |
Understanding how the herpes thymidine kinase orchestrates optimal sugar and nucleobase conformations to accommodate its substrate at the active site: a chemical approach.
Topics: Antiviral Agents; Binding Sites; Bridged Bicyclo Compounds; Carbohydrates; Crystallography, X-Ray; D | 2005 |
Entrapment of retroviral vector producer cells in three-dimensional alginate scaffolds for potential use in cancer gene therapy.
Topics: Alginates; Animals; Antiviral Agents; Cell Culture Techniques; Cells, Immobilized; Ganciclovir; Gene | 2007 |
N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Topics: Adenosine Triphosphate; Animals; Antiviral Agents; Arabinonucleosides; Binding, Competitive; Cell Pr | 2006 |
Intraocular antiviral penetration.
Topics: Acyclovir; Administration, Topical; Antiviral Agents; Arabinonucleotides; Eye; Eye Diseases; Herpes | 1982 |
Combined chemotherapy of cutaneous herpes simplex infection of the guinea pig.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinonucleosides; Deoxyuridine; Drug Therapy, Combination; F | 1983 |
Anti-herpes simplex virus and anti-human cell growth activity of E-5-propenyl-2'-deoxyuridine and the concept of selective protection in antivirus chemotherapy.
Topics: Antiviral Agents; Cell Division; Cells, Cultured; Deoxyuridine; Herpes Simplex; Humans; Simplexvirus | 1980 |
Antiherpes activity of [E]-5-(1-propenyl)-2'-deoxyuridine and 5-(1-propenyl)-1-beta-D-arabinofuranosyluracil.
Topics: Animals; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Cell Division; Cell Line; Chl | 1981 |
Comparison of the in vitro and in vivo anti-herpes activities of 1-beta-D-arabinofuranosylthymine and its 5'-monophosphate.
Topics: Animals; Antiviral Agents; Arabinonucleosides; Arabinonucleotides; Cell Line; Cell Survival; Cytopat | 1982 |
Preferential inhibition of 5-trifluoromethyl-2'-deoxyuridine phosphorylation by 5'-amino-5'-deoxythymidine in uninfected versus herpes simplex virus-infected cells.
Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Chlorocebus aethiops; Dideoxynucleosides; HeLa | 1983 |
Effect of azone and propylene glycol on penetration of trifluorothymidine through skin and efficacy of different topical formulations against cutaneous herpes simplex virus infections in guinea pigs.
Topics: Administration, Topical; Animals; Azepines; Diffusion; Female; Guinea Pigs; Herpes Simplex; Pharmace | 1984 |
Thymine arabinoside (Ara-T) topical and iontophoretic application for herpes simplex virus type 1 and type 2 skin infections in hairless mice.
Topics: Administration, Topical; Animals; Antiviral Agents; Arabinonucleosides; Drug Evaluation, Preclinical | 1984 |
In vitro metabolism of 1-beta-D-arabinofuranosylcytosine and 1-beta-2'-fluoroarabino-5-iodocytosine in normal and herpes simplex type 1 virus-infected cells.
Topics: Antiviral Agents; Cytarabine; Herpes Simplex; In Vitro Techniques; Phosphorylation; Thymidine | 1982 |
Effect of treatment with 1-beta-D-arabinofuranosylthymine of experimental encephalitis induced by herpes simplex virus in mice.
Topics: Animals; Antiviral Agents; Arabinonucleosides; Dose-Response Relationship, Drug; Encephalitis; Femal | 1980 |
Herpes thymidine kinase mutants with altered catalytic efficiencies obtained by random sequence selection.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Catalysis; Escherichia coli; Herpes Simplex; Kine | 1994 |
Reactivation of thymidine kinase-defective herpes simplex virus is enhanced by nucleoside.
Topics: Acyclovir; Animals; Antiviral Agents; Chlorocebus aethiops; Defective Viruses; Gene Deletion; Herpes | 1996 |
Herpes simplex virus type 1 corneal infection results in periocular disease by zosteriform spread.
Topics: Adolescent; Animals; beta-Galactosidase; Chlorocebus aethiops; Corneal Diseases; Dermatitis, Periora | 2001 |
Cellular and herpesvirus polymerases: their significance for chemotherapy.
Topics: Animals; Arabinonucleosides; DNA; DNA, Viral; Drug Evaluation, Preclinical; Herpes Simplex; Humans; | 1979 |
Activities of 5,6-dihydro-5-azathymidine against herpes simplex virus infections in mice.
Topics: Animals; Aza Compounds; Female; Herpes Simplex; Male; Mice; Mice, Inbred ICR; Thymidine | 1979 |
In vitro antiherpesviral activity of 5-alkyl derivatives of 1-beta-D-arabinofuranosyluracil.
Topics: Arabinofuranosyluracil; Cell Division; Cytopathogenic Effect, Viral; DNA; Herpes Simplex; Thymidine; | 1979 |
Efficacy of 5,6-dihydro-5-azathymidine against cutaneous herpes simplex virus in hairless mice.
Topics: Animals; Anti-Bacterial Agents; Herpes Simplex; Male; Mice; Mice, Inbred Strains; Skin Diseases, Inf | 1977 |
Letter: Treatment of herpes simplex with co-trimoxazole.
Topics: Amantadine; Drug Antagonism; Drug Combinations; Herpes Simplex; Humans; Penicillins; Sulfamethoxazol | 1975 |
Letter: Treatment of herpes simplex with co-trimoxazole.
Topics: Drug Combinations; Herpes Simplex; Humans; Immunity, Cellular; Lymphocytes; Sulfamethoxazole; Thymid | 1975 |
Ultrastructural localization of defined sequences of viral RNA and DNA by in situ hybridization of biotinylated DNA probes on sections of herpes simplex virus type 1 infected cells.
Topics: Animals; Biotin; Cells, Cultured; DNA Probes; DNA, Viral; Fibroblasts; Herpes Simplex; Microscopy, E | 1991 |
Antiviral activity of 5-iodo-2'-deoxyuridine and related drugs in human keratinocytes infected in vitro with herpes simplex virus type 1.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Drug Interactions; Guinea Pigs; Herpes Simplex; Humans | 1991 |
Antiviral therapy. New drugs and their uses.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Amantadine; Antiviral Agents; Chickenpox; Common Cold | 1986 |
Antiviral chemotherapy.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Herpes Simplex; Herpes Zoster; Huma | 1988 |
Human newborn natural killer cell responses to activation by monoclonal antibodies. Effect of culture with herpes simplex virus.
Topics: Antibodies, Monoclonal; Cells, Cultured; Cytotoxicity, Immunologic; DNA, Viral; Fibroblasts; Herpes | 1989 |
Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.
Topics: Acyclovir; Animals; Antiviral Agents; Bromodeoxyuridine; Drug Resistance, Microbial; Herpes Simplex; | 1989 |
Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity.
Topics: Acyclovir; Adult; Animals; Antiviral Agents; Arabinonucleosides; Cloning, Molecular; DNA Restriction | 1987 |
Trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19F nuclear magnetic resonance in a murine hepatitis model.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatitis, Viral, Animal; Her | 1987 |
A search for new anti-herpes virus compounds.
Topics: Adenosine; Antiviral Agents; Chemical Phenomena; Chemistry; Dansyl Compounds; Female; Herpes Simplex | 1987 |
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Cell Line; Chemical Phenomena; Chemistry; Deoxyuridine | 1988 |
Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with trifluorothymidine, phosphonoformate and acycloguanosine against herpes simplex viruses.
Topics: Acyclovir; Animals; Antiviral Agents; Deoxyuridine; DNA, Viral; Drug Combinations; Drug Resistance, | 1985 |
Isolation and differentiation of herpes simplex virus and Trichomonas vaginalis in cell culture.
Topics: Animals; Arabinonucleosides; Cells, Cultured; Cricetinae; Cytopathogenic Effect, Viral; Diagnosis, D | 1985 |
Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates.
Topics: Acyclovir; Autoradiography; Bromodeoxycytidine; Deoxycytidine; Herpes Simplex; Humans; Mutation; Sim | 1985 |
Potential treatment of herpes simplex virus encephalitis by brain-specific delivery of trifluorothymidine using a dihydropyridine in equilibrium pyridinium salt type redox delivery system.
Topics: Animals; Antiviral Agents; Blood-Brain Barrier; Brain Chemistry; Chromatography, High Pressure Liqui | 1986 |
Management of viral infections in AIDS patients.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Cytomegalovirus Infections; Herpes | 1987 |
Nucleoside pools of acyclovir-treated herpes simplex type 1 infected cells.
Topics: Acyclovir; Animals; Cells, Cultured; Chlorocebus aethiops; Foscarnet; Herpes Simplex; Humans; Kineti | 1985 |
Resolution of resistant chronic herpetic lesions with zidovudine in a patient with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Chronic Disease; Herpes Simplex; Humans; Male; Opportunis | 1988 |
Possible drug interaction during therapy with azidothymidine and acyclovir for AIDS.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Antiviral Agents; Drug Interactions; Herpes Si | 1987 |
Antiviral agents.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Amantadine; Antiviral Agents; Ganciclovir; Herpes Sim | 1987 |
Cultured lymphoid cell lines from normal subjects: membrane associated immunoglobulins studied by the mixed antiglobulin reaction.
Topics: Animals; Cell Line; Cell Membrane; Epitopes; Erythrocytes; Goats; Herpes Simplex; Humans; Immune Adh | 1972 |
Incorporation of idoxuridine analogs into corneal herpes simplex virus.
Topics: Animals; Autoradiography; Bromodeoxyuridine; Cornea; DNA, Viral; Epithelium; Floxuridine; Fluorourac | 1972 |
Herpes simplex encephalitis.
Topics: Encephalitis; Herpes Simplex; Humans; Simplexvirus; Thymidine | 1968 |
Lymphocyte interferon production and transformation after Herpes simplex infections in humans.
Topics: Antibodies, Viral; Antigens, Viral; Cells, Cultured; Cytopathogenic Effect, Viral; Fibroblasts; HeLa | 1974 |
Target-organ treatment of neurotropic virus diseases: efficacy as a chemotherapy tool and comparison of activity of adenine arabinoside, cytosine arabinoside, idoxuridine, and trifluorothymidine.
Topics: Adenine; Animals; Antiviral Agents; Arabinose; Brain; Cytarabine; Fluorine; Herpes Simplex; Idoxurid | 1972 |
Immunosuppressive, antiviral and antitumor activities of cytarabine derivatives.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cricetinae; Cytarabine; DNA; Esters; Graft Rejecti | 1972 |