Page last updated: 2024-11-06

thymidine and HIV

thymidine has been researched along with HIV in 92 studies

HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.

Research Excerpts

ExcerptRelevanceReference
"Novel derivatives of the anti-HIV-1 agent, TSAO-T, bearing at the N-3 position alkylating groups or photoaffinity labels were prepared and evaluated for their anti-HIV activity."7.74Novel N-3 substituted TSAO-T derivatives: synthesis and anti-HIV-evaluation. ( Balzarini, J; Bonache, MC; Camarasa, MJ; Pérez-Pérez, MJ; Quesada, E; San-Félix, A; Sheen, CW; Sluis-Cremer, N, 2008)
"To evaluate whether an inter-individual variability in the activity of thymidine kinase (TK) and deoxycytidine kinase (dCK), which are involved in the first step of phosphorylation of some nucleoside analogues, exists in antiretroviral-naive, HIV-seropositive patients."7.73Thymidine kinase and deoxycytidine kinase activity in mononuclear cells from antiretroviral-naive HIV-infected patients. ( Antonelli, G; Antonelli, L; Butera, O; Gianotti, N; Girardi, E; Iaiani, G; Lazzarin, A; Mazzi, R; Parisi, SG; Turriziani, O, 2005)
"The novel 5-chloro-, 5-bromo-, and 5-iodo-derivatives of 3'-fluoro-2',3'-dideoxyuridine (FddUrd), designated FddCIUrd, FddBrUrd, and FddIUrd, respectively, have been synthesized and evaluated for their antiretrovirus activity against human immunodeficiency virus (HIV) and murine Moloney sarcoma virus."7.675-Halogeno-3'-fluoro-2',3'-dideoxyuridines as inhibitors of human immunodeficiency virus (HIV): potent and selective anti-HIV activity of 3'-fluoro-2',3'-dideoxy-5-chlorouridine. ( Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Pauwels, R; Schols, D; Van Aerschot, A, 1989)
"The effect of 3'-azido-2',3'-dideoxythymidine (AZT) on the human immunodeficiency virus (HIV)-associated giant cell formation was studied in vitro."7.67Effect of 3'-azido-2',3'-dideoxythymidine (AZT) and neutralizing antibody on human immunodeficiency virus (HIV)-induced cytopathic effects: implication of giant cell formation for the spread of virus in vivo. ( Kobayashi, N; Matsuda, A; Nakashima, H; Tochikura, T; Ueda, T; Yamamoto, N, 1987)
"Six HIV-antigenaemic patients with AIDS or AIDS-related complex were studied to assess the effect of treatment with low-dose zidovudine (250 mg) in 6-hourly doses on HIV antigen (HIV-Ag) levels in cerebrospinal fluid (CSF)."7.67Decline of HIV antigen levels in cerebrospinal fluid during treatment with low-dose zidovudine. ( Cload, P; Danner, SA; de Gans, J; de Wolf, F; Derix, MM; Eeftinck Schattenkerk, JK; Goudsmit, J; Lange, JM; Ongerboer de Visser, BW, 1988)
"Among 16 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex studied serially, 12 had or developed antigenemia ranging from 16 to 3006 pg/mL in plasma."6.66Human immunodeficiency virus (HIV) antigenemia (p24) in the acquired immunodeficiency syndrome (AIDS) and the effect of treatment with zidovudine (AZT). ( Despotes, JC; Emeson, EE; Falk, LA; Jackson, GG; Knigge, M; Mack, D; Paul, DA; Rubenis, M, 1988)
"18 men with longstanding human immunodeficiency virus (HIV) antigenaemia but no symptoms received zidovudine in low-dose regimens (250 mg 6-hourly, 500 mg 6-hourly, or 500 mg 12-hourly) with or without acyclovir."5.06Effect of zidovudine on serum human immunodeficiency virus antigen levels in symptom-free subjects. ( Cload, P; Coutinho, RA; de Gans, J; de Wolf, F; Fiddian, AP; Goudsmit, J; Lange, JM; Schellekens, PT; van der Noordaa, J, 1988)
"During zidovudine and stavudine treatment, HIV-1 selects several mutations (thymidine-associated mutations, TAMs) in the reverse transcriptase gene that confer high- and moderate-levels of resistance, respectively, to these nucleoside reverse transcriptase inhibitors (NRTIs)."4.82Primer unblocking by HIV-1 reverse transcriptase and resistance to nucleoside RT inhibitors (NRTIs). ( Goldschmidt, V; Marquet, R, 2004)
"Zidovudine is a potent in vitro inhibitor of human immunodeficiency virus (HIV) with varying efficacy against other retroviruses."4.77Spectrum of antiviral activity and mechanism of action of zidovudine. An overview. ( Barry, DW; Furman, PA, 1988)
"Novel derivatives of the anti-HIV-1 agent, TSAO-T, bearing at the N-3 position alkylating groups or photoaffinity labels were prepared and evaluated for their anti-HIV activity."3.74Novel N-3 substituted TSAO-T derivatives: synthesis and anti-HIV-evaluation. ( Balzarini, J; Bonache, MC; Camarasa, MJ; Pérez-Pérez, MJ; Quesada, E; San-Félix, A; Sheen, CW; Sluis-Cremer, N, 2008)
"To evaluate whether an inter-individual variability in the activity of thymidine kinase (TK) and deoxycytidine kinase (dCK), which are involved in the first step of phosphorylation of some nucleoside analogues, exists in antiretroviral-naive, HIV-seropositive patients."3.73Thymidine kinase and deoxycytidine kinase activity in mononuclear cells from antiretroviral-naive HIV-infected patients. ( Antonelli, G; Antonelli, L; Butera, O; Gianotti, N; Girardi, E; Iaiani, G; Lazzarin, A; Mazzi, R; Parisi, SG; Turriziani, O, 2005)
"Oxygen-sulfur exchange at the C-4 carbonyl of several modified pyrimidine nucleosides, including 3'-azido-3'-deoxythymidine (AZT), is described in an effort to enhance the lipophilicity and, thereby, the delivery to the central nervous system of the sulfur analogues without compromising the anti-HIV activities of the parental structures."3.68Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders. ( Horwitz, JP; Kessel, D; Meltsner, BR; Palomino, E, 1990)
" Neither 3'-isocyano-3'-deoxythymidine (11) nor 3'-isocyano-2',3'-dideoxyuridine (12) showed anti-HIV activity at noncytotoxic concentrations."3.68Synthesis, antiretrovirus effects, and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine. ( Balzarini, J; De Clercq, E; Hiebl, J; Zbiral, E, 1990)
"The thymidine analog 3'-azido-3'-deoxythymidine (BW A509U, azidothymidine) can inhibit human immunodeficiency virus (HIV) replication effectively in the 50-500 nM range [Mitsuya, H."3.67Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. ( Bolognesi, DP; Broder, S; Freeman, GA; Furman, PA; Fyfe, JA; Lehrman, SN; Mitsuya, H; Rideout, JL; St Clair, MH; Weinhold, K, 1986)
"The ability of granulocyte-macrophage colony-stimulating factor (GM-CSF) and 3'-azido-3'-deoxythymidine (AZT) to inhibit human immunodeficiency virus (HIV) in the U-937 monocytic cell line was examined."3.67Synergistic activity of granulocyte-macrophage colony-stimulating factor and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro. ( Gillis, JM; Hammer, SM, 1987)
"The novel 5-chloro-, 5-bromo-, and 5-iodo-derivatives of 3'-fluoro-2',3'-dideoxyuridine (FddUrd), designated FddCIUrd, FddBrUrd, and FddIUrd, respectively, have been synthesized and evaluated for their antiretrovirus activity against human immunodeficiency virus (HIV) and murine Moloney sarcoma virus."3.675-Halogeno-3'-fluoro-2',3'-dideoxyuridines as inhibitors of human immunodeficiency virus (HIV): potent and selective anti-HIV activity of 3'-fluoro-2',3'-dideoxy-5-chlorouridine. ( Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Pauwels, R; Schols, D; Van Aerschot, A, 1989)
"The effect of D-penicillamine on the replication of the Human Immunodeficiency Virus (HIV) in H9 T-lymphoblastoid cells was evaluated."3.67Effect of D-penicillamine on the expression and propagation of the human immunodeficiency virus by H9 T-lymphoblastoid cells. ( Bitterlich, G; Dierich, MP; Hengster, P; Hofbauer, J; Larcher, C; Myones, BL; Schulz, TF; Sölder, B; Wachter, H, 1989)
"The 3'-fluoro-and 3'-azido-substituted derivatives of 2',3'-dideoxythymidine (ddThd), 2',3'-dideoxyuridine (ddUrd), 2',3'-dideoxy-5-ethyluridine (ddEtUrd) and 2',3'-dideoxycytidine (ddCyd) have been synthesized and evaluated for their anti-retrovirus activity [against human immunodeficiency virus (HIV) and murine Moloney sarcoma virus (MSV)]."3.67Anti-retrovirus activity of 3'-fluoro- and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside analogues. ( Baba, M; Balzarini, J; De Clerq, E; Herdewijn, P; Pauwels, R, 1988)
"'Ampligen', a non-toxic, mismatched polymer of double-stranded RNA with antiviral and immunomodulatory activities reduced the concentration of zidovudine (azidothymidine, AZT; 'Retrovir', Wellcome) required for inhibitory activity against human immunodeficiency virus (HIV) in vitro."3.67Mismatched double-stranded RNA (ampligen) reduces concentration of zidovudine (azidothymidine) required for in-vitro inhibition of human immunodeficiency virus. ( Carter, WA; Mitchell, WM; Montefiori, DC; Robinson, WE; Strayer, DR, 1987)
"Five dose regimens of 2',3'-dideoxycytidine (ddC) were administered, intravenously for 2 weeks then orally for 4 or more weeks, to 20 patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)."3.67Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT). ( Allain, JP; Dubinsky, R; Fischl, MA; Klecker, RW; McAtee, N; McNeely, MC; Perno, CF; Thomas, RV; Wills, RJ; Yarchoan, R, 1988)
"In a study of treatment by zidovudine in 106 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex, an acute meningo-encephalitic illness developed in 4 of 21 patients within 17 days after the dose of zidovudine had had to be reduced because of myelotoxicity."3.67Acute meningo-encephalitis on dose reduction of zidovudine. ( Forster, S; Helbert, M; Jeffries, D; Kocsis, A; Peddle, B; Pinching, AJ; Robinson, D, 1988)
"2',3'-Dideoxythymidine (ddThd) and its 2',3'-unsaturated derivative 2',3'-dideoxythymidinene (ddeThd) are potent and selective inhibitors of human immunodeficiency virus (HIV) in vitro."3.67Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro. ( Baba, M; De Clercq, E; Desmyter, J; Herdewijn, P; Pauwels, R; Vandeputte, M, 1987)
"The effect of 3'-azido-2',3'-dideoxythymidine (AZT) on the human immunodeficiency virus (HIV)-associated giant cell formation was studied in vitro."3.67Effect of 3'-azido-2',3'-dideoxythymidine (AZT) and neutralizing antibody on human immunodeficiency virus (HIV)-induced cytopathic effects: implication of giant cell formation for the spread of virus in vivo. ( Kobayashi, N; Matsuda, A; Nakashima, H; Tochikura, T; Ueda, T; Yamamoto, N, 1987)
"The effect of 3'-azido-3'-deoxythymidine (AZT) on replication of human immunodeficiency virus (HIV) in various hematopoietic cell lines was investigated."3.67Suppression of human immunodeficiency virus replication by 3'-azido-3'-deoxythymidine in various human hematopoietic cell lines in vitro: augmentation of the effect by lentinan. ( Kaneko, Y; Kobayashi, N; Nakashima, H; Tochikura, TS; Yamamoto, N, 1987)
"Six HIV-antigenaemic patients with AIDS or AIDS-related complex were studied to assess the effect of treatment with low-dose zidovudine (250 mg) in 6-hourly doses on HIV antigen (HIV-Ag) levels in cerebrospinal fluid (CSF)."3.67Decline of HIV antigen levels in cerebrospinal fluid during treatment with low-dose zidovudine. ( Cload, P; Danner, SA; de Gans, J; de Wolf, F; Derix, MM; Eeftinck Schattenkerk, JK; Goudsmit, J; Lange, JM; Ongerboer de Visser, BW, 1988)
"Among 16 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex studied serially, 12 had or developed antigenemia ranging from 16 to 3006 pg/mL in plasma."2.66Human immunodeficiency virus (HIV) antigenemia (p24) in the acquired immunodeficiency syndrome (AIDS) and the effect of treatment with zidovudine (AZT). ( Despotes, JC; Emeson, EE; Falk, LA; Jackson, GG; Knigge, M; Mack, D; Paul, DA; Rubenis, M, 1988)
"In patients not requiring HAART, treatment of hepatitis B should preferably consist of drugs without activity against HIV, such as pegylated interferon or adefovir."2.44[Hepatitis B in patients with HIV infection]. ( Barreiro, P; García-Samaniego, J; Martín-Carbonero, L, 2008)
"Patients with the acquired immunodeficiency syndrome (AIDS) die of overwhelming infections as a consequence of the destruction of the T4 subset of lymphocytes."2.37Developmental therapeutics and the acquired immunodeficiency syndrome. ( Broder, S; Chabner, BA; DeVita, VT; Fauci, AS; Kovacs, JA, 1987)
" At concentrations of up to 50 microM no natural 2'-deoxynucleosides, including thymidine, were able to reverse the toxic effects of AZT."1.27Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity. ( Carlisle, R; Schinazi, RF; Sommadossi, JP; Zhou, Z, 1988)

Research

Studies (92)

TimeframeStudies, this research(%)All Research%
pre-199071 (77.17)18.7374
1990's9 (9.78)18.2507
2000's10 (10.87)29.6817
2010's2 (2.17)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Palomino, E1
Meltsner, BR1
Kessel, D1
Horwitz, JP1
Herdewijn, P8
Balzarini, J11
De Clercq, E10
Pauwels, R7
Baba, M6
Broder, S12
Vanderhaeghe, H2
Sigaloff, KC1
Kayiwa, J1
Musiime, V1
Calis, JC1
Kaudha, E1
Mukuye, A1
Matama, C1
Nankya, I1
Nakatudde, L1
Dekker, JT1
Hamers, RL1
Mugyenyi, P1
Rinke De Wit, TF1
Kityo, C1
Barreiro, P2
Martín-Carbonero, L1
García-Samaniego, J1
López Bernaldo de Quirós, JC1
Gaynor, JW1
Cosstick, R1
de Mendoza, C1
Paxinos, E1
Camino, N1
Núñez, M1
Soriano, V1
Calvo, KC1
Wang, X1
Koser, GF1
Goldschmidt, V1
Marquet, R1
Ross, L1
Parkin, N1
Chappey, C1
Fisher, R1
Clair, MS1
Bates, M1
Tisdale, M1
Lanier, ER1
Turriziani, O1
Butera, O1
Gianotti, N1
Parisi, SG1
Mazzi, R1
Girardi, E1
Iaiani, G1
Antonelli, L1
Lazzarin, A1
Antonelli, G1
Wirden, M1
Malet, I1
Derache, A1
Marcelin, AG1
Roquebert, B1
Simon, A1
Kirstetter, M1
Joubert, LM1
Katlama, C1
Calvez, V1
Park, AY1
Moon, HR1
Kim, KR1
Chun, MW1
Jeong, LS1
Bonache, MC1
Quesada, E1
Sheen, CW1
Sluis-Cremer, N1
Pérez-Pérez, MJ1
Camarasa, MJ1
San-Félix, A1
Xu, ZQ1
Qiu, YL1
Chokekijchai, S1
Mitsuya, H5
Zemlicka, J1
Bochkarev, AV1
Zavgorodniĭ, SG1
Zhdanov, AS1
Gurskaia, GV1
Chen, MS2
Suttmann, RT1
Wu, JC1
Prisbe, EJ1
Almer, H1
Classon, B1
Samuelsson, B1
Kvarnström, I1
Yuzhakov, AA1
Chidgeavadze, ZG1
Beabealash-villi, RS1
Hiebl, J1
Zbiral, E1
Wigerinck, P1
Van Aerschot, A2
Janssen, G1
Claes, P1
Camerman, N1
Mastropaolo, D1
Camerman, A1
Furman, PA3
Fyfe, JA3
St Clair, MH1
Weinhold, K1
Rideout, JL2
Freeman, GA2
Lehrman, SN1
Bolognesi, DP1
Vogt, M1
Schooley, RT4
Hirsch, MS6
Nakashima, H6
Matsui, T2
Harada, S2
Kobayashi, N3
Matsuda, A3
Ueda, T3
Yamamoto, N8
Vogt, MW3
Hartshorn, KL2
Chou, TC3
Coleman, LA2
Crumpacker, C1
DeVita, VT1
Fauci, AS1
Kovacs, JA1
Chabner, BA1
Kaplan, JC3
Ueno, R3
Kuno, S3
Herzyk, P1
Beveridge, A1
Neidle, S1
Berenbaum, MC1
Lin, TS3
Schinazi, RF3
Prusoff, WH3
Hammer, SM1
Gillis, JM1
Smith, MS1
Brian, EL1
Pagano, JS2
Looney, DJ1
Wong-Staal, F1
Webb, TR1
Majumdar, C1
Abbotts, J1
Wilson, SH1
Mansuri, MM1
Starrett, JE1
Ghazzouli, I1
Hitchcock, MJ1
Sterzycki, RZ1
Brankovan, V1
August, EM1
Sommadossi, JP2
Schols, D1
Bitterlich, G1
Larcher, C1
Sölder, B1
Hengster, P1
Myones, BL1
Hofbauer, J1
Schulz, TF1
Wachter, H1
Dierich, MP1
Desmyter, J2
Goubau, P1
Vandeputte, M2
Richman, DD2
Kornbluth, RS1
Carson, DA1
Cooney, DA1
Dalal, M1
Kang, GJ1
Cupp, JE1
DeClercq, E1
Johns, DG2
Lin, JC1
Zhang, ZX1
Smith, MC1
Biron, K1
De Clerq, E1
Yarchoan, R3
Durno, AG1
Paradis, TJ1
Agyei-Aye, K1
Baker, DC1
Mitchell, WM1
Montefiori, DC1
Robinson, WE1
Strayer, DR1
Carter, WA1
Perno, CF1
Thomas, RV1
Klecker, RW1
Allain, JP2
Wills, RJ1
McAtee, N1
Fischl, MA1
Dubinsky, R1
McNeely, MC1
de Wolf, F2
Lange, JM3
Goudsmit, J3
Cload, P2
de Gans, J3
Schellekens, PT1
Coutinho, RA1
Fiddian, AP1
van der Noordaa, J1
Reiss, P1
Boucher, CA1
Danner, SA2
Fleury, HJ1
Morere, G1
Delord, B1
Faivre, R1
Helbert, M1
Robinson, D1
Peddle, B1
Forster, S1
Kocsis, A1
Jeffries, D1
Pinching, AJ1
Steel, M1
Tiessens, G1
Portegies, P1
Weber, J1
Cardin, AD1
Bowlin, TL1
Krstenansky, JL1
Kinney-Thomas, E1
Hamamoto, Y1
Barry, DW1
Tochikura, T1
Tochikura, TS1
Kaneko, Y1
Ikuta, K2
Imai, H2
Ueda, S2
Suehiro, S2
Kato, S2
Jackson, GG1
Paul, DA1
Falk, LA1
Rubenis, M1
Despotes, JC1
Mack, D1
Knigge, M1
Emeson, EE1
Derix, MM1
Eeftinck Schattenkerk, JK1
Ongerboer de Visser, BW1
Lefrere, JJ1
Courouce, AM1
Salmon, C1
Permin, H1
Dickmeiss, E1
Petersen, CS1
Ersbøll, J1
Mathiesen, L1
Krebs, HJ1
Glaser, V1
Matthes, E1
Lehmann, C1
Scholz, D1
Rosenthal, HA1
Langen, P1
Torrence, PF1
Kinjo, J1
Lesiak, K1
Carlisle, R1
Zhou, Z1
Barnes, DM1
Chaisson, RE1
Leuther, M1
Volberding, PA1
Blumberg, RS1
Byington, R1
Ito, M1
Shigeta, S1
Jablon, L1
Lyerly, HK1
Cohen, OJ1
Weinhold, KJ1
Gallo, RC1
Elwell, LP1
Ferone, R1
Hill, JA1
Ray, PH1
Richards, CA1
Singer, SC1
Knick, VB1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Uridine Supplementation, Mitochondrial Function, and Glucose Metabolism in HIV[NCT00471614]Phase 23 participants (Actual)Interventional2007-04-30Completed
A Randomized Pilot Study for the Treatment of AIDS or AIDS Related Complex With an Alternating or Simultaneous Combination Regimen of AZT and 2',3'-Dideoxyinosine[NCT00001267]Phase 342 participants Interventional1990-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for thymidine and HIV

ArticleYear
[Hepatitis B in patients with HIV infection].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 7

    Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; Comorbidity; Deox

2008
[Tenofovir DF in rescue regimens].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 8

    Topics: Adenine; Anti-HIV Agents; Antimetabolites; Clinical Trials, Phase III as Topic; Drug Resistance, Mul

2008
Primer unblocking by HIV-1 reverse transcriptase and resistance to nucleoside RT inhibitors (NRTIs).
    The international journal of biochemistry & cell biology, 2004, Volume: 36, Issue:9

    Topics: Adenosine Triphosphate; DNA Primers; Drug Resistance, Multiple, Viral; Foscarnet; HIV; HIV Reverse T

2004
Developmental therapeutics and the acquired immunodeficiency syndrome.
    Annals of internal medicine, 1987, Volume: 106, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Deoxyribonucleosides; HIV; Humans; Interferons

1987
Progress in the development of antiviral therapy for HTLV-III-associated diseases.
    Important advances in oncology, 1987

    Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; HIV; Humans; Phosphonoace

1987
Spectrum of antiviral activity and mechanism of action of zidovudine. An overview.
    The American journal of medicine, 1988, Aug-29, Volume: 85, Issue:2A

    Topics: Animals; Antiviral Agents; HIV; Humans; Retroviridae; Thymidine; Virus Replication; Zidovudine

1988
Treatment of human immunodeficiency virus infections.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Therapy, Combination; HIV; Humans; Ribavi

1987
Strategies for the future chemotherapy of human immunodeficiency virus (HIV).
    Haematology and blood transfusion, 1987, Volume: 31

    Topics: Acquired Immunodeficiency Syndrome; Drug Evaluation; HIV; Humans; Thymidine; Zidovudine

1987
Development of antiretroviral therapy for the acquired immunodeficiency syndrome and related disorders. A progress report.
    The New England journal of medicine, 1987, Feb-26, Volume: 316, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; HIV; Humans; Structure-Activity Relationship; Thymidine; Zidovud

1987

Trials

4 trials available for thymidine and HIV

ArticleYear
[Chemotherapy and immunoprophylaxis of HIV infection].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1986, Nov-25, Volume: 75, Issue:48

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Foscarnet; HIV; Huma

1986
Effect of zidovudine on serum human immunodeficiency virus antigen levels in symptom-free subjects.
    Lancet (London, England), 1988, Feb-20, Volume: 1, Issue:8582

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antigens, Viral; Antiviral Agents; Double-Blind Metho

1988
Human immunodeficiency virus (HIV) antigenemia (p24) in the acquired immunodeficiency syndrome (AIDS) and the effect of treatment with zidovudine (AZT).
    Annals of internal medicine, 1988, Volume: 108, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antigens, Viral; Antiviral Agents; Clinica

1988
"On the shelf" AIDS drug in clinical trial.
    Science (New York, N.Y.), 1987, Oct-16, Volume: 238, Issue:4825

    Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Fusidic Acid; HIV; Humans; Thymidine;

1987

Other Studies

79 other studies available for thymidine and HIV

ArticleYear
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: AIDS Dementia Complex; Animals; Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Chemistr

1990
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:8

    Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribon

1987
Short communication: high rates of thymidine analogue mutations and dual-class resistance among HIV-infected Ugandan children failing first-line antiretroviral therapy.
    AIDS research and human retroviruses, 2013, Volume: 29, Issue:6

    Topics: Amino Acid Substitution; Anti-HIV Agents; Child; Child, Preschool; Cross-Sectional Studies; Drug Res

2013
Dinucleotides containing 3'-S-phosphorothiolate linkages.
    Methods in molecular biology (Clifton, N.J.), 2011, Volume: 764

    Topics: Antiviral Agents; Chemistry, Pharmaceutical; Dinucleoside Phosphates; Endonucleases; Hepatitis B; He

2011
Different viral rebound following discontinuation of antiretroviral therapy in cases of infection with viruses carrying L74V or thymidine-associated mutations.
    Journal of clinical microbiology, 2004, Volume: 42, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Amino Acid Substitution; Anti-HIV Agents; CD4 Lymphocyte Count;

2004
Bis-ketol nucleoside triesters as prodrugs of the antiviral nucleoside triphosphate analogues of 3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine.
    Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:3

    Topics: Anti-HIV Agents; Cell Line; Esters; HIV; Humans; Molecular Structure; Nucleosides; Prodrugs; Stavudi

2004
Phenotypic impact of HIV reverse transcriptase M184I/V mutations in combination with single thymidine analog mutations on nucleoside reverse transcriptase inhibitor resistance.
    AIDS (London, England), 2004, Aug-20, Volume: 18, Issue:12

    Topics: Adenine; Algorithms; Anti-HIV Agents; Databases, Genetic; Didanosine; Dideoxynucleosides; Drug Resis

2004
Thymidine kinase and deoxycytidine kinase activity in mononuclear cells from antiretroviral-naive HIV-infected patients.
    AIDS (London, England), 2005, Mar-25, Volume: 19, Issue:5

    Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Deoxycytidine Kinase; Fema

2005
Clonal analyses of HIV quasispecies in patients harbouring plasma genotype with K65R mutation associated with thymidine analogue mutations or L74V substitution.
    AIDS (London, England), 2005, Mar-24, Volume: 19, Issue:6

    Topics: Amino Acid Substitution; Clone Cells; Genotype; HIV; HIV Infections; Humans; Mutation; Thymidine

2005
Synthesis of novel L-N-MCd4T as a potent anti-HIV agent.
    Organic & biomolecular chemistry, 2006, Nov-21, Volume: 4, Issue:22

    Topics: Anti-HIV Agents; Bridged Bicyclo Compounds; HIV; Humans; Lymphocytes; Microbial Sensitivity Tests; M

2006
Novel N-3 substituted TSAO-T derivatives: synthesis and anti-HIV-evaluation.
    Nucleosides, nucleotides & nucleic acids, 2008, Volume: 27, Issue:4

    Topics: Azides; Benzophenones; Cell Line; Drug Design; HIV; HIV Reverse Transcriptase; HIV-1; HIV-2; Protein

2008
Unsaturated acyclic analogues of 2'-deoxyadenosine and thymidine containing fluorine: synthesis and biological activity.
    Journal of medicinal chemistry, 1995, Mar-17, Volume: 38, Issue:6

    Topics: Adenine; Animals; Antineoplastic Agents; Antiviral Agents; Cattle; Deoxyadenosines; HIV; Humans; Hyd

1995
[X-ray structural study of 3'-O-methylthiomethylthymidine and 3'-O-methylsulfinylmethylthymidine--potential inhibitors of HIV].
    Bioorganicheskaia khimiia, 1995, Volume: 21, Issue:3

    Topics: Antiviral Agents; HIV; Nucleic Acid Conformation; Thymidine; X-Ray Diffraction

1995
Metabolism of 4'-azidothymidine. A compound with potent and selective activity against the human immunodeficiency virus.
    The Journal of biological chemistry, 1992, Jan-05, Volume: 267, Issue:1

    Topics: Cell Line; DNA; HIV; Humans; Kinetics; Phosphorylation; Substrate Specificity; T-Lymphocytes; Thymid

1992
Synthesis of a phosphonomethyl analogue of 3'-deoxy-3-fluorothymidine.
    Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1991, Volume: 45, Issue:7

    Topics: Antiviral Agents; Cells, Cultured; HIV; Humans; Thymidine

1991
A new method of synthesis of 3'-mercapto-3'-deoxythymidine.
    Nucleic acids symposium series, 1991, Issue:24

    Topics: Antiviral Agents; Cell Line; HIV; Humans; T-Lymphocytes; Thymidine; Zidovudine

1991
Synthesis, antiretrovirus effects, and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:2

    Topics: Antimetabolites; Antiviral Agents; Cell Survival; Chemical Phenomena; Chemistry; Dideoxynucleosides;

1990
Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:2

    Topics: Animals; Antiviral Agents; Cell Transformation, Viral; Cells, Cultured; Chemical Phenomena; Chemistr

1990
Structure of the anti-human immunodeficiency virus agent 3'-fluoro-3'-deoxythymidine and electronic charge calculations for 3'-deoxythymidines.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:9

    Topics: Antiviral Agents; Dideoxynucleosides; HIV; Hydrogen Bonding; Molecular Conformation; Molecular Struc

1990
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:21

    Topics: Antiviral Agents; Cell Survival; HIV; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Phosphory

1986
Inhibition of replication and cytopathic effect of human T cell lymphotropic virus type III/lymphadenopathy-associated virus by 3'-azido-3'-deoxythymidine in vitro.
    Antimicrobial agents and chemotherapy, 1986, Volume: 30, Issue:6

    Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; HIV; HIV Antigens; Human

1986
Ribavirin antagonizes the effect of azidothymidine on HIV replication.
    Science (New York, N.Y.), 1987, Mar-13, Volume: 235, Issue:4794

    Topics: Cell Line; HIV; Humans; Lymphocytes; Monocytes; Phosphorylation; Phytohemagglutinins; Ribavirin; Rib

1987
Antiviral therapy.
    Scientific American, 1987, Volume: 256, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Cytomegalovirus; DNA, Viral; Drug R

1987
Dextran sulphate, a potent anti-HIV agent in vitro having synergism with zidovudine.
    Lancet (London, England), 1987, Jun-13, Volume: 1, Issue:8546

    Topics: Antiviral Agents; Dextran Sulfate; Dextrans; Drug Synergism; HIV; Humans; Thymidine; Zidovudine

1987
Conformational properties of 3'-azido-3'deoxy-thymidine (AZT), an inhibitor of HIV reverse transcriptase.
    Biochemical and biophysical research communications, 1987, Jun-30, Volume: 145, Issue:3

    Topics: Antiviral Agents; HIV; Models, Molecular; Molecular Conformation; Reverse Transcriptase Inhibitors;

1987
Anti-HIV synergy between dextran sulphate and zidovudine.
    Lancet (London, England), 1987, Aug-22, Volume: 2, Issue:8556

    Topics: Dextran Sulfate; Dextrans; Drug Synergism; HIV; Thymidine; Zidovudine

1987
Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus.
    Biochemical pharmacology, 1987, Sep-01, Volume: 36, Issue:17

    Topics: Antiviral Agents; Deoxycytidine; HIV; Humans; Monocytes; Retroviridae Proteins; RNA-Directed DNA Pol

1987
Anti-HIV synergism between dextran sulphate and zidovudine.
    Lancet (London, England), 1987, Oct-03, Volume: 2, Issue:8562

    Topics: Antiviral Agents; Dextran Sulfate; Dextrans; Drug Synergism; HIV; Humans; Thymidine; Zidovudine

1987
Synergistic activity of granulocyte-macrophage colony-stimulating factor and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:7

    Topics: Antiviral Agents; Cell Line; Drug Synergism; Fluorescent Antibody Technique; HIV; Humans; Interleuki

1987
Resumption of virus production after human immunodeficiency virus infection of T lymphocytes in the presence of azidothymidine.
    Journal of virology, 1987, Volume: 61, Issue:12

    Topics: Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; DNA, Viral; Drug Resistance, Microbial; H

1987
Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells.
    Science (New York, N.Y.), 1988, Apr-29, Volume: 240, Issue:4852

    Topics: Antigens, Differentiation, T-Lymphocyte; Cell Line; Dextran Sulfate; Dextrans; Dideoxynucleosides; D

1988
1-(2,3-Anhydro-beta-D-lyxofuranosyl)cytosine derivatives as potential inhibitors of the human immunodeficiency virus.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:7

    Topics: Ancitabine; Chemical Phenomena; Chemistry; Cytarabine; Cytidine; HIV; Magnetic Resonance Spectroscop

1988
Studies on the mechanism of human immunodeficiency virus reverse transcriptase. Steady-state kinetics, processivity, and polynucleotide inhibition.
    The Journal of biological chemistry, 1988, Oct-25, Volume: 263, Issue:30

    Topics: Algorithms; DNA Replication; DNA-Directed DNA Polymerase; HIV; Kinetics; Poly C; Poly T; Polynucleot

1988
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:2

    Topics: Antiviral Agents; Bone Marrow; Dideoxynucleosides; HIV; Stavudine; Thymidine; Zidovudine

1989
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.
    The Journal of biological chemistry, 1989, Apr-15, Volume: 264, Issue:11

    Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Deoxycytidine; Deoxyribonucleotides; Dideoxynuc

1989
5-Halogeno-3'-fluoro-2',3'-dideoxyuridines as inhibitors of human immunodeficiency virus (HIV): potent and selective anti-HIV activity of 3'-fluoro-2',3'-dideoxy-5-chlorouridine.
    Molecular pharmacology, 1989, Volume: 35, Issue:5

    Topics: Antiviral Agents; Cell Transformation, Viral; Deoxycytidine; Dideoxynucleosides; Halogens; HIV; Phos

1989
Effect of D-penicillamine on the expression and propagation of the human immunodeficiency virus by H9 T-lymphoblastoid cells.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:8

    Topics: Cells, Cultured; HIV; HIV Antigens; Humans; Penicillamine; Spectrometry, Fluorescence; T-Lymphocytes

1989
Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus.
    Journal of virological methods, 1987, Volume: 16, Issue:3

    Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Deoxycyti

1987
Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages.
    The Journal of experimental medicine, 1987, Oct-01, Volume: 166, Issue:4

    Topics: Adenosine Kinase; Cell Line; Deoxyadenosines; Deoxycytidine; Deoxycytidine Kinase; Dideoxyadenosine;

1987
2',3'-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis.
    Molecular pharmacology, 1987, Volume: 32, Issue:6

    Topics: Animals; Antiviral Agents; Deoxycytidine; Deoxycytosine Nucleotides; HIV; Humans; Leukemia L1210; Mi

1987
The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species.
    Biochemical pharmacology, 1988, Mar-01, Volume: 37, Issue:5

    Topics: Animals; Antiviral Agents; Cell Line; Deoxycytidine; HIV; Humans; Mice; Mice, Inbred C3H; Moloney mu

1988
Anti-human immunodeficiency virus agent 3'-azido-3'-deoxythymidine inhibits replication of Epstein-Barr virus.
    Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:2

    Topics: Cell Line; Cytomegalovirus; Herpesvirus 3, Human; Herpesvirus 4, Human; HIV; Simplexvirus; Thymidine

1988
Inhibition of infectivity and replication of HIV-2 and SIV in helper T-cells by 2',3'-dideoxynucleosides in vitro.
    AIDS research and human retroviruses, 1988, Volume: 4, Issue:2

    Topics: Cytopathogenic Effect, Viral; Deoxyadenosines; Deoxycytidine; Dideoxyadenosine; HIV; In Vitro Techni

1988
Anti-retrovirus activity of 3'-fluoro- and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside analogues.
    Biochemical pharmacology, 1988, Jul-15, Volume: 37, Issue:14

    Topics: Animals; Antimetabolites; Antiviral Agents; Cell Division; Deoxycytidine; Deoxycytidine Kinase; Dide

1988
Synergistic interaction of 2',3'-dideoxycytidine and recombinant interferon-alpha-A on replication of human immunodeficiency virus type 1.
    The Journal of infectious diseases, 1988, Volume: 158, Issue:2

    Topics: Antiviral Agents; Cell Line; Deoxycytidine; Drug Synergism; HIV; Humans; Interferon Type I; Leukocyt

1988
Synthesis and evaluation of a series of 1-(3-alkyl-2,3-dideoxy-alpha,beta-D-erythro-pentofuranosyl)thymines.
    Carbohydrate research, 1988, Dec-01, Volume: 183, Issue:2

    Topics: Acetylation; Chemical Phenomena; Chemistry; Chemistry, Physical; Chromatography, High Pressure Liqui

1988
Mismatched double-stranded RNA (ampligen) reduces concentration of zidovudine (azidothymidine) required for in-vitro inhibition of human immunodeficiency virus.
    Lancet (London, England), 1987, Apr-18, Volume: 1, Issue:8538

    Topics: Antiviral Agents; Cell Line; HIV; Humans; Poly I-C; Poly U; Polyribonucleotides; Thymidine; Virus Re

1987
Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).
    Lancet (London, England), 1988, Jan-16, Volume: 1, Issue:8577

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Deoxycytidine; Drug Administration

1988
Resumption of HIV antigen production during continuous zidovudine treatment.
    Lancet (London, England), 1988, Feb-20, Volume: 1, Issue:8582

    Topics: Acquired Immunodeficiency Syndrome; Antigens, Viral; Antiviral Agents; HIV; Humans; Thymidine; Zidov

1988
Isolation of HIV from mononuclear cells of patients receiving zidovudine.
    Lancet (London, England), 1988, Apr-16, Volume: 1, Issue:8590

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Antiviral Agents; HIV; Humans; Leuk

1988
Acute meningo-encephalitis on dose reduction of zidovudine.
    Lancet (London, England), 1988, Jun-04, Volume: 1, Issue:8597

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; AIDS-Related Complex; Antiviral Agents; Fo

1988
IVth international AIDS conference.
    Lancet (London, England), 1988, Jul-02, Volume: 2, Issue:8601

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies, Viral; Child; Congresses as Topic; Female; He

1988
Acute meningoencephalitis on dose reduction of zidovudine.
    Lancet (London, England), 1988, Sep-03, Volume: 2, Issue:8610

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; HIV; Humans; Meningoencephalitis; Thymidine; Viru

1988
AIDS: the virus, antivirals and vaccines.
    British journal of hospital medicine, 1987, Volume: 37, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Antimony; Antiviral Agents; Foscarnet; Genes, Viral; HIV; Humans

1987
Inhibition of lymphocyte proliferation by synthetic peptides homologous to human plasma apolipoproteins B and E.
    Biochemical and biophysical research communications, 1988, Jul-29, Volume: 154, Issue:2

    Topics: Apolipoproteins B; Apolipoproteins E; Binding Sites; Cell Division; Heparin; HIV; Humans; Lymphocyte

1988
Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.
    Biochemical and biophysical research communications, 1987, Jan-15, Volume: 142, Issue:1

    Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Dideoxynu

1987
Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro.
    Biochemical pharmacology, 1987, Feb-01, Volume: 36, Issue:3

    Topics: Antiviral Agents; Deoxycytidine; Fluorescence; HIV; Humans; In Vitro Techniques; Monocytes; Thymidin

1987
Substances affecting the infection and replication of human immunodeficiency virus (HIV).
    AIDS research, 1986, Volume: 2 Suppl 1

    Topics: Cell Line; Cytopathogenic Effect, Viral; Deltaretrovirus; Dinoprostone; HIV; Humans; Interferon-gamm

1986
Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:6

    Topics: Antigens, Viral; Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Dideoxynucleosides

1987
Effect of 3'-azido-2',3'-dideoxythymidine (AZT) and neutralizing antibody on human immunodeficiency virus (HIV)-induced cytopathic effects: implication of giant cell formation for the spread of virus in vivo.
    Virology, 1987, Volume: 159, Issue:1

    Topics: Antibodies, Viral; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Antiviral Agents; Cel

1987
Suppression of human immunodeficiency virus replication by 3'-azido-3'-deoxythymidine in various human hematopoietic cell lines in vitro: augmentation of the effect by lentinan.
    Japanese journal of cancer research : Gann, 1987, Volume: 78, Issue:6

    Topics: Cell Line; Drug Synergism; Hematopoietic Stem Cells; HIV; Humans; Lentinan; Polysaccharides; T-Lymph

1987
Amplification of human immuno-deficiency virus production from a virus-producing cell line in culture at high cell density.
    Japanese journal of cancer research : Gann, 1987, Volume: 78, Issue:7

    Topics: Cell Line; Culture Media; Electrophoresis, Polyacrylamide Gel; HIV; Humans; Membrane Proteins; Thymi

1987
Suppression by neurotropin of production of human immuno-deficiency virus by the virus-producing MOLT-4 cell line.
    Japanese journal of cancer research : Gann, 1987, Volume: 78, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Antigens, Surface; Antigens, Viral; Cell Line; HIV; Humans; Poly

1987
Decline of HIV antigen levels in cerebrospinal fluid during treatment with low-dose zidovudine.
    AIDS (London, England), 1988, Volume: 2, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Antigens, Viral; Central Nervous System Diseases; HIV; HIV Antig

1988
HIV antigenemia and zidovudine.
    AIDS (London, England), 1988, Volume: 2, Issue:3

    Topics: Antigens, Viral; Antiviral Agents; HIV; HIV Antigens; Humans; Thymidine; Zidovudine

1988
[HIV infection and AIDS. Paris, 25-29 January 1988].
    Ugeskrift for laeger, 1988, Apr-18, Volume: 150, Issue:16

    Topics: Acquired Immunodeficiency Syndrome; Antibody Formation; HIV; Humans; Thymidine; Zidovudine

1988
[Zidovudin (Retrovir). A new antiviral agents against human immunodeficiency viruses (HIV)].
    Ugeskrift for laeger, 1988, Jan-25, Volume: 150, Issue:4

    Topics: Antiviral Agents; Chemical Phenomena; Chemistry; HIV; Thymidine; Zidovudine

1988
The effect of zidovudine on antigen levels in HIV infection.
    New York state journal of medicine, 1988, Volume: 88, Issue:5

    Topics: Acyclovir; Antigens, Viral; Antiviral Agents; Drug Therapy, Combination; HIV; HIV Antigens; HIV Sero

1988
Phosphorylation, anti-HIV activity and cytotoxicity of 3'-fluorothymidine.
    Biochemical and biophysical research communications, 1988, Jun-16, Volume: 153, Issue:2

    Topics: Animals; Antiviral Agents; Cell Division; Cell Line; Cell Survival; Cytidine Diphosphate; Cytopathog

1988
AIDS dementia: synthesis and properties of a derivative of 3'-azido-3'-deoxythymidine (AZT) that may become 'locked' in the central nervous system.
    FEBS letters, 1988, Jul-04, Volume: 234, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Animals; Brain; Cell Line; Chemical Phenomena; Chemistry; Dement

1988
Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity.
    Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:7

    Topics: Antiviral Agents; Cytidine; HIV; Humans; In Vitro Techniques; Macrophages; Stem Cells; Thymidine; Ur

1988
Significant changes in HIV antigen level in the serum of patients treated with azidothymidine.
    The New England journal of medicine, 1986, Dec-18, Volume: 315, Issue:25

    Topics: Acquired Immunodeficiency Syndrome; Antigens, Viral; Antiviral Agents; HIV; HIV Antigens; Humans; Th

1986
Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:2

    Topics: Antiviral Agents; Drug Synergism; HIV; Humans; Interferon Type I; Recombinant Proteins; Thymidine; V

1987
Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)].
    Antiviral research, 1987, Volume: 7, Issue:3

    Topics: Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; Drug Interactions; Glycyrrhetinic Acid; G

1987
Azidothymidine (AZT).
    Connecticut medicine, 1987, Volume: 51, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; HIV; Humans; Thymidine; Zidovudine

1987
Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine.
    AIDS research and human retroviruses, 1987,Spring, Volume: 3, Issue:1

    Topics: Antigen-Presenting Cells; Antiviral Agents; Cell Line; Cell Survival; HIV; Humans; Lymphocyte Activa

1987
Dideoxynucleosides are less inhibitory in vitro against human immunodeficiency virus type 2 (HIV-2) than against HIV-1.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:12

    Topics: Antiviral Agents; Cell Line; Drug Resistance, Microbial; HIV; Humans; T-Lymphocytes; Thymidine; Viru

1987
The AIDS virus.
    Scientific American, 1987, Volume: 256, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Animals; Chlorocebus aethiops; Genes, Viral; History, 20th Centu

1987
Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U).
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:2

    Topics: Antiviral Agents; DNA Replication; DNA, Bacterial; Drug Resistance, Microbial; Enterobacteriaceae; E

1987