thymidine and Glioma
thymidine has been researched along with Glioma in 139 studies
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "This phase II study in recurrent high-grade glioma evaluated the response rate, toxicities, and time to treatment failure of high-dose carboplatin modulated by a 24-h infusion of thymidine (75 g/m(2))." | 9.10 | A phase II trial of thymidine and carboplatin for recurrent malignant glioma: a North American Brain Tumor Consortium Study. ( Chang, SM; Cloughesy, T; Fink, K; Greenberg, H; Hess, K; Junck, L; Kuhn, JG; Mehta, M; Nicolas, K; Prados, MD; Robins, HI; Schiff, D; Yung, WK, 2002) |
| " The purpose of this study was to evaluate (11)C-4DST uptake in patients with newly diagnosed glioma and to correlate the results with proliferative activity and tumor grade, in comparison with L-[methyl-(11)C]-methionine ((11)C-MET)." | 7.83 | Correlation of 4'-[methyl-(11)C]-thiothymidine uptake with Ki-67 immunohistochemistry and tumor grade in patients with newly diagnosed gliomas in comparison with (11)C-methionine uptake. ( Kawai, N; Kudomi, N; Maeda, Y; Nishiyama, Y; Tanaka, K; Toyohara, J; Yamamoto, H; Yamamoto, Y, 2016) |
| "The effect of genistein, a protein tyrosine kinase and topoisomerase II inhibitor, on the DNA synthesis rate was studied in 21 human glioma specimens obtained at routine craniotomies for tumor resection." | 7.75 | Rapid inhibition of ongoing DNA synthesis in human glioma tissue by genistein. ( Cruz, MH; Ohlsson Lindblom, I; Siden, A; Yakisich, JS, 2009) |
| "The authors have previously shown that medroxyprogesterone acetate (MPA) inhibits growth and increases drug sensitivity in C6 glioma with myeloid bodies." | 7.74 | Medroxyprogesterone acetate induces c6 glioma chemosensitization via antidepressant-like lysosomal phospholipidosis/myelinosis in vitro. ( Altinoz, MA; Bilir, A; Del Maestro, RF; Gedikoglu, G; Ozcan, E; Ozdilli, K; Sav, A, 2007) |
| " This study examines the predictive value of positron emission tomography (PET) using [18F] fluorothymidine (FLT), an imaging biomarker of cell proliferation, in patients with recurrent malignant gliomas treated with bevacizumab in combination with irinotecan." | 7.74 | Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study. ( Chen, W; Cloughesy, T; Czernin, J; Delaloye, S; Geist, C; Lai, A; Phelps, ME; Pope, W; Satyamurthy, N; Sayre, J; Silverman, DH, 2007) |
| "We have recently shown that endothelin-1 activates two types of Ca2+-permeable nonselective cation channels (NSCC-1 and NSCC-2) in C6 glioma cells." | 7.71 | Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells. ( Hashimoto, N; Kawanabe, Y; Masaki, T, 2002) |
| " Recently, it has been shown that free geranylgeraniol (GG-OH) and farnesol (F-OH) can be utilized by C6 glioma cells for protein isoprenylation." | 7.70 | Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. ( Andres, DA; Crick, DC; Danesi, R; Macchia, M; Waechter, CJ, 1998) |
| "We have recently shown that glioma cell lines, as well as cells of human malignant gliomas in situ, synthesize tropoelastin." | 7.70 | Cell surface aggregation of elastin receptor molecules caused by suramin amplified signals leading to proliferation of human glioma cells. ( Hinek, A; Jung, S; Rutka, JT, 1999) |
| "Tamoxifen has been shown to inhibit the proliferation of human gliomas in vitro." | 7.69 | A comparison of the relative chemosensitivity of human gliomas to tamoxifen and n-desmethyltamoxifen in vitro. ( Kristofik, MP; Randall, MS; Rehn, T; Selker, RG; Vertosick, FT, 1994) |
| "Treatment of rat C6 glioma cells with the tricyclic antidepressant desipramine induces opioid binding." | 7.69 | A monoclonal anti-idiotypic antibody to opioid receptors labels desipramine-induced opioid binding sites on rat C6 glioma cells and attenuates thymidine incorporation into DNA. ( Barg, J; Belcheva, MM; Coscia, CJ; Johnson, FE; Levy, R; McHale, RJ; McLachlan, JA; Vogel, Z, 1994) |
| "The antiviral agents ganciclovir, 1-beta-D-arabinofuranosylthymine (araT), acyclovir, and 5-iodo-5'-amino-2',5'-dideoxyuridine were cytotoxic to rat C6 glioma cells expressing retrovirally transferred herpes simplex virus (HSV) type 1 thymidine kinase (TK) coding sequence, with concentrations that inhibited cell survival by 50% (IC50 values) of 0." | 7.69 | Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells. ( Breakefield, XO; Davidson, BL; Hughes, TL; Roessler, BJ; Shewach, DS; Zerbe, LK, 1994) |
| "The cytotoxic, antiproliferative, and radiosensitizing effects of thymidine (a nucleoside metabolite) were studied using the C6 glioma cell line in vitro." | 7.68 | Radiosensitization of C6 glioma by thymidine and 41.8 degrees C hyperthermia. ( Cohen, JD; Javid, MJ; Robins, HI, 1990) |
| "Effects of trifluoroacetic acid (TFA) on cell growth, DNA, glycoprotein, and dolichol-linked oligosaccharides synthesis and ribonucleotide triphosphate concentrations were examined in exponentially growing C6 murine glioma cells." | 7.68 | Effects of trifluoroacetic acid, a halothane metabolite, on C6 glioma cells. ( Ling, YH; Ma, TG; McClure, GD; Tseng, MT, 1990) |
| "8 degrees C hyperthermia were used to sensitize C6 glioma cells to carboplatin cytotoxicity in vitro." | 7.68 | Sensitization of C6 glioma to carboplatin cytotoxicity by hyperthermia and thymidine. ( Cohen, JD; Javid, MJ; Robins, HI, 1990) |
| " This study demonstrates that phorbol ester pretreatment of a LAK cell-sensitive glioma cell line (SNB-19) induced a significant decrease in the susceptibility of cells to LAK cell-mediated lysis." | 7.68 | Effect of phorbol esters on the susceptibility of a glioma cell line to lymphokine-activated killer cell activity. ( Alterman, RL; Kornblith, PL; Maleci, A; Moskal, JR; Sundstrom, D, 1990) |
| " The mitogenic properties of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) were examined in three human malignant glioma cell lines (T98G, U87, and U138)." | 7.68 | Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium. ( Kelly, RH; Kristofik, MP; Pollack, IF; Randall, MS; Selker, RG; Vertosick, FT, 1990) |
| "This paper studies the influence of uridine on the effects exerted by D-glucosamine in rat C6 glioma cells." | 7.67 | Uridine enhances the cytotoxic effect of D-glucosamine in rat C6 glioma cells. ( Calvaruso, G; Romano, N; Taibi, G; Tesoriere, G; Torregrossa, MV, 1986) |
| "The Na+ uptake into neuroblastoma x glioma hybrid cells was measured in Hepes-buffered EMEM containing 10% calf serum and 5 mM ouabain in the presence and absence of amiloride (1." | 7.66 | Membrane potential and sodium flux in neuroblastoma X glioma hybrid cells: effects of amiloride and serum. ( O'Donnell, ME; Villereal, ML, 1982) |
| "Cholecystokinin (CCK) is a gut-brain peptide has been described to be able to induce mitosis according to recent studies." | 5.35 | Cholecystokinin (CCK) and CCK receptor expression by human gliomas: Evidence for an autocrine/paracrine stimulatory loop. ( Adams, EF; Buchfelder, M; Oikonomou, E, 2008) |
| "This phase II study in recurrent high-grade glioma evaluated the response rate, toxicities, and time to treatment failure of high-dose carboplatin modulated by a 24-h infusion of thymidine (75 g/m(2))." | 5.10 | A phase II trial of thymidine and carboplatin for recurrent malignant glioma: a North American Brain Tumor Consortium Study. ( Chang, SM; Cloughesy, T; Fink, K; Greenberg, H; Hess, K; Junck, L; Kuhn, JG; Mehta, M; Nicolas, K; Prados, MD; Robins, HI; Schiff, D; Yung, WK, 2002) |
| " The purpose of this study was to evaluate (11)C-4DST uptake in patients with newly diagnosed glioma and to correlate the results with proliferative activity and tumor grade, in comparison with L-[methyl-(11)C]-methionine ((11)C-MET)." | 3.83 | Correlation of 4'-[methyl-(11)C]-thiothymidine uptake with Ki-67 immunohistochemistry and tumor grade in patients with newly diagnosed gliomas in comparison with (11)C-methionine uptake. ( Kawai, N; Kudomi, N; Maeda, Y; Nishiyama, Y; Tanaka, K; Toyohara, J; Yamamoto, H; Yamamoto, Y, 2016) |
| "The effect of genistein, a protein tyrosine kinase and topoisomerase II inhibitor, on the DNA synthesis rate was studied in 21 human glioma specimens obtained at routine craniotomies for tumor resection." | 3.75 | Rapid inhibition of ongoing DNA synthesis in human glioma tissue by genistein. ( Cruz, MH; Ohlsson Lindblom, I; Siden, A; Yakisich, JS, 2009) |
| "The authors have previously shown that medroxyprogesterone acetate (MPA) inhibits growth and increases drug sensitivity in C6 glioma with myeloid bodies." | 3.74 | Medroxyprogesterone acetate induces c6 glioma chemosensitization via antidepressant-like lysosomal phospholipidosis/myelinosis in vitro. ( Altinoz, MA; Bilir, A; Del Maestro, RF; Gedikoglu, G; Ozcan, E; Ozdilli, K; Sav, A, 2007) |
| " This study examines the predictive value of positron emission tomography (PET) using [18F] fluorothymidine (FLT), an imaging biomarker of cell proliferation, in patients with recurrent malignant gliomas treated with bevacizumab in combination with irinotecan." | 3.74 | Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study. ( Chen, W; Cloughesy, T; Czernin, J; Delaloye, S; Geist, C; Lai, A; Phelps, ME; Pope, W; Satyamurthy, N; Sayre, J; Silverman, DH, 2007) |
| " The human glioma cell lines U87 MG, U251 MG and U138 MG were treated with purines and pyrimidines for 24 or 48 h and proliferation was measured by [3H]-thymidine incorporation, flow cytometry and cell counting." | 3.72 | Extracellular nucleotides and nucleosides induce proliferation and increase nucleoside transport in human glioma cell lines. ( Bernardi, A; Horn, AP; Jacques-Silva, MC; Lenz, G; Morrone, FB; Rodnight, R; Schwartsmann, G, 2003) |
| "We have recently shown that endothelin-1 activates two types of Ca2+-permeable nonselective cation channels (NSCC-1 and NSCC-2) in C6 glioma cells." | 3.71 | Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells. ( Hashimoto, N; Kawanabe, Y; Masaki, T, 2002) |
| " Recently, it has been shown that free geranylgeraniol (GG-OH) and farnesol (F-OH) can be utilized by C6 glioma cells for protein isoprenylation." | 3.70 | Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. ( Andres, DA; Crick, DC; Danesi, R; Macchia, M; Waechter, CJ, 1998) |
| " In the present study, butyrate treatment caused decreases in thymidine incorporation in the early passages (45-60) of C6 glioma cells." | 3.70 | Alterations in Ca2+ signaling, and c-fos and nur77 expression are associated with sodium butyrate-induced differentiation of C6 glioma cell. ( Jang, TH; Sun, SH, 2000) |
| "We have recently shown that glioma cell lines, as well as cells of human malignant gliomas in situ, synthesize tropoelastin." | 3.70 | Cell surface aggregation of elastin receptor molecules caused by suramin amplified signals leading to proliferation of human glioma cells. ( Hinek, A; Jung, S; Rutka, JT, 1999) |
| "Treatment of rat C6 glioma cells with the tricyclic antidepressant desipramine induces opioid binding." | 3.69 | A monoclonal anti-idiotypic antibody to opioid receptors labels desipramine-induced opioid binding sites on rat C6 glioma cells and attenuates thymidine incorporation into DNA. ( Barg, J; Belcheva, MM; Coscia, CJ; Johnson, FE; Levy, R; McHale, RJ; McLachlan, JA; Vogel, Z, 1994) |
| "Tamoxifen has been shown to inhibit the proliferation of human gliomas in vitro." | 3.69 | A comparison of the relative chemosensitivity of human gliomas to tamoxifen and n-desmethyltamoxifen in vitro. ( Kristofik, MP; Randall, MS; Rehn, T; Selker, RG; Vertosick, FT, 1994) |
| "The antiviral agents ganciclovir, 1-beta-D-arabinofuranosylthymine (araT), acyclovir, and 5-iodo-5'-amino-2',5'-dideoxyuridine were cytotoxic to rat C6 glioma cells expressing retrovirally transferred herpes simplex virus (HSV) type 1 thymidine kinase (TK) coding sequence, with concentrations that inhibited cell survival by 50% (IC50 values) of 0." | 3.69 | Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells. ( Breakefield, XO; Davidson, BL; Hughes, TL; Roessler, BJ; Shewach, DS; Zerbe, LK, 1994) |
| "Opioid agonists inhibit DNA synthesis in C6 rat glioma cells that express opioid receptors, induced by desipramine (DMI)." | 3.69 | Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells. ( Barg, J; Belcheva, MM; Coscia, CJ; Johnson, FE; Levy, R; McHale, RJ; Saya, D; Vogel, Z; Zimlichman, R, 1994) |
| "Transfection of a human dopamine D3 receptor cDNA in a neuroblastoma-glioma hybrid cell line (NG 108-15) provided clonal cell lines stably expressing up to 600 fmol per mg protein of [125I]iodosulpiride binding sites." | 3.69 | Functional coupling of the human dopamine D3 receptor in a transfected NG 108-15 neuroblastoma-glioma hybrid cell line. ( Dimitriadou, V; Griffon, N; Lévesque, D; Martres, MP; Pilon, C; Schwartz, JC; Sokoloff, P, 1994) |
| "To shed light on the metabolic changes in glioma following therapy, uptake changes among 18F-fluoro-2'-deoxyuridine (18FUdR), 14C-thymidine (dThd), 14C-methionine (Met) and 3H-deoxyglucose (DG) in glioma model after chemotherapy were studied, as a means for interpreting clinical PET results, together with the changes in the bromodeoxyuridine (BUdR) labeling index." | 3.68 | Metabolic changes of glioma following chemotherapy: an experimental study using four PET tracers. ( Ishiwata, K; Kameyama, M; Katakura, R; Sato, K; Yoshimoto, T, 1992) |
| "Direct cell counting and extent of [3H]thymidine incorporation demonstrated valproate to inhibit C6 glioma proliferation rate in a dose-dependent manner with a 1 mM concentration achieving 50% inhibition." | 3.68 | The anticonvulsant valproate teratogen restricts the glial cell cycle at a defined point in the mid-G1 phase. ( Martin, ML; Regan, CM, 1991) |
| "8 degrees C hyperthermia were used to sensitize C6 glioma cells to carboplatin cytotoxicity in vitro." | 3.68 | Sensitization of C6 glioma to carboplatin cytotoxicity by hyperthermia and thymidine. ( Cohen, JD; Javid, MJ; Robins, HI, 1990) |
| "Effects of trifluoroacetic acid (TFA) on cell growth, DNA, glycoprotein, and dolichol-linked oligosaccharides synthesis and ribonucleotide triphosphate concentrations were examined in exponentially growing C6 murine glioma cells." | 3.68 | Effects of trifluoroacetic acid, a halothane metabolite, on C6 glioma cells. ( Ling, YH; Ma, TG; McClure, GD; Tseng, MT, 1990) |
| "The cytotoxic, antiproliferative, and radiosensitizing effects of thymidine (a nucleoside metabolite) were studied using the C6 glioma cell line in vitro." | 3.68 | Radiosensitization of C6 glioma by thymidine and 41.8 degrees C hyperthermia. ( Cohen, JD; Javid, MJ; Robins, HI, 1990) |
| " The mitogenic properties of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) were examined in three human malignant glioma cell lines (T98G, U87, and U138)." | 3.68 | Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium. ( Kelly, RH; Kristofik, MP; Pollack, IF; Randall, MS; Selker, RG; Vertosick, FT, 1990) |
| "In the present study the effect of cocaine on thymidine, uridine and leucine incorporation was assessed in primary cortical glial and C6 glioma cells." | 3.68 | Effect of cocaine on macromolecular syntheses and cell proliferation in cultured glial cells. ( Bansinath, M; Garg, UC; Turndorf, H, 1993) |
| " This study demonstrates that phorbol ester pretreatment of a LAK cell-sensitive glioma cell line (SNB-19) induced a significant decrease in the susceptibility of cells to LAK cell-mediated lysis." | 3.68 | Effect of phorbol esters on the susceptibility of a glioma cell line to lymphokine-activated killer cell activity. ( Alterman, RL; Kornblith, PL; Maleci, A; Moskal, JR; Sundstrom, D, 1990) |
| " The potential proliferative activity of these different neoplasms, evaluated as in vitro 3H-thymidine labeling index (LI), has been determined in 46 mature astrocytomas, 19 anaplasic astrocytomas, 25 glioblastomas, 5 cystic craniopharyngiomas, 6 metastatic tumors, 4 primary C." | 3.67 | Cell kinetic investigations in brain tumors studied by serial stereotactic biopsy. ( Allegranza, A; Broggi, G; Costa, A; Ferraresi, S; Franzini, A; Giorgi, C, 1989) |
| "The effects of 2 specific calcium channel blockers, verapamil and nimodipine, on the proliferation of human glioma tumour cells were investigated in vitro." | 3.67 | Inhibitory effect of calcium channel blockers on proliferation of human glioma cells in vitro. ( Kunert-Radek, J; Lyson, K; Pawlikowski, M; Radek, A; Stepien, H, 1989) |
| "To determine whether tumor necrosis factor is of potential value for the treatment of human malignant gliomas, we studied the effects of human recombinant tumor necrosis factor (rTNF-alpha) on the morphology, incorporation of tritiated thymidine, and proliferation of 5 established cell lines derived from human malignant gliomas and 3 normal human brain cell cultures." | 3.67 | The effects of human recombinant tumor necrosis factor on glioma-derived cell lines: cellular proliferation, cytotoxicity, morphological and radioreceptor studies. ( Aggarwal, BB; Bar-Shiva, E; Berens, ME; Bodell, WJ; Eessalu, TE; Giblin, JR; McCulloch, JR; Rosenblum, ML; Rutka, JT; Tokuda, K, 1988) |
| "The effects of several benzodiazepines (diazepam, clonazepam, Ro 15-1788 and Ro 5-4864) on cell proliferation of 2 human gliomas were estimated in vitro by means of [3H]-thymidine uptake assay." | 3.67 | Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro. ( Kunert-Radek, J; Pawlikowski, M; Radek, A; Stepien, H, 1988) |
| "This paper studies the influence of uridine on the effects exerted by D-glucosamine in rat C6 glioma cells." | 3.67 | Uridine enhances the cytotoxic effect of D-glucosamine in rat C6 glioma cells. ( Calvaruso, G; Romano, N; Taibi, G; Tesoriere, G; Torregrossa, MV, 1986) |
| "The Na+ uptake into neuroblastoma x glioma hybrid cells was measured in Hepes-buffered EMEM containing 10% calf serum and 5 mM ouabain in the presence and absence of amiloride (1." | 3.66 | Membrane potential and sodium flux in neuroblastoma X glioma hybrid cells: effects of amiloride and serum. ( O'Donnell, ME; Villereal, ML, 1982) |
| "The penetration of [3H]thymidine, [3H]D-leucine, [125I]albumin, and the drugs [3H]5-fluorouracil and [3H]vinblastine into human glioma spheroids (in vitro tumor models) was studied by a method based on rapid freezing, freeze drying, vapor fixation, wax embedding, dry sectioning, and contact autoradiography." | 3.66 | Penetration of substances into tumor tissue--a methodological study on cellular spheroids. ( Carlsson, J; Malmqvist, M; Nederman, T, 1981) |
| "Twelve patients with gliomas received 3H-thymidine intraarterially in combination with an i." | 3.66 | The stathmokinetic (mitostatic) effect of vincristine and vinblastine on human gliomas. ( Hoshino, T; Muraoka, I; Wilson, CB, 1979) |
| " In the present study, however, changes in intracellular cyclic AMP level in several lines of cultured cells (normal 3T3 and SV40 and polyomavirus-transformed 3T3 cells; 3T6, C6 GLIOMA, MOUSE L, and Novikoff rat hepatoma cells) by treatment with papaverine, prostaglandine E1 or isoproterenol did not correlate with the inhibition of the uridine, hypoxanthine or deoxyglucose transport rates by these chemicals." | 3.65 | Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic AMP levels and rate of transport of neucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells. ( Plagemann, PG; Sheppard, JR, 1975) |
| "Four patients received 3H-thymidine 4 to 7 days and vinblastine 4 to 6 hours prior to operation for recurrent malignant gliomas (three glioblastomas and one anaplastic astrocytoma)." | 3.65 | Chemotherapeutic implications of growth fraction and cell cycle time in glioblastomas. ( Barker, M; Hoshino, T; Rosenblum, ML; Wilson, CB, 1975) |
| "Tritiated thymidine (3-H-T) was administered intravenously to seven patients with cerebral gliomas." | 3.65 | Gemistocytic astrocytes in gliomas. An autoradiographic study. ( Ellis, WG; Hoshino, T; Wilson, BC, 1975) |
| "The amino sugar, D-glucosamine, inhibits the preformed route of thymidine metabolism in rat C6 glioma cells." | 3.65 | The inhibition of thymidine metabolism in tumor cells treated with D-glucosamine. ( Friedman, SJ; Kimball, T; Skehan, PJ; Trotter, CD, 1977) |
| "Cholecystokinin (CCK) is a gut-brain peptide has been described to be able to induce mitosis according to recent studies." | 1.35 | Cholecystokinin (CCK) and CCK receptor expression by human gliomas: Evidence for an autocrine/paracrine stimulatory loop. ( Adams, EF; Buchfelder, M; Oikonomou, E, 2008) |
| "Gliomas are tumors derived from glia or their precursors within the central nervous system." | 1.34 | STI1 promotes glioma proliferation through MAPK and PI3K pathways. ( Chiarini, LB; Erlich, RB; Kahn, SA; Lima, FR; Linden, R; Martins, RA; Martins, VR; Moura Neto, V; Muras, AG, 2007) |
| " Therefore, we have investigated the effects of the orally bioavailable Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) on the radiosensitivity of human tumor cells in vitro and grown as tumor xenografts." | 1.32 | Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin. ( Brady, KJ; Bull, EE; Burgan, WE; Camphausen, K; Carter, DJ; Cerra, MA; Dote, H; Hollingshead, MG; Oswald, KA; Tofilon, PJ, 2004) |
| "Malignant gliomas are frequent and the prognosis is poor." | 1.31 | Interferon gamma inhibits proliferation and hyaluronic acid adhesion of human malignant glioma cells in vitro. ( Domula, M; Knüpfer, H; Knüpfer, MM; Van Gool, S; Wolff, JE, 2000) |
| " In dose-response studies, IGF-I mRNA levels decreased to 27% of control levels (cells maintained in serum-free media) after treatment with 5 ng/ml dexamethasone, while half-maximal inhibition was achieved with approximately 0." | 1.28 | Regulation of insulin-like growth factor I production in rat C6 glioma cells: possible role as an autocrine/paracrine growth factor. ( Karpen, CW; Lorentzen, LR; Lowe, WL; Meyer, T, 1992) |
| " The dose-response curve for choline generation and DNA synthesis were comparable." | 1.28 | Activation of phospholipase D by platelet-derived growth factor (PDGF) in rat C6 glioma cells: possible role in mitogenic signal transduction. ( Nakashima, T; Nozawa, Y; Okano, Y; Sakai, N; Yamada, H; Zhang, W, 1992) |
| "We studied brain tumors induced by avian sarcoma virus and ethylnitrosourea, and transplanted RG-2 intracerebral and subcutaneous gliomas." | 1.27 | Regional thymidine transport and incorporation in experimental brain and subcutaneous tumors. ( Blasberg, R; Fenstermacher, J; Groothuis, D; Molnar, P; Owens, E; Zaharko, D, 1984) |
Research
Studies (139)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 55 (39.57) | 18.7374 |
| 1990's | 58 (41.73) | 18.2507 |
| 2000's | 24 (17.27) | 29.6817 |
| 2010's | 2 (1.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Takami, Y | 1 |
| Yamamoto, Y | 2 |
| Ueno, M | 1 |
| Chiba, Y | 1 |
| Norikane, T | 1 |
| Hatakeyama, T | 1 |
| Miyake, K | 1 |
| Toyohara, J | 2 |
| Nishiyama, Y | 2 |
| Tanaka, K | 1 |
| Maeda, Y | 1 |
| Yamamoto, H | 1 |
| Kudomi, N | 1 |
| Kawai, N | 1 |
| Yakisich, JS | 1 |
| Ohlsson Lindblom, I | 1 |
| Siden, A | 1 |
| Cruz, MH | 1 |
| Sun, YX | 1 |
| Wright, HT | 1 |
| Janciauskiene, S | 1 |
| Yoon, JT | 1 |
| Palazzo, AF | 1 |
| Xiao, D | 1 |
| Delohery, TM | 1 |
| Warburton, PE | 1 |
| Bruce, JN | 1 |
| Thompson, WJ | 1 |
| Sperl, G | 1 |
| Whitehead, C | 1 |
| Fetter, J | 1 |
| Pamukcu, R | 1 |
| Gundersen, GG | 1 |
| Weinstein, IB | 1 |
| D'Onofrio, M | 1 |
| Arcella, A | 1 |
| Bruno, V | 1 |
| Ngomba, RT | 1 |
| Battaglia, G | 1 |
| Lombari, V | 1 |
| Ragona, G | 1 |
| Calogero, A | 1 |
| Nicoletti, F | 1 |
| Ross, BD | 1 |
| Chenevert, TL | 1 |
| Garwood, M | 1 |
| Kim, B | 1 |
| Stegman, LD | 1 |
| Ben-Yoseph, O | 1 |
| Zwolshen, J | 1 |
| Rehemtulla, A | 1 |
| Sunkara, PS | 1 |
| Chou, RC | 1 |
| Langan, TJ | 1 |
| Morrone, FB | 1 |
| Jacques-Silva, MC | 1 |
| Horn, AP | 1 |
| Bernardi, A | 1 |
| Schwartsmann, G | 1 |
| Rodnight, R | 1 |
| Lenz, G | 1 |
| Bauréus-Koch, C | 1 |
| Nyberg, G | 1 |
| Widegren, B | 1 |
| Salford, LG | 1 |
| Persson, BR | 1 |
| Barth, RF | 2 |
| Yang, W | 2 |
| Al-Madhoun, AS | 1 |
| Johnsamuel, J | 1 |
| Byun, Y | 2 |
| Chandra, S | 1 |
| Smith, DR | 1 |
| Tjarks, W | 2 |
| Eriksson, S | 2 |
| Bull, EE | 1 |
| Dote, H | 1 |
| Brady, KJ | 1 |
| Burgan, WE | 1 |
| Carter, DJ | 1 |
| Cerra, MA | 1 |
| Oswald, KA | 1 |
| Hollingshead, MG | 1 |
| Camphausen, K | 1 |
| Tofilon, PJ | 1 |
| Guo, M | 1 |
| Roman, RJ | 1 |
| Falck, JR | 1 |
| Edwards, PA | 1 |
| Scicli, AG | 1 |
| Davis, FB | 1 |
| Tang, HY | 1 |
| Shih, A | 1 |
| Keating, T | 1 |
| Lansing, L | 1 |
| Hercbergs, A | 1 |
| Fenstermaker, RA | 1 |
| Mousa, A | 1 |
| Mousa, SA | 1 |
| Davis, PJ | 1 |
| Lin, HY | 1 |
| Thirumamagal, BT | 1 |
| Altinoz, MA | 1 |
| Gedikoglu, G | 1 |
| Sav, A | 1 |
| Ozcan, E | 1 |
| Ozdilli, K | 1 |
| Bilir, A | 1 |
| Del Maestro, RF | 1 |
| Erlich, RB | 1 |
| Kahn, SA | 1 |
| Lima, FR | 1 |
| Muras, AG | 1 |
| Martins, RA | 1 |
| Linden, R | 1 |
| Chiarini, LB | 1 |
| Martins, VR | 1 |
| Moura Neto, V | 1 |
| Chen, W | 1 |
| Delaloye, S | 1 |
| Silverman, DH | 1 |
| Geist, C | 1 |
| Czernin, J | 1 |
| Sayre, J | 1 |
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| Phelps, ME | 1 |
| Cloughesy, T | 2 |
| Oikonomou, E | 1 |
| Buchfelder, M | 1 |
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| Froelich, JS | 1 |
| Leuchtenberger, C | 1 |
| Charlton, RR | 1 |
| Venter, JC | 1 |
| Mary, JY | 1 |
| Acker, H | 1 |
| Holtermann, G | 1 |
| Carlsson, J | 4 |
| Nederman, T | 2 |
| Korosue, K | 1 |
| Takeshita, I | 2 |
| Mannoji, H | 1 |
| Fukui, M | 2 |
| Berdel, WE | 1 |
| Greiner, E | 1 |
| Fink, U | 1 |
| Zänker, KS | 1 |
| Stavrou, D | 1 |
| Trappe, A | 1 |
| Fahlbusch, R | 1 |
| Reichert, A | 1 |
| Rastetter, J | 1 |
| Molnar, P | 1 |
| Groothuis, D | 1 |
| Blasberg, R | 1 |
| Zaharko, D | 1 |
| Owens, E | 1 |
| Fenstermacher, J | 1 |
| DiSorbo, DM | 1 |
| Litwack, G | 1 |
| O'Donnell, ME | 1 |
| Villereal, ML | 1 |
| Malmqvist, M | 2 |
| Wiezsaecker, M | 1 |
| Hoshino, T | 8 |
| Kobayashi, S | 1 |
| Nakada, S | 1 |
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| Saqr, HE | 1 |
| Lee, MC | 1 |
| Burkman, AM | 1 |
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| Tani, E | 1 |
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| Pilon, C | 1 |
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Reviews
2 reviews available for thymidine and Glioma
| Article | Year |
|---|---|
Normal human granulopoiesis revisited. I. Blood data.
Topics: Blood Cell Count; Glioma; Granulocytes; Half-Life; Hematopoiesis; Hematopoietic Stem Cells; Humans; | 1984 |
In vitro chemosensitivity testing and its clinical application in human gliomas.
Topics: Amino Acids; Antineoplastic Agents; Biological Factors; Brain Neoplasms; Colorimetry; Coloring Agent | 1989 |
Trials
1 trial available for thymidine and Glioma
| Article | Year |
|---|---|
A phase II trial of thymidine and carboplatin for recurrent malignant glioma: a North American Brain Tumor Consortium Study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Drug Admi | 2002 |
Other Studies
136 other studies available for thymidine and Glioma
| Article | Year |
|---|---|
Correlation of 4'-[methyl-
Topics: Aged; Biological Transport; Equilibrative Nucleoside Transporter 1; Female; Gene Expression Regulati | 2018 |
Correlation of 4'-[methyl-(11)C]-thiothymidine uptake with Ki-67 immunohistochemistry and tumor grade in patients with newly diagnosed gliomas in comparison with (11)C-methionine uptake.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biological Transport; Brain Neoplasms; Carbon Radioisoto | 2016 |
Rapid inhibition of ongoing DNA synthesis in human glioma tissue by genistein.
Topics: Adult; Aged; Animals; Anticarcinogenic Agents; Brain Neoplasms; DNA; Dose-Response Relationship, Dru | 2009 |
Glioma cell activation by Alzheimer's peptide Abeta1-42, alpha1-antichymotrypsin, and their mixture.
Topics: alpha 1-Antichymotrypsin; Amyloid beta-Peptides; Base Sequence; DNA Primers; DNA, Neoplasm; Gene Exp | 2002 |
CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 3T3 Cells; Animals; Antine | 2002 |
Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells.
Topics: Amino Acids; Bridged Bicyclo Compounds, Heterocyclic; Cell Division; Cells, Cultured; Cyclin D1; Cyc | 2003 |
Evaluation of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on the 9L rat brain tumor model using MRI.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Su | 2003 |
In vitro synchronization of mammalian astrocytic cultures by serum deprivation.
Topics: Animals; Animals, Newborn; Astrocytes; Bromodeoxyuridine; Cell Cycle; Cells, Cultured; Culture Media | 2003 |
Extracellular nucleotides and nucleosides induce proliferation and increase nucleoside transport in human glioma cell lines.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Brain Neoplasms; Cell Division; DNA; Extra | 2003 |
Radiation sterilisation of cultured human brain tumour cells for clinical immune tumour therapy.
Topics: Brain Neoplasms; Cell Division; Cell Survival; Cesium Radioisotopes; Genetic Therapy; Glioblastoma; | 2004 |
Boron-containing nucleosides as potential delivery agents for neutron capture therapy of brain tumors.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Division; Glioma; Hum | 2004 |
Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin.
Topics: Administration, Oral; Animals; Benzoquinones; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Com | 2004 |
Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A.
Topics: Amidines; Antineoplastic Agents; Arachidonic Acid; Blotting, Western; Brain Neoplasms; Cell Line, Tu | 2005 |
Acting via a cell surface receptor, thyroid hormone is a growth factor for glioma cells.
Topics: Animals; Cell Growth Processes; Cell Line, Tumor; Enzyme Activation; Glioma; Integrin alphaVbeta3; M | 2006 |
Preparation and biological evaluation of 10B-enriched 3-[5-{2-(2,3-dihydroxyprop-1-yl)-o-carboran-1-yl}pentan-1-yl]thymidine (N5-2OH), a new boron delivery agent for boron neutron capture therapy of brain tumors.
Topics: Animals; Binding Sites; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Calcium; Gl | 2006 |
Medroxyprogesterone acetate induces c6 glioma chemosensitization via antidepressant-like lysosomal phospholipidosis/myelinosis in vitro.
Topics: Animals; Antidepressive Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplast | 2007 |
STI1 promotes glioma proliferation through MAPK and PI3K pathways.
Topics: Astrocytes; Binding Sites; Cell Line, Tumor; Cell Proliferation; Glioma; Heat-Shock Proteins; Humans | 2007 |
Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chem | 2007 |
Cholecystokinin (CCK) and CCK receptor expression by human gliomas: Evidence for an autocrine/paracrine stimulatory loop.
Topics: Autocrine Communication; Brain Neoplasms; Caspase 3; Caspase Inhibitors; Cell Line, Tumor; Cell Prol | 2008 |
Further in vitro studies of large cell glioblastomas. 1. Nuclear and nucleolar RNA. 2. Autoradiographic studies of the cell division cycle.
Topics: Autoradiography; Cell Division; Cell Nucleolus; Cell Nucleus; Colchicine; DNA; Glioma; Humans; In Vi | 1967 |
Cell cycle-specific changes in beta-adrenergic receptor concentrations in C6 glioma cells.
Topics: Animals; Cell Cycle; Cell Line; DNA, Neoplasm; Glioma; Kinetics; Mitosis; Pindolol; Rats; Receptors, | 1980 |
Methodological aspects of microelectrode measurements in cellular spheroids.
Topics: Animals; Autoradiography; Cell Aggregation; Cells, Cultured; Cricetinae; Culture Media; Glioma; Huma | 1983 |
Interferon effects on multiplication, cytoplasmic protein and GFAP content, and morphology in human glioma cells.
Topics: Cell Division; Cell Line; DNA, Neoplasm; Glial Fibrillary Acidic Protein; Glioma; Humans; Interferon | 1983 |
Cytotoxic effects of alkyl-lysophospholipids in human brain tumor cells.
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Cell Survival; Cells, Cultured; Glioma; Histocy | 1984 |
Regional thymidine transport and incorporation in experimental brain and subcutaneous tumors.
Topics: Animals; Biological Transport; Brain; Brain Neoplasms; Carbon Radioisotopes; DNA Replication; Glioma | 1984 |
Vitamin B6 kills hepatoma cells in culture.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Count; Cell Division; | 1982 |
Membrane potential and sodium flux in neuroblastoma X glioma hybrid cells: effects of amiloride and serum.
Topics: Amiloride; Animals; Blood; Cell Line; Dose-Response Relationship, Drug; Glioma; Hybrid Cells; Membra | 1982 |
Penetration of substances into tumor tissue--a methodological study on cellular spheroids.
Topics: Albumins; Biological Transport; Cell Line; Clone Cells; Fluorouracil; Glioma; Humans; Leucine; Model | 1981 |
Effect of tritiated thymidine on the kinetics and viability of 9L cells in vitro.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Line; Cell Survival; Colony-Forming Units Assay; Gliom | 1981 |
Stimulation of DNA synthesis and pyrimidine deoxyribonucleoside transport systems in mouse glioma and mouse neuroblastoma cells by inorganic mercury.
Topics: Animals; Cells, Cultured; Deoxyribonucleosides; DNA; Glioma; Mercury; Mice; Neoplasms, Experimental; | 1980 |
Gangliosides have a bimodal effect on DNA synthesis in U-1242 MG human glioma cells.
Topics: Cell Line; DNA Replication; Dose-Response Relationship, Drug; Gangliosides; Glioma; Humans; Kinetics | 1995 |
Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor.
Topics: Alkaloids; Antibiotics, Antineoplastic; Apoptosis; Autoradiography; Blotting, Northern; Blotting, We | 1995 |
Alterations in the synthesis of insulin-like growth factor binding proteins and insulin-like growth factors in rat C6 glioma cells transfected with a gap junction connexin43 cDNA.
Topics: Animals; Animals, Newborn; Astrocytes; Blotting, Northern; Carrier Proteins; Cell Division; Cell Lin | 1993 |
Effect of cocaine on macromolecular syntheses and cell proliferation in cultured glial cells.
Topics: Animals; Animals, Newborn; Brain Neoplasms; Cell Division; Cells, Cultured; Cocaine; DNA; Glioma; Gl | 1993 |
Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells.
Topics: Acyclovir; Adenoviruses, Human; Animals; Arabinonucleosides; Avian Sarcoma Viruses; Brain Neoplasms; | 1994 |
Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes.
Topics: Actins; Animals; Animals, Newborn; Astrocytes; Base Sequence; Brain; Cell Line; Cells, Cultured; DNA | 1995 |
Role of calmodulin-dependent phosphorylation of elongation factor 2 in the proliferation of rat glial cells.
Topics: Animals; Animals, Newborn; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell D | 1994 |
Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells.
Topics: Animals; Antibodies, Anti-Idiotypic; beta-Endorphin; Calcium; Desipramine; DNA, Neoplasm; Dose-Respo | 1994 |
Functional coupling of the human dopamine D3 receptor in a transfected NG 108-15 neuroblastoma-glioma hybrid cell line.
Topics: Animals; Cyclic AMP; Ergolines; Genes, fos; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotrip | 1994 |
A comparison of the relative chemosensitivity of human gliomas to tamoxifen and n-desmethyltamoxifen in vitro.
Topics: Colorimetry; Coloring Agents; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gl | 1994 |
Cytotoxicity of the cocaine metabolite benzoylecgonine.
Topics: Animals; Cell Death; Cell Division; Cell Survival; Cocaine; DNA, Neoplasm; Glioma; Hybrid Cells; Mic | 1994 |
Human osteosarcoma (U-2 OS) cells express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptors and synthesize IGF-II: autocrine growth stimulation by IGF-II via the IGF-I receptor
Topics: Animals; Binding, Competitive; Blood; Blotting, Northern; Blotting, Western; Bone Neoplasms; Cell Di | 1994 |
Selective induction of alpha 1 isoform of (Na+ + K+)-ATPase by insulin/insulin-like growth factor-I in cultured rat astrocytes.
Topics: Adenylyl Cyclases; Animals; Animals, Newborn; Astrocytes; Ca(2+) Mg(2+)-ATPase; Cell Division; Cells | 1993 |
A monoclonal anti-idiotypic antibody to opioid receptors labels desipramine-induced opioid binding sites on rat C6 glioma cells and attenuates thymidine incorporation into DNA.
Topics: Animals; Antibodies, Monoclonal; Brain Neoplasms; Cell Division; Cell Membrane; Colorimetry; Densito | 1994 |
Responses of human glioblastoma cells to human natural tumor necrosis factor-alpha: susceptibility, mechanism of resistance and cytokine production studies.
Topics: Cell Division; Colony-Forming Units Assay; Coloring Agents; Cytokines; Dinoprostone; Drug Resistance | 1993 |
Preliminary observations on the in vitro toxicity of N-butylbenzenesulfonamide: a newly discovered neurotoxin.
Topics: Animals; Biomarkers; Cell Death; Cell Division; Cell Line; DNA Replication; Glioma; Kinetics; L-Lact | 1993 |
Antiproliferative effect of multiple autocrine loop blockade in human malignant glioma cell lines.
Topics: Antibodies, Monoclonal; Cell Movement; Cells, Cultured; Fibroblast Growth Factor 2; Glioma; Glucose- | 1995 |
CCKB receptor activation results in increased [3H]thymidine incorporation in rat glioma C6 cells.
Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Cell Division; Cholecystokinin; Devazepide; DNA; Gl | 1995 |
Inhibition of the proliferation of human neural neoplastic cell lines by cysteamine.
Topics: Blood-Brain Barrier; Brain Neoplasms; Cell Cycle; Cell Division; Cell Line; Cysteamine; DNA, Neoplas | 1996 |
Altered phospholipid metabolism in sodium butyrate-induced differentiation of C6 glioma cells.
Topics: Acylation; Animals; Arachidonic Acid; Butyrates; Butyric Acid; Calcium; Chloroform; Glioma; Glutamat | 1997 |
Modulation of motility and proliferation of glioma cells by hepatocyte growth factor.
Topics: Adolescent; Adult; Aged; Base Sequence; Brain Neoplasms; Cell Division; Cell Movement; DNA Primers; | 1997 |
Quantitative study of calcium uptake by tumorigenic bone (TE-85) and neuroblastoma x glioma (NG108-15) cells exposed to extremely-low-frequency (ELF) electric fields.
Topics: Animals; Biological Transport; Bone Neoplasms; Calcium; Cattle; Cell Division; DNA, Neoplasm; Electr | 1997 |
Opioid receptor and calcium channel regulation of adenylyl cyclase, modulated by GM1, in NG108-15 cells: competitive interactions.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Aminopterin; Binding, Competitive; Calcium Channels; Cho | 1997 |
In vitro efficacy of anti-glial fibrillary acidic protein monoclonal antibodies against human malignant glioma cell lines.
Topics: Antibodies, Monoclonal; Cell Division; Cell Survival; Glial Fibrillary Acidic Protein; Glioma; Human | 1997 |
Improved method to prepare RNA-free DNA from mammalian cells.
Topics: Animals; Chromatography, High Pressure Liquid; DNA, Neoplasm; Glioma; Osmolar Concentration; Rats; R | 1997 |
Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells.
Topics: Animals; Cell Division; Diterpenes; Electrophoresis, Polyacrylamide Gel; Farnesol; Glioma; Hydroxyme | 1998 |
Serum mitogenic activity on in vitro glial cells in Neurofibromatosis type 1.
Topics: Animals; Dose-Response Relationship, Drug; Glioma; Humans; Lymphocytes; Mitogens; Mitosis; Molecular | 1998 |
Protein kinase C is involved in cholecystokinin octapeptide-induced proliferative action in rat glioma C6 cells.
Topics: Animals; Blotting, Western; Carcinogens; Enzyme Activation; Glioma; Isoenzymes; Protein Kinase C; Pr | 1998 |
Epidermal growth factor receptor and labeling index are independent prognostic factors in glial tumor outcome.
Topics: Adolescent; Adult; Aged; Cell Division; ErbB Receptors; Female; Glioma; Humans; Male; Middle Aged; M | 1998 |
Light-induced photoactivation of hypericin affects the energy metabolism of human glioma cells by inhibiting hexokinase bound to mitochondria.
Topics: Anthracenes; Apoptosis; Energy Metabolism; Enzyme Inhibitors; Glioma; Hexokinase; Humans; Hydrogen-I | 1998 |
Cell surface aggregation of elastin receptor molecules caused by suramin amplified signals leading to proliferation of human glioma cells.
Topics: Cell Division; Culture Media, Serum-Free; Cyclin-Dependent Kinases; Cyclins; Dose-Response Relations | 1999 |
Control of proliferation and survival of C6 glioma cells with modification of the nerve growth factor autocrine system.
Topics: Animals; Autocrine Communication; Cell Count; Cell Division; Cell Survival; Cycloheximide; Glioma; N | 1999 |
A globin fragment, LVV-hemorphin-7, induces [3H]thymidine incorporation in a neuronal cell line via the AT4 receptor.
Topics: Angiotensin II; Binding, Competitive; DNA; Glioma; Hemoglobins; Hybrid Cells; Losartan; Neuroblastom | 1999 |
Interferon gamma inhibits proliferation and hyaluronic acid adhesion of human malignant glioma cells in vitro.
Topics: Cell Adhesion; Cell Division; Cell Survival; Glioma; Humans; Hyaluronan Receptors; Hyaluronic Acid; | 2000 |
Alterations in Ca2+ signaling, and c-fos and nur77 expression are associated with sodium butyrate-induced differentiation of C6 glioma cell.
Topics: Adenosine Triphosphate; Animals; Butyrates; Calcium; Calcium Signaling; Cell Differentiation; Chelat | 2000 |
Monoclonal anti-GD3 antibodies selectively inhibit the proliferation of human malignant glioma cells in vitro.
Topics: Antibodies, Monoclonal; Cell Division; Central Nervous System Neoplasms; Drug Screening Assays, Anti | 2000 |
Growth hormone and insulin-like growth factor-I: effects on the growth of glioma cell lines.
Topics: Animals; Cell Division; Central Nervous System Neoplasms; DNA; Female; Gene Expression Regulation, N | 2001 |
Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells.
Topics: Acetamides; Animals; Brain Neoplasms; Calcium; Calcium Channel Blockers; Calcium Channels; DNA; Drug | 2002 |
Double-stranded ribonucleic acid decreases c6 rat glioma cell proliferation in part by activating protein kinase R and decreasing insulin-like growth factor I levels.
Topics: Animals; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Division; Cell Line; Coloring Agents; | 2002 |
Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic AMP levels and rate of transport of neucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells.
Topics: Animals; Biological Transport, Active; Bucladesine; Carcinoma, Hepatocellular; Cell Division; Cell L | 1975 |
Gemistocytic astrocytes in gliomas. An autoradiographic study.
Topics: Adolescent; Adult; Aged; Astrocytes; Astrocytoma; Autoradiography; Brain Neoplasms; Frontal Lobe; Gl | 1975 |
Morphological differentiation of cultured mouse glioblastoma cells induced by dibutyryl cyclic adenosine monophosphate.
Topics: Animals; Bucladesine; Butyrates; Cell Differentiation; Cell Line; Cells, Cultured; Cyclic GMP; DNA, | 1975 |
Effect of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride on experimental brain tumors.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Drug Evaluation, Preclinical; Ependymoma | 1979 |
The stathmokinetic (mitostatic) effect of vincristine and vinblastine on human gliomas.
Topics: Adult; Aged; Biopsy; Brain; Brain Neoplasms; Female; Glioma; Humans; Male; Middle Aged; Mitotic Inde | 1979 |
[Kinetics of neutrophil granulocytes in man].
Topics: Basophils; Cell Survival; Glioma; Humans; Leukemia, Lymphoid; Neutrophils; Thymidine | 1978 |
The inhibition of thymidine metabolism in tumor cells treated with D-glucosamine.
Topics: Cell Line; DNA, Neoplasm; Glioma; Glucosamine; Kinetics; Neoplasms, Experimental; Thymidine | 1977 |
Effects of bacterial agarase on agarose gel in cell culture.
Topics: Bacteria; Cell Line; Cells, Cultured; Culture Media; DNA, Neoplasm; Glioma; Glycoside Hydrolases; Hu | 1977 |
Environmental factors in glial tumor response to 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea: effect of cell confluence.
Topics: Cell Cycle; Cell Survival; Cells, Cultured; DNA, Neoplasm; Glioma; Lomustine; Neoplasms, Experimenta | 1977 |
Chemotherapeutic implications of growth fraction and cell cycle time in glioblastomas.
Topics: Biopsy; Cell Division; Cerebral Ventricle Neoplasms; Cerebral Ventricles; Glioma; Humans; Mitosis; M | 1975 |
Tumor growth regulation by modulation of basic fibroblast growth factor.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Cell Line; DNA Replication; Fibroblast Growth Fa | 1992 |
Activation of phospholipase D by platelet-derived growth factor (PDGF) in rat C6 glioma cells: possible role in mitogenic signal transduction.
Topics: Animals; Choline; DNA Replication; DNA, Neoplasm; Enzyme Activation; Glioma; Glycerophospholipids; K | 1992 |
Murine monoclonal antibodies cytotoxic to human glioma cells in vitro.
Topics: Adult; Animals; Antibodies, Monoclonal; Astrocytes; Cytotoxicity Tests, Immunologic; Glioma; Humans; | 1992 |
Metabolic changes of glioma following chemotherapy: an experimental study using four PET tracers.
Topics: Animals; Body Weight; Carbon Radioisotopes; Deoxyglucose; DNA Replication; DNA, Neoplasm; Dose-Respo | 1992 |
Contribution of labeled carbon dioxide to PET imaging of carbon-11-labeled compounds.
Topics: Acetates; Animals; Brain Neoplasms; Carbon Dioxide; Carbon Radioisotopes; Dogs; Glioma; Glucose; Hum | 1992 |
Regulation of insulin-like growth factor I production in rat C6 glioma cells: possible role as an autocrine/paracrine growth factor.
Topics: Animals; Blotting, Northern; Cell Division; Cell Line; Cycloheximide; Dexamethasone; DNA Replication | 1992 |
Effects of RF power absorption in mammalian cells.
Topics: Animals; Cell Division; Cell Line; Cell Membrane Permeability; DNA Replication; Energy Metabolism; E | 1992 |
[The effect of the synthetic leu-enkephalin analog dalargin on the proliferative activity of glioma C6 cells and on the intensity of their DNA synthesis].
Topics: Animals; Brain Neoplasms; Cell Division; Cell Line; DNA, Neoplasm; Drug Interactions; Enkephalin, Le | 1992 |
Sertoli cells in culture secrete paracrine factor(s) that inhibit peritubular myoid cell proliferation: identification of heparinoids as likely candidates.
Topics: Animals; Cell Division; Cell Line; DNA; Glioma; Glycosaminoglycans; Growth Inhibitors; Heparin; Hepa | 1991 |
Measurement of thymidine replacement in patients with high grade gliomas, head and neck tumors, and high grade sarcomas after continuous intravenous infusions of 5-iododeoxyuridine.
Topics: Animals; Cell Line; Combined Modality Therapy; DNA, Neoplasm; Flow Cytometry; Glioma; Head and Neck | 1992 |
Transient heat shock in mid-G1-phase of the C6 glioma cell cycle impairs entry into S-phase.
Topics: Animals; Cell Line; DNA; G1 Phase; Glioma; Hot Temperature; Rats; S Phase; Thymidine | 1991 |
Bispecific antibody-directed antitumor activity of human CD4+ helper/killer T cells induced by anti-CD3 monoclonal antibody plus interleukin 2.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Calcimycin; CD3 Compl | 1991 |
Effects of the PAF-analog and -antagonist CV-6209 on cultured human glioma cell lines.
Topics: Cell Division; Cell Line; Cell Survival; DNA Replication; Glioma; Humans; Kinetics; Methionine; Neur | 1991 |
The anticonvulsant valproate teratogen restricts the glial cell cycle at a defined point in the mid-G1 phase.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; Cell Survival; DNA Replication; G1 Phase; Glioma; Kin | 1991 |
Transcriptional regulation of ferritin messenger ribonucleic acid levels by insulin in cultured rat glioma cells.
Topics: Actins; Animals; Cycloheximide; Dactinomycin; Drug Stability; Ferritins; Glioma; Insulin; Insulin-Li | 1991 |
Diacylglycerol formation and DNA synthesis in endothelin-stimulated rat C6 glioma cells: the possible role of phosphatidylcholine breakdown.
Topics: Animals; Diglycerides; DNA; Endothelins; Glioma; Phosphatidylcholines; Thymidine; Tumor Cells, Cultu | 1991 |
Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.
Topics: Blotting, Northern; Blotting, Southern; Cell Cycle; Cell Division; Cell Line; Dexamethasone; DNA Rep | 1990 |
Stimulation of cell growth and DNA synthesis by peripheral benzodiazepine.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cell Division; Cell Line; DNA Replication; DNA, Neoplas | 1990 |
Response of malignant glioma cell lines to activation and inhibition of protein kinase C-mediated pathways.
Topics: Animals; Brain; Brain Neoplasms; Cell Division; DNA, Neoplasm; Epidermal Growth Factor; Glioma; Huma | 1990 |
Insulin-like growth factor-I receptors in human glial tumors.
Topics: Binding, Competitive; Brain Neoplasms; Cell Membrane; Chromatography, Affinity; DNA, Neoplasm; Gliom | 1990 |
Sensitization of C6 glioma to carboplatin cytotoxicity by hyperthermia and thymidine.
Topics: Animals; Antineoplastic Agents; Carboplatin; Cell Survival; Combined Modality Therapy; Dose-Response | 1990 |
Effects of trifluoroacetic acid, a halothane metabolite, on C6 glioma cells.
Topics: Animals; Cell Division; DNA, Neoplasm; Glioma; Glycoproteins; Glycosylation; Leucine; Mannose; Mice; | 1990 |
Radiosensitization of C6 glioma by thymidine and 41.8 degrees C hyperthermia.
Topics: Animals; Cell Line; Glioma; Hyperthermia, Induced; Radiation Dosage; Radiation Tolerance; Radiation- | 1990 |
Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium.
Topics: Brain Neoplasms; Cell Division; Culture Media; Epidermal Growth Factor; Glioma; Humans; Iodine Radio | 1990 |
Effect of phorbol esters on the susceptibility of a glioma cell line to lymphokine-activated killer cell activity.
Topics: Cell Division; Glioma; Humans; Killer Cells, Lymphokine-Activated; Phorbol 12,13-Dibutyrate; Phorbol | 1990 |
Cell kinetics of intracerebrally implanted RG-C6 tumors in rats--effects of intracarotid hyperosmolar mannitol measured by 3H-thymidine autoradiography and bromodeoxyuridine uptake.
Topics: Animals; Autoradiography; Brain Neoplasms; Bromodeoxyuridine; Carotid Artery, Internal; Cell Cycle; | 1988 |
Cell kinetic investigations in brain tumors studied by serial stereotactic biopsy.
Topics: Adolescent; Adult; Astrocytoma; Biopsy; Brain Neoplasms; Cell Division; Child; Child, Preschool; Fem | 1989 |
Inhibitory effect of calcium channel blockers on proliferation of human glioma cells in vitro.
Topics: Calcium; Calcium Channel Blockers; Cell Division; Glioma; Humans; Nimodipine; Thymidine; Tumor Cells | 1989 |
The effects of human recombinant tumor necrosis factor on glioma-derived cell lines: cellular proliferation, cytotoxicity, morphological and radioreceptor studies.
Topics: Cell Division; Cell Survival; Glioma; Humans; Radioligand Assay; Receptors, Cell Surface; Receptors, | 1988 |
Stimulation of glucose analogue uptake by cerebral microvessel endothelial cells by a product released by astrocytes.
Topics: 3-O-Methylglucose; Animals; Astrocytes; Blood-Brain Barrier; Brain; Cells, Cultured; Culture Media; | 1989 |
Brain damage by AIDS under active study.
Topics: Acquired Immunodeficiency Syndrome; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Cell | 1987 |
Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro.
Topics: Astrocytoma; Benzodiazepines; Benzodiazepinones; Cell Division; Clonazepam; Diazepam; Female; Flumaz | 1988 |
[Effects of cytokines on cultured microvascular endothelial cells derived from gerbil brain].
Topics: Animals; Brain; Cells, Cultured; DNA; Endothelium, Vascular; Gerbillinae; Glioma; Humans; Interferon | 1988 |
Prostaglandins: antiproliferative effect of PGD 2 on cultured human glioma cells.
Topics: Cell Division; Cell Line; Dinoprost; Dinoprostone; Glioma; Humans; Prostaglandin D2; Prostaglandins | 1986 |
Cell kinetics of gliomas by serial stereotactic biopsy.
Topics: Adolescent; Adult; Cell Cycle; Cell Division; Child; Female; Glioma; Humans; Magnetic Resonance Spec | 1986 |
Uridine enhances the cytotoxic effect of D-glucosamine in rat C6 glioma cells.
Topics: Animals; Cell Line; Cell Survival; Drug Synergism; Glioma; Glucosamine; Mannose; Rats; Thymidine; Ur | 1986 |
Therapeutic levels of sodium valproate inhibit mitotic indices in cells of neural origin.
Topics: Animals; Cell Adhesion; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Glioma; M | 1985 |
Cellular pharmacology of doxorubicin in sensitive and resistant rat glioblastoma cells in culture.
Topics: Animals; Brain Neoplasms; Cell Count; Cell Division; Cells, Cultured; Doxorubicin; Drug Resistance; | 1986 |
Stem cell studies of human malignant brain tumors. Part 2: Proliferation kinetics of brain-tumor cells in vitro in early-passage cultures.
Topics: Brain Neoplasms; Cell Division; Cells, Cultured; Glioma; Humans; Kinetics; Thymidine | 1985 |
Two-dimensional diffusion limited system for cell growth.
Topics: Animals; Cell Division; Cell Line; Culture Techniques; Diffusion; DNA Replication; Flow Cytometry; G | 1985 |
The deficient density-dependent growth control of human malignant glioma cells and virus-transformed glia-like cells in culture.
Topics: Autoradiography; Cell Count; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplasti | 1973 |
Screening of carcinostatic agents in organ culture.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma; Cerebellar Neoplasms; Chickens; Culture Techniques; | 1968 |
[3H-thymidin-autoradiography of experimentally produced tumors of the nervous system of the rat].
Topics: Animals; Autoradiography; Brain Neoplasms; DNA, Neoplasm; Glioma; Neoplasms, Experimental; Neoplasms | 1968 |
Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine).
Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Culture Techniques; DNA; Floxuridine; Fluorouracil; | 1968 |
Prolonged carotid arterial radiosensitizer infusion and radiation therapy of mouse gliomas.
Topics: Animals; Brain Neoplasms; Bromine; Carotid Arteries; Catheterization; Craniotomy; Cytidine; Deoxyrib | 1972 |
[Proliferative activity of neuroglial tumors].
Topics: Adult; Animals; Astrocytoma; Autoradiography; Brain Neoplasms; Child, Preschool; Ependymoma; Female; | 1970 |
Cell kinetics of human gliomas.
Topics: Astrocytoma; Autoradiography; Brain; Brain Neoplasms; Carbon Isotopes; DNA; Glioblastoma; Glioma; Hu | 1972 |
Tissue culture studies of children's tumours.
Topics: Autoradiography; Child; Culture Media; Culture Techniques; Cytotoxicity Tests, Immunologic; Freezing | 1973 |
[Cyclic AMP and malignant glioma. II. Effects of cyclic AMP on the growth of glial tumors].
Topics: Animals; Cell Division; Cells, Cultured; Cyclic AMP; Glioma; HeLa Cells; Rats; Thymidine; Tritium | 1973 |
Sodium uptake associated with activation of action potential ionophores of cultured neuroblastoma and muscle cells.
Topics: Action Potentials; Animals; Biological Transport; Cell Membrane Permeability; Clone Cells; Glioma; H | 1973 |
Effect of corticosteroid on protein and nucleic acid synthesis in human glial tumor cells.
Topics: Brain Neoplasms; Cell Line; DNA, Neoplasm; Dose-Response Relationship, Drug; Glioma; Humans; In Vitr | 1973 |
[Blood brain barrier for thymidine in experimentally produced tumors of the central nervous system of the rat].
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain Neoplasms; DNA, Neoplasm; Glioma; Neoplasms, Ex | 1971 |
Tumors of the nervous system induced by ethylnitrosourea administered either intracerebrally of subcutaneously to newborn rats. Morphological and biochemical characteristics.
Topics: Animals; Brain; Brain Neoplasms; Desmosterol; DNA; DNA, Neoplasm; Ependymoma; Female; Glioma; Neuril | 1972 |
The effect of chemotherapeutic agents on the incorporation of DNA precursors by experimental brain tumors.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Bone Marrow; Brain; Brain Neoplasms; Carbon Iso | 1972 |
Kinetics of gliomas in rat and man.
Topics: Animals; Autoradiography; Brain Neoplasms; Carbon Isotopes; DNA, Neoplasm; Glioma; Humans; Kinetics; | 1972 |
[Radioautographic study of cell proliferation in rat primary gliomas induced by 9,10-dimethyl-1,2-benzanthracene].
Topics: Animals; Autoradiography; Benz(a)Anthracenes; Cell Division; Cerebellar Neoplasms; Cerebellum; Gliom | 1971 |
Growth behaviour of human brain tumours in matrix cultures in fresh autologous serum.
Topics: Autoradiography; Blood; Brain Neoplasms; Culture Media; Fibrin Foam; Glioma; Growth; Humans; Meningi | 1970 |