thymidine has been researched along with Folic Acid Deficiency in 48 studies
Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Folate deficiency is known to induce chromosomal abnormalities." | 1.28 | Nutritional folate-deficiency in Chinese hamster ovary cells. Chromosomal abnormalities associated with perturbations in nucleic acid precursors. ( Borman, LS; Branda, RF; Libbus, BL; Ventrone, CH, 1990) |
| "Thymidine deficiency has been reported to increase DNA replication errors and hence increase mutagenesis." | 1.27 | Theoretical involvement of vitamin B6 in tumour initiation. ( Prior, FG, 1985) |
| "In patients with folate and/or vitamin B12 deficiency, the addition of appropriate vitamins to marrow and lymphocyte cultures enhanced the incorporation of 3H-dU into DNA." | 1.26 | In vitro DNA synthesis by bone marrow cells and PHA-stimulated lymphocytes. Suppression by nonradioactive thymidine of the incorporation of 3H-deoxyuridine into DNA: enhancement of incorporation when inadequate vitamin B12 or folate is corrected. ( Das, KC; Herbert, V; Manusselis, C, 1980) |
| "If thymine was present in this medium, an unlimited exponential growth was possible." | 1.24 | Growth of Lactobacillus acidophilus in the absence of folic acid. ( Soska, J, 1966) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (85.42) | 18.7374 |
| 1990's | 5 (10.42) | 18.2507 |
| 2000's | 1 (2.08) | 29.6817 |
| 2010's | 1 (2.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martiniova, L | 1 |
| Field, MS | 1 |
| Finkelstein, JL | 1 |
| Perry, CA | 1 |
| Stover, PJ | 1 |
| LEEVY, CM | 1 |
| TEN-HOVE, W | 1 |
| FRANK, O | 1 |
| BAKER, H | 1 |
| SCHMID, JR | 1 |
| FRICK, PG | 1 |
| Burman, JF | 1 |
| Mollin, DL | 1 |
| Lin, HL | 1 |
| Chen, CJ | 1 |
| Tsai, WC | 1 |
| Yen, JH | 1 |
| Liu, HW | 1 |
| Wickramasinghe, SN | 5 |
| Saunders, JE | 1 |
| Cooper, BA | 1 |
| Das, KC | 3 |
| Garewal, G | 1 |
| Mohanty, D | 1 |
| Okabe, T | 1 |
| Ishizawa, S | 1 |
| Ishii, T | 1 |
| Kataoka, K | 1 |
| Matsuki, S | 1 |
| Nauss, KM | 1 |
| Connor, AM | 1 |
| Newberne, PM | 1 |
| Hayman, RJ | 2 |
| Van Der Weyden, MB | 4 |
| Manusselis, C | 1 |
| Herbert, V | 4 |
| Barbiroli, B | 1 |
| König, G | 1 |
| Bovina, C | 1 |
| Formiggini, G | 1 |
| Tolomelli, B | 1 |
| Marchetti, M | 1 |
| Koury, MJ | 2 |
| Horne, DW | 2 |
| Brown, ZA | 1 |
| Pietenpol, JA | 1 |
| Blount, BC | 1 |
| Ames, BN | 1 |
| Hard, R | 1 |
| Koury, ST | 1 |
| Zittoun, J | 2 |
| Zittoun, R | 2 |
| Marquet, J | 2 |
| Bilski-Pasquier, G | 1 |
| Sultan, C | 1 |
| Tomkins, AM | 1 |
| Badcock, J | 1 |
| James, WP | 1 |
| Rose, IS | 1 |
| Brumley, J | 1 |
| Herzlich, BC | 1 |
| Ranginwala, M | 1 |
| Nawabi, I | 1 |
| Libbus, BL | 1 |
| Borman, LS | 2 |
| Ventrone, CH | 1 |
| Branda, RF | 2 |
| James, SJ | 1 |
| Yin, L | 1 |
| Chanarin, I | 1 |
| Deacon, R | 1 |
| Lumb, M | 1 |
| Perry, J | 1 |
| Leeming, RJ | 1 |
| Hamon, CG | 1 |
| Tomkyns, JG | 1 |
| Matthews, JH | 1 |
| Prior, FG | 1 |
| Coovadia, HM | 2 |
| Parent, MA | 2 |
| Loening, WE | 2 |
| Wesley, A | 1 |
| Burgess, B | 1 |
| Hallett, F | 1 |
| Brain, P | 1 |
| Grace, J | 1 |
| Naidoo, J | 1 |
| Smythe, PM | 2 |
| Vos, GH | 2 |
| Longland, JE | 1 |
| Burgess, BJ | 1 |
| Poirier, LA | 1 |
| Koutts, J | 1 |
| Cooper, M | 1 |
| Weinstein, WM | 1 |
| L'Hélias, C | 1 |
| Moffatt, B | 2 |
| Tisman, G | 1 |
| Brenner, L | 1 |
| Sakamoto, S | 1 |
| Takaku, F | 1 |
| Soska, J | 1 |
| Landureau, JC | 1 |
| Van der Weyden, M | 1 |
| Rother, M | 1 |
| Firkin, B | 1 |
| Chabner, BA | 1 |
| Chello, PL | 1 |
| Bertino, JR | 1 |
| Hoffbrand, AV | 1 |
| Axelrod, AE | 1 |
| Higashi, O | 1 |
| Arakawa, T | 1 |
| Narisawa, K | 1 |
| Yoshida, T | 1 |
| Karita, M | 1 |
| Todo, A | 1 |
| Waxman, S | 1 |
| Metz, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Folates in the Care of the Male Infertility[NCT01407432] | Phase 3 | 162 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thymidine and Folic Acid Deficiency
| Article | Year |
|---|---|
Cobalamin-folate interrelations.
Topics: Anemia, Megaloblastic; Animals; Central Nervous System Diseases; Coenzymes; Folic Acid; Folic Acid D | 1989 |
Epithelial cell renewal of the small intestinal mucosa.
Topics: Celiac Disease; Cell Differentiation; Cell Division; Cell Movement; Colchicine; Cytological Techniqu | 1974 |
46 other studies available for thymidine and Folic Acid Deficiency
| Article | Year |
|---|---|
Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.
Topics: Animals; Deoxyuridine; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Glycine Hy | 2015 |
FOLIC ACID DEFICIENCY AND HEPATIC DNA SYNTHESIS.
Topics: Avitaminosis; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; DNA; Folic Aci | 1964 |
[NUTRITIONAL FOLIC ACID DEFICIENCY ANEMIA. STUDIES WITH H3-LABELLED FOLIC ACID, CO58-LABELLED VITAMIN B12, FE59- AND H3-LABELLED THYMIDIN].
Topics: Anemia; Anemia, Macrocytic; Corrinoids; Folic Acid; Folic Acid Deficiency; Humans; Radioisotopes; Th | 1965 |
The value of the deoxyuridine suppression test in megaloblastic anaemia.
Topics: Anemia, Megaloblastic; Antimetabolites; Deoxyuridine; Folic Acid Deficiency; Humans; Predictive Valu | 1978 |
In vitro folate deficiency induces apoptosis by a p53, Fas (Apo-1, CD95) independent, bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes.
Topics: Apoptosis; Cells, Cultured; Down-Regulation; fas Receptor; Folic Acid; Folic Acid Deficiency; Humans | 2006 |
Incorporation of radioactive precursors into the nucleic acids of bone marrow cells from patients wtih vitamin B12 or folate deficiency.
Topics: Anemia, Megaloblastic; Bone Marrow; Carbon Radioisotopes; DNA; Folic Acid Deficiency; Humans; In Vit | 1980 |
Normal deoxyuridine-suppression test in folate deficiency.
Topics: Bone Marrow; Deoxyuridine; False Negative Reactions; Folic Acid Deficiency; Humans; Male; Thymidine | 1984 |
Derangement of DNA synthesis in erythroleukaemia. Normal deoxyuridine suppression and impaired thymidine incorporation in bone marrow culture.
Topics: Adolescent; Adult; Anemia, Megaloblastic; Bone Marrow; Cells, Cultured; Deoxyuridine; DNA; Female; F | 1980 |
Erythrocyte aging changes evaluated by the deoxyuridine suppression test.
Topics: Adult; Aged; Bone Marrow; Deoxyuridine; DNA; Erythrocyte Aging; Erythrocyte Indices; Folic Acid Defi | 1982 |
Alterations in immune function in rats caused by dietary lipotrope deficiency: effect of culture medium, 2-mercaptoethanol and mitogen dose on the in vitro lymphocyte transformation response.
Topics: Animals; Cells, Cultured; Choline Deficiency; Concanavalin A; Culture Media; Dose-Response Relations | 1982 |
Phytohemagglutinin-stimulated normal human peripheral blood lymphocytes in folate-depleted medium: an in vitro model for megaloblastic hemopoiesis.
Topics: Cells, Cultured; Culture Media; DNA; Erythrocytes, Abnormal; Folic Acid Deficiency; Hematopoiesis; H | 1980 |
In vitro DNA synthesis by bone marrow cells and PHA-stimulated lymphocytes. Suppression by nonradioactive thymidine of the incorporation of 3H-deoxyuridine into DNA: enhancement of incorporation when inadequate vitamin B12 or folate is corrected.
Topics: Bone Marrow; Cells, Cultured; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Lymphocy | 1980 |
Distribution of pteroylglutamates during liver regeneration after partial hepatectomy in folic acid-deficient rats.
Topics: Animals; DNA; Folic Acid; Folic Acid Deficiency; Liver; Liver Regeneration; Male; Pteroylpolyglutami | 1980 |
Apoptosis mediates and thymidine prevents erythroblast destruction in folate deficiency anemia.
Topics: Animals; Apoptosis; Bone Marrow; DNA Damage; Erythroid Precursor Cells; Female; Folic Acid Deficienc | 1994 |
Apoptosis of late-stage erythroblasts in megaloblastic anemia: association with DNA damage and macrocyte production.
Topics: Anemia, Megaloblastic; Animals; Apoptosis; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; C | 1997 |
[Anaemia induced by vitamin B12 or folate deficiency: diagnostic value of the "dU suppression" test (author's transl)].
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anemia, Sideroblastic; Bone Marrow; Deoxyuridine; | 1978 |
Deoxyuridine metabolism in human megaloblastic marrow cells.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid De | 1979 |
Effect of folate and cobalamin compounds on the deoxyuridine suppression test in vitamin B12 and folate deficiency.
Topics: Deoxyuridine; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Vitamin B 12; Vita | 1978 |
Altered morphology and pathways of DNA synthesis in small intestinal epithelium in dietary folate deficiency [proceedings].
Topics: Animals; Deoxyuridine; DNA; Epithelium; Folic Acid Deficiency; Intestinal Mucosa; Intestine, Small; | 1976 |
Folate-deficient human lymphoblasts: changes in deoxynucleotide metabolism and thymidylate cycle activities.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuridine; Dose-Re | 1991 |
Synergy of inhibition of DNA synthesis in human bone marrow by azidothymidine plus deficiency of folate and/or vitamin B12?
Topics: Bone Marrow; Deoxyuridine; DNA; Folic Acid Deficiency; Humans; Pyrimidines; Tetrahydrofolates; Thymi | 1990 |
Nutritional folate-deficiency in Chinese hamster ovary cells. Chromosomal abnormalities associated with perturbations in nucleic acid precursors.
Topics: Animals; Cell Cycle; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Culture Media; Folic | 1990 |
Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats.
Topics: Animals; Choline; Choline Deficiency; Deoxyuridine; Diet; DNA Damage; DNA Replication; Folic Acid; F | 1989 |
The effect of folic acid and 5-formyltetrahydrofolic acid on folate-deficient HEp 2 cells in culture.
Topics: Folic Acid; Folic Acid Deficiency; Formyltetrahydrofolates; Humans; Tetrahydrofolates; Thymidine; Tu | 1989 |
Nutritional folate deficiency in Chinese hamster ovary cells. I. Characterization of the pleiotropic response and its modulation by nucleic acid precursors.
Topics: Animals; Cell Adhesion; Cell Cycle; Cell Division; Cell Line; Cell Survival; Cricetinae; Disease Mod | 1989 |
Acquired folate deficiency in phytohaemagglutinin-stimulated human lymphocytes.
Topics: Cells, Cultured; Culture Media; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Folic Ac | 1986 |
Theoretical involvement of vitamin B6 in tumour initiation.
Topics: DNA; DNA Repair; Estrogens; Female; Folic Acid Deficiency; Humans; Isoniazid; Neoplasms; Niacin; Thy | 1985 |
An evaluation of factors associated with the depression of immunity in malnutrition and in measles.
Topics: Antibody Formation; B-Lymphocytes; Cell Count; Child; Child, Preschool; Diet Therapy; Folic Acid Def | 1974 |
Rate of incorporation of tritiated thymidine into DNA of normoblastic and megaloblastic bone marrow cells in vitro.
Topics: Alcoholism; Anemia, Hypochromic; Anemia, Macrocytic; Bone Marrow; Bone Marrow Cells; Deoxyuridine; D | 1974 |
Radio-isotopic assessment of phytohaemagglutinin-stimulated lymphocytes from patients with protein calorie malnutrition.
Topics: Anemia, Hypochromic; Child; Child, Preschool; DNA; Folic Acid Deficiency; Humans; Infant; Lectins; L | 1974 |
Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma.
Topics: Adenine; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Choline; Diet; FIGLU Test; Folic | 1973 |
Effect ot trimethoprim on folate metabolism in human bone marrow.
Topics: Adult; Anemia, Macrocytic; Anti-Infective Agents; Bone Marrow; Culture Techniques; Deoxyuridine; Dep | 1973 |
[Mutations and alterations in the transmission of genetic information in Drosophila melanogaster by injection of diapausing chrysalids (Pieris brassicae) treated with pterins].
Topics: Animals; Cell Fractionation; DNA; Drosophila melanogaster; Extrachromosomal Inheritance; Female; Fol | 1972 |
DNA synthesis during human eosinopoiesis.
Topics: Anemia, Macrocytic; Autoradiography; Bone Marrow; Bone Marrow Cells; DNA; Eosinophilia; Eosinophils; | 1972 |
The dU suppression test using 125 I-UdR to define biochemical megaloblastosis.
Topics: Anemia, Macrocytic; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; In Vi | 1973 |
[Thymidylate synthetase activity in bone marrow cells of folic acid deflcient rats (author's transl)].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Carbon Radioisotopes; Deoxyuridine; DNA; Folic Acid Deficie | 1973 |
Growth of Lactobacillus acidophilus in the absence of folic acid.
Topics: Amino Acids; Folic Acid Deficiency; In Vitro Techniques; Lactobacillus acidophilus; Nucleosides; Pur | 1966 |
[Biological role of vitamin B 12: analysis of strict vitamin requirement of cell line of insects in vitro].
Topics: Aminopterin; Cell Division; Cell Line; Coleoptera; Culture Techniques; Folic Acid; Folic Acid Defici | 1970 |
Observations on cell proliferation in human myelocytes.
Topics: Anemia, Sideroblastic; Autoradiography; Bone Marrow; Bone Marrow Cells; Cell Division; Cell Nucleus; | 1971 |
Megaloblastic maturation masked by iron deficiency: a biochemical basis.
Topics: Anemia, Hypochromic; Anemia, Macrocytic; Bone Marrow; Culture Techniques; Deferoxamine; Deoxyuridine | 1972 |
Antitumor activity of a folate-cleaving enzyme, carboxypeptidase G 1 .
Topics: Animals; Antineoplastic Agents; Carboxypeptidases; Carcinoma 256, Walker; Cell Division; Cell Line; | 1972 |
Lymphocyte transformation in megaloblastic anaemia: morphology and DNA synthesis.
Topics: Anemia, Macrocytic; Anemia, Pernicious; Chromosomes; Culture Techniques; Deoxyuridine; DNA; Folic Ac | 1970 |
Immune processes in vitamin deficiency states.
Topics: Antibody Formation; Antigen-Antibody Reactions; Avitaminosis; Erythrocytes; Folic Acid Deficiency; H | 1971 |
Hypersegmentation of megakaryocytes in a folic acid deficient child.
Topics: Bone Marrow; Cell Nucleus; Child; Child, Preschool; DNA; Female; Folic Acid; Folic Acid Deficiency; | 1971 |
Proliferation and differentiation of hematopoietic cells in hematologic disorders. 1. In vitro radioautographic study of megaloblast in vitamin B12 and folic acid deficiency.
Topics: Adult; Aged; Anemia, Macrocytic; Culture Techniques; Erythrocytes; Folic Acid Deficiency; Hematopoie | 1968 |
Defective DNA synthesis in human megaloblastic bone marrow: effects of homocysteine and methionine.
Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow; Deoxyuridine; DNA; Folic Acid Deficienc | 1969 |