thymidine has been researched along with Electron Transport Chain Deficiencies, Mitochondrial in 10 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "All oral nucleoside analogues against hepatitis B virus, with an exception of telbivudine, have been reported causing lactic acidosis (LA)." | 8.89 | Lactic acidosis during telbivudine treatment for HBV: a case report and literature review. ( Hu, P; Huang, XY; Jin, JL; Lu, JH; Luo, SS; Weng, XH; Zhang, JM, 2013) |
| "All oral nucleoside analogues against hepatitis B virus, with an exception of telbivudine, have been reported causing lactic acidosis (LA)." | 4.89 | Lactic acidosis during telbivudine treatment for HBV: a case report and literature review. ( Hu, P; Huang, XY; Jin, JL; Lu, JH; Luo, SS; Weng, XH; Zhang, JM, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, L | 2 |
| Eriksson, S | 1 |
| Stamp, C | 1 |
| Whitehall, JC | 1 |
| Smith, ALM | 1 |
| Houghton, D | 1 |
| Bradshaw, C | 1 |
| Stoll, EA | 1 |
| Blain, AP | 1 |
| Turnbull, DM | 1 |
| Greaves, LC | 1 |
| Lopez-Gomez, C | 1 |
| Levy, RJ | 1 |
| Sanchez-Quintero, MJ | 1 |
| Juanola-Falgarona, M | 1 |
| Barca, E | 2 |
| Garcia-Diaz, B | 2 |
| Tadesse, S | 1 |
| Garone, C | 2 |
| Hirano, M | 3 |
| Jin, JL | 1 |
| Hu, P | 1 |
| Lu, JH | 1 |
| Luo, SS | 1 |
| Huang, XY | 1 |
| Weng, XH | 1 |
| Zhang, JM | 1 |
| Mojahed, H | 1 |
| Gutierrez, P | 1 |
| Pizzorno, G | 1 |
| Tanji, K | 1 |
| Arias-Mendoza, F | 1 |
| Quinzii, CM | 1 |
| Sun, R | 1 |
| Moran, NF | 2 |
| Bain, MD | 1 |
| Muqit, MM | 1 |
| Bax, BE | 2 |
| Baine, M | 1 |
| El-Hattab, AW | 1 |
| Scaglia, F | 1 |
| MartÃ, R | 1 |
| Spinazzola, A | 1 |
| Nishino, I | 1 |
| Nishigaki, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Deoxythymidine and Deoxycytidine Treatment for Thymidine Kinase 2 (TK2) Deficiency[NCT03639701] | Phase 1/Phase 2 | 23 participants (Actual) | Interventional | 2017-05-16 | Active, not recruiting | ||
| The Safety, Tolerability, Pharmacodynamics, and Efficacy of Erythrocyte Encapsulated Thymidine Phosphorylase (EE-TP) in Patients With MNGIE[NCT03866954] | Phase 2 | 0 participants (Actual) | Interventional | 2024-11-30 | Withdrawn (stopped due to Change of circumstances with Commercial partner) | ||
| Nutritional Assessment in Patients Affected by Mitochondrial Cytopathy[NCT02375438] | 26 participants (Actual) | Observational | 2014-12-31 | Completed | |||
| A Phase II, Monocenter, Single Arm Study To Assess The Safety and Efficacy Of Combination Deoxycytidine and Deoxythymidine For Mitochondrial Depletion Disorders[NCT04802707] | Phase 2 | 50 participants (Anticipated) | Interventional | 2021-10-18 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for thymidine and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Lactic acidosis during telbivudine treatment for HBV: a case report and literature review.
Topics: Acidosis, Lactic; Adult; Antiviral Agents; Hepatitis B, Chronic; Humans; Male; Mitochondrial Disease | 2013 |
Thymidine kinase 2 enzyme kinetics elucidate the mechanism of thymidine-induced mitochondrial DNA depletion.
Topics: Deoxycytidine; DNA, Mitochondrial; Humans; Kinetics; Mitochondrial Diseases; Mitochondrial Proteins; | 2014 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options.
Topics: DNA Replication; DNA, Mitochondrial; Humans; Liver Transplantation; Mitochondrial Diseases; Mitochon | 2013 |
7 other studies available for thymidine and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Mutational analyses of human thymidine kinase 2 reveal key residues in ATP-Mg
Topics: Adenosine Triphosphate; Catalysis; Humans; Mitochondrial Diseases; Thymidine; Thymidine Kinase | 2022 |
Age-associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon.
Topics: Aging; Animals; Cell Proliferation; Colon; Electron Transport Complex I; Female; Mice, Inbred C57BL; | 2021 |
Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency.
Topics: Animals; Antimetabolites; Deoxycytidine Monophosphate; Disease Models, Animal; DNA, Mitochondrial; D | 2017 |
Deoxynucleoside stress exacerbates the phenotype of a mouse model of mitochondrial neurogastrointestinal encephalopathy.
Topics: Age Factors; Animals; Body Weight; Brain; Deoxyribonucleosides; Disease Models, Animal; Intestinal P | 2014 |
Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIE.
Topics: Adult; Deoxyuridine; Drug Delivery Systems; Erythrocyte Transfusion; Erythrocytes; Fatal Outcome; Fe | 2008 |
Mitochondrial neurogastrointestinal encephalopathy without elevated thymidine levels.
Topics: Biomarkers; Bone Marrow Transplantation; Brain Diseases, Metabolic; Enzyme Replacement Therapy; Gast | 2010 |
Thymidine phosphorylase deficiency causes MNGIE: an autosomal recessive mitochondrial disorder.
Topics: Blotting, Southern; Brain Diseases; Chromatography, High Pressure Liquid; Genes, Recessive; Genetic | 2004 |