thymidine has been researched along with Down Syndrome in 32 studies
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The gene for cystathionine beta-synthase (CBS) is located on chromosome 21 and is overexpressed in children with Down syndrome (DS), or trisomy 21." | 7.71 | Homocysteine metabolism in children with Down syndrome: in vitro modulation. ( Chango, A; James, SJ; Melnyk, S; Pogribna, M; Pogribny, I; Yi, P, 2001) |
| "The gene for cystathionine beta-synthase (CBS) is located on chromosome 21 and is overexpressed in children with Down syndrome (DS), or trisomy 21." | 3.71 | Homocysteine metabolism in children with Down syndrome: in vitro modulation. ( Chango, A; James, SJ; Melnyk, S; Pogribna, M; Pogribny, I; Yi, P, 2001) |
| " Similar dose-response curves were established for Down's syndrome leukocytes and controls." | 1.26 | DNA repair and frequency of x-ray and u.v.-light induced chromosome aberrations in leukocytes from patients with Down's syndrome. ( Bui, TH; Funes-Cravioto, F; Hansson, K; Lambert, B; Lindsten, J, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (90.63) | 18.7374 |
| 1990's | 2 (6.25) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SCHMID, W | 2 |
| MITTWOCH, U | 1 |
| YUNIS, JJ | 1 |
| HOOK, EB | 1 |
| MAYER, M | 1 |
| DEMYER, W | 1 |
| PALMER, C | 1 |
| Epstein, LB | 2 |
| Epstein, CJ | 1 |
| Franceschi, C | 2 |
| Licastro, F | 2 |
| Chiricolo, M | 1 |
| Bonetti, F | 1 |
| Zannotti, M | 2 |
| Fabris, N | 1 |
| Mocchegiani, E | 1 |
| Fantini, MP | 1 |
| Paolucci, P | 2 |
| Masi, M | 2 |
| Sikora, E | 1 |
| Radziszewska, E | 1 |
| Kmieć, T | 1 |
| Maślińska, D | 1 |
| Pogribna, M | 1 |
| Melnyk, S | 1 |
| Pogribny, I | 1 |
| Chango, A | 1 |
| Yi, P | 1 |
| James, SJ | 1 |
| Barinsky, IF | 1 |
| Dementiev, IV | 1 |
| Shvetsova, TP | 1 |
| Ugryumov, EP | 1 |
| Ryabova, MV | 1 |
| Bugbee, SJ | 1 |
| Sutnick, AI | 2 |
| Millman, I | 1 |
| Blumberg, BS | 2 |
| Lambert, B | 1 |
| Hansson, K | 1 |
| Bui, TH | 1 |
| Funes-Cravioto, F | 1 |
| Lindsten, J | 1 |
| Davidenkova, EF | 1 |
| Sokolova, SM | 1 |
| Butomo, IV | 1 |
| Khitrikova, LE | 1 |
| Chukhlovin, AB | 1 |
| Cavicchi, S | 1 |
| Murphy, M | 1 |
| Hyun, W | 1 |
| Hunte, B | 1 |
| Levine, AD | 1 |
| Sweeney, JE | 1 |
| Höhmann, CF | 1 |
| Oster-Granite, ML | 1 |
| Coyle, JT | 1 |
| Hayakawa, H | 1 |
| Matsui, I | 1 |
| Higurashi, M | 1 |
| Kobayashi, N | 1 |
| Agarwal, SS | 1 |
| Gerstley, BJ | 1 |
| London, WT | 1 |
| Loeb, LA | 1 |
| Cave, MD | 1 |
| Levitsky, JM | 1 |
| Nadler, HL | 1 |
| Monteleone, P | 1 |
| Hsia, DY | 1 |
| Hecht, F | 2 |
| Case, MP | 1 |
| Lovrien, EW | 1 |
| Higgins, JV | 1 |
| Thuline, HC | 1 |
| Melnyk, J | 1 |
| Sasaki, M | 1 |
| Obara, Y | 1 |
| Vischer, D | 1 |
| Palmer, CG | 1 |
| Conneally, PM | 1 |
| Christian, JC | 1 |
| Mikkelsen, M | 1 |
| Fitzgerald, PH | 1 |
| Hamer, JW | 1 |
| Orye, E | 1 |
| Coetsier, H | 1 |
| Hooft, C | 1 |
| Clarkson, B | 1 |
| Fried, J | 1 |
| Strife, A | 1 |
| Sakai, Y | 1 |
| Ota, K | 1 |
| Okita, T | 1 |
| Nagao, T | 1 |
| Lampkin, BC | 1 |
| Hug, G | 1 |
| Rigas, DA | 1 |
| Elsasser, P | 1 |
| O'Brien, RL | 1 |
| Poon, P | 1 |
| Kline, E | 1 |
| Parker, JW | 1 |
| Fowler, I | 1 |
| Hollingsworth, DR | 1 |
| Traurig, H | 1 |
| Paton, GR | 1 |
| Silver, MF | 1 |
| Allison, AC | 1 |
| Kukharenko, VI | 1 |
| Kuliev, AM | 1 |
| Grinberg, KN | 1 |
| Terskikh, VV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-Blind Placebo Controlled, Cross-over Trial of Subcutaneous B12 on Behavioral and Metabolic Measures in Children With Autism.[NCT00273650] | Phase 2/Phase 3 | 30 participants (Actual) | Interventional | 2005-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thymidine and Down Syndrome
| Article | Year |
|---|---|
SEX CHROMATIN.
Topics: Animals; Autoradiography; Bombyx; Cell Division; Cell Nucleus; Chromosome Aberrations; Chromosome Di | 1964 |
31 other studies available for thymidine and Down Syndrome
| Article | Year |
|---|---|
DNA REPLICATION PATTERNS OF HUMAN CHROMOSOMES.
Topics: Autoradiography; Cell Division; Chromosomes; Chromosomes, Human; DNA; DNA Replication; Down Syndrome | 1963 |
D.N.A. REPLICATION ANALYSIS IN IDENTIFYING THE CYTOGENETIC DEFECT IN DOWN'S SYNDROME (MONGOLISM).
Topics: Autoradiography; Chromosomes; Cytogenetic Analysis; DNA; Down Syndrome; Humans; Thymidine; Tritium | 1965 |
CLOSED METOPIC SUTURE WITH TRIGONOCEPHALY IN DOWN'S SYNDROME.
Topics: Chromosome Aberrations; Chromosome Disorders; Craniosynostoses; Dermatoglyphics; Diagnosis, Differen | 1965 |
T-lymphocyte function and sensitivity to interferon in trisomy 21.
Topics: Adolescent; Adult; B-Lymphocytes; Cell Division; Child; Child, Preschool; Concanavalin A; DNA; Down | 1980 |
Deficiency of autologous mixed lymphocyte reactions and serum thymic factor level in Down's syndrome.
Topics: Adolescent; Adult; Aging; Child; Down Syndrome; Female; Humans; Immunologic Deficiency Syndromes; Ly | 1981 |
The impaired transcription factor AP-1 DNA binding activity in lymphocytes derived from subjects with some symptoms of premature aging.
Topics: Adolescent; Adult; Child; DNA; Down Syndrome; Electrophoresis; Humans; Lymphocyte Activation; Lympho | 1993 |
Homocysteine metabolism in children with Down syndrome: in vitro modulation.
Topics: Adenosine; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Cystathionine; Cystath | 2001 |
Investigation of the nature of Australia antigen. I: The absence of biological activity of Australia antigen in human blood leukocyte culture.
Topics: Adolescent; Adult; Chromosome Aberrations; DNA Nucleotidyltransferases; Down Syndrome; Female; Hepat | 1975 |
DNA repair and frequency of x-ray and u.v.-light induced chromosome aberrations in leukocytes from patients with Down's syndrome.
Topics: Adult; Chromosome Aberrations; Chromosomes; DNA Repair; DNA Replication; Dose-Response Relationship, | 1976 |
[Possible disorder of tissue immunity function in mothers who have given birth to a child with Down's disease].
Topics: Adult; Age Factors; DNA; Down Syndrome; Female; Humans; Lectins; Lymphocytes; Thymidine | 1977 |
T and B lypmhocyte subpopulations in Down's syndrome. A study on non-institutionalised subjects.
Topics: Adolescent; Adult; B-Lymphocytes; Child; Child, Preschool; Concanavalin A; Down Syndrome; Humans; Le | 1978 |
A role for tumor necrosis factor-alpha and interferon-gamma in the regulation of interleukin-4-induced human thymocyte proliferation in vitro. Heightened sensitivity in the Down syndrome (trisomy 21) thymus.
Topics: Cell Division; DNA Probes; Down Syndrome; Humans; Interferon-gamma; Interleukin-4; Thymidine; Thymus | 1992 |
Neurogenesis of the basal forebrain in euploid and trisomy 16 mice: an animal model for developmental disorders in Down syndrome.
Topics: Acetylcholinesterase; Animals; Cell Differentiation; Cholinergic Fibers; Disease Models, Animal; Dow | 1989 |
Hyperblastic response to dilute P.H.A. in Down's syndrome.
Topics: Adolescent; Child; Child, Preschool; Down Syndrome; Female; Humans; Infant; Infant, Newborn; Lectins | 1968 |
DNA polymerase activity as an index of lymphocyte stimulation: studies in Down's syndrome.
Topics: Adolescent; Adult; Antigens; Blood Proteins; DNA Nucleotidyltransferases; Down Syndrome; Female; gam | 1970 |
Tritiated thymidine uptake by group G chromosomes of female individuals with Down's syndrome.
Topics: Blood; Chromosomes; Down Syndrome; Female; Humans; Thymidine; Tritium | 1966 |
Enzyme studies during lymphocyte stimulation with phytohemagglutinin in Down's syndrome.
Topics: Acid Phosphatase; Alkaline Phosphatase; Down Syndrome; Glucosephosphate Dehydrogenase; Humans; Lecti | 1967 |
Nonrandomness of translocations in man: preferential entry of chromosomes into 13-15-21 translocations.
Topics: Autoradiography; Chromosome Aberrations; Chromosomes, Human, 13-15; Chromosomes, Human, 21-22 and Y; | 1968 |
Hypersensitivity of lymphocytes in Down's syndrome shown by mixed leukocyte culture experiments.
Topics: Chromosome Aberrations; Culture Techniques; Down Syndrome; Humans; Leukocytes; Lymphocytes; Mosaicis | 1969 |
Spontaneous fragility of an abnormally wide secondary constriction region in a human chromosome no. 9.
Topics: Autoradiography; Chromosome Aberrations; Chromosomes, Human, 6-12 and X; Cytogenetics; Down Syndrome | 1969 |
Translocations of D chromosomes in two families: t(13q14q) and t(13q14q)+(13p14p).
Topics: Adult; Autoradiography; Blood Group Antigens; Chromosome Aberrations; Chromosome Mapping; Chromosome | 1969 |
DNA replication analysis of six 13-15--21 translocation families.
Topics: Autoradiography; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 13-15; Chromosome | 1967 |
Third case of chronic lymphocytic leukaemia in a carrier of the inherited Ch1 chromosome.
Topics: Aged; Autoradiography; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 21-22 and Y | 1969 |
A probable pericentric inversion of a G-G translocation chromosome in a mentally retarded child with mongoloid traits.
Topics: Autoradiography; Chromosome Aberrations; Chromosomes, Human, 19-20; Dermatoglyphics; Down Syndrome; | 1969 |
Studies of cellular proliferation in human leukemia. 3. Behavior of leukemic cells in three adults with acute leukemia given continuous infusions of 3H-thymidine for 8 or 10 days.
Topics: Acute Disease; Adult; Aged; Autoradiography; Bone Marrow; Bone Marrow Cells; Cell Division; Cell Nuc | 1970 |
A neonate with Down's syndrome and transient abnormal myelopoiesis: serial blood and bone marrow studies.
Topics: Alkaline Phosphatase; Bilirubin; Bone Marrow Examination; Coombs Test; Diagnosis, Differential; Down | 1970 |
Impaired in vitro response of circulating lymphocytes to phytohemagglutinin in Down's syndrome: dose- and time-response curves and relation to cellular immunity.
Topics: Adult; Carbon Isotopes; Child; Child, Preschool; Culture Techniques; DNA; Down Syndrome; Female; Hum | 1970 |
Susceptibility of chromosomes from patients with Down's syndrome to 7,12-dimethylbenz(a) anthracene-induced aberrations in vitro.
Topics: Adolescent; Adult; Benz(a)Anthracenes; Carcinogens; Chromatids; Chromosome Aberrations; DNA; DNA Rep | 1971 |
Response to stimulation in vitro of lymphocytes from patients with Down's syndrome.
Topics: Down Syndrome; Humans; Intellectual Disability; Lectins; Lymphocyte Activation; Lymphocytes; Thymidi | 1973 |
Comparison of cell cycle time in normal and trisomic cells.
Topics: Abnormalities, Multiple; Autoradiography; Biopsy; Cell Division; Cells, Cultured; Chromosomes, Human | 1974 |
Cell cycles in human diploid and aneuploid strains.
Topics: Aneuploidy; Autoradiography; Cell Division; Cell Line; Cells, Cultured; Chromosome Aberrations; Chro | 1974 |