thymidine has been researched along with Cystic Fibrosis in 22 studies
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the isolation of thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus from unusual infection sites of patients with chronic soft tissue infection, tympanitis, bronchitis, peritonitis, and septicemia." | 7.74 | Thymidine-dependent Staphylococcus aureus small-colony variants: human pathogens that are relevant not only in cases of cystic fibrosis lung disease. ( Besier, S; Brade, V; Ehrhart, A; Hunfeld, KP; Saum, SH; Siegel, E; Wichelhaus, TA; Zander, J, 2008) |
| "During a 1-year period, the prevalence of thymidine-dependent (TD) Staphylococcus aureus in patients at two geographically distinct cystic fibrosis (CF) centers was determined." | 7.67 | Prevalence of thymidine-dependent Staphylococcus aureus in patients with cystic fibrosis. ( Gage, PA; Gilligan, PH; Muszynski, MJ; Wait, KR; Welch, DF, 1987) |
| "Cystic fibrosis is a monogenic recessive disorder found predominantly in Caucasian population." | 5.38 | Poly thymidine polymorphism and cystic fibrosis in a non-Caucasian population. ( Bazzaz, JT; Douki, MR; Larijani, B; Niaki, HA; Tabaripour, R; Yaghmaei, P, 2012) |
| " The activities of oxacillin, fusidic acid, clindamycin, gentamicin, rifampin, vancomycin, linezolid, quinupristin-dalfopristin, daptomycin, tigecycline, moxifloxacin, telavancin, and oritavancin have been examined in THP-1 macrophages infected by a stable thymidine-dependent SCV strain in comparison with normal-phenotype and revertant isogenic strains isolated from the same cystic fibrosis patient." | 3.75 | Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a ( Denis, O; Nguyen, HA; Struelens, MJ; Theunis, A; Tulkens, PM; Van Bambeke, F; Vergison, A, 2009) |
| "We report the isolation of thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus from unusual infection sites of patients with chronic soft tissue infection, tympanitis, bronchitis, peritonitis, and septicemia." | 3.74 | Thymidine-dependent Staphylococcus aureus small-colony variants: human pathogens that are relevant not only in cases of cystic fibrosis lung disease. ( Besier, S; Brade, V; Ehrhart, A; Hunfeld, KP; Saum, SH; Siegel, E; Wichelhaus, TA; Zander, J, 2008) |
| "Trimethoprim-sulfamethoxazole (SXT)-resistant Staphylococcus aureus thymidine-dependent small-colony variants (TD-SCVs) are frequently isolated from the airways of cystic fibrosis (CF) patients, often in combination with isogenic normal strains if patients were treated with SXT for extended periods." | 3.74 | In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureus. ( Chatterjee, I; Deiwick, S; Fischer, A; Herrmann, M; Kahl, BC; Kriegeskorte, A; Peters, G; Proctor, RA; Theimann, N, 2008) |
| "Thymidine-dependent small-colony variants (SCVs) of Staphylococcus aureus are frequently associated with persistent and recurrent infections in cystic fibrosis patients." | 3.74 | Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureus. ( Besier, S; Brade, V; Dehghani, F; Loitsch, S; Saum, SH; Wichelhaus, TA; Zander, J, 2008) |
| "Thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus can be isolated from the airway secretions of patients suffering from cystic fibrosis (CF) and are implicated in persistent and treatment-resistant infections." | 3.74 | The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates. ( Besier, S; Brade, V; Kahl, BC; Kraiczy, P; Wichelhaus, TA; Zander, J, 2008) |
| "The study's purpose was to understand the molecular basis for different clinical phenotypes of the 5T variant, a tract of 5 thymidines in intron 8 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which disrupts processing of CFTR mRNA and reduces synthesis from the corresponding CFTR alleles." | 3.73 | CFTR 5T variant has a low penetrance in females that is partially attributable to its haplotype. ( Anderson, B; Anguiano, A; Buller, A; Hantash, F; Huang, S; McGinniss, MJ; Milunsky, A; Quan, F; Redman, J; Strom, C; Sun, W, 2006) |
| "During a 1-year period, the prevalence of thymidine-dependent (TD) Staphylococcus aureus in patients at two geographically distinct cystic fibrosis (CF) centers was determined." | 3.67 | Prevalence of thymidine-dependent Staphylococcus aureus in patients with cystic fibrosis. ( Gage, PA; Gilligan, PH; Muszynski, MJ; Wait, KR; Welch, DF, 1987) |
| "Cultured skin fibroblasts derived from unrelated patients with diagnosed cystic fibrosis were compared with those from one normal individual in respect to thymidine and uridine uptake." | 3.66 | Nucleoside uptake in normal and cystic fibrosis fibroblasts in vitro. ( Limbosch, S; Poliard, A; Van Geffel, R, 1980) |
| "Cystic fibrosis is a monogenic recessive disorder found predominantly in Caucasian population." | 1.38 | Poly thymidine polymorphism and cystic fibrosis in a non-Caucasian population. ( Bazzaz, JT; Douki, MR; Larijani, B; Niaki, HA; Tabaripour, R; Yaghmaei, P, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (31.82) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 9 (40.91) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| de Souza, DC | 2 |
| Cogo, LL | 2 |
| Palmeiro, JK | 2 |
| Dalla-Costa, LM | 2 |
| de Oliveira Tomaz, AP | 1 |
| Riedi, CA | 2 |
| Rosario Filho, NA | 2 |
| Tomaz, APO | 1 |
| Conte, D | 1 |
| Delgado-Valverde, M | 1 |
| Fernández-Echauri, P | 1 |
| Batista-Díaz, N | 1 |
| Pascual-Hernández, A | 1 |
| Tkadlec, J | 1 |
| Vařeková, E | 1 |
| Pantůček, R | 1 |
| Doškař, J | 1 |
| Růžičková, V | 1 |
| Botka, T | 1 |
| Fila, L | 1 |
| Melter, O | 1 |
| Besier, S | 3 |
| Zander, J | 3 |
| Siegel, E | 1 |
| Saum, SH | 2 |
| Hunfeld, KP | 1 |
| Ehrhart, A | 1 |
| Brade, V | 3 |
| Wichelhaus, TA | 3 |
| Nguyen, HA | 1 |
| Denis, O | 1 |
| Vergison, A | 1 |
| Theunis, A | 1 |
| Tulkens, PM | 1 |
| Struelens, MJ | 1 |
| Van Bambeke, F | 1 |
| Tabaripour, R | 1 |
| Niaki, HA | 1 |
| Douki, MR | 1 |
| Bazzaz, JT | 1 |
| Larijani, B | 1 |
| Yaghmaei, P | 1 |
| Disset, A | 1 |
| Michot, C | 1 |
| Harris, A | 1 |
| Buratti, E | 1 |
| Claustres, M | 1 |
| Tuffery-Giraud, S | 1 |
| Kahl, BC | 3 |
| Belling, G | 1 |
| Becker, P | 1 |
| Chatterjee, I | 2 |
| Wardecki, K | 1 |
| Hilgert, K | 1 |
| Cheung, AL | 1 |
| Peters, G | 2 |
| Herrmann, M | 2 |
| Cleeve, VJ | 1 |
| Perry, JD | 1 |
| Cresswell, G | 1 |
| Orr, KE | 1 |
| Sun, W | 1 |
| Anderson, B | 1 |
| Redman, J | 1 |
| Milunsky, A | 1 |
| Buller, A | 1 |
| McGinniss, MJ | 1 |
| Quan, F | 1 |
| Anguiano, A | 1 |
| Huang, S | 1 |
| Hantash, F | 1 |
| Strom, C | 1 |
| Kriegeskorte, A | 1 |
| Fischer, A | 1 |
| Deiwick, S | 1 |
| Theimann, N | 1 |
| Proctor, RA | 1 |
| Dehghani, F | 1 |
| Loitsch, S | 1 |
| Kraiczy, P | 1 |
| Limbosch, S | 1 |
| Poliard, A | 1 |
| Van Geffel, R | 1 |
| Strasberg, PM | 1 |
| Noreau, D | 1 |
| McGlynn-Steele, L | 1 |
| Koultchitski, G | 1 |
| Ray, PN | 1 |
| George, RH | 1 |
| Healing, DE | 1 |
| Sparham, PD | 1 |
| Lobban, DI | 1 |
| Speller, DC | 1 |
| Lam, LF | 1 |
| Shapiro, BL | 1 |
| Barranco, SC | 1 |
| Bolton, WE | 1 |
| Haenelt, BR | 1 |
| Abell, CW | 1 |
| Gilligan, PH | 1 |
| Gage, PA | 1 |
| Welch, DF | 1 |
| Muszynski, MJ | 1 |
| Wait, KR | 1 |
| Houck, JC | 1 |
| Cheng, FL | 1 |
22 other studies available for thymidine and Cystic Fibrosis
| Article | Year |
|---|---|
Thymidine-auxotrophic Staphylococcus aureus small-colony variant bacteremia in a patient with cystic fibrosis.
Topics: Anti-Bacterial Agents; Bacteremia; Cystic Fibrosis; Drug Resistance, Bacterial; Genes, Bacterial; Ge | 2020 |
Emergence of Thymidine-Dependent Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Patients in Southern Brazil.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Proteins; Brazil; Child; Child, Preschool; | 2021 |
[Small-colony variants of Staphylococcus aureus: Usefulness of various test for diagnosis and susceptibility study].
Topics: Anti-Bacterial Agents; Bacteriological Techniques; Clone Cells; Colony Count, Microbial; Culture Med | 2014 |
Characterization of Staphylococcus aureus Strains Isolated from Czech Cystic Fibrosis Patients: High Rate of Ribosomal Mutation Conferring Resistance to MLS(B) Antibiotics as a Result of Long-Term and Low-Dose Azithromycin Treatment.
Topics: Anti-Bacterial Agents; Azithromycin; Cross Infection; Cystic Fibrosis; Czech Republic; Drug Resistan | 2015 |
Thymidine-dependent Staphylococcus aureus small-colony variants: human pathogens that are relevant not only in cases of cystic fibrosis lung disease.
Topics: Adult; Bronchitis; Child; Cystic Fibrosis; Female; Humans; Male; Middle Aged; Peritonitis; Pneumonia | 2008 |
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype a
Topics: Anti-Bacterial Agents; Cell Line; Cystic Fibrosis; Dose-Response Relationship, Drug; Fusidic Acid; G | 2009 |
Poly thymidine polymorphism and cystic fibrosis in a non-Caucasian population.
Topics: Adolescent; Base Sequence; Child; Child, Preschool; Cystic Fibrosis; Cystic Fibrosis Transmembrane C | 2012 |
A T3 allele in the CFTR gene exacerbates exon 9 skipping in vas deferens and epididymal cell lines and is associated with Congenital Bilateral Absence of Vas Deferens (CBAVD).
Topics: Adult; Alleles; Alternative Splicing; Caco-2 Cells; Cell Line; Cystic Fibrosis; Cystic Fibrosis Tran | 2005 |
Thymidine-dependent Staphylococcus aureus small-colony variants are associated with extensive alterations in regulator and virulence gene expression profiles.
Topics: Bacterial Proteins; Bacterial Toxins; Cystic Fibrosis; Gene Expression Profiling; Genes, Regulator; | 2005 |
Thymidine-dependent meticillin-resistant Staphylococcus aureus: a potentially unrecognized reservoir of MRSA in hospital patients?
Topics: Adult; Carrier State; Cystic Fibrosis; Humans; Male; Methicillin Resistance; Staphylococcal Infectio | 2006 |
CFTR 5T variant has a low penetrance in females that is partially attributable to its haplotype.
Topics: Alleles; Base Sequence; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female | 2006 |
In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Culture Media; Cystic Fibrosis; Drug Resistance, Bacteria | 2008 |
Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Cell Line; Cystic Fibrosis; Dihydropteroate Synthase; Fluorouracil; Folic Aci | 2008 |
The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Cystic Fibrosis; Drug Resistance, Bacterial; Humans; Micr | 2008 |
Nucleoside uptake in normal and cystic fibrosis fibroblasts in vitro.
Topics: Cells, Cultured; Cystic Fibrosis; Fibroblasts; Humans; Nucleosides; Thymidine; Uridine | 1980 |
PCR-based test for two cystic fibrosis mutations (A455E, 711 + 1 G-->T) common among French Canadians.
Topics: Canada; Cystic Fibrosis; DNA Primers; France; Guanine; Humans; Introns; Mutation; Polymerase Chain R | 1997 |
Thymidine-requiring Haemophilus influenzae and Staphylococcus aureus.
Topics: Child; Culture Media; Cystic Fibrosis; Haemophilus influenzae; Humans; Sputum; Staphylococcus aureus | 1977 |
Thymidine-requiring Staphylococcus aureus.
Topics: Cystic Fibrosis; Drug Resistance, Microbial; Humans; Staphylococcus aureus; Thymidine; Trimethoprim | 1978 |
Differential incorporation of 3H-thymidine into DNA in cultured skin fibroblasts derived from patients with cystic fibrosis and controls.
Topics: Adolescent; Adult; Cell Division; Child; Cystic Fibrosis; DNA; Female; Fibroblasts; Humans; Male; Th | 1979 |
Differences in the incorporation of thymidine into DNA of normal and cystic fibrosis fibroblasts in vitro.
Topics: Bromodeoxyuridine; Cadmium; Cell Division; Cell Line; Cystic Fibrosis; DNA; Genotype; Kinetics; Thym | 1976 |
Prevalence of thymidine-dependent Staphylococcus aureus in patients with cystic fibrosis.
Topics: Culture Media; Cystic Fibrosis; Drug Combinations; Humans; Respiratory System; Staphylococcus aureus | 1987 |
Defects in the cell cycle of fibroblasts obtained from patients with cystic fibrosis.
Topics: Autoradiography; Cell Division; Cell Line; Cells, Cultured; Culture Media; Cystic Fibrosis; Fibrobla | 1974 |