thymidine has been researched along with Colonic Neoplasms in 218 studies
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The metabolism of 5-fluorouracil (5-FU) was monitored non-invasively in two xenografts, a hypopharynx carcinoma and a colon carcinoma (CSM) by 19F-magnetic resonance spectroscopy following an i." | 7.69 | 5-Fluorouracil metabolism and cytotoxicity after pre-treatment with methotrexate or thymidine in human hypopharynx and colon carcinoma xenografts: a 19F-nuclear magnetic resonance spectroscopy study in vivo. ( Baumgart, F; Köpf-Maier, P; Tausch-Treml, R; Ziessow, D, 1996) |
| "In an in vitro study, the effect of ciprofloxacin was examined on proliferation of HT-29 human colon carcinoma cell line." | 7.69 | In vitro effect of ciprofloxacin on HT-29 human colon carcinoma cell line: assessment of cell proliferation by thymidine uptake and silver nucleolar organizer regions (AgNOR) histomorphometry. ( Dayan, D; Nyska, A; Rabau, M, 1995) |
| "A human colon adenocarcinoma cell line (GC3TK-) was selected for thymidine kinase (TK) deficiency from cloned parental cells (GC3C1) by exposure to 5-bromodeoxyuridine (BrdUrd)." | 7.68 | Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency. ( Germain, G; Houghton, JA; Houghton, PJ; Pennington, J; Radparvar, S; Rahman, A, 1990) |
| "Exposure to dehydroepiandrosterone caused a concentration-dependent accumulation of HT-29 human colonic adenocarcinoma cells in S-phase and sensitization toward the cytotoxic effects of fluorouracil deoxyriboside but not 5-fluorouracil." | 7.68 | Biochemical modulation of 5-fluoropyrimidine toxicity by dehydroepiandrosterone in human colonic adenocarcinoma cells. ( Holbrook, CT; Klann, RC; Nyce, J, 1990) |
| "In order to determine the contribution of thymidine (dThd) salvage to intrinsic resistance to antimetabolites (5-fluoropyrimidines, antifolates) in the human colon adenocarcinoma xenograft, H X GC3, a subline deficient in thymidine kinase has been developed." | 7.67 | Development and characterization of a human colon adenocarcinoma xenograft deficient in thymidine salvage. ( Germain, G; Houghton, JA; Houghton, PJ; Torrance, PM, 1987) |
| "Administration of high-dose uridine or cytidine (3500 mg/kg) resulted in severe hypothermia of 6-10 degrees C in mice." | 7.67 | Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites. ( Lankelma, J; Laurensse, EJ; Leyva, A; Peters, GJ; Pinedo, HM; van Groeningen, CJ, 1987) |
| "Aspirin has also been shown to inhibit cell proliferation in human tumor cell lines and to induce apoptosis in colonic mucosa of familial polyposis patients." | 5.30 | Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma Caco-2 cells. ( Acquaviva, AM; Apicella, A; Di Popolo, A; Memoli, A; Pignata, S; Ricchi, P; Zarrilli, R, 1997) |
| " However, we recently reviewed rectal biopsies from 152 subjects (43 controls, 84 with adenomas, 25 resected for colon cancer) processed for in vitro 3H-thymidine autoradiography, and attempted to correlate various proliferative parameters with clinical and pathological variables by means of multiple regression analysis." | 4.79 | Reliability of rectal epithelial kinetic patterns as an intermediate biomarker of colon cancer. ( Anti, M; Armelao, F; Gasbarrini, G; Marra, G; Percesepe, A, 1994) |
| "Leptin is a growth factor in colonic epithelial cells and one that may provide a biological explanation for the observed associations between obesity, physical activity, and colon cancer." | 3.71 | Leptin is a growth factor for colonic epithelial cells. ( Hardwick, JC; Offerhaus, GJ; Peppelenbosch, MP; Van Den Brink, GR; Van Deventer, SJ, 2001) |
| "Spheroids of the human adenocarcinoma cell line SW 707 were incubated in media containing 14C-FDG, 3H-methionine or 3H-thymidine for 1 hr at 1, 4, 8, 24 and 48 hr after exposure to a single radiation dose of 6 Gy together with control spheroids." | 3.70 | Tumor cell spheroids as a model for evaluation of metabolic changes after irradiation. ( Heiss, P; Mattes, J; Matzen, K; Schwaiger, M; Senekowitsch-Schmidtke, R; Truckenbrodt, R, 1998) |
| "The activity of a novel thymidylate synthase inhibitor, 1843U89, against WiDr human colon carcinoma multicellular tumor spheroids was investigated." | 3.69 | Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89 at physiological thymidine concentrations. ( Banks, SD; Barrett, LL; Dickerson, S; Pendergast, W; Smith, GK; Waters, KA, 1994) |
| "The metabolism of 5-fluorouracil (5-FU) was monitored non-invasively in two xenografts, a hypopharynx carcinoma and a colon carcinoma (CSM) by 19F-magnetic resonance spectroscopy following an i." | 3.69 | 5-Fluorouracil metabolism and cytotoxicity after pre-treatment with methotrexate or thymidine in human hypopharynx and colon carcinoma xenografts: a 19F-nuclear magnetic resonance spectroscopy study in vivo. ( Baumgart, F; Köpf-Maier, P; Tausch-Treml, R; Ziessow, D, 1996) |
| "In an in vitro study, the effect of ciprofloxacin was examined on proliferation of HT-29 human colon carcinoma cell line." | 3.69 | In vitro effect of ciprofloxacin on HT-29 human colon carcinoma cell line: assessment of cell proliferation by thymidine uptake and silver nucleolar organizer regions (AgNOR) histomorphometry. ( Dayan, D; Nyska, A; Rabau, M, 1995) |
| " In contrast to PNA, ABL (25 micrograms/ml) inhibited incorporation of [3H]-thymidine into DNA of HT29 colon cancer cells by 87% (95% confidence limit, 85-89%), Caco-2 colon cancer cells by 16% (95% confidence limit, 12-20%), MCF-7 breast cancer cells by 50% (95% confidence limit, 47-52%), and Rama-27 rat mammary fibroblasts by 55% (95% confidence limit, 51-60%) when these cells were grown for 24 h in serum-free medium." | 3.68 | Reversible inhibition of proliferation of epithelial cell lines by Agaricus bisporus (edible mushroom) lectin. ( Fernig, DG; Milton, JD; Rhodes, JM; Smith, JA; Yu, L, 1993) |
| "A human colon adenocarcinoma cell line (GC3TK-) was selected for thymidine kinase (TK) deficiency from cloned parental cells (GC3C1) by exposure to 5-bromodeoxyuridine (BrdUrd)." | 3.68 | Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency. ( Germain, G; Houghton, JA; Houghton, PJ; Pennington, J; Radparvar, S; Rahman, A, 1990) |
| "Exposure to dehydroepiandrosterone caused a concentration-dependent accumulation of HT-29 human colonic adenocarcinoma cells in S-phase and sensitization toward the cytotoxic effects of fluorouracil deoxyriboside but not 5-fluorouracil." | 3.68 | Biochemical modulation of 5-fluoropyrimidine toxicity by dehydroepiandrosterone in human colonic adenocarcinoma cells. ( Holbrook, CT; Klann, RC; Nyce, J, 1990) |
| "In order to determine the contribution of thymidine (dThd) salvage to intrinsic resistance to antimetabolites (5-fluoropyrimidines, antifolates) in the human colon adenocarcinoma xenograft, H X GC3, a subline deficient in thymidine kinase has been developed." | 3.67 | Development and characterization of a human colon adenocarcinoma xenograft deficient in thymidine salvage. ( Germain, G; Houghton, JA; Houghton, PJ; Torrance, PM, 1987) |
| "Administration of high-dose uridine or cytidine (3500 mg/kg) resulted in severe hypothermia of 6-10 degrees C in mice." | 3.67 | Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites. ( Lankelma, J; Laurensse, EJ; Leyva, A; Peters, GJ; Pinedo, HM; van Groeningen, CJ, 1987) |
| "The incidence of in vitro tetraploidy during logarithmic growth in dermal fibroblast monolayer cultures from normals without a family cancer history and affected with heritable colon cancer syndromes, familial polyposis coli (FPC) and the Gardner syndrome (GS) was assayed by (1) examination of metaphase preparations for percentage of tetraploids (4N nuclei); (2) determination of [3H]thymidine incorporation (average cpm/cell); and (3) measurement by flow cytophotometry of the percentage of cells with greater than 4C DNA content." | 3.67 | Detection of in vitro tetraploidy in heritable colon cancer syndromes. Confirmation by three different assays. ( Danes, BS; Deschner, EE, 1984) |
| " Explants of X56, an adenocarcinoma of colon, and HXG2, an amelanotic melanoma, both maintained by serial transplantation in athymic mice, were sequentially incubated in vitro with 14C-thymidine, one of several concentrations of adriamycin, and then 3H-thymidine." | 3.67 | Adriamycin response of two human tumor xenografts using a double-radiolabel organ culture method. ( Sullivan, JL; Sullivan, LG, 1989) |
| "Twenty-seven patients with colorectal adenocarcinoma, (12) non-small cell bronchogenic carcinoma, (11) gastric adenocarcinoma (3), and adenocarcinoma of unknown primary lesion (1) were treated with the combination of thymidine (TdR), 5-fluorouracil (FU), and N-phosphonacetyl-L-aspartic acid (PALA)." | 3.67 | Sequential administration of thymidine, 5-fluorouracil, and PALA. A phase I-II study. ( Bedikian, A; Benvenuto, JA; Bodey, GP; Chiuten, DF; Freireich, EJ; Loo, TL; Miller, A; Valdivieso, M, 1985) |
| " 5-Hydroxymethyldeoxyuridine, a thymidine analog, was preferentially cytotoxic for two lines of human colon adenocarcinoma cells compared to a cell line derived from normal human fetal intestine." | 3.67 | [The selective toxicity of 5-hydroxymethyldeoxyuridine for the cells of human adenocarcinoma of the large intestine]. ( Lockshin, A; Meshcherikova, VV, 1989) |
| "Twenty-eight patients with advanced adenocarcinoma were treated with a combination of thymidine, 5-FU, and PALA." | 3.67 | Phase I-II clinical trial of thymidine, 5-FU, and PALA given in combination. ( Bedikian, A; Bodey, GP; Chiuten, DF; Freireich, EJ; Valdivieso, M, 1985) |
| "The chemotherapeutic activity of thymidine (dThd) was tested against four human tumor xenografts growing in nude mice, including a melanoma, an oat cell carcinoma of the lung, a colon carcinoma, and a breast carcinoma." | 3.66 | Activity of thymidine as a chemotherapeutic agent against human tumor xenografts in nude mice. ( Howell, SB; Jenkins, RS; Streifel, J, 1979) |
| "Tritiated thymidine incorporation by peripheral human lymphocytes stimulated with phytohemagglutinin (PHA) was investigated in 18 colorectal carcinoma patients (seven with localized tumor and 11 with metastatic tumors)." | 3.65 | Phytohemagglutinin-stimulated immune response. Assay in colorectal carcinoma patients. ( Kaplan, MS; Kummerfeld, KB; Lundak, RL; Mino, FO, 1975) |
| "Two rats with chemically induced transplantable adenocarcinomas of the colon were given pulses of [3H]thymidine, and autoradiography with electron microscopes was used to compare the degrees of differentiation of the stem cells of the tumor and colon." | 3.65 | Ultrastructural comparison of differentiation of stem cells of murine adenocarcinomas of colon and breast with their normal counterparts. ( Martinez-Hernandez, A; Nakane, PK; Pierce, GB; Ward, JM, 1977) |
| "Subjects at high risk for colon cancer received different doses of fish oil on a 30-day randomized double-blind trial to evaluate the chemopreventive effect of n-3 fatty acids against colorectal cancer." | 2.67 | n-3 PUFA and alpha-tocopherol control of tumor cell proliferation. ( Anti, M; Armelao, F; Bartoli, GM; Franceschelli, P; Luberto, C; Marra, G; Palozza, P; Piccioni, E; Sgarlata, E, 1993) |
| "Deoxyuridine monophosphate levels were greatly increased when cells were exposed to 5-FU alone, and were even larger with the addition of dipyridamole." | 2.38 | Biochemical modulation of fluorouracil by dipyridamole: preclinical and clinical experience. ( Grem, JL, 1992) |
| " A model established on the gene dosage effect, which likely results of these chromosome imbalances, may be proposed: (1) increase of thymidine kinase activity (chromosome 17q) and thus of the salvage pathway of thymidine synthesis (2) decrease of thymidine de novo pathways by decreased of thymidylate synthase (chromosome 18) and of dihydrofolate reductase (chromosome 5q) and thus accumulation of 2'-deoxyuridine-5'-P, which saves 2'-deoxycytidine 5'-P (3) decrease of cytidylate (or uridylate) kinase (chromosome 1p) and thus accumulation of 2-deoxycytidine-5-PP and of uridine-5-P (UMP) decreasing the metabolisation of orotidine-5'-P, precursor of 2-deoxycytidine-5-PP, which (4) saves -D-5-ribosyl-PP (PRPP) or even conversion of orotidine-5'-P in PRPP." | 2.37 | Induction of increased salvage pathways of nucleotide synthesis by dosage effect due to chromosome imbalances may be fundamental in carcinogenesis: the example of colorectal carcinoma. ( Dutrillaux, B; Muleris, M, 1986) |
| "For patients with right colon cancer (10/35), mixed type EMT was in the majority, while epithelial type EMT was the main subgroup in patients with left colon cancer (25/35)." | 1.56 | Correlation Research of Thymidine Synthase Expression in Circulating Tumor Cell and Clinical Characteristics of Colon Cancer. ( Ji, X; Jiang, Y; Li, Y; Liu, K; Shi, Y; Zhao, R, 2020) |
| "Colon cancer is the third leading cause of cancer-related deaths worldwide." | 1.36 | The effects of arsenic trioxide on DNA synthesis and genotoxicity in human colon cancer cells. ( Graham, B; Rogers, C; Stevens, JJ; Tchounwou, PB; Walker, AM, 2010) |
| "The blockade of 5-LOX inhibits colon cancer cell proliferation both in vitro and in vivo and may prove a beneficial chemopreventive therapy in colon cancer." | 1.35 | Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. ( Adrian, TA; Bell, RH; Bentrem, DJ; Ding, XZ; Kennedy, TJ; Melstrom, LG; Rao, SM; Salabat, MR; Strouch, M; Talamonti, MS; Ternent, CA; Witt, RC, 2008) |
| "A panel of colon cancer cell lines was assayed for response to camptothecin-thymidine combinations by measuring colony formation, cell cycle distribution, and senescence." | 1.35 | Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11. ( Cox, A; Hansen, LT; Helleday, T; Meuth, M; Phear, G; Rodriguez, R; Scorah, J; Spang-Thomsen, M, 2008) |
| "Juvenile Batten disease is a neurodegenerative disease caused by accelerated apoptotic death of photoreceptors and neurons attributable to defects in the CLN3 gene." | 1.31 | The CLN3 gene is a novel molecular target for cancer drug discovery. ( Amalfitano, A; Boustany, RM; Chang, J; Guo, WX; Jansen, PJ; Persaud-Sawin, DA; Proia, AD; Rylova, SN, 2002) |
| "Magnolol was not cytotoxic at these concentrations and this indicates that it may have an inhibitory effect on cell proliferation in the subcultured cancer cell lines." | 1.31 | Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis. ( Chang, HC; Lee, WS; Lin, CH; Lin, SY; Liu, JD; Yeh, SD, 2002) |
| "[3H]Thymidine labeling was differentially stimulated by short chain fatty acids in both cell types and greater DNA synthesis rates were observed in malignant colonocytes (P < 0." | 1.31 | Short chain fatty acids differentially modulate cellular phenotype and c-myc protein levels in primary human nonmalignant and malignant colonocytes. ( Basson, MD; Emenaker, NJ, 2001) |
| "Forty-three human colon cancers were obtained from surgical resection and maintained under organotypical culture conditions for 48 h." | 1.31 | Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions. ( Bigg, DC; Bronckart, Y; Chaboteaux, C; da Costa, PM; Decaestecker, C; Gordover, L; Harper, L; Kiss, R; Lavergne, O; Lesueur-Ginot, L; Malonne, H; Philippart, P, 2000) |
| " The objective of the present study was to assess the pharmacokinetic profile of (N)-MCT in C57BL/6 mice bearing nontransduced MC38 and MC38/HSV-tk tumors." | 1.31 | Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene. ( Agbaria, R; Ben-Zvi, Z; Candotti, F; Elezra, M; Ford, H; Johns, DG; Marquez, VE; Morris, JC; Noy, R, 2002) |
| "Aspirin has also been shown to inhibit cell proliferation in human tumor cell lines and to induce apoptosis in colonic mucosa of familial polyposis patients." | 1.30 | Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma Caco-2 cells. ( Acquaviva, AM; Apicella, A; Di Popolo, A; Memoli, A; Pignata, S; Ricchi, P; Zarrilli, R, 1997) |
| "The number of colonies of hepatic metastasis correlated well with the area under the curve of the distributed amount of the tumor cells in the liver, regardless of the injection route; the correlation line was identical for each injection route." | 1.30 | Importance of hepatic first-pass removal in metastasis of colon carcinoma cells. ( Irimura, T; Izumi, Y; Kato, Y; Mizuno, N; Sugiyama, Y, 1998) |
| "The methionine uptake was found to increase shortly after therapy." | 1.29 | Application of alpha-aminoisobutyric acid, L-methionine, thymidine and 2-fluoro-2-deoxy-D-glucose to monitor effects of chemotherapy in a human colon carcinoma cell line. ( Berger, MR; Haberkorn, U; Morr, I; Oberdorfer, F; Schaider, H; van Kaick, G, 1996) |
| "JAK3 mRNA was neither detected in colon cancer cells nor did IL-4 treatment cause phosphorylation of JAK3." | 1.29 | Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells. ( Murata, T; Noguchi, PD; Puri, RK, 1995) |
| "Mice colon cancers and colon-carcinoma cell lines are stimulated to grow by gastrin, and gastrin receptors have been found in the majority of human colon-tumor specimens." | 1.29 | Hypergastrinemia in rats with azoxymethane-induced colon cancers. ( Calderopoli, R; Contegiacomo, A; D'Adamo, G; D'Agostino, L; Daniele, B; Mazzacca, G; Pignata, S; Pizzi, C; Squame, G; Tritto, G, 1995) |
| "In 173 patients with operable gastric cancer and in 127 patients with colorectal cancer, the relations between thymidine uptake by cancer cells in semi-solid media, their clinico-pathologic features and survival times, were studied." | 1.29 | [Prediction of prognosis of patients with gastrointestinal cancer based on thymidine uptake]. ( Aotake, T; Fujii, H; Katoh, Y; Shimomatsuya, T; Tanigawa, N; Yamakawa, M, 1994) |
| "Head and neck cancers were sensitive in vitro, in decreasing order, to peplomycin, cisplatin, bleomycin, 5-fluorouracil, mitomycin C, and doxorubicin." | 1.28 | Chemosensitivity of head and neck cancer with the rapid thymidine incorporation assay and its clinical application. ( Fujieda, S; Ohtsubo, T; Saito, H; Tanigawa, N, 1992) |
| "Determined by clonogenic assay in human colon cancer HT-29 cells, the cell survivals for AZT, 10 microM, dipyridamole, 5 microM, and methotrexate (MTX), 0." | 1.28 | Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells. ( Taniki, T; Weber, G; Zhen, YS, 1992) |
| "We have compared the ability of cancer tissue to proliferate in native-state culture to the stage and histological grade of four major types of human carcinomas: breast, ovarian, colon, and lung." | 1.28 | Cancer biology for individualized therapy: correlation of growth fraction index in native-state histoculture with tumor grade and stage. ( Bordin, GM; Connors, KM; Hoffman, RM; Robb, JA; Umbreit, JN; Vescio, RA; Youngkin, T, 1990) |
| "Azidothymidine (10 microM) was synergistically cytotoxic with 5-fluorouracil (0." | 1.28 | Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells. ( Ichikawa, S; Nagai, M; Natsumeda, Y; Weber, G, 1990) |
| "When colon cancer cells were cultivated for 1 day or longer in adriamycin-containing medium no nuclear fluorescence was observed." | 1.27 | Cytofluorescence localization of adriamycin in resistant colon cancer cells. ( Caignard, A; Chauffert, B; Jeannin, JF; Leclerc, A; Martin, F, 1984) |
| "3 microM dThd was sufficient to completely protect sensitive cells from 5-fluoro-2'-deoxyuridine, and 5,8-dideazaisofolic acid at concentrations that produced over 80% lethality in unprotected cells and the same concentration of dThd in combination with 100 microM hypoxanthine fully protected sensitive cells from greater than 99% methotrexate-induced cell lethality." | 1.27 | Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine. ( Bertino, JR; Handschumacher, RE; Sobrero, AF, 1985) |
| "A phase I study of weekly iv thymidine (TdR) and 5-FU was carried out in patients with advanced colorectal carcinoma using two dosage schedules." | 1.27 | Phase I evaluation and pharmacokinetic study of weekly iv thymidine and 5-FU in patients with advanced colorectal carcinoma. ( Chun, H; Kemeny, N; Lynch, G; Martin, D; Young, C, 1985) |
| "In HCT 116 cells, a human colon cancer cell line, the levels of thymidine (0." | 1.27 | Augmentation of methotrexate cytotoxicity in human colon cancer cells achieved through inhibition of thymidine salvage by dipyridamole. ( Fischer, PH; Pangallo, CA; Van Mouwerik, TJ; Willson, JK, 1987) |
| "Both normal and colonic cancer cells, when cultured in the presence of these agents, cease to increase their cell numbers." | 1.26 | Antiproliferative agents and differential survival between normal and cancer cells. ( Kwong, LK; Tsuboi, KK, 1978) |
| "Screening for colon cancer is discussed with a selective diagnostic approach and with emphasis on this approach in early diagnosis of asymptomatic high risk patients." | 1.26 | Efforts in cancer diagnosis: national task forces--large bowel cancer. ( Copeland, MM, 1976) |
| "Suspensions of desquamated colonic cancer cells were obtained from patients with cancer of the large bowel by colonic exfoliative cytology and from resected specimens of colonic cancer by an exfoliative technique." | 1.26 | Cell viability studies on the exfoliated colonic cancer cell. ( Giles, GR; Rosenberg, IL; Russell, CW, 1978) |
| "More precise definition of the cytokinetic parameters of human tumor growth will clearly help both in predicting the outcome of disease in individual patients and in planning the dosage schedules of single chemotherapeutic agents and combinations of agents to achieve optimal results." | 1.25 | Growth kinetics of solid tumors. Implications for chemotherapy. ( Curby, WA; Rosenoer, VM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 115 (52.75) | 18.7374 |
| 1990's | 71 (32.57) | 18.2507 |
| 2000's | 27 (12.39) | 29.6817 |
| 2010's | 4 (1.83) | 24.3611 |
| 2020's | 1 (0.46) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, Y | 1 |
| Liu, K | 1 |
| Shi, Y | 1 |
| Li, Y | 1 |
| Ji, X | 1 |
| Zhao, R | 1 |
| Gustafsson, SB | 1 |
| Lindgren, T | 1 |
| Jonsson, M | 1 |
| Jacobsson, SO | 1 |
| Rodriguez, R | 2 |
| Hansen, LT | 1 |
| Phear, G | 2 |
| Scorah, J | 2 |
| Spang-Thomsen, M | 1 |
| Cox, A | 1 |
| Helleday, T | 1 |
| Meuth, M | 2 |
| Melstrom, LG | 1 |
| Bentrem, DJ | 1 |
| Salabat, MR | 1 |
| Kennedy, TJ | 1 |
| Ding, XZ | 1 |
| Strouch, M | 1 |
| Rao, SM | 1 |
| Witt, RC | 1 |
| Ternent, CA | 1 |
| Talamonti, MS | 1 |
| Bell, RH | 1 |
| Adrian, TA | 1 |
| Stevens, JJ | 1 |
| Graham, B | 1 |
| Walker, AM | 1 |
| Tchounwou, PB | 1 |
| Rogers, C | 1 |
| Chadha, VD | 1 |
| Dhawan, DK | 1 |
| Moroz, MA | 1 |
| Kochetkov, T | 1 |
| Cai, S | 1 |
| Wu, J | 1 |
| Shamis, M | 1 |
| Nair, J | 1 |
| de Stanchina, E | 1 |
| Serganova, I | 1 |
| Schwartz, GK | 1 |
| Banerjee, D | 1 |
| Bertino, JR | 3 |
| Blasberg, RG | 1 |
| Golubovskaya, VM | 1 |
| Palma, NL | 1 |
| Zheng, M | 1 |
| Ho, B | 1 |
| Magis, A | 1 |
| Ostrov, D | 1 |
| Cance, WG | 1 |
| López-Conejo, MT | 1 |
| Olmo, N | 1 |
| Turnay, J | 1 |
| López De Silanes, I | 1 |
| Lizarbe, MA | 1 |
| Noy, R | 1 |
| Ben-Zvi, Z | 1 |
| Elezra, M | 1 |
| Candotti, F | 1 |
| Ford, H | 1 |
| Morris, JC | 1 |
| Marquez, VE | 1 |
| Johns, DG | 1 |
| Agbaria, R | 1 |
| de Bruin, M | 1 |
| Smid, K | 3 |
| Laan, AC | 1 |
| Noordhuis, P | 2 |
| Fukushima, M | 1 |
| Hoekman, K | 1 |
| Pinedo, HM | 4 |
| Peters, GJ | 5 |
| COLE, JW | 1 |
| MCKALEN, A | 1 |
| Saleem, A | 1 |
| Dutta, J | 1 |
| Malegaonkar, D | 1 |
| Rasheed, F | 1 |
| Rasheed, Z | 1 |
| Rajendra, R | 1 |
| Marshall, H | 1 |
| Luo, M | 1 |
| Li, H | 1 |
| Rubin, EH | 1 |
| Teng, MW | 1 |
| Kershaw, MH | 1 |
| Moeller, M | 1 |
| Smyth, MJ | 1 |
| Darcy, PK | 1 |
| Parasassi, T | 1 |
| Brunelli, R | 1 |
| Bracci-Laudiero, L | 1 |
| Greco, G | 1 |
| Gustafsson, AC | 1 |
| Krasnowska, EK | 1 |
| Lundeberg, J | 1 |
| Lundeberg, T | 1 |
| Pittaluga, E | 1 |
| Romano, MC | 1 |
| Serafino, A | 1 |
| Liu, ES | 1 |
| Shin, VY | 2 |
| Ye, YN | 2 |
| Luo, JC | 1 |
| Wu, WK | 2 |
| Cho, CH | 2 |
| Yau, K | 1 |
| Price, P | 2 |
| Pillai, RG | 1 |
| Aboagye, E | 1 |
| Singh, R | 1 |
| Fouladi-Nashta, AA | 1 |
| Li, D | 1 |
| Halliday, N | 1 |
| Barrett, DA | 1 |
| Sinclair, KD | 1 |
| Styers, TJ | 1 |
| Kekec, A | 1 |
| Brown, JD | 1 |
| Cajica, J | 1 |
| Pan, PS | 1 |
| Parry, E | 1 |
| Carroll, CL | 1 |
| Medina, I | 1 |
| Corral, R | 1 |
| Lapera, S | 1 |
| Otrubova, K | 1 |
| Pan, CM | 1 |
| McGuire, KL | 1 |
| McAlpine, SR | 1 |
| Barbour, KW | 1 |
| Berger, FG | 1 |
| Wen, Q | 1 |
| Rodgers, G | 1 |
| Rodgers, S | 1 |
| Deschner, EE | 7 |
| Nakamura, S | 1 |
| Kino, I | 1 |
| Baba, S | 1 |
| Gabbert, H | 1 |
| Wagner, R | 1 |
| Höhn, P | 1 |
| Benz, C | 1 |
| Choti, M | 1 |
| Newcomer, L | 1 |
| Cadman, E | 1 |
| Au, JL | 1 |
| Rustum, YM | 8 |
| Ledesma, EJ | 1 |
| Mittelman, A | 3 |
| Creaven, PJ | 2 |
| Trotter, GA | 2 |
| Morgan, GR | 2 |
| Goeting, N | 1 |
| Cooper, AJ | 2 |
| Taylor, I | 2 |
| Alpers, DH | 1 |
| Philpott, G | 1 |
| Grimme, NL | 1 |
| Margolis, DM | 1 |
| Mattern, MR | 1 |
| Paone, RF | 1 |
| Day, RS | 1 |
| Martin, F | 2 |
| Caignard, A | 2 |
| Jeannin, JF | 2 |
| Leclerc, A | 2 |
| Martin, M | 1 |
| Danes, BS | 1 |
| Sternberg, A | 1 |
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6 reviews available for thymidine and Colonic Neoplasms
| Article | Year |
|---|---|
Treatment of cultured human colon carcinoma cells with fluorinated pyrimidines.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Culture Media; Drug Evaluation, Preclinical; Fluorourac | 1980 |
Reliability of rectal epithelial kinetic patterns as an intermediate biomarker of colon cancer.
Topics: Adenoma; Anticarcinogenic Agents; Autoradiography; Biomarkers, Tumor; Cell Division; Colonic Neoplas | 1994 |
Intermediate biomarkers of increased risk for colorectal cancer: comparison of different methods of analysis and modifications by chemopreventive interventions.
Topics: Anticarcinogenic Agents; Biomarkers; Biomarkers, Tumor; Cell Cycle; Cell Division; Colonic Neoplasms | 1992 |
Biochemical modulation of fluorouracil by dipyridamole: preclinical and clinical experience.
Topics: Colonic Neoplasms; Deoxyuridine; Dipyridamole; DNA Damage; DNA, Neoplasm; Drug Interactions; Fluorou | 1992 |
[Ki-67 antigen, a cell cycle and tumor growth marker].
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Flow Cytometry; G1 Phase; Human | 1991 |
Induction of increased salvage pathways of nucleotide synthesis by dosage effect due to chromosome imbalances may be fundamental in carcinogenesis: the example of colorectal carcinoma.
Topics: Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, 1-3; Chromosomes, Human, 16-18; Chr | 1986 |
5 trials available for thymidine and Colonic Neoplasms
| Article | Year |
|---|---|
Current studies of methotrexate and 5-fluorouracil and their interaction in human tumor cells.
Topics: Animals; Cells, Cultured; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug The | 1983 |
n-3 PUFA and alpha-tocopherol control of tumor cell proliferation.
Topics: Adenomatous Polyposis Coli; Autoradiography; Cell Division; Colonic Neoplasms; Colorectal Neoplasms; | 1993 |
Phase I study of thymidine plus 5-fluorouracil infusions in advanced colorectal carcinoma.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Female; Flu | 1979 |
A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Drug Evaluat | 1985 |
Tumor cytotoxicity. Quantitative changes in DNA synthesis as an indicator.
Topics: Animals; Antineoplastic Agents; Autoradiography; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Clinica | 1966 |
207 other studies available for thymidine and Colonic Neoplasms
| Article | Year |
|---|---|
Correlation Research of Thymidine Synthase Expression in Circulating Tumor Cell and Clinical Characteristics of Colon Cancer.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; China; Colonic Neoplasms; Epithelial Cells; Epith | 2020 |
Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antioxidants; Cannabinoid Receptor Antagonists; Can | 2009 |
Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Colonic Neo | 2008 |
Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model.
Topics: Adenoma; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Cell Proliferation; Colonic Neoplasms; Col | 2008 |
The effects of arsenic trioxide on DNA synthesis and genotoxicity in human colon cancer cells.
Topics: Arsenic Trioxide; Arsenicals; Colonic Neoplasms; Comet Assay; DNA Damage; DNA Replication; HT29 Cell | 2010 |
Ultrastructural changes in rat colon following 1,2-dimethylhydrazine-induced colon carcinogenesis: protection by zinc.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Glucose; Male; Rats; Rats, Sprague-Dawley; | 2010 |
Imaging colon cancer response following treatment with AZD1152: a preclinical analysis of [18F]fluoro-2-deoxyglucose and 3'-deoxy-3'-[18F]fluorothymidine imaging.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Dideoxynucleosides; Fluorine Ra | 2011 |
A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Coloni | 2013 |
Interaction of fibronectin with human colon adenocarcinoma cells: effect on the in vivo tumorigenic capacity.
Topics: Adenocarcinoma; Alkaline Phosphatase; Animals; Antigens, CD; Cell Adhesion; Colonic Neoplasms; Fibro | 2002 |
Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Colo | 2002 |
Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells.
Topics: Cell Line; Colonic Neoplasms; Humans; Kinetics; Purine-Nucleoside Phosphorylase; Ribosemonophosphate | 2003 |
STUDIES ON THE MORPHOGENESIS OF ADENOMATOUS POLYPS IN THE HUMAN COLON.
Topics: Adenomatous Polyps; Autoradiography; Colonic Neoplasms; Humans; Morphogenesis; Polyps; Thymidine; Tr | 1963 |
The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor.
Topics: Adenocarcinoma; Carrier Proteins; Cell Cycle; Cell Division; Colon; Colonic Neoplasms; CpG Islands; | 2004 |
Immunotherapy of cancer using systemically delivered gene-modified human T lymphocytes.
Topics: Animals; Carcinoma; Cell Proliferation; Colonic Neoplasms; Cytokines; Fluoresceins; Humans; Immunoth | 2004 |
Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms.
Topics: Acetylcysteine; beta Catenin; Cadherins; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiatio | 2005 |
Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract.
Topics: Animals; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Complex Mixt | 2005 |
A mechanistic study of colon cancer growth promoted by cigarette smoke extract.
Topics: Antibodies; Arachidonate 5-Lipoxygenase; Benzoquinones; Cell Line; Cell Line, Tumor; Cell Proliferat | 2005 |
Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase inhibitors.
Topics: Adenocarcinoma; Biological Transport, Active; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Ne | 2006 |
Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation.
Topics: Adenocarcinoma; Adenosine; Alkaline Phosphatase; Antimetabolites, Antineoplastic; Cell Differentiati | 2006 |
Synthesis of Sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29.
Topics: Amino Acids; Antineoplastic Agents; Colonic Neoplasms; Depsipeptides; HT29 Cells; Humans; Inhibitory | 2006 |
Cell death in response to antimetabolites directed at thymidylate synthase.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bl | 2008 |
A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.
Topics: Acid Anhydride Hydrolases; Alleles; Amino Acid Sequence; Ataxia Telangiectasia Mutated Proteins; Bas | 2008 |
Observations on the Paneth cell in human ileum.
Topics: Autoradiography; Colonic Neoplasms; Humans; Ileostomy; Ileum; Intestinal Mucosa; Male; Middle Aged; | 1967 |
Ex vivo autoradiography of the human gastrointestinal tract: a new approach to cell kinetic studies of surgically removed tumor-bearing organs.
Topics: Adult; Autoradiography; Cell Division; Colonic Neoplasms; Digestive System Physiological Phenomena; | 1983 |
The relation between tumor cell proliferation and vascularization in differentiated and undifferentiated colon carcinomas in the rat.
Topics: Animals; Autoradiography; Cell Division; Colonic Neoplasms; Mitotic Index; Neoplasms, Experimental; | 1982 |
Thymidine enhancement of methotrexate and 5-fluorouracil toxicity in cultured human colon carcinoma.
Topics: Cells, Cultured; Colonic Neoplasms; Drug Interactions; Flow Cytometry; Fluorouracil; Humans; Kinetic | 1984 |
Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.
Topics: Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Infusions, Parenter | 1982 |
Prognostic factors and in vitro cytotoxic sensitivity in colorectal cancer.
Topics: Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Colonic Neoplasms; Floxuridine | 1984 |
Control of thymidine incorporation in mucosal explants from patients with chronic ulcerative colitis.
Topics: Cell Transformation, Neoplastic; Colitis, Ulcerative; Colon; Colonic Neoplasms; Cyclic AMP; DNA; Hum | 1980 |
Eukaryotic DNA repair is blocked at different steps by inhibitors of DNA topoisomerases and of DNA polymerases alpha and beta.
Topics: Cell Line; Colonic Neoplasms; Cytarabine; Dideoxynucleosides; DNA Polymerase I; DNA Polymerase II; D | 1982 |
Selection by trypsin of two sublines of rat colon cancer cells forming progressive or regressive tumors.
Topics: Animals; Cell Line; Cell Separation; Colonic Neoplasms; Cytological Techniques; Mice; Mice, Nude; Ne | 1983 |
Detection of in vitro tetraploidy in heritable colon cancer syndromes. Confirmation by three different assays.
Topics: Cells, Cultured; Colonic Neoplasms; Colonic Polyps; DNA, Neoplasm; Flow Cytometry; Gardner Syndrome; | 1984 |
A combination of 5-fluorouracil and thymidine in advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Colonic Neoplasms; Drug Sy | 1984 |
Clinical trial of sequential N-phosphonacetyl-L-aspartate, thymidine, and 5-fluorouracil in advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Ataxia; Colonic Neoplasm | 1984 |
Cell cycle parameters and prognosis of colorectal cancer.
Topics: Aged; Colonic Neoplasms; Female; Humans; Interphase; Male; Middle Aged; Mitosis; Prognosis; Rectal N | 1984 |
Chemotherapeutic efficacy of 5-fluorouracil with concurrent thymidine infusion against transplantable colon tumors in rodents.
Topics: Animals; Colonic Neoplasms; Drug Therapy, Combination; Female; Fluorouracil; Male; Mice; Mice, Inbre | 1984 |
Cell proliferation in gastrointestinal carcinogenesis.
Topics: Animals; Autoradiography; Cell Division; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; | 1984 |
Cytofluorescence localization of adriamycin in resistant colon cancer cells.
Topics: Animals; Biological Transport, Active; Cell Line; Cell Nucleus; Cell Survival; Colonic Neoplasms; Cy | 1984 |
Classification and risk assessment of individuals with familial polyposis, Gardner's syndrome, and familial non-polyposis colon cancer from [3H]thymidine labeling patterns in colonic epithelial cells.
Topics: Colonic Neoplasms; Colonic Polyps; DNA Replication; Gardner Syndrome; Humans; Risk; Thymidine; Triti | 1984 |
Tritiated thymidine (phi p, phi h) labeling distribution as a marker for hereditary predisposition to colon cancer.
Topics: Adolescent; Adult; Aged; Child; Clinical Laboratory Techniques; Colon; Colonic Neoplasms; Epithelium | 1983 |
Relationship of colonic mucosal background to neoplastic proliferative activity in dimethylhydrazine-treated mice.
Topics: 1,2-Dimethylhydrazine; Animals; Bacterial Vaccines; Cell Division; Citrobacter; Colonic Neoplasms; D | 1981 |
Alkaline phosphatase in HT-29, a human colon cancer cell line: influence of sodium butyrate and hyperosmolality.
Topics: Alkaline Phosphatase; Butyrates; Cell Line; Colonic Neoplasms; Cycloheximide; Enzyme Induction; Huma | 1981 |
Potentiation of the anti-tumor activity of 5FU by thymidine and its correlation with the formation of (5FU)RNA.
Topics: Animals; Colonic Neoplasms; DNA, Neoplasm; Drug Synergism; Drug Therapy, Combination; Fluorouracil; | 1980 |
Combination clinical trials with thymidine and fluorouracil: a phase I and clinical pharmacologic evaluation.
Topics: Adult; Aged; Bone Marrow; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Female; Flu | 1980 |
Effect of thymidine on the toxicity, antitumor activity, and metabolism of 1-beta-D-arabinofuranosylcytosine in rats bearing a chemically induced colon carcinoma.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Biotransformation; Colonic Neoplasms; Cytarabine; De | 1980 |
The cell population kinetics and response to an S-phase specific agent of three transplantable colon tumor lines.
Topics: Adenocarcinoma; Animals; Carcinoma; Cell Cycle; Cell Division; Colonic Neoplasms; Cytarabine; Mice; | 1980 |
Hypergastrinemia in rats with azoxymethane-induced colon cancers.
Topics: Animals; Azoxymethane; Cell Division; Colonic Neoplasms; Gastrins; Male; Ornithine Decarboxylase; Ra | 1995 |
Interleukin 1 modulates growth of human renal carcinoma cells in vitro.
Topics: Carcinoma, Renal Cell; Cell Division; Cell Line; Colonic Neoplasms; Culture Media; Humans; Interleuk | 1995 |
Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil.
Topics: Cell Division; Cell Line; Colonic Neoplasms; DNA, Neoplasm; Drug Resistance; Fluorouracil; Gene Ampl | 1995 |
Antibiotic C3368-A, a fungus-derived nucleoside transport inhibitor, potentiates the activity of antitumor drugs.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzofurans; Biological Transport; Carc | 1995 |
The effect of extracellular calcium on colonocytes: evidence for differential responsiveness based upon degree of cell differentiation.
Topics: Alkaline Phosphatase; Calcium; Carcinoembryonic Antigen; Cell Cycle; Cell Differentiation; Cell Divi | 1995 |
Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells.
Topics: Biotransformation; Cell Division; Colonic Neoplasms; DNA, Neoplasm; Drug Synergism; Fluorouracil; Hu | 1994 |
SMS 201.995 (Sandostatin) enhances in-vitro effects of 5-fluorouracil in colorectal cancer.
Topics: Adenocarcinoma; Carcinoma; Colonic Neoplasms; Colorimetry; Drug Synergism; Fluorouracil; Humans; Oct | 1995 |
Aberrant cell cycle inhibition pattern in human colon carcinoma cell lines after exposure to 5-fluorouracil.
Topics: Cell Cycle; Colonic Neoplasms; DNA; Drug Interactions; Fluorouracil; Humans; Leucovorin; S Phase; Th | 1995 |
Dependence of 5-fluorouracil-mediated radiosensitization on DNA-directed effects.
Topics: Cell Cycle; Colonic Neoplasms; DNA; Fluorouracil; Humans; Radiation-Sensitizing Agents; Thymidine; T | 1994 |
Reduced insulin receptor expression and function in human colonic Caco-2 cells by ras and polyoma middle T oncogenes.
Topics: Antigens, Polyomavirus Transforming; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Ce | 1994 |
Cell cycle control processes determine cytostasis or cytotoxicity in thymineless death of colon cancer cells.
Topics: Adenocarcinoma; Apoptosis; Cell Cycle; Cell Survival; Colonic Neoplasms; G1 Phase; Humans; Leucine; | 1994 |
Correlation between [3H]thymidine and proliferating cell nuclear antigen (PCNA)/cyclin indices in archival, formaldehyde-fixed human colorectal tissues.
Topics: Adenocarcinoma; Antigens, Neoplasm; Colonic Neoplasms; Humans; Immunohistochemistry; In Vitro Techni | 1993 |
[Prediction of prognosis of patients with gastrointestinal cancer based on thymidine uptake].
Topics: Aged; Colonic Neoplasms; Female; Humans; Male; Middle Aged; Multivariate Analysis; Prognosis; Propor | 1994 |
Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89 at physiological thymidine concentrations.
Topics: Antineoplastic Agents; Carcinoma; Cell Division; Colonic Neoplasms; Humans; Indoles; Isoindoles; Met | 1994 |
(R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]- bis[5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione] dimethanesulfonate (DMP 840), a novel bis-naphthalimide with potent nonselective tumoricidal activity in vitro.
Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Division; Clinical Trials, Phase I as Topic; Colonic | 1994 |
Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells.
Topics: Acyltransferases; Antineoplastic Agents; Cell Division; Cell Survival; Colonic Neoplasms; Folic Acid | 1993 |
Reversible inhibition of proliferation of epithelial cell lines by Agaricus bisporus (edible mushroom) lectin.
Topics: Adenocarcinoma; Adult; Agaricus; Aged; Animals; Arachis; Binding Sites; Breast Neoplasms; Carbohydra | 1993 |
Colonic epithelial proliferation indices before and after colon cancer removal.
Topics: Adult; Aged; Aged, 80 and over; Cell Division; Colonic Diseases; Colonic Neoplasms; Epithelium; Fema | 1993 |
5-Fluorouracil metabolism and cytotoxicity after pre-treatment with methotrexate or thymidine in human hypopharynx and colon carcinoma xenografts: a 19F-nuclear magnetic resonance spectroscopy study in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma; Colonic Neoplasms; Fluorine Radioisotopes; Fluo | 1996 |
Receptors for interleukin (IL)-4 do not associate with the common gamma chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells.
Topics: Antigens, CD; Cell Line; Colonic Neoplasms; DNA Replication; Humans; Interleukin-4; Iodine Radioisot | 1995 |
Application of alpha-aminoisobutyric acid, L-methionine, thymidine and 2-fluoro-2-deoxy-D-glucose to monitor effects of chemotherapy in a human colon carcinoma cell line.
Topics: Aminoisobutyric Acids; Antineoplastic Agents; Carbon Radioisotopes; Colonic Neoplasms; Deoxyglucose; | 1996 |
Mechanisms for the involvement of DNA methylation in colon carcinogenesis.
Topics: Base Sequence; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytosine; DNA; DNA (Cytosine-5-)- | 1996 |
Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta.
Topics: Animals; Base Sequence; Carrier Proteins; Cell Division; Colonic Neoplasms; Culture Media, Serum-Fre | 1996 |
Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells.
Topics: Alleles; Apoptosis; Base Sequence; bcl-2-Associated X Protein; Codon; Colonic Neoplasms; Cyclin-Depe | 1996 |
In vitro effect of ciprofloxacin on HT-29 human colon carcinoma cell line: assessment of cell proliferation by thymidine uptake and silver nucleolar organizer regions (AgNOR) histomorphometry.
Topics: Carcinoma; Cell Division; Cell Survival; Ciprofloxacin; Colonic Neoplasms; Humans; Nucleolus Organiz | 1995 |
The intrinsic radiosensitivity of some human tumor cells throughout their cell cycles.
Topics: Cell Cycle; Cell Division; Cell Survival; Cesium Radioisotopes; Colonic Neoplasms; DNA, Neoplasm; Do | 1997 |
TPA induces transglutaminase C and inhibits cell growth in the colon carcinoma cell line SW620.
Topics: Apoptosis; Cell Division; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Activation; En | 1997 |
Glutathione conjugation of chlorambucil: measurement and modulation by plant polyphenols.
Topics: Antineoplastic Agents, Alkylating; Cell Division; Cell Survival; Chlorambucil; Chromatography, High | 1997 |
Short-chain fatty acids promote the migration of colonic epithelial cells in vitro.
Topics: Animals; Caco-2 Cells; Carbon Radioisotopes; Cell Division; Cell Movement; Colonic Neoplasms; Cycloh | 1997 |
Differential effects of deoxycholic acid on proliferation of neoplastic and differentiated colonocytes in vitro.
Topics: Blotting, Western; Cell Division; Colon; Colonic Neoplasms; Deoxycholic Acid; Humans; Isoenzymes; Pr | 1997 |
Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma Caco-2 cells.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apolipoprotein A-I; Apoptosis; Aspirin; Blo | 1997 |
5-Fluorouracil-resistant colonic tumors are highly responsive to sodium butyrate/interleukin-2 bitherapy in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Butyrates; | 1997 |
Differential effects of somatostatin analogues on proliferation of murine colonic cancer cells in vitro.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Cell Division; | 1997 |
Parametric image reconstruction using spectral analysis of PET projection data.
Topics: Algorithms; Astrocytoma; Biophysical Phenomena; Biophysics; Brain Neoplasms; Carbon Radioisotopes; C | 1998 |
Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluorouracil.
Topics: Animals; Biological Availability; Biotransformation; Colonic Neoplasms; Dihydrouracil Dehydrogenase | 1998 |
Importance of hepatic first-pass removal in metastasis of colon carcinoma cells.
Topics: Animals; Cell Line; Colonic Neoplasms; Humans; Kinetics; Liver Neoplasms; Male; Mathematics; Mice; M | 1998 |
Mechanism of initial distribution of blood-borne colon carcinoma cells in the liver.
Topics: Animals; Colonic Neoplasms; Humans; Injections, Intravenous; Liposomes; Macrophages; Male; Microsphe | 1998 |
Tumor cell spheroids as a model for evaluation of metabolic changes after irradiation.
Topics: Adenocarcinoma; Carbon Radioisotopes; Colonic Neoplasms; Deoxyglucose; Humans; In Vitro Techniques; | 1998 |
Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells.
Topics: Apoptosis; Cell Division; Cell Survival; Colonic Neoplasms; Fas Ligand Protein; Gene Expression Regu | 1998 |
Dietary determinants of colorectal proliferation in the normal mucosa of subjects with previous colon adenomas.
Topics: Adenomatous Polyps; Adult; Aged; Animals; Antioxidants; beta Carotene; Biopsy; Cell Division; Colon; | 1999 |
The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Bromouracil; Carrier Proteins; Cell Survival; Colonic Neoplasm | 1999 |
Lactoferrin inhibits G1 cyclin-dependent kinases during growth arrest of human breast carcinoma cells.
Topics: Breast Neoplasms; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Division; Colonic Neopla | 1999 |
Radiolabeled thymidine: a sensitive tracer for early tumor response and recurrence after irradiation.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Colonic Neoplasms; Humans; Mice; Mice, Nude; Neoplas | 1999 |
Isolation and characterization of a thymidylate synthase-deficient human colon tumor cell line.
Topics: Catalysis; Cell Separation; Colonic Neoplasms; Genetic Complementation Test; Humans; Mutation, Misse | 1999 |
Interleukin-4 mediates cell growth inhibition through activation of Stat1.
Topics: Animals; Burkitt Lymphoma; Cell Division; Colonic Neoplasms; DNA-Binding Proteins; Humans; Interleuk | 2000 |
Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions.
Topics: Antineoplastic Agents; Biopsy; Camptothecin; Cell Division; Colon; Colonic Neoplasms; Culture Techni | 2000 |
An antibody for macrophage migration inhibitory factor suppresses tumour growth and inhibits tumour-associated angiogenesis.
Topics: Adenocarcinoma; Animals; Antibodies, Monoclonal; Cells, Cultured; Colonic Neoplasms; Endothelium, Va | 2000 |
Anti-metastatic effect of the sialyl Lewis-X analog GSC-150 on the human colon carcinoma derived cell line KM12-HX in the mouse.
Topics: Animals; Antineoplastic Agents; Cell Adhesion; Cell Line; Colonic Neoplasms; Glycosphingolipids; Hum | 2001 |
Short chain fatty acids differentially modulate cellular phenotype and c-myc protein levels in primary human nonmalignant and malignant colonocytes.
Topics: Aged; Alkaline Phosphatase; Butyrates; Cell Separation; Cell Survival; Cells, Cultured; Colon; Colon | 2001 |
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Rela | 2001 |
Thymidine incorporation is highly predictive of colony formation and can be used for high-throughput screening.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Survival; Chickens; CHO Cells; Colonic Neoplasms | 2001 |
Leptin is a growth factor for colonic epithelial cells.
Topics: Adenocarcinoma; Animals; Bromodeoxyuridine; Carrier Proteins; Colonic Neoplasms; Epithelium; Female; | 2001 |
Serum factors attenuating the anti-tumor activity of 5-fluorouracil.
Topics: Antimetabolites, Antineoplastic; Colonic Neoplasms; Cytokines; DNA, Neoplasm; Drug Interactions; Dru | 2001 |
Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Calcium; Cell Cycle; Cell Cycle Pr | 2002 |
The CLN3 gene is a novel molecular target for cancer drug discovery.
Topics: Adenoviridae; Animals; Apoptosis; Ceramides; Colonic Neoplasms; DNA, Antisense; Gene Expression Regu | 2002 |
Selectivity of action of 5-FU: biochemical basis.
Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans | 1979 |
Ultrastructure of 1,2-dimethylhydrazine-induced adenocarcinomas in rat colon.
Topics: Adenocarcinoma; Animals; Cell Cycle; Cell Differentiation; Cell Membrane; Cell Nucleus; Colonic Neop | 1978 |
Effects of cyanate, thiocyanate, and amygdalin on metabolite uptake in normal and neoplastic tissues of the rat.
Topics: Amino Acids; Amygdalin; Animals; Colonic Neoplasms; Cyanates; Liver Neoplasms, Experimental; Male; N | 1979 |
Activity of thymidine as a chemotherapeutic agent against human tumor xenografts in nude mice.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Breast Neoplasms; Colonic Neoplasms; Humans; Lung Neopl | 1979 |
Evaluation of cytotoxic agents in human colonic tumor xenografts and mouse gastrointestinal tissues using a 3H-thymidine fractional incorporation assay.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Digestive System; Drug Evaluation, Preclinical; D | 1979 |
Cell viability studies on the exfoliated colonic cancer cell.
Topics: Cell Separation; Cell Survival; Colonic Neoplasms; Esterases; Humans; Neoplasm Seeding; Thymidine; T | 1978 |
Antiproliferative agents and differential survival between normal and cancer cells.
Topics: Adenocarcinoma; Aspartic Acid; Cell Cycle; Cell Division; Cell Line; Cell Survival; Colonic Neoplasm | 1978 |
In vitro responsiveness of human gastric carcinoma to pentagastrin.
Topics: Breast Neoplasms; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Female; Humans; In Vitro Techni | 1977 |
Tritiated thymidine incorporation into epithelial cells of normal-appearing colorectal mucosa of cancer patients.
Topics: Adult; Aged; Cell Division; Colon; Colonic Neoplasms; DNA; Epithelial Cells; Epithelium; Female; Hum | 1977 |
Ultrastructural comparison of differentiation of stem cells of murine adenocarcinomas of colon and breast with their normal counterparts.
Topics: Adenocarcinoma; Animals; Cell Differentiation; Colon; Colonic Neoplasms; Epithelial Cells; Epitheliu | 1977 |
Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; DNA, Neoplasm; Mice; Neoplasm Transplantation; Ne | 1977 |
Human colonic tumor cell kinetics: potential for therapy.
Topics: Adenocarcinoma; Adenoma; Cell Cycle; Cells, Cultured; Colonic Neoplasms; DNA; DNA-Directed DNA Polym | 1977 |
Efforts in cancer diagnosis: national task forces--large bowel cancer.
Topics: Adult; Antilymphocyte Serum; Bile Acids and Salts; Carcinoembryonic Antigen; Chondro-4-Sulfatase; Co | 1976 |
The significance of nonspecific injury for colon carcinogenesis in rats.
Topics: Animals; Cecal Neoplasms; Cecum; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Foreign-Body | 1975 |
Growth kinetics of solid tumors. Implications for chemotherapy.
Topics: Acute Disease; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Cul | 1975 |
The detection of aberrant DNA synthesis in a member of a high-risk cancer family.
Topics: Adult; Autoradiography; Barium Sulfate; Biopsy; Cell Division; Colon; Colonic Neoplasms; DNA; Epithe | 1975 |
Phytohemagglutinin-stimulated immune response. Assay in colorectal carcinoma patients.
Topics: Adult; Aged; Carcinoma; Colonic Neoplasms; Humans; Immunity, Cellular; Lectins; Lymphocytes; Middle | 1975 |
Chemosensitivity of head and neck cancer with the rapid thymidine incorporation assay and its clinical application.
Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Child; Cisplatin; Colonic Neopl | 1992 |
Sodium butyrate stimulates polyamine biosynthesis in colon cancer cells.
Topics: Animals; Biogenic Polyamines; Biological Transport; Butyrates; Butyric Acid; Colonic Neoplasms; Dose | 1992 |
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Topics: Animals; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Leucovo | 1992 |
Stimulation of 5-fluorouracil metabolic activation by interferon-alpha in human colon carcinoma cells.
Topics: Adenosine; Biotransformation; Cell Line; Colonic Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Int | 1992 |
Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells.
Topics: beta Carotene; Breast Neoplasms; Carotenoids; Cell Division; Cell Line; Colonic Neoplasms; DNA, Neop | 1992 |
Interaction of legume lectins with the cellular metabolism of differentiated Caco-2 cells.
Topics: Colonic Neoplasms; Fucose; Glucosamine; Humans; Lectins; Microvilli; Phytohemagglutinins; Plant Lect | 1992 |
Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells.
Topics: Adenocarcinoma; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; DNA Replic | 1992 |
Linear-quadratic analysis of radiosensitization by halogenated pyrimidines. I. Radiosensitization of human colon cancer cells by iododeoxyuridine.
Topics: Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Radiation; Humans; Idoxuridine; In Vit | 1992 |
Linear-quadratic analysis of radiosensitization by halogenated pyrimidines. II. Radiosensitization of human colon cancer cells by bromodeoxyuridine.
Topics: Bromodeoxyuridine; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Radiation; Humans; | 1992 |
IGF-I and IGF-I receptor in mouse colon cancer cells.
Topics: Animals; Autoradiography; Binding, Competitive; Cell Division; Cell Line; Colonic Neoplasms; DNA Rep | 1991 |
Comparative DNA strand breakage induced by FUra and FdUrd in human ileocecal adenocarcinoma (HCT-8) cells: relevance to cell growth inhibition.
Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; DNA; DNA Damage; Dose-Response Relationship, Drug; | 1991 |
Diffusion and binding of monoclonal antibody TNT-1 in multicellular tumor spheroids.
Topics: Adenocarcinoma; Antibodies, Monoclonal; Autoradiography; Binding Sites, Antibody; Cell Division; Col | 1991 |
Isolation and characterization of normal and neoplastic colonic epithelial cell populations.
Topics: Animals; Cells, Cultured; Colon; Colonic Neoplasms; Dimethylhydrazines; Epithelium; In Vitro Techniq | 1991 |
The proliferative and morphologic responses of a colon carcinoma cell line (LIM 1215) require the production of two autocrine factors.
Topics: Actins; Amino Acid Sequence; Antisense Elements (Genetics); Base Sequence; Blotting, Western; Cell D | 1991 |
Biochemical modulation of 5-fluoropyrimidine toxicity by dehydroepiandrosterone in human colonic adenocarcinoma cells.
Topics: Adenocarcinoma; Carbon Radioisotopes; Colonic Neoplasms; Dehydroepiandrosterone; Fluorouracil; Human | 1990 |
Cancer biology for individualized therapy: correlation of growth fraction index in native-state histoculture with tumor grade and stage.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Division; Colonic Neoplasms; DNA Replication; Female; Humans; L | 1990 |
Growth-promoting effects of gastrin on mouse colon cancer cells in vitro: absence of autocrine effects.
Topics: Animals; Antibodies; Benzamides; Cell Cycle; Cell Division; Colonic Neoplasms; Gastrins; Growth Subs | 1990 |
Normal human colon cells suppress malignancy when fused with colon cancer cells.
Topics: Animals; Cell Communication; Cell Fusion; Cells, Cultured; Colon; Colonic Neoplasms; DNA; Humans; Im | 1990 |
Incorporation of iododeoxyuridine into neoplastic DNA: a fraudulent magic bullet?
Topics: Cell Survival; Colonic Neoplasms; DNA, Neoplasm; Humans; Idoxuridine; Liver; Liver Neoplasms; Thymid | 1990 |
Effect of 5-fluorouracil combination therapy on RNA processing in human colonic carcinoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Nucleolus; Cell Survival; Colonic Neoplasms; Fl | 1990 |
Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency.
Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; Cytosol; Fluorouracil; Humans; Kinetics; Thymidine | 1990 |
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
Topics: Animals; Cell Line; Cell Survival; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Kinetics | 1990 |
Vanadate supplements and 1,2-dimethylhydrazine induced colon cancer in mice: increased thymidine incorporation without enhanced carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines | 1986 |
Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.
Topics: Animals; Biotransformation; Cell Division; Colonic Neoplasms; DNA; Drug Synergism; Fluorouracil; Fol | 1987 |
Ornithine decarboxylase and diamine oxidase in human colon carcinoma cell line CaCo-2 in culture.
Topics: Amine Oxidase (Copper-Containing); Cell Line; Colonic Neoplasms; Humans; Ornithine Decarboxylase; Su | 1989 |
Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency.
Topics: Adenocarcinoma; Animals; Cell Division; Cell Line; Cell Survival; Clone Cells; Colonic Neoplasms; De | 1989 |
Early colonic dysplasia: comparison of differential mucin staining and tritiated thymidine labeling.
Topics: Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA, Neoplasm; Intestinal Mucosa; Male; Mitos | 1985 |
[The selective toxicity of 5-hydroxymethyldeoxyuridine for the cells of human adenocarcinoma of the large intestine].
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Survival; Cells, Cultured; Colonic Neoplasms; Dose-Respo | 1989 |
Adriamycin response of two human tumor xenografts using a double-radiolabel organ culture method.
Topics: Adenocarcinoma; Animals; Carbon Radioisotopes; Colonic Neoplasms; Doxorubicin; Drug Screening Assays | 1989 |
Ultraviolet irradiation produces cytotoxic synergy and increased DNA interstrand crosslinking with cis- and trans-diamminedichloroplatinum(II).
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cisplatin; Colonic Neoplasms; DNA Replicat | 1989 |
Expression of platelet-derived growth factor (PDGF)-related transcripts and synthesis of biologically active PDGF-like proteins by human malignant epithelial cell lines.
Topics: Binding, Competitive; Breast Neoplasms; Carcinoma; Cell Line; Colonic Neoplasms; Epithelium; Female; | 1988 |
Lower rates of thymidine incorporation into DNA of skin fibroblasts from patients with adenomatosis of the colon and rectum.
Topics: Acetoxyacetylaminofluorene; Adult; Child; Colonic Neoplasms; DNA; Female; Fibroblasts; Humans; Male; | 1986 |
Endogenous thymidine and hypoxanthine are a source of error in evaluating methotrexate cytotoxicity by clonogenic assays using undialyzed fetal bovine serum.
Topics: Adenocarcinoma; Animals; Cattle; Cell Adhesion; Colonic Neoplasms; Colony-Forming Units Assay; Cultu | 1986 |
Increased levels of DNA lesions induced by leucovorin-5-fluoropyrimidine in human colon adenocarcinoma.
Topics: Adenocarcinoma; Aphidicolin; Cell Line; Cell Survival; Colonic Neoplasms; Diterpenes; DNA; DNA Damag | 1988 |
Cellular growth modulation. I. Effects of extracellular matrix and tumor cell conditioned medium.
Topics: Adenomatous Polyposis Coli; Animals; Carcinoembryonic Antigen; Cell Division; Cell Line; Cell Transf | 1986 |
[The effect of UFT on thymidine kinase and thymidylate synthetase activities and autoradiograph in DMH-induced colon cancer in rat].
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Autoradiography; Col | 1987 |
Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Cell Line; Col | 1985 |
Rate of incorporation of radiolabelled nucleosides does not necessarily reflect the metabolic state of cells in culture: effects of latent mycoplasma contamination.
Topics: Cell Line; Colonic Neoplasms; Humans; Lung Neoplasms; Mycoplasma Infections; Pyrimidine Nucleosides; | 1988 |
Cellular proliferation in proximal and distal rat colon during 1,2-dimethylhydrazine-induced carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Autoradiography; Carcinogens; Cell Division; Colonic | 1988 |
Proliferative and metastatic potential of exfoliated colorectal cancer cells.
Topics: Animals; Autoradiography; Cell Division; Colonic Neoplasms; Female; Humans; Lung Neoplasms; Mice; Mi | 1986 |
Augmentation of methotrexate cytotoxicity in human colon cancer cells achieved through inhibition of thymidine salvage by dipyridamole.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Drug Synergism; Guanine; Humans; Hypoxant | 1987 |
Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites.
Topics: Animals; Body Temperature; Brain; Colonic Neoplasms; Cytidine; Cytidine Deaminase; Dose-Response Rel | 1987 |
Tritiated-thymidine labeling of rectal epithelial cells in 'non-prep' biopsies of individuals at increased risk for colonic neoplasia.
Topics: Aged; Biopsy; Cell Division; Colonic Neoplasms; Epithelium; Female; Humans; Male; Middle Aged; Rectu | 1987 |
Refeeding of fasting rats stimulates DNA synthesis in implanted colon carcinoma.
Topics: Adenocarcinoma; Animals; Colon; Colonic Neoplasms; DNA, Neoplasm; Fasting; Food; Gastrointestinal Ho | 1986 |
Modulation of fluorouracil metabolism and cytotoxicity by nitrothiobenzylinosine.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Fluorouracil; Humans; Inosine; Thioinosine; Thymidine | 1986 |
Development and characterization of a human colon adenocarcinoma xenograft deficient in thymidine salvage.
Topics: Adenocarcinoma; Animals; Carcinoembryonic Antigen; Colonic Neoplasms; Fluorouracil; Humans; Isoenzym | 1987 |
Selective modulation of 5-fluorouracil action in patients with colorectal carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Humans; Ki | 1985 |
Enhancement of growth factor-induced DNA synthesis by colon tumor-promoting bile acids in Swiss 3T3 cells. Their different mode of action from that of phorbol esters.
Topics: Animals; Bile Acids and Salts; Carcinogens; Cell Line; Colonic Neoplasms; Deoxycholic Acid; DNA; Fib | 1985 |
Phase I evaluation and pharmacokinetic study of weekly iv thymidine and 5-FU in patients with advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration | 1985 |
Cell kinetics and in vitro clonogenicity of primary colorectal cancer: clinicopathological relationships and the implications for chemotherapy.
Topics: Adenocarcinoma; Cells, Cultured; Clone Cells; Colonic Neoplasms; Humans; Kinetics; Neoplasm Staging; | 1985 |
Assay for the determination of human carcinoma cells in circulating blood.
Topics: Adult; Aged; Carcinoma; Carcinoma, Squamous Cell; Cell Line; Centrifugation, Density Gradient; Colon | 1985 |
Potential for selective enhancement of the in vivo metabolism of 1-beta-D-arabinofuranosylcytosine in rats by thymidine pretreatment.
Topics: Animals; Biotransformation; Colonic Neoplasms; Cytarabine; Deoxycytosine Nucleotides; Drug Therapy, | 1985 |
Growth kinetics of human colorectal carcinoma.
Topics: Adenocarcinoma; Colonic Neoplasms; Humans; Kinetics; Rectal Neoplasms; Thymidine; Tritium | 1985 |
Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). II. Biomarker studies.
Topics: Colon; Colonic Neoplasms; Cytogenetics; Fibroblasts; Genetic Carrier Screening; Genetic Linkage; Gen | 1985 |
Phase I-II clinical trial of thymidine, 5-FU, and PALA given in combination.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic | 1985 |
Mixed function oxidase activities of established human colon carcinoma cell lines in the activation of cyclophosphamide.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Cell Line; Cell Survival; Colonic Neoplasms; Cyclo | 1985 |
Evidence for a growth-stimulating fraction in the rat proximal intestine after small bowel resection.
Topics: Adaptation, Physiological; Animals; Autoradiography; Cell Division; Colonic Neoplasms; DNA; Fibrobla | 1985 |
The synergistic lethal interaction of cis-diamminedichloroplatinum and natural nucleosides is related to increased DNA cross-links.
Topics: Adenosine; Carcinoma; Cell Line; Cell Survival; Cisplatin; Colonic Neoplasms; Cytidine; DNA; Drug Sy | 1985 |
Sequential administration of thymidine, 5-fluorouracil, and PALA. A phase I-II study.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Carcinom | 1985 |
[Estimation of tumor sensitivity in vitro. II. Studies with the solid Ehrlich carcinoma of the mouse and the GW 77, a heterotransplanted human carcinoma].
Topics: Animals; Antibiotics, Antineoplastic; Autoradiography; Carcinoma; Carcinoma, Ehrlich Tumor; Colonic | 1970 |
Inhibition of DNA polymerases and neoplastic cells by selected SH inhibitors.
Topics: Animals; Antineoplastic Agents; Arsenicals; Benzoates; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Ch | 1972 |
Stimulation of cells by antibody.
Topics: Animals; Antibodies, Neoplasm; Carcinoma; Cell Line; Colonic Neoplasms; Cross Reactions; DNA, Neopla | 1973 |
Morphological and autoradiographical investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice.
Topics: Adenocarcinoma; Animals; Autoradiography; Colonic Neoplasms; Duodenum; Female; Ileum; Intestinal Neo | 1973 |
Phase I and II studies of 2'-deoxy-5-(trifluoromethyl)-uridine (NSC-75520).
Topics: Blood Cell Count; Bone Marrow; Breast Neoplasms; Colonic Neoplasms; Deoxyuridine; Female; Floxuridin | 1971 |
Lymphocyte stimulation by phytohemagglutinin and tumor cells of malignant effusions.
Topics: Antigens, Neoplasm; Ascitic Fluid; Breast Neoplasms; Cells, Cultured; Colonic Neoplasms; Female; Hum | 1974 |
DNA replication and degradation in mammalian tissues. V. A series of slow-growing rat renal tumors and a variety of human cancers.
Topics: Adenocarcinoma; Adenocarcinoma, Scirrhous; Animals; Breast Neoplasms; Carcinoma, Hepatocellular; Col | 1969 |
The colonic pericryptal fibroblast sheath: replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. 3. Replication and differentiation in human hyperplastic and adenomatous polyps.
Topics: Autoradiography; Cell Differentiation; Cell Division; Collagen; Colon; Colonic Neoplasms; Endoplasmi | 1971 |
Activation of host lymphocytes cultured with cancer cells treated with neuraminidase.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; Culture Tec | 1971 |
Biochemical approaches to prediction of response in solid tumors.
Topics: Adenocarcinoma; Antineoplastic Agents; Carbon Isotopes; Carcinoma, Hepatocellular; Carcinoma, Squamo | 1971 |
Proliferative changes in the colon.
Topics: Animals; Cell Division; Colon; Colonic Neoplasms; DNA; Epithelial Cells; Epithelium; Growth Disorder | 1974 |
Antigen solubilized from human solid tumours: lymphocyte stimulation and cutaneous delayed hypersensitivity.
Topics: Antigens, Neoplasm; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Female; Hodgkin Disease; Humans; | 1973 |
Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine.
Topics: Adenocarcinoma; Animals; Antigens, Neoplasm; Autoradiography; Body Weight; Carbon Isotopes; Colonic | 1973 |
Lymphocyte transformation in large bowel cancer.
Topics: Adenocarcinoma; Adult; Aged; Carbon Isotopes; Colonic Neoplasms; Hemolysis; Humans; Intestinal Neopl | 1973 |
Phytohaemagglutinin-induced lymphocyte transformation in patients before and after resection of large intestinal cancer.
Topics: Anus Neoplasms; Colonic Neoplasms; Humans; Intestinal Neoplasms; Intestine, Large; Lectins; Lymphocy | 1973 |
Disturbance of cell-mediated immunity in patients with carcinoma of colon and rectum.
Topics: Adenocarcinoma; Adult; Aged; Autoradiography; Colonic Neoplasms; DNA; Female; Humans; Immunity, Cell | 1973 |
Cell proliferation in colonic mucosa and carcinoma of the colon.
Topics: Animals; Colon; Colonic Neoplasms; Disease Models, Animal; DNA; Humans; Intestinal Mucosa; Intestina | 1973 |
Pathogenesis of hyperplastic polyps of the colon: a hypothesis based on ultrastructure and in vitro cell kinetics.
Topics: Autoradiography; Cell Count; Cells, Cultured; Colon; Colonic Neoplasms; Epithelium; Humans; Intestin | 1974 |
Recent concepts in the development of colon cancer.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Diet; DNA, Neoplasm; Envir | 1974 |
Experimentally induced cancer of the colon.
Topics: Animals; Autoradiography; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Female; Hydrazines; | 1974 |
Persistence of gastrointestinal-specific antigens in primary culture of human colon epithelium.
Topics: Adult; Antigens; Autoantibodies; Autoradiography; Colitis, Ulcerative; Colon; Colonic Neoplasms; Cul | 1968 |
Response of DNA thymine synthesis in human tumor and normal tissue to 5-fluorouracil.
Topics: Breast Neoplasms; Carbon Isotopes; Chromatography, Paper; Colon; Colonic Neoplasms; Depression, Chem | 1972 |
Studies concerning the regional lymph node in cancer. 3. Response of regional lymph node cells from breast and colon cancer patients to PHA stimulation.
Topics: Adolescent; Adult; Aged; Breast Diseases; Breast Neoplasms; Cells, Cultured; Colonic Neoplasms; Fema | 1972 |
Analysis of the cell kinetics of human solid tumors.
Topics: Adult; Aged; Biopsy; Bone Neoplasms; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Colo | 1971 |
Cytotoxic penetration and concentration in human malignant tumours.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Female; Fluorouracil; Humans; Injections | 1969 |
A physiological study of isolated human tumours.
Topics: Adenocarcinoma; Adhesiveness; Autoradiography; Colonic Neoplasms; DNA, Neoplasm; Humans; Intestinal | 1970 |
Access of drugs to tumours of the large intestine.
Topics: Autoradiography; Colonic Neoplasms; Humans; Mustard Compounds; Perfusion; Rectal Neoplasms; Sulfur I | 1970 |
Nucleic acid metabolism in proliferating and differentiating colonic cells of man and in neoplastic lesions of the colon.
Topics: Autoradiography; Cell Differentiation; Cell Division; Colon; Colonic Neoplasms; DNA; Glucosyltransfe | 1971 |
In vitro uptake of tritiated thymidine by carcinoma of the human colon.
Topics: Adenocarcinoma; Autoradiography; Colonic Neoplasms; DNA, Neoplasm; Humans; In Vitro Techniques; Thym | 1966 |
[Remarks on the morphogenesis and evolution of adenomatous polyps of the colon on the basis of the histoautoradiographic study of the in vitro uptake of tritiated thymidine. Preliminary studies].
Topics: Autoradiography; Colonic Neoplasms; Cystadenoma; Humans; Thymidine; Tritium | 1966 |